ABCG2 cDNA ORF clone, Canis lupus familiaris(dog)

Gene
Clones
gRNAs

Summary

Gene Symbol	ABCG2
Entrez Gene ID	478472
Full Name	ATP binding cassette subfamily G member 2
Synonyms	BCRP
General protein information	Preferred Names ATP binding cassette subfamily G member 2 Names ATP-binding cassette sub-family G member 2 ATP binding cassette subfamily G member 2 (Junior blood group) ATP-binding cassette protein G2 breast cancer resistance protein
Gene Type	protein-coding
Organism	Canis lupus familiaris(dog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001048021.1	NP_001041486.1	ATP-binding cassette sub-family G member 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	ABCG2	NP_004818.2
Pan troglodytes (chimpanzee)	ABCG2	XP_526633.3
Canis lupus familiaris (dog)	ABCG2	NP_001041486.1
Gallus gallus (chicken)	ABCG2	XP_421638.4
Anopheles gambiae (African malaria mosquito)	WHITE_ANOGA	XP_310530.3
Caenorhabditis elegans (roundworm)	wht-7	NP_001040881.1
Oryza sativa (rice)	Os03g0157400	NP_001049014.1
	ABCG2	NP_001028091.1
Bos taurus (cattle)	ABCG2	NP_001032555.2
Rattus norvegicus (Norway rat)	Abcg2	NP_852046.1
Drosophila melanogaster (fruit fly)	w	NP_476787.1
Caenorhabditis elegans (roundworm)	wht-4	NP_494495.2
Kluyveromyces lactis	KLLA0D04554g	XP_453265.1
Arabidopsis thaliana (thale cress)	AT5G06530	NP_850781.2
Xenopus tropicalis (tropical clawed frog)	abcg2	NP_001039227.1
Mus musculus (house mouse)	Abcg2	NP_036050.1
Saccharomyces cerevisiae (baker's yeast)	ADP1	NP_009937.2
Eremothecium gossypii	AGOS_AER190W	NP_985047.1
Caenorhabditis elegans (roundworm)	wht-1	NP_498322.1
Neurospora crassa	NCU02544	XP_965675.1
Danio rerio (zebrafish)	abcg2a	NP_001036240.1
Magnaporthe oryzae (rice blast fungus)	MGG_01563	XP_003714538.1

Gene Ontology
Bibliography

Related articles in PubMed

Immunohistochemical Expression of P-glycoprotein and Breast Cancer Resistance Protein in Canine Mammary Hyperplasia, Neoplasia and Supporting Stroma.
Levi M, Brunetti B, Sarli G, Benazzi C
Journal of comparative pathology155(4)277-285(2016 Nov)

Evaluation of ABCG2 and p63 expression in canine cornea and cultivated corneal epithelial cells.
Morita M, Fujita N, Takahashi A, Nam ER, Yui S, Chung CS, Kawahara N, Lin HY, Tsuzuki K, Nakagawa T, Nishimura R
Veterinary ophthalmology18(1)59-68(2015 Jan)

The regulation of the expression of ABCG2 gene through mitogen-activated protein kinase pathways in canine lymphoid tumor cell lines.
Tomiyasu H, Goto-Koshino Y, Fujino Y, Ohno K, Tsujimoto H
The Journal of veterinary medical science76(2)237-42(2014 Mar)

Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells.
Paw?owski KM, Mucha J, Majchrzak K, Motyl T, Kr?l M
BMC veterinary research9119(2013 Jun)

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.
Lagas JS, van Waterschoot RA, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH
Molecular cancer therapeutics9(2)319-26(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Malignant and invasive tumours were more likely to express PGP and/or BCRP in luminal and stromal components and evaluation of these markers could provide valuable information for the identification of tumours characterized by an aggressive and chemoresistant phenotype.
Title: Immunohistochemical Expression of P-glycoprotein and Breast Cancer Resistance Protein in Canine Mammary Hyperplasia, Neoplasia and Supporting Stroma.

expression in corneal epithelium and marker for corneal epithelial cell proliferation
Title: Evaluation of ABCG2 and p63 expression in canine cornea and cultivated corneal epithelial cells.

MAPK/ERK and JNK pathways downregulate ABCG2 gene expression, which is upregulated by unidentified but possibly PKC-dependent pathways, in several types of canine lymphoid tumor cells.
Title: The regulation of the expression of ABCG2 gene through mitogen-activated protein kinase pathways in canine lymphoid tumor cell lines.

expression and role in multidrug resistance of mammary cancer cells
Title: Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells.

