hh cDNA ORF clone, Drosophila melanogaster(fruit fly)
| Gene Symbol | hh |
| Entrez Gene ID | 42737 |
| Full Name | hedgehog |
| Synonyms | CG4637,Dmel\CG4637,HH,Hg,Hh,Mir,Mrt,anon-WO0134654.19,anon-WO0182946.19,bar,bar-3,bar3,hg,l(3)hh,l(3)neo56,l(3)neo57 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Drosophila melanogaster(fruit fly) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001038976.1 | NP_001034065.1 | hedgehog |
| Xenopus tropicalis (tropical clawed frog) | shh | XP_002932544.2 |
| Homo sapiens (human) | SHH | NP_000184.1 |
| Mus musculus (house mouse) | Shh | NP_033196.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001412 | XP_321721.5 |
| Bos taurus (cattle) | SHH | XP_002687031.2 |
| Rattus norvegicus (Norway rat) | Shh | NP_058917.1 |
| Gallus gallus (chicken) | SHH | NP_990152.1 |
| Danio rerio (zebrafish) | shha | NP_571138.1 |
| Danio rerio (zebrafish) | shhb | NP_571274.2 |
| SHH | XP_001106515.2 | |
| Canis lupus familiaris (dog) | SHH | XP_850450.1 |
| Pan troglodytes (chimpanzee) | SHH | XP_001147185.2 |
| Drosophila melanogaster (fruit fly) | hh | NP_001034065.1 |
Related articles in PubMed
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data.
Matthews BB, Dos Santos G, Crosby MA, Emmert DB, St Pierre SE, Gramates LS, Zhou P, Schroeder AJ, Falls K, Strelets V, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1721-36(2015 Jun)
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.
Crosby MA, Gramates LS, Dos Santos G, Matthews BB, St Pierre SE, Zhou P, Schroeder AJ, Falls K, Emmert DB, Russo SM, Gelbart WM,
G3 (Bethesda, Md.)5(8)1737-49(2015 Jun)
Sequence finishing and mapping of Drosophila melanogaster heterochromatin.
Hoskins RA, Carlson JW, Kennedy C, Acevedo D, Evans-Holm M, Frise E, Wan KH, Park S, Mendez-Lago M, Rossi F, Villasante A, Dimitri P, Karpen GH, Celniker SE
Science (New York, N.Y.)316(5831)1625-8(2007 Jun)
The Release 5.1 annotation of Drosophila melanogaster heterochromatin.
Smith CD, Shu S, Mungall CJ, Karpen GH
Science (New York, N.Y.)316(5831)1586-91(2007 Jun)
Combined evidence annotation of transposable elements in genome sequences.
Quesneville H, Bergman CM, Andrieu O, Autard D, Nouaud D, Ashburner M, Anxolabehere D
PLoS computational biology1(2)166-75(2005 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These findings show that in the wing disc, Hh distributions and signaling are dependent upon basal release and uptake, and on cytoneme-mediated movement.
Title: Essential basal cytonemes take up Hedgehog in the
Hedgehog (Hh) signaling regulates TORC1 through E2F1 and the cyclin D/Cdk4 complex in the Drosophila eye.
Title: Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.
In ovary escort cells (ECs) both Hh and Yki limit production of BMP ligands to allow germline differentiation. Loss of Yki produced a more severe germarial phenotype than loss of Hh signaling and principally induced a different BMP ligand. Moreover, Yki activity reporters and epistasis tests showed that Yki does not mediate the key actions of Hh signaling in ECs.
Title: Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the
Data show that Hedgehog (Hh) stimulates the binding of Smoothened (Smo) to a plasma membrane-associated kinase Gilgamesh (Gish)/CK1gamma and that Gish fine-tunes Hh pathway activity by phosphorylating a Ser/Thr cluster of Smo carboxyl-terminal intracellular tail (C-tail).
Title: Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
HEXIM ensures the integrity of Hedgehog signaling in wing imaginal disc, by a yet unknown mechanism. To our knowledge, this is the first time that the physiological function of HEXIM has been addressed in such details in vivo.
Title: Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development.
The following hh gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the hh cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OFa05754 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001038976.1 | |
| Accession Version | NM_001038976.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1416bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-24 | |
| Organism | Drosophila melanogaster(fruit fly) | |
| Product | hedgehog | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NT_033777). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.26 URL :: http://flybase.org ##Genome-Annotation-Data-END## | |
1 | ATGGATAACC ACAGCTCAGT GCCTTGGGCC AGTGCCGCCA GTGTCACCTG TCTCTCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001034065.1 |
| CDS | 386..1801 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001038976.1 |
ORF Insert Sequence:
1 | ATGGATAACC ACAGCTCAGT GCCTTGGGCC AGTGCCGCCA GTGTCACCTG TCTCTCCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data. |
|
Gene Model Annotations for Drosophila melanogaster: The Rule-Benders. |
|
Sequence finishing and mapping of Drosophila melanogaster heterochromatin. |
|
The Release 5.1 annotation of Drosophila melanogaster heterochromatin. |
|
Combined evidence annotation of transposable elements in genome sequences. |