| Gene Symbol | Dync2li1 |
| Entrez Gene ID | 298767 |
| Full Name | dynein cytoplasmic 2 light intermediate chain 1 |
| Synonyms | RGD1310286 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
gRNAs
The following Dync2li1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dync2li1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa04358 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001013940.1 | |
| Accession Version | NM_001013940.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-19 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | cytoplasmic dynein 2 light intermediate chain 1 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079201.1. On Apr 20, 2005 this sequence version replaced XM_216632.3. ##Evidence-Data-START## Transcript exon combination :: BC079201.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001013962.1 |
| CDS | 83..1018 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001013940.1 |
1 | ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa29094 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006239695.3 | |
| Accession Version | XM_006239695.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | cytoplasmic dynein 2 light intermediate chain 1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239695.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006239757.1 |
| CDS | 139..1194 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006239695.3 |
1 | ATGCCCAGTG AAACTCTCTG GGAAATCGCG AAGGCCGAGG TAGAGAAACG GAGATGCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
DYNC2LI1 mutations broaden the clinical spectrum of dynein-2 defects. |
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome. |
Recombinant human cytoplasmic dynein heavy chain 1 and 2: observation of dynein-2 motor activity in vitro. |
Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. |
A novel dynein light intermediate chain colocalizes with the retrograde motor for intraflagellar transport at sites of axoneme assembly in chlamydomonas and Mammalian cells. |
