Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
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| Gene Symbol | Full Name |
|---|---|
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase |
| RHOA | ras homolog family member A |
| CDC42 | cell division cycle 42 |
| CDK5 | cyclin-dependent kinase 5 |
| CFL1 | cofilin 1 (non-muscle) |
| CFL2 | cofilin 2 (muscle) |
| DCC | DCC netrin 1 receptor |
| DPYSL2 | dihydropyrimidinase-like 2 |
| EFNA1 | ephrin-A1 |
| EFNA2 | ephrin-A2 |
| EFNA3 | ephrin-A3 |
| EFNA4 | ephrin-A4 |
| EFNA5 | ephrin-A5 |
| EFNB1 | ephrin-B1 |
| EFNB2 | ephrin-B2 |
| EFNB3 | ephrin-B3 |
| EPHA2 | EPH receptor A2 |
| EPHA1 | EPH receptor A1 |
| EPHA3 | EPH receptor A3 |
| EPHA4 | EPH receptor A4 |
| EPHA5 | EPH receptor A5 |
| EPHA7 | EPH receptor A7 |
| EPHA8 | EPH receptor A8 |
| EPHB1 | EPH receptor B1 |
| EPHB2 | EPH receptor B2 |
| EPHB3 | EPH receptor B3 |
| EPHB4 | EPH receptor B4 |
| EPHB6 | EPH receptor B6 |
| FES | FES proto-oncogene, tyrosine kinase |
| FYN | FYN proto-oncogene, Src family tyrosine kinase |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
| GSK3B | glycogen synthase kinase 3 beta |
| HRAS | Harvey rat sarcoma viral oncogene homolog |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
| KRAS | Kirsten rat sarcoma viral oncogene homolog |
| L1CAM | L1 cell adhesion molecule |
| ABLIM1 | actin binding LIM protein 1 |
| LIMK1 | LIM domain kinase 1 |
| LIMK2 | LIM domain kinase 2 |
| MET | MET proto-oncogene, receptor tyrosine kinase |
| NCK1 | NCK adaptor protein 1 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog |
| NTN3 | netrin 3 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 |
| PAK2 | p21 protein (Cdc42/Rac)-activated kinase 2 |
| PAK3 | p21 protein (Cdc42/Rac)-activated kinase 3 |
| PLXNA1 | plexin A1 |
| PLXNA2 | plexin A2 |
| PLXNB1 | plexin B1 |
| PLXNB3 | plexin B3 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha |
| PPP3R2 | protein phosphatase 3, regulatory subunit B, beta |
| MAPK1 | mitogen-activated protein kinase 1 |
| MAPK3 | mitogen-activated protein kinase 3 |
| PTK2 | protein tyrosine kinase 2 |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) |
| RASA1 | RAS p21 protein activator (GTPase activating protein) 1 |
| RGS3 | regulator of G-protein signaling 3 |
| ROBO1 | roundabout guidance receptor 1 |
| ROBO2 | roundabout guidance receptor 2 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
| SLIT1 | slit guidance ligand 1 |
| SLIT3 | slit guidance ligand 3 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B |
| NCK2 | NCK adaptor protein 2 |
| SEMA7A | semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) |
| UNC5C | unc-5 netrin receptor C |
| NRP1 | neuropilin 1 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
| SLIT2 | slit guidance ligand 2 |
| NTN1 | netrin 1 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E |
| SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3 |
| PLXNC1 | plexin C1 |
| PAK4 | p21 protein (Cdc42/Rac)-activated kinase 4 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
| SEMA6C | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B |
| SEMA4F | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| NTNG1 | netrin G1 |
| ABLIM3 | actin binding LIM protein family, member 3 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 |
| SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 |