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation
Title: Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.

The following ABCG2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ABCG2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OCe33867	NM_001048021.1 Latest version!	Canis lupus familiaris ATP binding cassette subfamily G member 2 (ABCG2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ABCG2 ( NM_001048021.1 ) cDNA ORF clone, Canis lupus familiaris(dog) -> NP_001041486.1 Canis lupus familiaris ATP binding cassette subfamily G member 2 (ABCG2), mRNA.

Price & Availability↑

CloneID	OCe33867
Clone ID Related Accession (Same CDS sequence)	NM_001048021.1
Accession Version	NM_001048021.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Canis lupus familiaris(dog)
Product	ATP-binding cassette sub-family G member 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ222459.1. On Sep 14, 2006 this sequence version replaced XM_535650.2. ##Evidence-Data-START## Transcript exon combination :: DQ222459.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA103936001, SAMEA103936002 [ECO:0000350] ##Evidence-Data-END##

ATGTCTTCTA ATAATGACCC AGTTTGTATC CCAATGTCAC AAAGAAGCAC CAATGACCTC 
TCCAGGATGA CCTCCAACGA CCTGAAGACA TCTACTGAAG TAGCCGTGTT AAGTTTTCAT 
AACATTTACT ATCGAGTAAA AGTAAAGAGT GGCTTTCTTC TTGGCCGAAA AACAGTTGAG 
AAAGAAATAC TAACAAATAT CAATGGTGTC ATGAGACCTG GCCTCAATGC CATTCTGGGA 
CCCACAGGTG GAAGCAAATC TTCGTTGTTA GATGTCTTAG CTGCAAGGAA AGATCCGCAT 
GGATTATCGG GAGATGTTTT GATAAATGGA GCACCTCGAC CTGCCAATTT CAAATGTAAT 
TCAGGTTATG TGGTACAAGA TGATGTCGTG ATGGGAACTC TGACAGTGAG AGAAAATTTA 
CAATTCTCAG CAGCTCTTCG GCTTCCAACA ACTACGACGA GTCATGAAAA AAATGAGCGA 
ATTAACAAGG TCATTCAGCA ATTAGGTCTG GATAAAGTGG CAGATTCCAA GGTTGGAACT 
CAGTTTATAC GCGGCGTGTC TGGAGGAGAA AGAAAAAGAA CTAGTATTGG AATGGAACTT 
ATTACTGATC CAGCCATCTT ATTTCTGGAT GAGCCCACAA CTGGCTTAGA CTCCAGCACA 
GCAAATGCTG TCCTTTTGCT CCTGAAGAGG ATGTCTGAAC AGGGACGAAC AATCATCTTC 
TCCATTCATC AGCCTCGTTA TTCTATCTTC AAGTTGTTTG ATAGCCTCAC CTTGTTGGCT 
GCAGGAAAAC TGATGTTCCA TGGGCCTGCC CAGGAGGCCT TGGGGTTCTT TGCGTCAGTG 
