NMS cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Gene Symbol	NMS
Entrez Gene ID	497196
Full Name	neuromedin S
General protein information	Preferred Names neuromedin S Names neuromedin-S neuromedin S precursor-related peptide/neuromedin S preproprotein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q22

mRNA and Protein(s)

mRNA Protein Name

NM_001012233.1 NP_001012233.1 neuromedin-S precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_001012233.1	NP_001012233.1	neuromedin-S precursor

Homologies

Mus musculus (house mouse)	Nms	NP_001011684.3
	LOC710021	XP_001105196.1
Bos taurus (cattle)	NMS	NP_001070990.1
Rattus norvegicus (Norway rat)	NMS	NP_001012233.1
Canis lupus familiaris (dog)	NMS	XP_005626065.1
Homo sapiens (human)	NMS	NP_001011717.1
Pan troglodytes (chimpanzee)	NMS	XP_001161586.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release.
Mori K, Ida T, Fudetani M, Mori M, Kaiya H, Hino J, Nakahara K, Murakami N, Miyazato M, Kangawa K
Scientific reports7(1)10468(2017 Sep)

Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.
Nakahara K, Akagi A, Shimizu S, Tateno S, Qattali AW, Mori K, Miyazato M, Kangawa K, Murakami N
Biochemical and biophysical research communications470(4)930-5(2016 Feb)

Involvement of neuromedin S in the oxytocin release response to suckling stimulus.
Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N
Biochemical and biophysical research communications375(1)49-53(2008 Oct)

Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S.
Miyazato M, Mori K, Ida T, Kojima M, Murakami N, Kangawa K
Regulatory peptides145(1-3)37-41(2008 Jan)

Endocrine and behavioral effects of neuromedin S.
J?szber?nyi M, Bagosi Z, Thurz? B, F?ldesi I, Telegdy G
Hormones and behavior52(5)631-9(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU.
Title: Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.

These results suggest that, in the rat, endogenous NMS plays an important role in the oxytocin release response to the suckling stimulus.
Title: Involvement of neuromedin S in the oxytocin release response to suckling stimulus.

NMS is implicated in the regulation of circadian rhythm and feeding behavior
Title: Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S.

Neuromedin S stimulates the HPA axis through the CRHR(1) pathway and evokes stereotyped behavior and anxiety through mesolimbic dopamine and corticotrophin releasing hormone release.
Title: Endocrine and behavioral effects of neuromedin S.

Neuromedins U and S may play different roles in the functional regulation of neuroendocrine axes.
Title: Expression of neuromedins S and U and their receptors in the hypothalamus and endocrine glands of the rat.

The following NMS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NMS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42449	NM_001012233.1 Latest version!	Rattus norvegicus neuromedin S (NMS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NMS ( NM_001012233.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001012233.1 Rattus norvegicus neuromedin S (NMS), mRNA.

Price & Availability↑

CloneID	ORa42449
Clone ID Related Accession (Same CDS sequence)	NM_001012233.1
Accession Version	NM_001012233.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	neuromedin-S precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB164465.1. On Apr 20, 2005 this sequence version replaced XM_576546.1. ##Evidence-Data-START## Transcript exon combination :: AB164465.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052297, SAMN02642596 [ECO:0000350] ##Evidence-Data-END##

ATGAAACATC CGTTCCCTCA GTTCCCTCCA ATCCTGGTCA TCTACTGCTT CTGTATGCTA 
CAGATCCCCT CCTCAGGAGC TTCTCCACCT TTAGCTGGTC CTCCTGATGG TTTGGATGCT 
GTGGACCCAG AGCGACTGGC ACACTTTCTG AACCAGAGGG AAACATGTTC TAACCAACCT 
AAGGAAAGCC GGGATGTATA CAAAAGGTTT TTATTTCACT ACTCCCGAGC TTGGAAGTCG 
ACACATCCAG TTAACTCCGA GTTTGCTCCC GTCCATCCAT TGATGCGCCT GGCCGCCAAG 
CTTCCCAGCA GAAGGATGAA AAGACTACCG CGATTGCTGC ACACAGATTC CAGGATGGCT 
ACTATAGACT TCCCTAAGAA GGATCCTACC ACCAGCTTGG GGCGGCCATT TTTCCTTTTC 
AGGCCTAGGA ATGGAAGATA CACTGACAAA GTCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001012233.1
CDS	17..475
Translation	MKHPFPQFPPILVIYCFCMLQIPSSGASPPLAGPPDGLDAVDPERLAHFLNQRETCSNQPKESRDVYKRFLFHYSRAWKSTHPVNSEFAPVHPLMRLAAKLPSRRMKRLPRLLHTDSRMATIDFPKKDPTTSLGRPFFLFRPRNGRYTDKVQ

Target ORF information:

RefSeq Version	NM_001012233.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus neuromedin S (NMS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001012233.1

ORF Insert Sequence:

ATGAAACATC CGTTCCCTCA GTTCCCTCCA ATCCTGGTCA TCTACTGCTT CTGTATGCTA 
CAGATCCCCT CCTCAGGAGC TTCTCCACCT TTAGCTGGTC CTCCTGATGG TTTGGATGCT 
GTGGACCCAG AGCGACTGGC ACACTTTCTG AACCAGAGGG AAACATGTTC TAACCAACCT 
AAGGAAAGCC GGGATGTATA CAAAAGGTTT TTATTTCACT ACTCCCGAGC TTGGAAGTCG 
ACACATCCAG TTAACTCCGA GTTTGCTCCC GTCCATCCAT TGATGCGCCT GGCCGCCAAG 
CTTCCCAGCA GAAGGATGAA AAGACTACCG CGATTGCTGC ACACAGATTC CAGGATGGCT 
ACTATAGACT TCCCTAAGAA GGATCCTACC ACCAGCTTGG GGCGGCCATT TTTCCTTTTC 
AGGCCTAGGA ATGGAAGATA CACTGACAAA GTCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of neuromedin U precursor-related peptide and its possible role in the regulation of prolactin release.
Scientific reports7(1)10468(2017 Sep)
Mori K,Ida T,Fudetani M,Mori M,Kaiya H,Hino J,Nakahara K,Murakami N,Miyazato M,Kangawa K

Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.
Biochemical and biophysical research communications470(4)930-5(2016 Feb)
Nakahara K,Akagi A,Shimizu S,Tateno S,Qattali AW,Mori K,Miyazato M,Kangawa K,Murakami N

Involvement of neuromedin S in the oxytocin release response to suckling stimulus.
Biochemical and biophysical research communications375(1)49-53(2008 Oct)
Sakamoto T,Mori K,Miyazato M,Kangawa K,Sameshima H,Nakahara K,Murakami N

Identification and functional analysis of a novel ligand for G protein-coupled receptor, Neuromedin S.
Regulatory peptides145(1-3)37-41(2008 Jan)
Miyazato M,Mori K,Ida T,Kojima M,Murakami N,Kangawa K

Endocrine and behavioral effects of neuromedin S.
Hormones and behavior52(5)631-9(2007 Dec)
J?szber?nyi M,Bagosi Z,Thurz? B,F?ldesi I,Telegdy G

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NMS cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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