Hes1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hes1
Entrez Gene ID	29577
Full Name	hes family bHLH transcription factor 1
General protein information	Preferred Names hes family bHLH transcription factor 1 Names transcription factor HES-1 RHL hairy and enhancer of split 1 hairy-like protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q22
Summary	may act as a transcriptional repressor; may inhibit cell adhesion molecule NCAM-dependent neurite outgrowth [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024360.3	NP_077336.3	transcription factor HES-1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	hes1	NP_001011194.1
Homo sapiens (human)	HES1	NP_005515.1
	LOC722024	XP_002803136.1
Mus musculus (house mouse)	Hes1	NP_032261.1
Rattus norvegicus (Norway rat)	Hes1	NP_077336.3
Pan troglodytes (chimpanzee)	HES1	XP_516956.1
Bos taurus (cattle)	HES1	NP_001029850.1
Danio rerio (zebrafish)	her6	NP_571154.1

Gene Ontology
Bibliography

Related articles in PubMed

Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate.
Wang SY, Ren M, Jiang HZ, Wang J, Jiang HQ, Yin X, Qi Y, Wang XD, Dong GT, Wang TH, Yang YQ, Feng HL
Neuroscience301276-88(2015 Aug)

Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-?/BMP signaling.
Zhang K, Zhang YQ, Ai WB, Hu QT, Zhang QJ, Wan LY, Wang XL, Liu CB, Wu JF
World journal of gastroenterology21(3)878-87(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Notch1 signaling appears to interact with TGF-beta/BMP signaling and co-regulates Hes1 expression in activated hepatic stellate cells.
Title: Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-?/BMP signaling.

Hes1 is upregulated and mediates cardioprotection provided by ischemic postconditioning and suggest that Hes1 is a potential new target for the treatment of ischemic cardiomyopathy.
Title: Hes1 is upregulated by ischemic postconditioning and contributes to cardioprotection.

Hes-1 may play an important role in the pathogenesis of asthma.
Title: [Relationship between Hes-1 and airway inflammation and remodeling in a rat model of asthma].

results indicate that HES1 acts as a master repressor, the silencing of which is required for proper glucocorticoid signaling.
Title: HES1 is a master regulator of glucocorticoid receptor-dependent gene expression.

The Jagged-2/Notch-1/Hes-1 signaling pathway is involved in intestinal epithelium regeneration early after I/R injury by increasing crypt epithelial cell proliferation.
Title: The jagged-2/notch-1/hes-1 pathway is involved in intestinal epithelium regeneration after intestinal ischemia-reperfusion injury.

The following Hes1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hes1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06930	NM_024360.3 Latest version!	Rattus norvegicus hes family bHLH transcription factor 1 (Hes1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hes1 ( NM_024360.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077336.3 Rattus norvegicus hes family bHLH transcription factor 1 (Hes1), mRNA.

