Ptger2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ptger2
Entrez Gene ID	81752
Full Name	prostaglandin E receptor 2
Synonyms	EP2,Ptger-ep2
General protein information	Preferred Names prostaglandin E receptor 2 Names prostaglandin E2 receptor EP2 subtype PGE receptor, EP2 subtype PGE2 receptor EP2 subtype prostaglandin E receptor 2 (subtype EP2) prostaglandin E receptor EP2 subtype prostaglandin E2 receptor EP2 subtype-like prostaglandin E2 receptor type 2 prostanoid EP2 receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 15 Map Location: 15p14
Summary	binds prostaglandin E2 and induces increased cAMP; may play a role in skeletal growth [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031088.1	NP_112350.1	prostaglandin E2 receptor EP2 subtype

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PTGER2	XP_522856.3
Bos taurus (cattle)	PTGER2	NP_777013.1
Danio rerio (zebrafish)	ptger2b	NP_001025421.1
	PTGER2	XP_001103621.1
Canis lupus familiaris (dog)	PTGER2	NP_001003170.1
Xenopus tropicalis (tropical clawed frog)	ptger2	XP_002936949.1
Homo sapiens (human)	PTGER2	NP_000947.2
Mus musculus (house mouse)	Ptger2	NP_032990.1
Danio rerio (zebrafish)	ptger2a	NP_956929.1
Rattus norvegicus (Norway rat)	Ptger2	NP_112350.1
Gallus gallus (chicken)	PTGER2	NP_001076834.1

Gene Ontology
Bibliography

Related articles in PubMed

Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons.
Parga JA, Garc?a-Garrote M, Mart?nez S, Raya ?, Labandeira-Garc?a JL, Rodr?guez-Pallares J
Molecular neurobiology(2017 Jul)

EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions.
Ota H, Katanosaka K, Murase S, Furuyashiki T, Narumiya S, Mizumura K
Scandinavian journal of medicine & science in sports(2017 Jul)

EP2 Receptor Signaling Regulates Microglia Death.
Fu Y, Yang MS, Jiang J, Ganesh T, Joe E, Dingledine R
Molecular pharmacology88(1)161-70(2015 Jul)

Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.
Ahluwalia A, Baatar D, Jones MK, Tarnawski AS
American journal of physiology. Gastrointestinal and liver physiology307(6)G602-10(2014 Sep)

Increased interleukin-1? and prostaglandin E2 expression in the spinal cord at 1 day after painful facet joint injury: evidence of early spinal inflammation.
Kras JV, Dong L, Winkelstein BA
Spine39(3)207-12(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that EP2 activation, which initially promotes microglial activation, later causes delayed death of activated microglia, potentially contributing to the resolution phase of neuroinflammation.
Title: EP2 Receptor Signaling Regulates Microglia Death.

EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression.
Title: Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.

In the spinal cord 1 day after painful joint injury there is increased expression of prostaglandin E2 receptor.
Title: Increased interleukin-1? and prostaglandin E2 expression in the spinal cord at 1 day after painful facet joint injury: evidence of early spinal inflammation.

Elastogenesis is spatially regulated by PGE-EP4 signaling in the ductus arteriosus.
Title: Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling.

EP2 receptor signaling pathways regulate classical activation of microglia
Title: EP2 receptor signaling pathways regulate classical activation of microglia.

The following Ptger2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptger2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13007	NM_031088.1 Latest version!	Rattus norvegicus prostaglandin E receptor 2 (Ptger2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ptger2 ( NM_031088.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112350.1 Rattus norvegicus prostaglandin E receptor 2 (Ptger2), mRNA.

Price & Availability↑

CloneID	ORa13007
Clone ID Related Accession (Same CDS sequence)	NM_031088.1
Accession Version	NM_031088.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1074bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	prostaglandin E2 receptor EP2 subtype
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U94708.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U94708.1, U48858.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689599, SAMEA2689601 [ECO:0000348] ##Evidence-Data-END##

ATGGACAATT CTTTCAATGA CTCCAGGCGA GTGGAGAACT GCGAGAGTCG TCAGTATCTC 
CTTTCGGACG AAAGCCCAGC CATCAGCTCG GTGATGTTCA CGGCCGGGGT TCTGGGAAAC 
CTCATCGCGC TGGCACTGTT GGCGCGCCGC TGGCGTGGGG ACACGGGGTG TAGCGCCGGC 
AGCAGGACCT CTATCTCCTT GTTCCACGTG CTGGTAACGG AACTGGTGCT CACCGACCTG 
CTGGGGACCT GCCTCATAAG CCCGGTGGTG CTGGCTTCTT ATTCGAGAAA CCAGACCCTA 
GTGGCCCTGG CTCCCGAAAG CCGCGCGTGT ACCTATTTCG CTTTCACTAT GACCTTCTTT 
AGTCTGGCCA CGATGCTCAT GCTCTTCGCC ATGGCCCTGG AACGCTACCT CGCCATCGGA 
CACCCTTACT TCTACAGGCG CCGCGTCTCT CGCCGCGGGG GTTTGGCGGT GCTGCCTGCC 
ATCTATGGGG TCTCCTTGCT CTTCTGTTCT CTGCCGCTGC TCAACTACGG GGAGTACGTC 
CAGTACTGTC CTGGGACGTG GTGCTTTATC CAGCACGGGA GGACCGCATA CCTTCAGCTG 
TACGCCACGG TGCTCCTGCT GCTCATCGTG GCTGTGCTCG GCTGCAACAT CAGTGTGATC 
CTCAACCTTA TTCGCATGCA GCTTCGGAGC AAAAGAAGCC GCTGCGGATT GTCTGGCAGT 
AGCCTGAGAG GCCCCGGGTC TCGCCGGAGA GGAGAAAGGA CTTCTATGGC GGAGGAGACG 
GACCACCTCA TTCTCCTGGC CATTATGACC ATCACCTTCG CTGTATGCTC CCTGCCTTTC 
ACAATCTTTG CTTATATGGA TGAAACCTCT TCCCGAAAGG AAAAGTGGGA CCTCCGAGCT 
CTTAGATTTT TATCAGTGAA CTCCATAATT GATCCTTGGG TTTTTGTCAT CCTTAGACCA 
CCAGTCCTGA GACTAATGCG CTCAGTCCTC TGTTGTCGGA CTTCACTGAG AGCACCGGAA 
GCTCCAGGAG CTTCCTGTTC GACCCAGCAG ACGGACCTCT GCGGACAGTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112350.1
CDS	43..1116
Translation	MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL

