Overview

About the GPCR downstream signaling pathway

G protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule.

The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.

975 geneClick for more »

Gene Symbol Full Name
ABR active BCR-related
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY3 adenylate cyclase 3
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADM adrenomedullin
ADORA1 adenosine A1 receptor
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA1D adrenoceptor alpha 1D
ADRA1B adrenoceptor alpha 1B
ADRA1A adrenoceptor alpha 1A
ADRA2A adrenoceptor alpha 2A
ADRA2B adrenoceptor alpha 2B
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
ADRBK1 adrenergic, beta, receptor kinase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
APLNR apelin receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANXA1 annexin A1
APP amyloid beta (A4) precursor protein
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOG ras homolog family member G
ARHGAP4 Rho GTPase activating protein 4
AVP arginine vasopressin
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
AVPR2 arginine vasopressin receptor 2
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
BDKRB1 bradykinin receptor B1
BDKRB2 bradykinin receptor B2
CXCR5 chemokine (C-X-C motif) receptor 5
BRS3 bombesin-like receptor 3
C3 complement component 3
C3AR1 complement component 3a receptor 1
C5 complement component 5
C5AR1 complement component 5a receptor 1
DAGLA diacylglycerol lipase, alpha
CALCA calcitonin-related polypeptide alpha
CALCB calcitonin-related polypeptide beta
CALCR calcitonin receptor
CASR calcium-sensing receptor
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCKBR cholecystokinin B receptor
CDC42 cell division cycle 42
CGA glycoprotein hormones, alpha polypeptide
CHRM1 cholinergic receptor, muscarinic 1
CHRM2 cholinergic receptor, muscarinic 2
CHRM3 cholinergic receptor, muscarinic 3
CHRM4 cholinergic receptor, muscarinic 4
CHRM5 cholinergic receptor, muscarinic 5
CCR1 chemokine (C-C motif) receptor 1
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
LTB4R leukotriene B4 receptor
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRHR2 corticotropin releasing hormone receptor 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DGKA diacylglycerol kinase, alpha 80kDa
DGKB diacylglycerol kinase, beta 90kDa
DGKG diacylglycerol kinase, gamma 90kDa
DGKQ diacylglycerol kinase, theta 110kDa
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
ECT2 epithelial cell transforming 2
S1PR1 sphingosine-1-phosphate receptor 1
LPAR1 lysophosphatidic acid receptor 1
S1PR3 sphingosine-1-phosphate receptor 3
EDN1 endothelin 1
EDN2 endothelin 2
EDN3 endothelin 3
EDNRA endothelin receptor type A

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