Price & Availability↑

CloneID	ORa06930
Clone ID Related Accession (Same CDS sequence)	NM_024360.3
Accession Version	NM_024360.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 846bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor HES-1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC061730.1. On Jun 10, 2007 this sequence version replaced NM_024360.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061730.1, D13417.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCAGCTG ATATAATGGA GAAAAATTCC TCGTCCCCGG TGGCTGCTAC CCCAGCCAGT 
GTCAACACGA CACCGGACAA ACCAAAGACA GCCTCTGAGC ACAGAAAGTC ATCAAAGCCT 
ATCATGGAGA AGAGGCGCCG GGCAAGAATA AATGAAAGTT TGAGCCAACT GAAAACACTG 
ATTTTGGATG CACTTAAGAA AGATAGCTCC CGGCATTCCA AGCTGGAGAA GGCAGACATT 
CTGGAAATGA CAGTGAAGCA CCTCCGGAAC CTGCAGCGGG CGCAGATGAC CGCCGCTCTC 
AGCACAGACC CGAGCGTGTT GGGGAAGTAC CGCGCCGGCT TCAGCGAGTG CATGAACGAG 
GTGACCCGCT TCCTGTCCAC GTGTGAGGGC GTTAACACCG AGGTGCGCAC TCGGCTGCTG 
GGCCACCTGG CCAACTGCAT GACCCAGATC AACGCCATGA CCTACCCCGG GCAGGCGCAC 
CCCGCCTTGC AGGCGCCGCC GCCGCCGCCC CCGTCAGGAC CTGGCGGTCC CCAGCACGCG 
CCATTCGCGC CGCCGCCGCC GCTTGTGCCC ATCCCCGGGG GCGCGGCGCC CCCTCCCGGC 
AGCGCACCCT GCAAGTTGGG CAGCCAGGCT GGAGAGGCTG CCAAGGTTTT TGGCGGCTTC 
CAAGTGGTGC CGGCTCCTGA CGGCCAATTT GCTTTCCTCA TCCCCAATGG GGCCTTCGCC 
CACAGCGGCC CGGTCATCCC GGTCTACACC AGCAACAGCG GGACCTCGGT GGGTCCTAAC 
GCAGTGTCGC CTTCCAGCGG CTCCTCGCTC ACTGCGGACT CCATGTGGAG GCCGTGGCGG 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077336.3
CDS	202..1047
Translation	MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRPWRN

Target ORF information:

RefSeq Version	NM_024360.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hes family bHLH transcription factor 1 (Hes1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024360.3

ORF Insert Sequence:

ATGCCAGCTG ATATAATGGA GAAAAATTCC TCGTCCCCGG TGGCTGCTAC CCCAGCCAGT 
GTCAACACGA CACCGGACAA ACCAAAGACA GCCTCTGAGC ACAGAAAGTC ATCAAAGCCT 
ATCATGGAGA AGAGGCGCCG GGCAAGAATA AATGAAAGTT TGAGCCAACT GAAAACACTG 
ATTTTGGATG CACTTAAGAA AGATAGCTCC CGGCATTCCA AGCTGGAGAA GGCAGACATT 
CTGGAAATGA CAGTGAAGCA CCTCCGGAAC CTGCAGCGGG CGCAGATGAC CGCCGCTCTC 
AGCACAGACC CGAGCGTGTT GGGGAAGTAC CGCGCCGGCT TCAGCGAGTG CATGAACGAG 
GTGACCCGCT TCCTGTCCAC GTGTGAGGGC GTTAACACCG AGGTGCGCAC TCGGCTGCTG 
GGCCACCTGG CCAACTGCAT GACCCAGATC AACGCCATGA CCTACCCCGG GCAGGCGCAC 
CCCGCCTTGC AGGCGCCGCC GCCGCCGCCC CCGTCAGGAC CTGGCGGTCC CCAGCACGCG 
CCATTCGCGC CGCCGCCGCC GCTTGTGCCC ATCCCCGGGG GCGCGGCGCC CCCTCCCGGC 
AGCGCACCCT GCAAGTTGGG CAGCCAGGCT GGAGAGGCTG CCAAGGTTTT TGGCGGCTTC 
CAAGTGGTGC CGGCTCCTGA CGGCCAATTT GCTTTCCTCA TCCCCAATGG GGCCTTCGCC 
CACAGCGGCC CGGTCATCCC GGTCTACACC AGCAACAGCG GGACCTCGGT GGGTCCTAAC 
GCAGTGTCGC CTTCCAGCGG CTCCTCGCTC ACTGCGGACT CCATGTGGAG GCCGTGGCGG 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate.
Neuroscience301276-88(2015 Aug)
Wang SY,Ren M,Jiang HZ,Wang J,Jiang HQ,Yin X,Qi Y,Wang XD,Dong GT,Wang TH,Yang YQ,Feng HL

Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-?/BMP signaling.
World journal of gastroenterology21(3)878-87(2015 Jan)
Zhang K,Zhang YQ,Ai WB,Hu QT,Zhang QJ,Wan LY,Wang XL,Liu CB,Wu JF

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Hes1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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