Gene Symbol | Pnpt1 |
Entrez Gene ID | 71701 |
Full Name | polyribonucleotide nucleotidyltransferase 1 |
Synonyms | 1200003F12Rik,Old35,PNPase,Pnptl1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Pnpt1 cDNA ORF clone
Gene Symbol | Pnpt1 |
Entrez Gene ID | 71701 |
Full Name | polyribonucleotide nucleotidyltransferase 1 |
Synonyms | 1200003F12Rik,Old35,PNPase,Pnptl1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006514813.3 | XP_006514876.1 | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X2 |
XM_006514813.4 | XP_006514876.1 | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X3 |
NM_027869.1 | NP_082145.1 | polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor |
NM_027869.2 | NP_082145.1 | polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor |
XM_011243751.2 | XP_011242053.1 | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 |
XM_011243751.3 | XP_011242053.1 | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 |
XM_030246330.1 | XP_030102190.1 | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X2 |
Canis lupus familiaris (dog) | PNPT1 | XP_538497.3 |
Bos taurus (cattle) | PNPT1 | NP_001179126.1 |
Drosophila melanogaster (fruit fly) | CG11337 | NP_001097990.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010791 | XP_318517.3 |
Homo sapiens (human) | PNPT1 | NP_149100.2 |
PNPT1 | XP_001112421.1 | |
Danio rerio (zebrafish) | pnpt1 | NP_001238761.1 |
Gallus gallus (chicken) | PNPT1 | XP_419282.4 |
Caenorhabditis elegans (roundworm) | BE0003N10.1 | NP_497324.3 |
Xenopus tropicalis (tropical clawed frog) | pnpt1 | NP_001017033.1 |
Pan troglodytes (chimpanzee) | PNPT1 | XP_515490.2 |
Mus musculus (house mouse) | Pnpt1 | NP_082145.1 |
Rattus norvegicus (Norway rat) | Pnpt1 | NP_001135843.1 |
Arabidopsis thaliana (thale cress) | AT5G14580 | NP_196962.1 |
Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase).
Shepherd DL, Hathaway QA, Pinti MV, Nichols CE, Durr AJ, Sreekumar S, Hughes KM, Stine SM, Martinez I, Hollander JM
Journal of molecular and cellular cardiology11015-25(2017 Sep)
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, Pogoda HM, N?rnberg G, Stiller B, Volk AE, Borck G, Hong JS, Goodyear RJ, Abidi O, N?rnberg P, Hofmann K, Richardson GP, Hammerschmidt M, Moser T, Wollnik B, Koehler CM, Teitell MA, Barakat A, Kubisch C
American journal of human genetics91(5)919-27(2012 Nov)
Correcting human mitochondrial mutations with targeted RNA import.
Wang G, Shimada E, Zhang J, Hong JS, Smith GM, Teitell MA, Koehler CM
Proceedings of the National Academy of Sciences of the United States of America109(13)4840-5(2012 Mar)
PNPASE regulates RNA import into mitochondria.
Wang G, Chen HW, Oktay Y, Zhang J, Allen EL, Smith GM, Fan KC, Hong JS, French SW, McCaffery JM, Lightowlers RN, Morse HC 3rd, Koehler CM, Teitell MA
Cell142(3)456-67(2010 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The data support an unanticipated role for PNPASE in mediating the translocation of RNAs into mitochondria
Title: PNPASE regulates RNA import into mitochondria.
The following Pnpt1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pnpt1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu45273 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514813.3 , XM_006514813.4 | |
Accession Version | XM_006514813.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006514813.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAAAC TCTATGCGGT TTTTACAGAT TATGAACATG ATAAAGTTTC CAGGGATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514876.1 |
CDS | 44..1522 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514813.3 |
1 | ATGGAGAAAC TCTATGCGGT TTTTACAGAT TATGAACATG ATAAAGTTTC CAGGGATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu45273 | |
Clone ID Related Accession (Same CDS sequence) | XM_006514813.3 , XM_006514813.4 | |
Accession Version | XM_006514813.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006514813.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAAAC TCTATGCGGT TTTTACAGAT TATGAACATG ATAAAGTTTC CAGGGATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514876.1 |
CDS | 946..2424 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006514813.4 |
1 | ATGGAGAAAC TCTATGCGGT TTTTACAGAT TATGAACATG ATAAAGTTTC CAGGGATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14519 | |
Clone ID Related Accession (Same CDS sequence) | NM_027869.1 , NM_027869.2 , XM_011243751.2 , XM_011243751.3 | |
Accession Version | NM_027869.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-28 | |
Organism | Mus musculus(house mouse) | |
Product | polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ507387.1. On or before Dec 1, 2013 this sequence version replaced XM_003689261.1, XM_918710.1, XM_918722.1, XM_918738.1, XM_918754.1, XM_918766.1, XM_918777.1, XM_904295.1. ##Evidence-Data-START## Transcript exon combination :: AJ507387.1, AK144151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_082145.1 |
CDS | 8..2359 |
Translation |
Target ORF information:
Target ORF information:
|
NM_027869.1 |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14519 | |
Clone ID Related Accession (Same CDS sequence) | NM_027869.1 , NM_027869.2 , XM_011243751.2 , XM_011243751.3 | |
Accession Version | NM_027869.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-25 | |
Organism | Mus musculus(house mouse) | |
Product | polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX000351.17, AK149419.1 and BG092250.1. On Jul 4, 2018 this sequence version replaced NM_027869.1. ##Evidence-Data-START## Transcript exon combination :: AJ507387.1, AK149419.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849384 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_082145.1 |
CDS | 15..2366 |
Translation |
Target ORF information:
Target ORF information:
|
NM_027869.2 |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14519 | |
Clone ID Related Accession (Same CDS sequence) | NM_027869.1 , NM_027869.2 , XM_011243751.2 , XM_011243751.3 | |
Accession Version | XM_011243751.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011243751.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011242053.1 |
CDS | 207..2558 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011243751.2 |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu14519 | |
Clone ID Related Accession (Same CDS sequence) | NM_027869.1 , NM_027869.2 , XM_011243751.2 , XM_011243751.3 | |
Accession Version | XM_011243751.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2352bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011243751.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011242053.1 |
CDS | 310..2661 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011243751.3 |
1 | ATGGCGGCCT GCAGGCTGTG CTGCTTGTGC CCGTGCCTCC GACCGCTGGG CTGCGGCCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu85910 | |
Clone ID Related Accession (Same CDS sequence) | XM_030246330.1 | |
Accession Version | XM_030246330.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1512bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACAAAG CTCCAGTTCC TCTAAGAATT GCCATGGAGA AACTCTATGC GGTTTTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030102190.1 |
CDS | 891..2402 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030246330.1 |
1 | ATGGACAAAG CTCCAGTTCC TCTAAGAATT GCCATGGAGA AACTCTATGC GGTTTTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Exploring the mitochondrial microRNA import pathway through Polynucleotide Phosphorylase (PNPase). |
A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss. |
Correcting human mitochondrial mutations with targeted RNA import. |
PNPASE regulates RNA import into mitochondria. |