Gene Symbol | MET |
Entrez Gene ID | 403438 |
Full Name | MET proto-oncogene, receptor tyrosine kinase |
Synonyms | c-Met |
General protein information |
|
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » MET cDNA ORF clone
Gene Symbol | MET |
Entrez Gene ID | 403438 |
Full Name | MET proto-oncogene, receptor tyrosine kinase |
Synonyms | c-Met |
General protein information |
|
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
XM_005628338.2 | XP_005628395.1 | hepatocyte growth factor receptor isoform X2 |
XM_005628338.3 | XP_005628395.1 | hepatocyte growth factor receptor isoform X2 |
XM_022427123.1 | XP_022282831.1 | hepatocyte growth factor receptor isoform X4 |
XM_022427122.1 | XP_022282830.1 | hepatocyte growth factor receptor isoform X3 |
XM_005628337.2 | XP_005628394.1 | hepatocyte growth factor receptor isoform X1 |
XM_005628337.3 | XP_005628394.1 | hepatocyte growth factor receptor isoform X1 |
NM_001002963.1 | NP_001002963.1 | hepatocyte growth factor receptor precursor |
Canis lupus familiaris (dog) | MET | NP_001002963.1 |
Rattus norvegicus (Norway rat) | Met | NP_113705.1 |
Gallus gallus (chicken) | MET | NP_990543.1 |
Homo sapiens (human) | MET | NP_001120972.1 |
Pan troglodytes (chimpanzee) | MET | NP_001129302.1 |
Bos taurus (cattle) | MET | NP_001013017.2 |
Mus musculus (house mouse) | Met | NP_032617.2 |
Danio rerio (zebrafish) | met | NP_001007125.1 |
Xenopus tropicalis (tropical clawed frog) | met | XP_002935001.1 |
MET | NP_001162100.1 |
Met interacts with EGFR and Ron in canine osteosarcoma.
McCleese JK, Bear MD, Kulp SK, Mazcko C, Khanna C, London CA
Veterinary and comparative oncology11(2)124-39(2013 Jun)
Plasma membrane ion fluxes and NFAT-dependent gene transcription contribute to c-met-induced epithelial scattering.
Langford PR, Keyes L, Hansen MD
Journal of cell science125(Pt 17)4001-13(2012 Sep)
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
The Journal of biological chemistry285(53)42075-85(2010 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Together, these data support the notion that Met, epidermal growth factor receptor and Ron interact in osteosarcoma cells and as such, may represent viable targets for therapeutic intervention.
Title: Met interacts with EGFR and Ron in canine osteosarcoma.
NFAT-dependent gene transcription is required for hepatocyte growth factor-induced cell scattering.
Title: Plasma membrane ion fluxes and NFAT-dependent gene transcription contribute to c-met-induced epithelial scattering.
study shows decorin blocks several biological activities mediated by Met signaling axis; these effects were mediated by downregulation of noncanonical beta-catenin levels; Myc was downregulated by decorin; phosphorylation of Myc at threonine 58 was induced
Title: Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation
Title: Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation.
These data demonstrate a novel association between Gab1 and Pak4 and identify Pak4 as a key integrator of cell migration and invasive growth downstream from the Met receptor.
Title: Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor.
The following MET gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MET cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe293078 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427123.1 | |
Accession Version | XM_022427123.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2856bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | hepatocyte growth factor receptor isoform X4 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGCCAGT TCAACCAAGT CCTCTTAACG TCTATATCCA CCTTCATCAA AGGAGACCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022282831.1 |
CDS | 110..2965 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022427123.1 |
1 | ATGGGCCAGT TCAACCAAGT CCTCTTAACG TCTATATCCA CCTTCATCAA AGGAGACCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe00356 | |
Clone ID Related Accession (Same CDS sequence) | NM_001002963.1 | |
Accession Version | NM_001002963.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4149bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Canis lupus familiaris(dog) | |
Product | hepatocyte growth factor receptor precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB118945.2. Sequence Note: This sequence has been modified as follows: removed 40 bp suspected to be vector contamination from the 5' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB118945.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103936001, SAMEA103936002 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAAGGCTC CTGCTGTGCT TGCACCTGGC ATCCTTGTGC TTCTGTTTAC CTTGGTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001002963.1 |
CDS | 20..4168 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001002963.1 |
1 | ATGAAGGCTC CTGCTGTGCT TGCACCTGGC ATCCTTGTGC TTCTGTTTAC CTTGGTGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16488 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628338.2 , XM_005628338.3 | |
Accession Version | XM_005628338.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4161bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | hepatocyte growth factor receptor isoform X2 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726084.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005628338.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTTCTCA CCATGAAGGC TCCTGCTGTG CTTGCACCTG GCATCCTTGT GCTTCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628395.1 |
CDS | 599..4759 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628338.2 |
1 | ATGCTTCTCA CCATGAAGGC TCCTGCTGTG CTTGCACCTG GCATCCTTGT GCTTCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16488 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628338.2 , XM_005628338.3 | |
Accession Version | XM_005628338.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4161bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | hepatocyte growth factor receptor isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005628338.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTTCTCA CCATGAAGGC TCCTGCTGTG CTTGCACCTG GCATCCTTGT GCTTCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628395.1 |
CDS | 266..4426 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628338.3 |
1 | ATGCTTCTCA CCATGAAGGC TCCTGCTGTG CTTGCACCTG GCATCCTTGT GCTTCTGTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16487 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628337.2 , XM_005628337.3 | |
Accession Version | XM_005628337.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4266bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | hepatocyte growth factor receptor isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726084.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005628337.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGGATGC GGATGCGGAG CGGCGCGGCG GGCGCGGGCC GGGCGCGGGG CGACAGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628394.1 |
CDS | 290..4555 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628337.2 |
1 | ATGCGGATGC GGATGCGGAG CGGCGCGGCG GGCGCGGGCC GGGCGCGGGG CGACAGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16487 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628337.2 , XM_005628337.3 | |
Accession Version | XM_005628337.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4266bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | hepatocyte growth factor receptor isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005628337.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGGATGC GGATGCGGAG CGGCGCGGCG GGCGCGGGCC GGGCGCGGGG CGACAGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628394.1 |
CDS | 17..4282 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628337.3 |
1 | ATGCGGATGC GGATGCGGAG CGGCGCGGCG GGCGCGGGCC GGGCGCGGGG CGACAGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16489 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427122.1 | |
Accession Version | XM_022427122.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4125bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | hepatocyte growth factor receptor isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGGATGC GGATGCGGAG CGGCGCGGCG GGCGCGGGCC GGGCGCGGGG CGACAGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022282830.1 |
CDS | 155..4279 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022427122.1 |
1 | ATGCGGATGC GGATGCGGAG CGGCGCGGCG GGCGCGGGCC GGGCGCGGGG CGACAGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Met interacts with EGFR and Ron in canine osteosarcoma. |
Plasma membrane ion fluxes and NFAT-dependent gene transcription contribute to c-met-induced epithelial scattering. |
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. |