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ak2 cDNA ORF clone, Danio rerio(zebrafish)

Summary

Gene Symbol ak2
Entrez Gene ID 321793
Full Name adenylate kinase 2
Synonyms wu:fb34f05,wu:fj80e03
General protein information
Preferred Names

adenylate kinase 2

Names

adenylate kinase 2, mitochondrial
Gene Type protein-coding
Organism Danio rerio(zebrafish)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_212596.1 NP_997761.1 adenylate kinase 2, mitochondrial
XM_005159648.3 XP_005159705.1 adenylate kinase 2, mitochondrial isoform X1

Pathways from BioSystems


Homologies


Homo sapiens (human) AK2 NP_001616.1
Gallus gallus (chicken) AK2 XP_004947909.1
Danio rerio (zebrafish) ak2 NP_997761.1
Oryza sativa (rice) Os11g0312400 NP_001067759.1
Xenopus tropicalis (tropical clawed frog) ak2 NP_001004791.1
Canis lupus familiaris (dog) AK2 XP_005617670.1
Bos taurus (cattle) AK2 NP_776314.1
Caenorhabditis elegans (roundworm) let-754 NP_498730.1
Arabidopsis thaliana (thale cress) ADK1 NP_201145.1
Mus musculus (house mouse) Ak2 NP_001029138.1
Kluyveromyces lactis KLLA0F13376g XP_455682.1
Eremothecium gossypii AGOS_AGR187W NP_986853.1
Magnaporthe oryzae (rice blast fungus) MGG_01058 XP_003717881.1
Arabidopsis thaliana (thale cress) AT5G50370 NP_199848.1
Oryza sativa (rice) Os12g0236400 NP_001066462.1
AK2 XP_001105613.2
Pan troglodytes (chimpanzee) AK2 XP_513289.2
Rattus norvegicus (Norway rat) Ak2 NP_112248.2
Drosophila melanogaster (fruit fly) Adk2 NP_523836.2
Anopheles gambiae (African malaria mosquito) KAD2_ANOGA XP_308155.2
Saccharomyces cerevisiae (baker's yeast) ADK1 NP_010512.1
Schizosaccharomyces pombe (fission yeast) adk1 NP_593685.1
Neurospora crassa NCU01550 XP_956253.2

Gene Ontology


Bibliography

Related articles in PubMed

Evolution of complexity in the zebrafish synapse proteome.
Bay?s ?, Collins MO, Reig-Viader R, Gou G, Goulding D, Izquierdo A, Choudhary JS, Emes RD, Grant SG
Nature communications814613(2017 Mar)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
Rissone A, Weinacht KG, la Marca G, Bishop K, Giocaliere E, Jagadeesh J, Felgentreff K, Dobbs K, Al-Herz W, Jones M, Chandrasekharappa S, Kirby M, Wincovitch S, Simon KL, Itan Y, DeVine A, Schlaeger T, Schambach A, Sood R, Notarangelo LD, Candotti F
The Journal of experimental medicine212(8)1185-202(2015 Jul)

Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency.
Iwanami N
Experimental hematology42(8)697-706(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
Title: Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.

Knockdown of zebrafish ak2 also leads to aberrant leukocyte development, stressing the evolutionarily conserved role of AK2.
Title: Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2.