Target ORF information:

RefSeq Version	NM_031088.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prostaglandin E receptor 2 (Ptger2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031088.1

ORF Insert Sequence:

ATGGACAATT CTTTCAATGA CTCCAGGCGA GTGGAGAACT GCGAGAGTCG TCAGTATCTC 
CTTTCGGACG AAAGCCCAGC CATCAGCTCG GTGATGTTCA CGGCCGGGGT TCTGGGAAAC 
CTCATCGCGC TGGCACTGTT GGCGCGCCGC TGGCGTGGGG ACACGGGGTG TAGCGCCGGC 
AGCAGGACCT CTATCTCCTT GTTCCACGTG CTGGTAACGG AACTGGTGCT CACCGACCTG 
CTGGGGACCT GCCTCATAAG CCCGGTGGTG CTGGCTTCTT ATTCGAGAAA CCAGACCCTA 
GTGGCCCTGG CTCCCGAAAG CCGCGCGTGT ACCTATTTCG CTTTCACTAT GACCTTCTTT 
AGTCTGGCCA CGATGCTCAT GCTCTTCGCC ATGGCCCTGG AACGCTACCT CGCCATCGGA 
CACCCTTACT TCTACAGGCG CCGCGTCTCT CGCCGCGGGG GTTTGGCGGT GCTGCCTGCC 
ATCTATGGGG TCTCCTTGCT CTTCTGTTCT CTGCCGCTGC TCAACTACGG GGAGTACGTC 
CAGTACTGTC CTGGGACGTG GTGCTTTATC CAGCACGGGA GGACCGCATA CCTTCAGCTG 
TACGCCACGG TGCTCCTGCT GCTCATCGTG GCTGTGCTCG GCTGCAACAT CAGTGTGATC 
CTCAACCTTA TTCGCATGCA GCTTCGGAGC AAAAGAAGCC GCTGCGGATT GTCTGGCAGT 
AGCCTGAGAG GCCCCGGGTC TCGCCGGAGA GGAGAAAGGA CTTCTATGGC GGAGGAGACG 
GACCACCTCA TTCTCCTGGC CATTATGACC ATCACCTTCG CTGTATGCTC CCTGCCTTTC 
ACAATCTTTG CTTATATGGA TGAAACCTCT TCCCGAAAGG AAAAGTGGGA CCTCCGAGCT 
CTTAGATTTT TATCAGTGAA CTCCATAATT GATCCTTGGG TTTTTGTCAT CCTTAGACCA 
CCAGTCCTGA GACTAATGCG CTCAGTCCTC TGTTGTCGGA CTTCACTGAG AGCACCGGAA 
GCTCCAGGAG CTTCCTGTTC GACCCAGCAG ACGGACCTCT GCGGACAGTT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prostaglandin EP2 Receptors Mediate Mesenchymal Stromal Cell-Neuroprotective Effects on Dopaminergic Neurons.
Molecular neurobiology(2017 Jul)
Parga JA,Garc?a-Garrote M,Mart?nez S,Raya ?,Labandeira-Garc?a JL,Rodr?guez-Pallares J

EP2 receptor plays pivotal roles in generating mechanical hyperalgesia after lengthening contractions.
Scandinavian journal of medicine & science in sports(2017 Jul)
Ota H,Katanosaka K,Murase S,Furuyashiki T,Narumiya S,Mizumura K

EP2 Receptor Signaling Regulates Microglia Death.
Molecular pharmacology88(1)161-70(2015 Jul)
Fu Y,Yang MS,Jiang J,Ganesh T,Joe E,Dingledine R

Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB.
American journal of physiology. Gastrointestinal and liver physiology307(6)G602-10(2014 Sep)
Ahluwalia A,Baatar D,Jones MK,Tarnawski AS

Increased interleukin-1? and prostaglandin E2 expression in the spinal cord at 1 day after painful facet joint injury: evidence of early spinal inflammation.
Spine39(3)207-12(2014 Feb)
Kras JV,Dong L,Winkelstein BA

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Ptger2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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