GGTTACCATT GTGAGCCCTA TAATAACCCT GCAGACTTCT TCTTGGATGT CATTAATGGA 
GACTCCTCTG CTGTGGTATT AAACAGAGAG GACCAAGAGG GTGAAGTCAA GGTGACTGAA 
GAGCCTTCCA AGAGAGGTAC TCCATTCATA GAAAGAATAG CTGAATTTTA TGCCAATTCT 
GACTTCTGCA GAAAAACAAA AGAGGAGTTA GATCAACTCT CAAAGAGTCA GAAAAGGAAG 
AGCTCAGCCT TTAAGGAGAT CACGTATGCC ACCTCCTTCT GTCAGCAACT CAAATGGATT 
TCCAAGCGTT CATTCAAAAA TTTACTGGGT AATCCCCAGG CCTCTATCGC TCAGATAATT 
GTAACAGTCA TCCTGGGATT GGTTTTAGGT GCCATTTTCT ATGATCTAAA AAATGATTCT 
ACAGGAATCC AGAATAGATC AGGGGTGCTC TTCTTTCTGA CAACCAACCA GTGTTTCAGC 
AGTGTGTCAG CTGTGGAGCT CCTTGTGGTT GAGAAGAAGC TTTTTATACA TGAATATATC 
AGTGGATACT ACAGAGTGTC ATCTTATTTC TTTGGAAAAC TGTTATCTGA TTTACTACCC 
ATGAGGATGT TACCAAGTAT TATATTTACT TGTATAATAT ACTTCTTGTT AGGATTGAAA 
CCAGTTGTGG AGGCCTTCTT CATCATGATG TTTACCCTTA TGATGGTGGC TTATTCAGCT 
AGTTCTATGG CGCTGGCCAT AGCAGCAGGC CAGAGTGTGG TATCCATAGC AACTCTCCTC 
ATGACCATCA CCTTTGTGTT TATGATGATA TTTTCAGGGC TGTTGGTAAA TCTCAGAACT 
GTTGGGCCTT GGCTCTCATG GCTTCAGTAC TTAAGCATTC CTCGATATGG TTATGCGGCT 
TTGCAGTATA ATGAATTTTT GGGACAAAAC TTCTGCCCAG GAGTCAATGT AACAACGAAT 
AATACCTGTA GCTATGCAAT ATGTACTGGC GAAGAATTTT TGCTAAACCA GGGCATCGAG 
CTCTCCCCTT GGGGCCTGTG GAAGAATCAC GTAGCCTTGG GATGCATGAT TGTTATCTTC 
CTTACAATTG CCTACCTAAA ATTGTTATTT CTTAAAAAAT ATTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001041486.1
CDS	111..2078
Translation	MSSNNDPVCIPMSQRSTNDLSRMTSNDLKTSTEVAVLSFHNIYYRVKVKSGFLLGRKTVEKEILTNINGVMRPGLNAILGPTGGSKSSLLDVLAARKDPHGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLPTTTTSHEKNERINKVIQQLGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPAILFLDEPTTGLDSSTANAVLLLLKRMSEQGRTIIFSIHQPRYSIFKLFDSLTLLAAGKLMFHGPAQEALGFFASVGYHCEPYNNPADFFLDVINGDSSAVVLNREDQEGEVKVTEEPSKRGTPFIERIAEFYANSDFCRKTKEELDQLSKSQKRKSSAFKEITYATSFCQQLKWISKRSFKNLLGNPQASIAQIIVTVILGLVLGAIFYDLKNDSTGIQNRSGVLFFLTTNQCFSSVSAVELLVVEKKLFIHEYISGYYRVSSYFFGKLLSDLLPMRMLPSIIFTCIIYFLLGLKPVVEAFFIMMFTLMMVAYSASSMALAIAAGQSVVSIATLLMTITFVFMMIFSGLLVNLRTVGPWLSWLQYLSIPRYGYAALQYNEFLGQNFCPGVNVTTNNTCSYAICTGEEFLLNQGIELSPWGLWKNHVALGCMIVIFLTIAYLKLLFLKKYS

