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KRT6C cDNA ORF clone, Homo sapiens(Human)

Gene Symbol KRT6C
Entrez Gene ID 286887
Full Name keratin 6C
Synonyms K6E,KRT6E,PPKNEFD
General protein information
Preferred Names

keratin 6C

Names

keratin, type II cytoskeletal 6C
CK-6C
CK-6E
K6C
cytokeratin-6C
cytokeratin-6E
keratin 6C, type II
keratin 6E
keratin K6h
type-II keratin Kb12

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

12

12q13.13

Summary Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jul 2009].
Disorder MIM:

612315


mRNA and Protein(s)

mRNA Protein Name
NM_173086.4 NP_775109.2 keratin, type II cytoskeletal 6C



Homo sapiens (human) KRT6C NP_775109.2
Pan troglodytes (chimpanzee) KRT6B XP_001143262.1


Related articles in PubMed

Focal PPK secondary to a novel KRT6C mutation (Pachyonychia congenita-K6c).
Wee JS, Smith FJ, Wilson NJ, O'Toole EA
Journal of the European Academy of Dermatology and Venereology : JEADV30(8)1415-6(2016 Aug)

Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.
Kubo A, Oura Y, Hirano T, Aoyama Y, Sato S, Nakamura K, Takae Y, Amagai M
The Journal of dermatology40(7)553-7(2013 Jul)

Mutations in a keratin 6 isomer (K6c) cause a type of focal palmoplantar keratoderma.
Bowden PE
The Journal of investigative dermatology130(2)336-8(2010 Feb)

Keratin K6c mutations cause focal palmoplantar keratoderma.
Wilson NJ, Messenger AG, Leachman SA, O'Toole EA, Lane EB, McLean WH, Smith FJ
The Journal of investigative dermatology130(2)425-9(2010 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

report on a novel mutation of KRT6C and highlight the inclusion of focal PPK secondary to KRT16 and KRT6C mutations as a milder phenotype within the spectrum of PC
Title: Focal PPK secondary to a novel KRT6C mutation (Pachyonychia congenita-K6c).

mutation c.1414G>A resulting in an p.Glu472Lys substitution associated with focal plantar keratoderma
Title: Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.

KRT6C mutations may have a role in focal palmoplantar keratoderma [commentary]
Title: Mutations in a keratin 6 isomer (K6c) cause a type of focal palmoplantar keratoderma.

Keratin K6c mutations cause focal palmoplantar keratoderma
Title: Keratin K6c mutations cause focal palmoplantar keratoderma.

The following KRT6C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT6C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18637 NM_173086.4
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Homo sapiens keratin 6C (KRT6C), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18637
Clone ID Related Accession (Same CDS sequence) NM_173086.4
Accession Version NM_173086.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1695bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product keratin, type II cytoskeletal 6C
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC110639.1 and AC055736.20. This sequence is a reference standard in the RefSeqGene project. On Aug 15, 2007 this sequence version replaced NM_173086.3. ##Evidence-Data-START## Transcript exon combination :: BC110639.1, L42611.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC
CTCAGGAGGC AGCTGGACAG CATCGTCGGG GAACGGGGCC GCCTGGACTC GGAGCTGAGA
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGATG AGATCAACTT CCTGAGAGCC
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA
TACGAGGAGA TTGCTCAGAG GAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA TGTCAAGAAG
CAGTGTGCCA GCCTGCAGGC TGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCACTC
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGATGTG
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC
GTTGGACAAG TCAACGTCTC TGTAGTACAG TCCACCATCT CCAGTGGCTA TGGCGGTGCC
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT
CTTGGCATTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG
AGCTACAAGC ACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_775109.2
CDS49..1743
Misc Feature(1)52..534
Misc Feature(2)52..54
Misc Feature(3)97..525
Misc Feature(4)226..228
Misc Feature(5)532..1473
Misc Feature(6)535..1464
Misc Feature(7)535..642
Misc Feature(8)643..699
Misc Feature(9)700..975
Misc Feature(10)976..1047
Misc Feature(11)1048..1464
Misc Feature(12)1288..1290
Misc Feature(13)1465..1740
Exon (1)1..588
Exon (2)589..803
Exon (3)804..864
Exon (4)865..960
Exon (5)961..1125
Exon (6)1126..1251
Exon (7)1252..1472
Exon (8)1473..1507
Exon (9)1508..2289
Translation

Target ORF information:

