Gene Symbol | Lynx1 |
Entrez Gene ID | 300018 |
Full Name | Ly6/neurotoxin 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Lynx1 cDNA ORF clone
gRNAs
Gene Symbol | Lynx1 |
Entrez Gene ID | 300018 |
Full Name | Ly6/neurotoxin 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017594762.1 | XP_017450251.1 | ly-6/neurotoxin-like protein 1 isoform X1 |
NM_001130546.1 | NP_001124018.1 | ly-6/neurotoxin-like protein 1 precursor |
Lynx1 and A?1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes.
Thomsen MS, Arvaniti M, Jensen MM, Shulepko MA, Dolgikh DA, Pinborg LH, H?rtig W, Lyukmanova EN, Mikkelsen JD
Neurobiology of aging4613-21(2016 Oct)
Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors.
Lyukmanova EN, Shulepko MA, Shenkarev ZO, Bychkov ML, Paramonov AS, Chugunov AO, Kulbatskii DS, Arvaniti M, Dolejsi E, Schaer T, Arseniev AS, Efremov RG, Thomsen MS, Dolezal V, Bertrand D, Dolgikh DA, Kirpichnikov MP
Scientific reports630698(2016 Aug)
NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.
Lyukmanova EN, Shenkarev ZO, Shulepko MA, Mineev KS, D'Hoedt D, Kasheverov IE, Filkin SY, Krivolapova AP, Janickova H, Dolezal V, Dolgikh DA, Arseniev AS, Bertrand D, Tsetlin VI, Kirpichnikov MP
The Journal of biological chemistry286(12)10618-27(2011 Mar)
A role for LYNX2 in anxiety-related behavior.
Tekinay AB, Nong Y, Miwa JM, Lieberam I, Ibanez-Tallon I, Greengard P, Heintz N
Proceedings of the National Academy of Sciences of the United States of America106(11)4477-82(2009 Mar)
SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium.
Arredondo J, Chernyavsky AI, Jolkovsky DL, Webber RJ, Grando SA
Journal of cellular physiology208(1)238-45(2006 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Lynx1 binds to multiple nAChR subtypes in the brain and that this interaction might have functional and pathophysiological implications in relation to Alzheimer's disease.
Title: Lynx1 and A?1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes.
The following Lynx1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lynx1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa02544 | |
Clone ID Related Accession (Same CDS sequence) | NM_001130546.1 | |
Accession Version | NM_001130546.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ly-6/neurotoxin-like protein 1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473950.2. On or before Jul 28, 2008 this sequence version replaced XM_001069286.1, XM_216965.3. ##Evidence-Data-START## Transcript exon combination :: CB717062.1, FM107114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGACCCACT TGCTGACAGT ATTCCTGGTG GCTCTGATGG GCCTGCCTGT GGCCCAGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001124018.1 |
CDS | 349..699 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGACCCACT TGCTGACAGT ATTCCTGGTG GCTCTGATGG GCCTGCCTGT GGCCCAGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa61955 | |
Clone ID Related Accession (Same CDS sequence) | XM_017594762.1 | |
Accession Version | XM_017594762.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 594bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | ly-6/neurotoxin-like protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCTGCG CTGCGGATCT GTTGCGGTGG CGGAGCCTAC TCCACCTGCC TGCGATGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017450251.1 |
CDS | 33..626 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGCTGCG CTGCGGATCT GTTGCGGTGG CGGAGCCTAC TCCACCTGCC TGCGATGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Lynx1 and A?1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes. |
Secreted Isoform of Human Lynx1 (SLURP-2): Spatial Structure and Pharmacology of Interactions with Different Types of Acetylcholine Receptors. |
NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1. |
A role for LYNX2 in anxiety-related behavior. |
SLURP-2: A novel cholinergic signaling peptide in human mucocutaneous epithelium. |