Target ORF information:

RefSeq Version	NM_001048021.1
Organism	Canis lupus familiaris(dog)
Definition	Canis lupus familiaris ATP binding cassette subfamily G member 2 (ABCG2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001048021.1

ORF Insert Sequence:

ATGTCTTCTA ATAATGACCC AGTTTGTATC CCAATGTCAC AAAGAAGCAC CAATGACCTC 
TCCAGGATGA CCTCCAACGA CCTGAAGACA TCTACTGAAG TAGCCGTGTT AAGTTTTCAT 
AACATTTACT ATCGAGTAAA AGTAAAGAGT GGCTTTCTTC TTGGCCGAAA AACAGTTGAG 
AAAGAAATAC TAACAAATAT CAATGGTGTC ATGAGACCTG GCCTCAATGC CATTCTGGGA 
CCCACAGGTG GAAGCAAATC TTCGTTGTTA GATGTCTTAG CTGCAAGGAA AGATCCGCAT 
GGATTATCGG GAGATGTTTT GATAAATGGA GCACCTCGAC CTGCCAATTT CAAATGTAAT 
TCAGGTTATG TGGTACAAGA TGATGTCGTG ATGGGAACTC TGACAGTGAG AGAAAATTTA 
CAATTCTCAG CAGCTCTTCG GCTTCCAACA ACTACGACGA GTCATGAAAA AAATGAGCGA 
ATTAACAAGG TCATTCAGCA ATTAGGTCTG GATAAAGTGG CAGATTCCAA GGTTGGAACT 
CAGTTTATAC GCGGCGTGTC TGGAGGAGAA AGAAAAAGAA CTAGTATTGG AATGGAACTT 
ATTACTGATC CAGCCATCTT ATTTCTGGAT GAGCCCACAA CTGGCTTAGA CTCCAGCACA 
GCAAATGCTG TCCTTTTGCT CCTGAAGAGG ATGTCTGAAC AGGGACGAAC AATCATCTTC 
TCCATTCATC AGCCTCGTTA TTCTATCTTC AAGTTGTTTG ATAGCCTCAC CTTGTTGGCT 
GCAGGAAAAC TGATGTTCCA TGGGCCTGCC CAGGAGGCCT TGGGGTTCTT TGCGTCAGTG 
GGTTACCATT GTGAGCCCTA TAATAACCCT GCAGACTTCT TCTTGGATGT CATTAATGGA 
GACTCCTCTG CTGTGGTATT AAACAGAGAG GACCAAGAGG GTGAAGTCAA GGTGACTGAA 
GAGCCTTCCA AGAGAGGTAC TCCATTCATA GAAAGAATAG CTGAATTTTA TGCCAATTCT 
GACTTCTGCA GAAAAACAAA AGAGGAGTTA GATCAACTCT CAAAGAGTCA GAAAAGGAAG 
AGCTCAGCCT TTAAGGAGAT CACGTATGCC ACCTCCTTCT GTCAGCAACT CAAATGGATT 
TCCAAGCGTT CATTCAAAAA TTTACTGGGT AATCCCCAGG CCTCTATCGC TCAGATAATT 
GTAACAGTCA TCCTGGGATT GGTTTTAGGT GCCATTTTCT ATGATCTAAA AAATGATTCT 
ACAGGAATCC AGAATAGATC AGGGGTGCTC TTCTTTCTGA CAACCAACCA GTGTTTCAGC 
AGTGTGTCAG CTGTGGAGCT CCTTGTGGTT GAGAAGAAGC TTTTTATACA TGAATATATC 
AGTGGATACT ACAGAGTGTC ATCTTATTTC TTTGGAAAAC TGTTATCTGA TTTACTACCC 
ATGAGGATGT TACCAAGTAT TATATTTACT TGTATAATAT ACTTCTTGTT AGGATTGAAA 
CCAGTTGTGG AGGCCTTCTT CATCATGATG TTTACCCTTA TGATGGTGGC TTATTCAGCT 
AGTTCTATGG CGCTGGCCAT AGCAGCAGGC CAGAGTGTGG TATCCATAGC AACTCTCCTC 
ATGACCATCA CCTTTGTGTT TATGATGATA TTTTCAGGGC TGTTGGTAAA TCTCAGAACT 
GTTGGGCCTT GGCTCTCATG GCTTCAGTAC TTAAGCATTC CTCGATATGG TTATGCGGCT 
TTGCAGTATA ATGAATTTTT GGGACAAAAC TTCTGCCCAG GAGTCAATGT AACAACGAAT 
AATACCTGTA GCTATGCAAT ATGTACTGGC GAAGAATTTT TGCTAAACCA GGGCATCGAG 
CTCTCCCCTT GGGGCCTGTG GAAGAATCAC GTAGCCTTGG GATGCATGAT TGTTATCTTC 
CTTACAATTG CCTACCTAAA ATTGTTATTT CTTAAAAAAT ATTCTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunohistochemical Expression of P-glycoprotein and Breast Cancer Resistance Protein in Canine Mammary Hyperplasia, Neoplasia and Supporting Stroma.
Journal of comparative pathology155(4)277-285(2016 Nov)
Levi M,Brunetti B,Sarli G,Benazzi C

Evaluation of ABCG2 and p63 expression in canine cornea and cultivated corneal epithelial cells.
Veterinary ophthalmology18(1)59-68(2015 Jan)
Morita M,Fujita N,Takahashi A,Nam ER,Yui S,Chung CS,Kawahara N,Lin HY,Tsuzuki K,Nakagawa T,Nishimura R

The regulation of the expression of ABCG2 gene through mitogen-activated protein kinase pathways in canine lymphoid tumor cell lines.
The Journal of veterinary medical science76(2)237-42(2014 Mar)
Tomiyasu H,Goto-Koshino Y,Fujino Y,Ohno K,Tsujimoto H

Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells.
BMC veterinary research9119(2013 Jun)
Paw?owski KM,Mucha J,Majchrzak K,Motyl T,Kr?l M

Breast cancer resistance protein and P-glycoprotein limit sorafenib brain accumulation.
Molecular cancer therapeutics9(2)319-26(2010 Feb)
Lagas JS,van Waterschoot RA,Sparidans RW,Wagenaar E,Beijnen JH,Schinkel AH