CALCB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CALCB
Entrez Gene ID	797
Full Name	calcitonin related polypeptide beta
Synonyms	CALC2,CGRP-II,CGRP2
General protein information	Preferred Names calcitonin related polypeptide beta Names calcitonin gene-related peptide 2 beta-CGRP beta-type CGRP calcitonin 2 calcitonin gene-related peptide II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11p15.2
Disorder MIM:	114160

mRNA and Protein(s)

mRNA	Protein	Name
NM_000728.4	NP_000719.1	calcitonin gene-related peptide 2 precursor
NM_000728.3	NP_000719.1	calcitonin gene-related peptide 2 precursor

Pathways from BioSystems

Homologies

	CALCB	XP_001092199.1
Mus musculus (house mouse)	Calca	NP_001029126.1
Canis lupus familiaris (dog)	CALCB	NP_001002948.1
Xenopus tropicalis (tropical clawed frog)	LOC100487527	XP_002941721.2
Pan troglodytes (chimpanzee)	CALCB	XP_003312979.1
Bos taurus (cattle)	CALCB	NP_001001149.1
Homo sapiens (human)	CALCB	NP_000719.1
Rattus norvegicus (Norway rat)	Calca	NP_001029127.1

Gene Ontology
Bibliography

Related articles in PubMed

Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.
Maruyama R, Shimizu M, Ishijima T, Nakai Y, Inoue J, Sato R
Bioscience, biotechnology, and biochemistry80(6)1149-54(2016 Jun)

Image-based genome-wide siRNA screen identifies selective autophagy factors.
Orvedahl A, Sumpter R Jr, Xiao G, Ng A, Zou Z, Tang Y, Narimatsu M, Gilpin C, Sun Q, Roth M, Forst CV, Wrana JL, Zhang YE, Luby-Phelps K, Xavier RJ, Xie Y, Levine B
Nature480(7375)113-7(2011 Dec)

Keratinocyte expression of calcitonin gene-related peptide ?: implications for neuropathic and inflammatory pain mechanisms.
Hou Q, Barr T, Gee L, Vickers J, Wymer J, Borsani E, Rodella L, Getsios S, Burdo T, Eisenberg E, Guha U, Lavker R, Kessler J, Chittur S, Fiorino D, Rice F, Albrecht P
Pain152(9)2036-51(2011 Sep)

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratac?s M, Costas J, de Cid R, Bay?s M, Gonz?lez JR, Baca-Garc?a E, de Diego Y, Fern?ndez-Aranda F, Fern?ndez-Piqueras J, Guitart M, Mart?n-Santos R, Martorell L, Mench?n JM, Roca M, S?iz-Ruiz J, Sanju?n J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A,
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(6)808-16(2009 Sep)

Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.
Kawanami Y, Morimoto Y, Kim H, Nakamura T, Machida K, Kido T, Asonuma E, Yatera K, Yoshii C, Kido M
Respiratory research108(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results suggest that C12orf39, CSTA, and CALCB are novel ATF4 target genes, and that C12orf39 promoter activity is activated by ATF4 through amino acid response element.
Title: Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.

Keratinocyte-derived CGRPbeta may modulate epidermal homeostasis through autocrine/paracrine signaling and may contribute to chronic pain under pathological conditions.
Title: Keratinocyte expression of calcitonin gene-related peptide ?: implications for neuropathic and inflammatory pain mechanisms.

Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.
Title: Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.

CGRP and ADM are two differentially regulated novel adipose tissue secretion factors exerting autocrine/paracrine roles.
Title: Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue.

The following CALCB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CALCB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02595	NM_000728.4 Latest version!	Homo sapiens calcitonin related polypeptide beta (CALCB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu02595	NM_000728.3	Homo sapiens calcitonin related polypeptide beta (CALCB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CALCB ( NM_000728.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000719.1 Homo sapiens calcitonin related polypeptide beta (CALCB), mRNA.

Price & Availability↑

CloneID	OHu02595
Clone ID Related Accession (Same CDS sequence)	NM_000728.4 , NM_000728.3
Accession Version	NM_000728.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	calcitonin gene-related peptide 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC090744.5, BI668461.1, AI937230.1 and X02404.1. On Nov 22, 2018 this sequence version replaced NM_000728.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092468.1, BI668461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000324229.11/ ENSP00000346017.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTTTCC GGAAGTTCTC CCCCTTCCTG GCTCTCAGTA TCTTGGTCCT GTACCAGGCG 
GGCAGCCTCC AGGCGGCGCC ATTCAGGTCT GCCCTGGAGA GCAGCCCAGA CCCGGCCACA 
CTCAGTAAAG AGGACGCGCG CCTCCTGCTG GCTGCACTGG TGCAGGACTA TGTGCAGATG 
AAGGCCAGTG AGCTGAAGCA GGAGCAGGAG ACACAGGGCT CCAGCTCCGC TGCCCAGAAG 
AGAGCCTGCA ACACTGCCAC CTGTGTGACT CATCGGCTGG CAGGCTTGCT GAGCAGATCA 
GGGGGCATGG TGAAGAGCAA CTTCGTGCCC ACCAATGTGG GTTCCAAAGC CTTTGGCAGG 
CGCCGCAGGG ACCTTCAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000719.1
CDS	81..464
Translation	MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA

Target ORF information:

RefSeq Version	NM_000728.4
Organism	Homo sapiens(human)
Definition	Homo sapiens calcitonin related polypeptide beta (CALCB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000728.4

