Rac1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rac1
Entrez Gene ID	38146
Full Name	CG2248 gene product from transcript CG2248-RB
Synonyms	2248,CG2248,D-Rac,D-Rac 1,D-Rac1,DRac,DRac1,DRacA,Dm Rac1,DmRAC,DmRAC1,Dmel\CG2248,Dmrac1,Drac,Drac1,Drac1a,DracA,GTPase Rac1,P40792,RAC1,Rac,Rac GTPase,Rac-1,Rac3,RacA,dRac,dRac1,drac1,rac,rac1
Gene Type	protein-coding
Organism	Drosophila melanogaster(fruit fly)
Genome	Chromosome: 3L Map Location: 61F5-61F5

mRNA and Protein(s)

mRNA	Protein	Name
NM_057602.4	NP_476950.1	Rac1, isoform A
NM_001274318.1	NP_001261247.1	Rac1, isoform B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RAC1	NP_001003274.1
Bos taurus (cattle)	RAC1	NP_776588.1
Danio rerio (zebrafish)	rac1a	NP_956065.1
Drosophila melanogaster (fruit fly)	Rac2	NP_001261517.1
	LOC717755	XP_001109586.2
Mus musculus (house mouse)	Rac1	NP_033033.1
Drosophila melanogaster (fruit fly)	Rac1	NP_476950.1
Arabidopsis thaliana (thale cress)	ROP1	NP_190698.1
Arabidopsis thaliana (thale cress)	RAC6	NP_195320.1
Xenopus tropicalis (tropical clawed frog)	rac1	NP_001004840.1
Rattus norvegicus (Norway rat)	Rac1	NP_599193.1
Gallus gallus (chicken)	RAC1	NP_990348.1
Pan troglodytes (chimpanzee)	RAC1	NP_001233310.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005445	XP_315449.4
Homo sapiens (human)	RAC1	NP_061485.1
Arabidopsis thaliana (thale cress)	ARAC1	NP_179371.1
Oryza sativa (rice)	Os02g0120800	NP_001045712.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)

Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects of development. Abl suppresses the actin-regulatory factor Enabled, and we find that Abl also acts through the GEF Trio to stimulate the signaling activity of Rac GTPase.
Title: The Abl pathway bifurcates to balance Enabled and Rac signaling in axon patterning in Drosophila.

Behavior-evoked activation of Rac1-dependent forgetting has a converging function for autism-risk genes.
Title: Inability to activate Rac1-dependent forgetting contributes to behavioral inflexibility in mutants of multiple autism-risk genes.

Rac1, a small GTPase, is specifically required in Eiger-mediated cell death. rac1 loss of function blocks Eiger-induced cell death, whereas Rac1 overexpression enhances Eiger-induced killing.
Title: Eiger-induced cell death relies on Rac1-dependent endocytosis.

We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development
Title: Rac1 is a novel interactor of Drosophila guanine nucleotide exchange factor GEFmeso.

PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.
Title: The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.

The following Rac1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rac1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OFa17130	NM_001274318.1 Latest version!	Drosophila melanogaster Rac1, transcript variant B (Rac1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00
OFa17130	NM_057602.4 Latest version!	Drosophila melanogaster Rac1, transcript variant A (Rac1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rac1 ( NM_057602.4 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_476950.1 Drosophila melanogaster Rac1, transcript variant A (Rac1), mRNA.