The following ak2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ak2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ODa37316 NM_212596.1
Latest version!		 Danio rerio adenylate kinase 2 (ak2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $174.30
$249.00
ODa24309 XM_005159648.3
Latest version!		 Danio rerio adenylate kinase 2 (ak2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $174.30
$249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ODa37316
Clone ID Related Accession (Same CDS sequence) NM_212596.1
Accession Version NM_212596.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 726bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-26
Organism Danio rerio(zebrafish)
Product adenylate kinase 2, mitochondrial
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC053160.1. ##Evidence-Data-START## Transcript exon combination :: BC053160.1, EL646213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3505370, SAMEA3505371 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCCCTA GCACACAAGA GGACGATACC GTCTCCGGTA TACGGAAAGG CATACGGGCC 
ATTCTGCTCG GGCCGCCCGG CGCGGGGAAG GGAACGCAGG CACCCAAGCT TGCAGAGAAA 
TACTGCGTGT GCCATTTAGC TACTGGGGAC ATGCTGAGGG CTATGGTGGC ATCTGGCTCA 
GAGCTCGGCC AGCGTCTAAA GGAAACCATG GATGCAGGCA AACTGGTGAG TGATGAGATG 
GTGGTGGAGC TCATAGACAA CAACCTGGAC ACACCATCAT GCAAGAATGG ATTCCTGCTG 
GACGGATTTC CCCGCACCGT CAAACAAGCA GAAATGCTGG ATGACCTCAT GGAGAAGCGT 
AGTGAGAAAC TGGACTCTGT TATTGAGTTC TCTGTCGATG ACTCCCTGCT GGTCCGCAGG 
ATCTGTGGAA GGCTCATTCA TCAGCCCAGC GGGCGATCTT ATCATGAAGA GTTTCATCCT 
CCCAAGGAGC ACATGAAGGA TGATGTGACC GGAGAACCTC TGATCCGCCG TAGTGATGAT 
AATGAAACTA CTCTGCGCTC TCGACTAGAG TCTTACCACA GGCAGACGTC TCCTCTAGTG 
CAGTACTACA GCGCCCGCGG CCTGCACACC GCCATCGATG CTTCTCAGTC CACCGACCTC 
GTCTTTGCCT CAATCCTCGC TGCCTTCTCT GCTGCTACCT GTAAAGATCT CGTTTATTTT 
GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_997761.1
CDS59..784
Translation

Target ORF information:

RefSeq Version NM_212596.1
Organism Danio rerio(zebrafish)
Definition Danio rerio adenylate kinase 2 (ak2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_212596.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGCCCCTA GCACACAAGA GGACGATACC GTCTCCGGTA TACGGAAAGG CATACGGGCC 
ATTCTGCTCG GGCCGCCCGG CGCGGGGAAG GGAACGCAGG CACCCAAGCT TGCAGAGAAA 
TACTGCGTGT GCCATTTAGC TACTGGGGAC ATGCTGAGGG CTATGGTGGC ATCTGGCTCA 
GAGCTCGGCC AGCGTCTAAA GGAAACCATG GATGCAGGCA AACTGGTGAG TGATGAGATG 
GTGGTGGAGC TCATAGACAA CAACCTGGAC ACACCATCAT GCAAGAATGG ATTCCTGCTG 
GACGGATTTC CCCGCACCGT CAAACAAGCA GAAATGCTGG ATGACCTCAT GGAGAAGCGT 
AGTGAGAAAC TGGACTCTGT TATTGAGTTC TCTGTCGATG ACTCCCTGCT GGTCCGCAGG 
ATCTGTGGAA GGCTCATTCA TCAGCCCAGC GGGCGATCTT ATCATGAAGA GTTTCATCCT 
CCCAAGGAGC ACATGAAGGA TGATGTGACC GGAGAACCTC TGATCCGCCG TAGTGATGAT 
AATGAAACTA CTCTGCGCTC TCGACTAGAG TCTTACCACA GGCAGACGTC TCCTCTAGTG 
CAGTACTACA GCGCCCGCGG CCTGCACACC GCCATCGATG CTTCTCAGTC CACCGACCTC 
GTCTTTGCCT CAATCCTCGC TGCCTTCTCT GCTGCTACCT GTAAAGATCT CGTTTATTTT 
GTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ODa24309
Clone ID Related Accession (Same CDS sequence) XM_005159648.3
Accession Version XM_005159648.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 708bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-06-14
Organism Danio rerio(zebrafish)
Product adenylate kinase 2, mitochondrial isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007130.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005159648.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCCCTA GCACACAAGA GGACGATACC GTCTCCGGTA TACGGAAAGG CATACGGGCC 
ATTCTGCTCG GGCCGCCCGG CGCGGGGAAG GGAACGCAGG CACCCAAGCT TGCAGAGAAA 
TACTGCGTGT GCCATTTAGC TACTGGGGAC ATGCTGAGGG CTATGGTGGC ATCTGGCTCA 
GAGCTCGGCC AGCGTCTAAA GGAAACCATG GATGCCGGCA AACTGGTGAG TGATGAGATG 
GTGGTGGAGC TCATAGACAA CAACCTGGAC ACACCAGCAT GCAAGAATGG ATTCCTGCTG 
GACGGATTTC CCCGCACCGT CAAACAAGCA GAAATGCTGG ATGACCTCAT GGAGAAGCGT 
AGTGAGAAAC TGGACTCTGT TATTGAGTTC TCTGTCGATG ACTCCCTGCT AGTCCGCAGG 
ATCTGTGGAA GGCTCATTCA TCAGCCCAGC GGGCGATCTT ATCATGAAGA GTTTCATCCT 
CCCAAGGAGC ACATGAAGGA TGATGTGACC GGAGAACCTC TGATCCGCCG TAGTGATGAT 
AATGAAACTA CTCTGCGCTC TCGACTAGAG TCTTACCACA GGCAGACGTC TCCTCTAGTG 
CAGTACTACA GCGCCCGCGG CCTGCACACC GCCATCGATG CTTCTCAGTC CACCGACCTC 
GTCTTTGCCT CAATCCTCGC TGCCTTCTCT GCTGCTACCT CTGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005159705.1
CDS93..800
Translation