RefSeq Version NM_173086.4
Organism Homo sapiens(Human)
Definition Homo sapiens keratin 6C (KRT6C), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_173086.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGCCAGCA CATCCACCAC CATCAGGAGC CACAGCAGCA GCCGCCGGGG TTTCAGTGCC 
AACTCAGCCA GGCTCCCTGG GGTCAGCCGC TCTGGCTTCA GCAGCATCTC CGTGTCCCGC
TCCAGGGGCA GTGGTGGCCT GGGTGGTGCA TGTGGAGGAG CTGGCTTTGG CAGCCGCAGT
CTGTATGGCC TGGGGGGCTC CAAGAGGATC TCCATTGGAG GGGGCAGCTG TGCCATCAGT
GGCGGCTATG GCAGCAGAGC CGGAGGCAGC TATGGCTTTG GTGGCGCCGG GAGTGGATTT
GGTTTCGGTG GTGGAGCCGG CATTGGCTTT GGTCTGGGTG GTGGAGCCGG CCTTGCTGGT
GGCTTTGGGG GCCCTGGCTT CCCTGTGTGC CCCCCTGGAG GCATCCAAGA GGTCACCGTC
AACCAGAGTC TCCTGACTCC CCTCAACCTG CAAATTGACC CCGCCATCCA GCGGGTGCGG
GCCGAGGAGC GTGAGCAGAT CAAGACCCTC AACAACAAGT TTGCCTCCTT CATCGACAAG
GTGCGGTTCC TAGAGCAGCA GAACAAGGTT CTGGACACCA AGTGGACCCT GCTGCAGGAG
CAGGGCACCA AGACTGTGAG GCAGAACCTG GAGCCGTTGT TCGAGCAGTA CATCAACAAC
CTCAGGAGGC AGCTGGACAG CATCGTCGGG GAACGGGGCC GCCTGGACTC GGAGCTGAGA
AACATGCAGG ACCTGGTGGA GGACCTCAAG AACAAATATG AGGATGAAAT CAACAAGCGC
ACAGCAGCAG AGAATGAATT TGTGACTCTG AAGAAGGATG TGGATGCTGC CTACATGAAC
AAGGTTGAAC TGCAAGCCAA GGCAGACACT CTCACAGATG AGATCAACTT CCTGAGAGCC
TTGTATGATG CAGAGCTGTC CCAGATGCAG ACCCACATCT CAGACACATC CGTGGTGCTA
TCCATGGACA ACAACCGCAA CCTGGACCTG GACAGCATCA TCGCTGAGGT CAAGGCCCAA
TACGAGGAGA TTGCTCAGAG GAGCCGGGCT GAGGCTGAGT CCTGGTACCA GACCAAGTAC
GAGGAGCTGC AGGTCACAGC AGGCAGACAT GGGGACGACC TGCGCAACAC CAAGCAGGAG
ATTGCTGAGA TCAACCGCAT GATCCAGAGG CTGAGATCTG AGATCGACCA TGTCAAGAAG
CAGTGTGCCA GCCTGCAGGC TGCCATTGCT GATGCTGAGC AGCGTGGGGA GATGGCACTC
AAGGATGCTA AGAACAAGCT GGAAGGGCTG GAGGATGCCC TGCAGAAGGC CAAGCAGGAC
CTGGCCCGGC TGCTGAAGGA GTACCAGGAG CTGATGAATG TCAAGCTGGC CCTGGATGTG
GAGATCGCCA CCTACCGCAA GCTGCTGGAG GGCGAGGAGT GCAGGCTGAA TGGCGAAGGC
GTTGGACAAG TCAACGTCTC TGTAGTACAG TCCACCATCT CCAGTGGCTA TGGCGGTGCC
AGCGGTGTCG GCAGTGGCTT AGGCCTGGGT GGAGGAAGCA GCTACTCCTA TGGCAGTGGT
CTTGGCATTG GAGGTGGCTT CAGTTCCAGC AGTGGCAGAG CCATTGGGGG TGGCCTCAGC
TCTGTTGGAG GCGGCAGTTC CACCATCAAG TACACCACCA CCTCCTCCTC CAGCAGGAAG
AGCTACAAGC ACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Focal PPK secondary to a novel KRT6C mutation (Pachyonychia congenita-K6c).
Journal of the European Academy of Dermatology and Venereology : JEADV30(8)1415-6(2016 Aug)
Wee JS,Smith FJ,Wilson NJ,O'Toole EA


book

Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.
The Journal of dermatology40(7)553-7(2013 Jul)
Kubo A,Oura Y,Hirano T,Aoyama Y,Sato S,Nakamura K,Takae Y,Amagai M


book

Mutations in a keratin 6 isomer (K6c) cause a type of focal palmoplantar keratoderma.
The Journal of investigative dermatology130(2)336-8(2010 Feb)
Bowden PE


book

Keratin K6c mutations cause focal palmoplantar keratoderma.
The Journal of investigative dermatology130(2)425-9(2010 Feb)
Wilson NJ,Messenger AG,Leachman SA,O'Toole EA,Lane EB,McLean WH,Smith FJ


 
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