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Lynx1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Lynx1
Entrez Gene ID 300018
Full Name Ly6/neurotoxin 1
General protein information
Preferred Names

Ly6/neurotoxin 1

Names

ly-6/neurotoxin-like protein 1
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

7

7q34

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017594762.1 XP_017450251.1 ly-6/neurotoxin-like protein 1 isoform X1
NM_001130546.1 NP_001124018.1 ly-6/neurotoxin-like protein 1 precursor

Pathways from BioSystems


Homologies


Bos taurus (cattle) LYNX1 NP_001039686.1
Mus musculus (house mouse) Lynx1 NP_035968.1
Homo sapiens (human) LYNX1 NP_803430.1
Pan troglodytes (chimpanzee) LYNX1 NP_001012437.1
Rattus norvegicus (Norway rat) Lynx1 NP_001124018.1
LYNX1 NP_001028116.1

Gene Ontology


Bibliography

Related articles in PubMed

Lynx1 and A?1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes.
Thomsen MS, Arvaniti M, Jensen MM, Shulepko MA, Dolgikh DA, Pinborg LH, H?rtig W, Lyukmanova EN, Mikkelsen JD
Neurobiology of aging4613-21(2016 Oct)

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.
Lyukmanova EN, Shulepko MA, Shenkarev ZO, Bychkov ML, Paramonov AS, Chugunov AO, Kulbatskii DS, Arvaniti M, Dolejsi E, Schaer T, Arseniev AS, Efremov RG, Thomsen MS, Dolezal V, Bertrand D, Dolgikh DA, Kirpichnikov MP
Scientific reports630698(2016 Aug)

NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.
Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP
The Journal of biological chemistry286(12)10618-27(2011 Mar)

A role for LYNX2 in anxiety-related behavior.
Tekinay AB, Nong Y, Miwa JM, Lieberam I, Ibanez-Tallon I, Greengard P, Heintz N
Proceedings of the National Academy of Sciences of the United States of America106(11)4477-82(2009 Mar)

SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium.
Arredondo J, Chernyavsky AI, Jolkovsky DL, Webber RJ, Grando SA
Journal of cellular physiology208(1)238-45(2006 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Lynx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lynx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa02544 NM_001130546.1
Latest version!		 Rattus norvegicus Ly6/neurotoxin 1 (Lynx1), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
ORa61955 XM_017594762.1
Latest version!		 Rattus norvegicus Ly6/neurotoxin 1 (Lynx1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa02544
Clone ID Related Accession (Same CDS sequence) NM_001130546.1
Accession Version NM_001130546.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 351bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-02
Organism Rattus norvegicus(Norway rat)
Product ly-6/neurotoxin-like protein 1 precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473950.2. On or before Jul 28, 2008 this sequence version replaced XM_001069286.1, XM_216965.3. ##Evidence-Data-START## Transcript exon combination :: CB717062.1, FM107114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
ATGACCCACT TGCTGACAGT ATTCCTGGTG GCTCTGATGG GCCTGCCTGT GGCCCAGGCT 
CTGGAGTGCC ACGTATGTGC CTACAATGGA GACAACTGCT TCAAACCCAT GCGATGCCCC 
GCCATGGCCA CCTACTGTAT GACCACTCGA ACTTACTTCA CCCCGTACCG GATGAAGGTG 
AGGAAGTCCT GTGTTCCCAG CTGCTTTGAG ACCGTGTACG ATGGCTACTC CAAGCACGCA 
TCTGCCACCT CCTGTTGCCA GTACTACCTG TGCAATGGTG CTGGCTTTGC TACCCCAGTG 
ACCTTGGCCC TGGTCCCGGC ACTCCTAGCT ACCTTCTGGA GCTTGCTATG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001124018.1
CDS349..699
Translation

Target ORF information:

RefSeq Version NM_001130546.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus Ly6/neurotoxin 1 (Lynx1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001130546.1

ORF Insert Sequence:

