Gene Symbol | Cfl2 |
Entrez Gene ID | 366624 |
Full Name | cofilin 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Cfl2 cDNA ORF clone
Gene Symbol | Cfl2 |
Entrez Gene ID | 366624 |
Full Name | cofilin 2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001108982.2 | NP_001102452.2 | cofilin-2 |
XM_006240104.3 | XP_006240166.1 | cofilin-2 isoform X1 |
Homo sapiens (human) | CFL2 | NP_619579.1 |
CFL2 | XP_001082579.2 | |
Canis lupus familiaris (dog) | CFL2 | XP_547771.2 |
Gallus gallus (chicken) | CFL2 | NP_001004406.1 |
Saccharomyces cerevisiae (baker's yeast) | COF1 | NP_013050.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03164 | XP_003716827.1 |
Arabidopsis thaliana (thale cress) | ADF6 | NP_565719.1 |
Pan troglodytes (chimpanzee) | CFL2 | XP_509898.2 |
Mus musculus (house mouse) | Cfl2 | NP_031714.1 |
Neurospora crassa | NCU01587 | XP_956498.2 |
Bos taurus (cattle) | CFL2 | NP_001069622.1 |
Rattus norvegicus (Norway rat) | Cfl2 | NP_001102452.2 |
Kluyveromyces lactis | KLLA0E00463g | XP_453967.1 |
Eremothecium gossypii | AGOS_ADR235W | NP_984331.1 |
Schizosaccharomyces pombe (fission yeast) | adf1 | NP_594741.1 |
Oryza sativa (rice) | Os03g0780400 | NP_001051449.1 |
Xenopus tropicalis (tropical clawed frog) | cfl2 | NP_001011156.1 |
Danio rerio (zebrafish) | cfl2 | NP_991263.1 |
Oryza sativa (rice) | Os12g0628100 | NP_001067327.1 |
Cofilin-2 controls actin filament length in muscle sarcomeres.
Kremneva E, Makkonen MH, Skwarek-Maruszewska A, Gateva G, Michelot A, Dominguez R, Lappalainen P
Developmental cell31(2)215-26(2014 Oct)
A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.
Yuan B, Wan P, Chu D, Nie J, Cao Y, Luo W, Lu S, Chen J, Yang Z
The American journal of pathology184(7)1967-80(2014 Jul)
Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance.
Gurniak CB, Chevessier F, Jokwitz M, J?nsson F, Perlas E, Richter H, Matern G, Boyl PP, Chaponnier C, F?rst D, Schr?der R, Witke W
European journal of cell biology93(5-6)252-66(2014 May-Jun)
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy.
Pieragostino D, Agnifili L, Fasanella V, D'Aguanno S, Mastropasqua R, Di Ilio C, Sacchetta P, Urbani A, Del Boccio P
Molecular bioSystems9(6)1108-16(2013 Jun)
Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance.
Agrawal PB, Joshi M, Savic T, Chen Z, Beggs AH
Human molecular genetics21(10)2341-56(2012 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
cofilin-2 evolved specific biochemical and cellular properties that allow it to control actin dynamics in sarcomeres, where filament pointed ends may contain a mixture of ADP- and ATP/ADP-Pi-actin subunits.
Title: Cofilin-2 controls actin filament length in muscle sarcomeres.
Cofilin phosphorylation mediates proliferation in response to platelet-derived growth factor-BB in rat aortic smooth muscle cells.
Title: Cofilin phosphorylation mediates proliferation in response to platelet-derived growth factor-BB in rat aortic smooth muscle cells.
The following Cfl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cfl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa08768 | |
Clone ID Related Accession (Same CDS sequence) | NM_001108982.2 | |
Accession Version | NM_001108982.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | cofilin-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07064323.1. On Nov 19, 2011 this sequence version replaced NM_001108982.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: FQ228820.1, FQ228857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCATCTG GAGTTACAGT GAATGATGAA GTCATCAAAG TTTTTAATGA TATGAAAGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001102452.2 |
CDS | 135..635 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001108982.2 |
1 | ATGGCATCTG GAGTTACAGT GAATGATGAA GTCATCAAAG TTTTTAATGA TATGAAAGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa29345 | |
Clone ID Related Accession (Same CDS sequence) | XM_006240104.3 | |
Accession Version | XM_006240104.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | cofilin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240104.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAAGTAA GAAAATCTTC TACCCAGGAG GAGATCAAAA AAAGAAAGAA AGCAGTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006240166.1 |
CDS | 270..719 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006240104.3 |
1 | ATGAAAGTAA GAAAATCTTC TACCCAGGAG GAGATCAAAA AAAGAAAGAA AGCAGTTCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cofilin-2 controls actin filament length in muscle sarcomeres. |
A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice. |
Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance. |
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma na?ve to therapy. |
Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. |