Price & Availability↑

CloneID	OFa17130
Clone ID Related Accession (Same CDS sequence)	NM_057602.4 , NM_001274318.1
Accession Version	NM_057602.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Rac1, isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). On Jan 16, 2013 this sequence version replaced NM_057602.3. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCAGGCGA TCAAGTGCGT CGTCGTGGGC GACGGAGCCG TGGGAAAGAC CTGCCTGCTG 
ATCAGCTACA CGACCAATGC CTTTCCCGGC GAGTACATAC CCACCGTGTT CGACAACTAC 
TCGGCCAACG TGATGGTGGA CGCCAAGCCC ATCAACCTGG GCCTGTGGGA TACGGCCGGG 
CAGGAGGACT ACGACCGACT GAGGCCACTG TCTTATCCCC AGACCGATGT CTTCCTCATC 
TGCTTCTCGC TGGTGAATCC GGCATCGTTC GAGAACGTGC GGGCCAAGTG GTATCCGGAG 
GTGCGCCACC ACTGCCCCAG CACGCCCATC ATCCTGGTGG GCACCAAGCT GGATTTGCGC 
GACGACAAGA ACACAATCGA AAAGCTGAGG GACAAGAAAC TGGCGCCCAT CACCTATCCG 
CAGGGCCTGG CCATGGCCAA GGAAATCGGA GCGGTCAAGT ATCTGGAGTG CTCGGCCCTG 
ACGCAGAAGG GTCTGAAAAC CGTTTTCGAC GAGGCCATCC GGTCGGTTTT GTGCCCCGTG 
CTGCAGCCCA AGTCCAAGCG CAAGTGCGCC CTGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_476950.1
CDS	338..916
Translation	MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIILVGTKLDLRDDKNTIEKLRDKKLAPITYPQGLAMAKEIGAVKYLECSALTQKGLKTVFDEAIRSVLCPVLQPKSKRKCALL

Target ORF information:

RefSeq Version	NM_057602.4
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Rac1, transcript variant A (Rac1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_057602.4

ORF Insert Sequence:

ATGCAGGCGA TCAAGTGCGT CGTCGTGGGC GACGGAGCCG TGGGAAAGAC CTGCCTGCTG 
ATCAGCTACA CGACCAATGC CTTTCCCGGC GAGTACATAC CCACCGTGTT CGACAACTAC 
TCGGCCAACG TGATGGTGGA CGCCAAGCCC ATCAACCTGG GCCTGTGGGA TACGGCCGGG 
CAGGAGGACT ACGACCGACT GAGGCCACTG TCTTATCCCC AGACCGATGT CTTCCTCATC 
TGCTTCTCGC TGGTGAATCC GGCATCGTTC GAGAACGTGC GGGCCAAGTG GTATCCGGAG 
GTGCGCCACC ACTGCCCCAG CACGCCCATC ATCCTGGTGG GCACCAAGCT GGATTTGCGC 
GACGACAAGA ACACAATCGA AAAGCTGAGG GACAAGAAAC TGGCGCCCAT CACCTATCCG 
CAGGGCCTGG CCATGGCCAA GGAAATCGGA GCGGTCAAGT ATCTGGAGTG CTCGGCCCTG 
ACGCAGAAGG GTCTGAAAAC CGTTTTCGAC GAGGCCATCC GGTCGGTTTT GTGCCCCGTG 
CTGCAGCCCA AGTCCAAGCG CAAGTGCGCC CTGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rac1 ( NM_001274318.1 ) cDNA ORF clone, Drosophila melanogaster(fruit fly) -> NP_001261247.1 Drosophila melanogaster Rac1, transcript variant B (Rac1), mRNA.

Price & Availability↑

CloneID	OFa17130
Clone ID Related Accession (Same CDS sequence)	NM_057602.4 , NM_001274318.1
Accession Version	NM_001274318.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 579bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-24
Organism	Drosophila melanogaster(fruit fly)
Product	Rac1, isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_037436). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END##

