TRPM5 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | TRPM5 |
| Entrez Gene ID | 29850 |
| Full Name | transient receptor potential cation channel subfamily M member 5 |
| Synonyms | LTRPC5,MTR1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_014555.3 | NP_055370.1 | transient receptor potential cation channel subfamily M member 5 |
| XM_017017628.1 | XP_016873117.1 | transient receptor potential cation channel subfamily M member 5 isoform X1 |
| Pan troglodytes (chimpanzee) | TRPM5 | XP_521720.4 |
| Mus musculus (house mouse) | Trpm5 | NP_064673.2 |
| Rattus norvegicus (Norway rat) | Trpm5 | NP_001178825.1 |
| Homo sapiens (human) | TRPM5 | NP_055370.1 |
| TRPM5 | XP_001093334.1 | |
| Bos taurus (cattle) | TRPM5 | XP_002699492.2 |
| Gallus gallus (chicken) | TRPM5 | XP_003641369.2 |
| Canis lupus familiaris (dog) | TRPM5 | XP_005631408.1 |
| Danio rerio (zebrafish) | trpm5 | NP_001121711.1 |
Related articles in PubMed
A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture.
Risso DS, Giuliani C, Antinucci M, Morini G, Garagnani P, Tofanelli S, Luiselli D
Appetite114240-247(2017 Jul)
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Shigeto M, Ramracheya R, Tarasov AI, Cha CY, Chibalina MV, Hastoy B, Philippaert K, Reinbothe T, Rorsman N, Salehi A, Sones WR, Vergari E, Weston C, Gorelik J, Katsura M, Nikolaev VO, Vennekens R, Zaccolo M, Galione A, Johnson PR, Kaku K, Ladds G, Rorsman P
The Journal of clinical investigation125(12)4714-28(2015 Dec)
Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis.
Oztuzcu S, Onat AM, Pehlivan Y, Alibaz-Oner F, Donmez S, Cetin GY, Yolbas S, Bozgeyik I, Yilmaz N, Ozgen M, Cagatay Y, Kisacik B, Koca SS, Pamuk ON, Sayarlioglu M, Direskeneli H, Demiryurek AT
In vivo (Athens, Greece)29(6)763-70(2015 Nov-Dec)
Role of the transient receptor potential (TRP) channel gene expressions and TRP melastatin (TRPM) channel gene polymorphisms in obesity-related metabolic syndrome.
Tabur S, Oztuzcu S, Duzen IV, Eraydin A, Eroglu S, Ozkaya M, Demiry?rek AT
European review for medical and pharmacological sciences19(8)1388-97(2015 Apr)
Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains.
Liu D, Zhang Z, Liman ER
The Journal of biological chemistry280(21)20691-9(2005 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The PKC-dependent effect of GLP-1 on membrane potential and electrical activity was mediated by activation of Na(+)-permeable TRPM4 and TRPM5 channels by mobilization of intracellular Ca(2+) from thapsigargin-sensitive Ca(2+) stores
Title: GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
Our results suggest roles of TRPM3 and TRPM5 gene variants in the susceptibility to or clinical expression of Systemic sclerosis
Title: Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis.
In a Turkish population, genetic polymorphism in TRPM5 genes modify individual susceptibility to metabolic syndrome.
Title: Role of the transient receptor potential (TRP) channel gene expressions and TRP melastatin (TRPM) channel gene polymorphisms in obesity-related metabolic syndrome.
TrpM5 expression was similar throughout the olfactory glomeruli.
Title: Differential localization of NT-3 and TrpM5 in glomeruli of the olfactory bulb of mice.
The TRPM5 gene rs34551253 (Ala456Thr) polymorphism may be associated with increased risk of developing primary open angle glaucoma in the Turkish population.
Title: Association transient receptor potential melastatin channel gene polymorphism with primary open angle glaucoma.
The following TRPM5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRPM5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu13598 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_014555.3 | |
| Accession Version | NM_014555.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3498bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-03 | |
| Organism | Homo sapiens(human) | |
| Product | transient receptor potential cation channel subfamily M member 5 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF177473.1 and AJ270996.1. On Jun 28, 2008 this sequence version replaced NM_014555.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF177473.1, BC093787.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 10607831 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## | |
1 | ATGCAGGATG TCCAAGGCCC CCGTCCCGGA AGCCCCGGGG ATGCTGAAGA CCGGCGGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_055370.1 |
| CDS | 10..3507 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_014555.3 |
ORF Insert Sequence:
1 | ATGCAGGATG TCCAAGGCCC CCGTCCCGGA AGCCCCGGGG ATGCTGAAGA CCGGCGGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu92173 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017017628.1 | |
| Accession Version | XM_017017628.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 3561bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | transient receptor potential cation channel subfamily M member 5 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGTCTGCAG GTGTGGCCAA CCTGAGGTGC CCTGAGTGGG CTCTAGAGGC CACCATGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_016873117.1 |
| CDS | 43..3603 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017017628.1 |
ORF Insert Sequence:
1 | ATGTCTGCAG GTGTGGCCAA CCTGAGGTGC CCTGAGTGGG CTCTAGAGGC CACCATGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
A bio-cultural approach to the study of food choice: The contribution of taste genetics, population and culture. |
|
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. |
|
Association of TRPM Channel Gene Polymorphisms with Systemic Sclerosis. |
|
Role of the transient receptor potential (TRP) channel gene expressions and TRP melastatin (TRPM) channel gene polymorphisms in obesity-related metabolic syndrome. |
|
Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains. |