1
61
121
181
241
301
ATGACCCACT TGCTGACAGT ATTCCTGGTG GCTCTGATGG GCCTGCCTGT GGCCCAGGCT 
CTGGAGTGCC ACGTATGTGC CTACAATGGA GACAACTGCT TCAAACCCAT GCGATGCCCC 
GCCATGGCCA CCTACTGTAT GACCACTCGA ACTTACTTCA CCCCGTACCG GATGAAGGTG 
AGGAAGTCCT GTGTTCCCAG CTGCTTTGAG ACCGTGTACG ATGGCTACTC CAAGCACGCA 
TCTGCCACCT CCTGTTGCCA GTACTACCTG TGCAATGGTG CTGGCTTTGC TACCCCAGTG 
ACCTTGGCCC TGGTCCCGGC ACTCCTAGCT ACCTTCTGGA GCTTGCTATG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa61955
Clone ID Related Accession (Same CDS sequence) XM_017594762.1
Accession Version XM_017594762.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 594bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product ly-6/neurotoxin-like protein 1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGAGCTGCG CTGCGGATCT GTTGCGGTGG CGGAGCCTAC TCCACCTGCC TGCGATGCGG 
TACAAACACC GCACGAAGTG TGTACAGATT CACTGTCAGA CTGCGGGAGG GACCTGGGAG 
CGGCCACGGG AGACCAAGAG CTCAAGCAGG GCCTCTGTGT CCTGCTTCTT CTCTGACCTG 
AGTTGGATCC AGGACCAGCT GCTGTCCTCC TGTTCCCTCC GACACTGTCC TCACAGCTCC 
GTCATGACCC ACTTGCTGAC AGTATTCCTG GTGGCTCTGA TGGGCCTGCC TGTGGCCCAG 
GCTCTGGAGT GCCACGTATG TGCCTACAAT GGAGACAACT GCTTCAAACC CATGCGATGC 
CCCGCCATGG CCACCTACTG TATGACCACT CGAACTTACT TCACCCCGTA CCGGATGAAG 
GTGAGGAAGT CCTGTGTTCC CAGCTGCTTT GAGACCGTGT ACGATGGCTA CTCCAAGCAC 
GCATCTGCCA CCTCCTGTTG CCAGTACTAC CTGTGCAATG GTGCTGGCTT TGCTACCCCA 
GTGACCTTGG CCCTGGTCCC GGCACTCCTA GCTACCTTCT GGAGCTTGCT ATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017450251.1
CDS33..626
Translation

Target ORF information:

RefSeq Version XM_017594762.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus Ly6/neurotoxin 1 (Lynx1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017594762.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGAGCTGCG CTGCGGATCT GTTGCGGTGG CGGAGCCTAC TCCACCTGCC TGCGATGCGG 
TACAAACACC GCACGAAGTG TGTACAGATT CACTGTCAGA CTGCGGGAGG GACCTGGGAG 
CGGCCACGGG AGACCAAGAG CTCAAGCAGG GCCTCTGTGT CCTGCTTCTT CTCTGACCTG 
AGTTGGATCC AGGACCAGCT GCTGTCCTCC TGTTCCCTCC GACACTGTCC TCACAGCTCC 
GTCATGACCC ACTTGCTGAC AGTATTCCTG GTGGCTCTGA TGGGCCTGCC TGTGGCCCAG 
GCTCTGGAGT GCCACGTATG TGCCTACAAT GGAGACAACT GCTTCAAACC CATGCGATGC 
CCCGCCATGG CCACCTACTG TATGACCACT CGAACTTACT TCACCCCGTA CCGGATGAAG 
GTGAGGAAGT CCTGTGTTCC CAGCTGCTTT GAGACCGTGT ACGATGGCTA CTCCAAGCAC 
GCATCTGCCA CCTCCTGTTG CCAGTACTAC CTGTGCAATG GTGCTGGCTT TGCTACCCCA 
GTGACCTTGG CCCTGGTCCC GGCACTCCTA GCTACCTTCT GGAGCTTGCT ATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Lynx1 and A?1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes.
Neurobiology of aging4613-21(2016 Oct)
Thomsen MS,Arvaniti M,Jensen MM,Shulepko MA,Dolgikh DA,Pinborg LH,H?rtig W,Lyukmanova EN,Mikkelsen JD


book

Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.
Scientific reports630698(2016 Aug)
Lyukmanova EN,Shulepko MA,Shenkarev ZO,Bychkov ML,Paramonov AS,Chugunov AO,Kulbatskii DS,Arvaniti M,Dolejsi E,Schaer T,Arseniev AS,Efremov RG,Thomsen MS,Dolezal V,Bertrand D,Dolgikh DA,Kirpichnikov MP


book

NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.
The Journal of biological chemistry286(12)10618-27(2011 Mar)
Lyukmanova EN,Shenkarev ZO,Shulepko MA,Mineev KS,D'Hoedt D,Kasheverov IE,Filkin SY,Krivolapova AP,Janickova H,Dolezal V,Dolgikh DA,Arseniev AS,Bertrand D,Tsetlin VI,Kirpichnikov MP


book

A role for LYNX2 in anxiety-related behavior.
Proceedings of the National Academy of Sciences of the United States of America106(11)4477-82(2009 Mar)
Tekinay AB,Nong Y,Miwa JM,Lieberam I,Ibanez-Tallon I,Greengard P,Heintz N


book

SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium.
Journal of cellular physiology208(1)238-45(2006 Jul)
Arredondo J,Chernyavsky AI,Jolkovsky DL,Webber RJ,Grando SA