ATGCAGGCGA TCAAGTGCGT CGTCGTGGGC GACGGAGCCG TGGGAAAGAC CTGCCTGCTG 
ATCAGCTACA CGACCAATGC CTTTCCCGGC GAGTACATAC CCACCGTGTT CGACAACTAC 
TCGGCCAACG TGATGGTGGA CGCCAAGCCC ATCAACCTGG GCCTGTGGGA TACGGCCGGG 
CAGGAGGACT ACGACCGACT GAGGCCACTG TCTTATCCCC AGACCGATGT CTTCCTCATC 
TGCTTCTCGC TGGTGAATCC GGCATCGTTC GAGAACGTGC GGGCCAAGTG GTATCCGGAG 
GTGCGCCACC ACTGCCCCAG CACGCCCATC ATCCTGGTGG GCACCAAGCT GGATTTGCGC 
GACGACAAGA ACACAATCGA AAAGCTGAGG GACAAGAAAC TGGCGCCCAT CACCTATCCG 
CAGGGCCTGG CCATGGCCAA GGAAATCGGA GCGGTCAAGT ATCTGGAGTG CTCGGCCCTG 
ACGCAGAAGG GTCTGAAAAC CGTTTTCGAC GAGGCCATCC GGTCGGTTTT GTGCCCCGTG 
CTGCAGCCCA AGTCCAAGCG CAAGTGCGCC CTGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001261247.1
CDS	338..916
Translation	MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWYPEVRHHCPSTPIILVGTKLDLRDDKNTIEKLRDKKLAPITYPQGLAMAKEIGAVKYLECSALTQKGLKTVFDEAIRSVLCPVLQPKSKRKCALL

Target ORF information:

RefSeq Version	NM_001274318.1
Organism	Drosophila melanogaster(fruit fly)
Definition	Drosophila melanogaster Rac1, transcript variant B (Rac1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001274318.1

ORF Insert Sequence:

ATGCAGGCGA TCAAGTGCGT CGTCGTGGGC GACGGAGCCG TGGGAAAGAC CTGCCTGCTG 
ATCAGCTACA CGACCAATGC CTTTCCCGGC GAGTACATAC CCACCGTGTT CGACAACTAC 
TCGGCCAACG TGATGGTGGA CGCCAAGCCC ATCAACCTGG GCCTGTGGGA TACGGCCGGG 
CAGGAGGACT ACGACCGACT GAGGCCACTG TCTTATCCCC AGACCGATGT CTTCCTCATC 
TGCTTCTCGC TGGTGAATCC GGCATCGTTC GAGAACGTGC GGGCCAAGTG GTATCCGGAG 
GTGCGCCACC ACTGCCCCAG CACGCCCATC ATCCTGGTGG GCACCAAGCT GGATTTGCGC 
GACGACAAGA ACACAATCGA AAAGCTGAGG GACAAGAAAC TGGCGCCCAT CACCTATCCG 
CAGGGCCTGG CCATGGCCAA GGAAATCGGA GCGGTCAAGT ATCTGGAGTG CTCGGCCCTG 
ACGCAGAAGG GTCTGAAAAC CGTTTTCGAC GAGGCCATCC GGTCGGTTTT GTGCCCCGTG 
CTGCAGCCCA AGTCCAAGCG CAAGTGCGCC CTGCTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Matthews BB,Dos Santos G,Crosby MA,Emmert DB,St Pierre SE,Gramates LS,Zhou P,Schroeder AJ,Falls K,Strelets V,Russo SM,Gelbart WM,

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Crosby MA,Gramates LS,Dos Santos G,Matthews BB,St Pierre SE,Zhou P,Schroeder AJ,Falls K,Emmert DB,Russo SM,Gelbart WM,

Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
Hoskins RA,Carlson JW,Kennedy C,Acevedo D,Evans-Holm M,Frise E,Wan KH,Park S,Mendez-Lago M,Rossi F,Villasante A,Dimitri P,Karpen GH,Celniker SE

The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Smith CD,Shu S,Mungall CJ,Karpen GH

Combined evidence annotation of transposable elements in genome sequences.
PLoS computational biology1(2)166-75(2005 Jul)
Quesneville H,Bergman CM,Andrieu O,Autard D,Nouaud D,Ashburner M,Anxolabehere D

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Rac1 cDNA ORF clone, Drosophila melanogaster(fruit fly)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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