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DNA glycosylase

DNA glycosylase is a kind of endonuclease initiating excision repair at various damaged or improper Bases in DNA. DNA glycosylase recognizes and removes damaged bases from DNA by cleaving the base–sugar (N-glycosylic) bond and downstream base excision repair enzymes restore the correct nucleotide.

Abscisic acid (ABA), a plant hormone, can be an inducer for DNA glycosylase. ABA functions in many plant developmental processes, including seed and bud dormancy, the control of organ size, and stomatal closure. It can also regulate numerous aspects of plant growth, development, and stress responses.

MUTYH gene can encode a DNA glycosylase involved in oxidative DNA damage repair.

Besides, GAPDH encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus.

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