Target ORF information:

RefSeq Version XM_005159648.3
Organism Danio rerio(zebrafish)
Definition Danio rerio adenylate kinase 2 (ak2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005159648.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCCCCTA GCACACAAGA GGACGATACC GTCTCCGGTA TACGGAAAGG CATACGGGCC 
ATTCTGCTCG GGCCGCCCGG CGCGGGGAAG GGAACGCAGG CACCCAAGCT TGCAGAGAAA 
TACTGCGTGT GCCATTTAGC TACTGGGGAC ATGCTGAGGG CTATGGTGGC ATCTGGCTCA 
GAGCTCGGCC AGCGTCTAAA GGAAACCATG GATGCCGGCA AACTGGTGAG TGATGAGATG 
GTGGTGGAGC TCATAGACAA CAACCTGGAC ACACCAGCAT GCAAGAATGG ATTCCTGCTG 
GACGGATTTC CCCGCACCGT CAAACAAGCA GAAATGCTGG ATGACCTCAT GGAGAAGCGT 
AGTGAGAAAC TGGACTCTGT TATTGAGTTC TCTGTCGATG ACTCCCTGCT AGTCCGCAGG 
ATCTGTGGAA GGCTCATTCA TCAGCCCAGC GGGCGATCTT ATCATGAAGA GTTTCATCCT 
CCCAAGGAGC ACATGAAGGA TGATGTGACC GGAGAACCTC TGATCCGCCG TAGTGATGAT 
AATGAAACTA CTCTGCGCTC TCGACTAGAG TCTTACCACA GGCAGACGTC TCCTCTAGTG 
CAGTACTACA GCGCCCGCGG CCTGCACACC GCCATCGATG CTTCTCAGTC CACCGACCTC 
GTCTTTGCCT CAATCCTCGC TGCCTTCTCT GCTGCTACCT CTGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Evolution of complexity in the zebrafish synapse proteome.
Nature communications814613(2017 Mar)
Bay?s ?,Collins MO,Reig-Viader R,Gou G,Goulding D,Izquierdo A,Choudhary JS,Emes RD,Grant SG


book

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J


book

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R


book

Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.
The Journal of experimental medicine212(8)1185-202(2015 Jul)
Rissone A,Weinacht KG,la Marca G,Bishop K,Giocaliere E,Jagadeesh J,Felgentreff K,Dobbs K,Al-Herz W,Jones M,Chandrasekharappa S,Kirby M,Wincovitch S,Simon KL,Itan Y,DeVine A,Schlaeger T,Schambach A,Sood R,Notarangelo LD,Candotti F


book

Zebrafish as a model for understanding the evolution of the vertebrate immune system and human primary immunodeficiency.
Experimental hematology42(8)697-706(2014 Aug)
Iwanami N