Gene Symbol | AKT1 |
Entrez Gene ID | 280991 |
Full Name | AKT serine/threonine kinase 1 |
Synonyms | AKT |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
ORF » Species Summary » Bos taurus » AKT1 cDNA ORF clone
gRNAs
Gene Symbol | AKT1 |
Entrez Gene ID | 280991 |
Full Name | AKT serine/threonine kinase 1 |
Synonyms | AKT |
General protein information |
|
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
mRNA | Protein | Name |
---|---|---|
NM_173986.2 | NP_776411.1 | RAC-alpha serine/threonine-protein kinase |
XM_024981593.1 | XP_024837361.1 | RAC-alpha serine/threonine-protein kinase isoform X2 |
XM_024981592.1 | XP_024837360.1 | RAC-alpha serine/threonine-protein kinase isoform X1 |
Bos taurus (cattle) | AKT1 | NP_776411.1 |
Caenorhabditis elegans (roundworm) | akt-2 | NP_510357.3 |
Homo sapiens (human) | AKT1 | NP_001014431.1 |
Canis lupus familiaris (dog) | AKT1 | XP_548000.3 |
Mus musculus (house mouse) | Akt1 | NP_033782.1 |
Gallus gallus (chicken) | AKT1 | NP_990386.1 |
Pan troglodytes (chimpanzee) | AKT1 | XP_001143158.2 |
AKT1 | XP_001085265.2 | |
Rattus norvegicus (Norway rat) | Akt1 | NP_150233.1 |
Danio rerio (zebrafish) | LOC100331515 | XP_003200336.2 |
Caenorhabditis elegans (roundworm) | akt-1 | NP_001023646.1 |
Xenopus tropicalis (tropical clawed frog) | akt1 | XP_004917249.1 |
Prostaglandin F2?-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle.
Rovani MT, Ilha GF, Gasperin BG, N?brega JE Jr, Siddappa D, Glanzner WG, Antoniazzi AQ, Bordignon V, Duggavathi R, Gon?alves PBD
Molecular reproduction and development84(6)486-494(2017 Jun)
The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes.
Andrade GM, da Silveira JC, Perrini C, Del Collado M, Gebremedhn S, Tesfaye D, Meirelles FV, Perecin F
PloS one12(9)e0185045(2017)
Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle.
G?mez BI, Gifford CA, Hallford DM, Hernandez Gifford JA
Animal reproduction science16397-104(2015 Dec)
Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling.
Trane AE, Hiob MA, Uy T, Pavlov D, Bernatchez P
European journal of pharmacology76646-55(2015 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the measurement of levels of PI3K-Akt pathway components in FCs from ovarian follicles carrying oocytes with distinct developmental competences is a useful tool to identify putative molecular pathways involved in the acquisition of oocyte competence.
Title: The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes.
These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
Title: Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle.
Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling
Title: Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling.
TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation.
Title: Tissue transglutaminase promotes serotonin-induced AKT signaling and mitogenesis in pulmonary vascular smooth muscle cells.
results suggest that PI3K-Akt activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta, and NF-kappaB.
Title: The phosphoinositide-3-kinase-Akt signaling pathway is important for Staphylococcus aureus internalization by endothelial cells.
The following AKT1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AKT1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa41644 | |
Clone ID Related Accession (Same CDS sequence) | NM_173986.2 | |
Accession Version | NM_173986.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Bos taurus(cattle) | |
Product | RAC-alpha serine/threonine-protein kinase | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X61036.1. On Jun 3, 2003 this sequence version replaced NM_173986.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X61036.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN03145412, SAMN03145413 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAACGACG TGGCCATCGT GAAGGAGGGC TGGCTGCACA AGCGAGGTGA GTACATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776411.1 |
CDS | 82..1524 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAACGACG TGGCCATCGT GAAGGAGGGC TGGCTGCACA AGCGAGGTGA GTACATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa228205 | |
Clone ID Related Accession (Same CDS sequence) | XM_024981592.1 | |
Accession Version | XM_024981592.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | RAC-alpha serine/threonine-protein kinase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037348.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAACGACG TGGCCATCGT GAAGGAGGGC TGGCTGCACA AGCGAGGTGA GTACATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024837360.1 |
CDS | 210..1652 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAACGACG TGGCCATCGT GAAGGAGGGC TGGCTGCACA AGCGAGGTGA GTACATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OBa228206 | |
Clone ID Related Accession (Same CDS sequence) | XM_024981593.1 | |
Accession Version | XM_024981593.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-05-06 | |
Organism | Bos taurus(cattle) | |
Product | RAC-alpha serine/threonine-protein kinase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037348.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGACGG AGCGGCCGCG GCCCAACACC TTCATCATCC GCTGCCTGCA GTGGACCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_024837361.1 |
CDS | 12..1169 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGACGG AGCGGCCGCG GCCCAACACC TTCATCATCC GCTGCCTGCA GTGGACCACG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Prostaglandin F2?-induced luteolysis involves activation of Signal transducer and activator of transcription 3 and inhibition of AKT signaling in cattle. |
The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. |
Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle. |
Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling. |