ORF Insert Sequence:

ATGGGTTTCC GGAAGTTCTC CCCCTTCCTG GCTCTCAGTA TCTTGGTCCT GTACCAGGCG 
GGCAGCCTCC AGGCGGCGCC ATTCAGGTCT GCCCTGGAGA GCAGCCCAGA CCCGGCCACA 
CTCAGTAAAG AGGACGCGCG CCTCCTGCTG GCTGCACTGG TGCAGGACTA TGTGCAGATG 
AAGGCCAGTG AGCTGAAGCA GGAGCAGGAG ACACAGGGCT CCAGCTCCGC TGCCCAGAAG 
AGAGCCTGCA ACACTGCCAC CTGTGTGACT CATCGGCTGG CAGGCTTGCT GAGCAGATCA 
GGGGGCATGG TGAAGAGCAA CTTCGTGCCC ACCAATGTGG GTTCCAAAGC CTTTGGCAGG 
CGCCGCAGGG ACCTTCAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CALCB ( NM_000728.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000719.1 Homo sapiens calcitonin related polypeptide beta (CALCB), mRNA.

Price & Availability↑

CloneID	OHu02595
Clone ID Related Accession (Same CDS sequence)	NM_000728.4 , NM_000728.3
Accession Version	NM_000728.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	calcitonin gene-related peptide 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI668461.1, AI937230.1 and X02404.1. On Mar 15, 2004 this sequence version replaced NM_000728.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092468.1, BI668461.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145313 [ECO:0000348] ##Evidence-Data-END##

ATGGGTTTCC GGAAGTTCTC CCCCTTCCTG GCTCTCAGTA TCTTGGTCCT GTACCAGGCG 
GGCAGCCTCC AGGCGGCGCC ATTCAGGTCT GCCCTGGAGA GCAGCCCAGA CCCGGCCACA 
CTCAGTAAAG AGGACGCGCG CCTCCTGCTG GCTGCACTGG TGCAGGACTA TGTGCAGATG 
AAGGCCAGTG AGCTGAAGCA GGAGCAGGAG ACACAGGGCT CCAGCTCCGC TGCCCAGAAG 
AGAGCCTGCA ACACTGCCAC CTGTGTGACT CATCGGCTGG CAGGCTTGCT GAGCAGATCA 
GGGGGCATGG TGAAGAGCAA CTTCGTGCCC ACCAATGTGG GTTCCAAAGC CTTTGGCAGG 
CGCCGCAGGG ACCTTCAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000719.1
CDS	74..457
Translation	MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQMKASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGRRRRDLQA

Target ORF information:

RefSeq Version	NM_000728.3
Organism	Homo sapiens(human)
Definition	Homo sapiens calcitonin related polypeptide beta (CALCB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000728.3

ORF Insert Sequence:

ATGGGTTTCC GGAAGTTCTC CCCCTTCCTG GCTCTCAGTA TCTTGGTCCT GTACCAGGCG 
GGCAGCCTCC AGGCGGCGCC ATTCAGGTCT GCCCTGGAGA GCAGCCCAGA CCCGGCCACA 
CTCAGTAAAG AGGACGCGCG CCTCCTGCTG GCTGCACTGG TGCAGGACTA TGTGCAGATG 
AAGGCCAGTG AGCTGAAGCA GGAGCAGGAG ACACAGGGCT CCAGCTCCGC TGCCCAGAAG 
AGAGCCTGCA ACACTGCCAC CTGTGTGACT CATCGGCTGG CAGGCTTGCT GAGCAGATCA 
GGGGGCATGG TGAAGAGCAA CTTCGTGCCC ACCAATGTGG GTTCCAAAGC CTTTGGCAGG 
CGCCGCAGGG ACCTTCAAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.
Bioscience, biotechnology, and biochemistry80(6)1149-54(2016 Jun)
Maruyama R,Shimizu M,Ishijima T,Nakai Y,Inoue J,Sato R

Image-based genome-wide siRNA screen identifies selective autophagy factors.
Nature480(7375)113-7(2011 Dec)
Orvedahl A,Sumpter R Jr,Xiao G,Ng A,Zou Z,Tang Y,Narimatsu M,Gilpin C,Sun Q,Roth M,Forst CV,Wrana JL,Zhang YE,Luby-Phelps K,Xavier RJ,Xie Y,Levine B

Keratinocyte expression of calcitonin gene-related peptide ?: implications for neuropathic and inflammatory pain mechanisms.
Pain152(9)2036-51(2011 Sep)
Hou Q,Barr T,Gee L,Vickers J,Wymer J,Borsani E,Rodella L,Getsios S,Burdo T,Eisenberg E,Guha U,Lavker R,Kessler J,Chittur S,Fiorino D,Rice F,Albrecht P

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(6)808-16(2009 Sep)
Gratac?s M,Costas J,de Cid R,Bay?s M,Gonz?lez JR,Baca-Garc?a E,de Diego Y,Fern?ndez-Aranda F,Fern?ndez-Piqueras J,Guitart M,Mart?n-Santos R,Martorell L,Mench?n JM,Roca M,S?iz-Ruiz J,Sanju?n J,Torrens M,Urretavizcaya M,Valero J,Vilella E,Estivill X,Carracedo A,

Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.
Respiratory research108(2009 Feb)
Kawanami Y,Morimoto Y,Kim H,Nakamura T,Machida K,Kido T,Asonuma E,Yatera K,Yoshii C,Kido M

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CALCB cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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