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HLA-C cDNA ORF clone, Homo sapiens(Human)

Gene Symbol HLA-C
Entrez Gene ID 3107
Full Name major histocompatibility complex, class I, C
Synonyms D6S204,HLA-JY3,HLAC,HLC-C,MHC,PSORS1
General protein information
Preferred Names

major histocompatibility complex, class I, C

Names

HLA class I histocompatibility antigen, Cw-1 alpha chain
HLA class I histocompatibility antigen, C alpha chain
HLA-C alpha chain
HLA-C antigen
MHC class I antigen heavy chain HLA-C
human leukocyte antigen-C alpha chain
major histocompatibility antigen HLA-C

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

6

6p21.33

Summary HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008].
Disorder MIM:

142840

Disorder Html: {Psoriasis susceptibility 1}, 177900 (3); {HIV-1

mRNA and Protein(s)

mRNA Protein Name
NM_001243042.1 NP_001229971.1 HLA class I histocompatibility antigen, Cw-1 alpha chain precursor
NM_002117.5 NP_002108.4 HLA class I histocompatibility antigen, Cw-1 alpha chain precursor



Pan troglodytes (chimpanzee) PATR-C NP_001012441.2
Homo sapiens (human) HLA-C NP_002108.4
Macaca mulatta (rhesus monkey) MAMU-B NP_001041710.1


Related articles in PubMed

Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.
Wakamatsu TH, Ueta M, Tokunaga K, Okada Y, Loureiro RR, Costa KA, Sallum JMF, Milhomens JA, Inoue C, Sotozono C, Gomes JÁP, Kinoshita S
JAMA ophthalmology135(4)355-360(2017 Apr)

HLA-C levels impact natural killer cell subset distribution and function.
Sips M, Liu Q, Draghi M, Ghebremichael M, Berger CT, Suscovich TJ, Sun Y, Walker BD, Carrington M, Altfeld M, Brouckaert P, De Jager PL, Alter G
Human immunology77(12)1147-1153(2016 Dec)

HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series.
Thorleifsdottir RH, Sigurdardottir SL, Sigurgeirsson B, Olafsson JH, Petersen H, Sigurdsson MI, Gudjonsson JE, Johnston A, Valdimarsson H
Journal of the American Academy of Dermatology75(5)889-896(2016 Nov)

Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis.
Saruhan-Direskeneli G, Hughes T, Yilmaz V, Durmus H, Adler A, Alahgholi-Hajibehzad M, Aysal F, Yentür SP, Akalin MA, Dogan O, Marx A, Gülsen-Parman Y, Oflazer P, Deymeer F, Sawalha AH
Clinical immunology (Orlando, Fla.)166-16781-8(2016 05)

Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.
Chandra A, Lahiri A, Senapati S, Basu B, Ghosh S, Mukhopadhyay I, Behra A, Sarkar S, Chatterjee G, Chatterjee R
Scientific reports624059(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The data suggested the association of IL12B with the psoriasis, however no evidence was observed for the epistatic effect of IL12B with HLA-Cw6 among the psoriasis patients in India.
Title: Association of IL12B risk haplotype and lack of interaction with HLA-Cw6 among the psoriasis patients in India.

the signal overall signal that NK cells receive from paternal HLA-C on trophoblasts depends on the ratio of activating and inhibitory KIR genes expressed by them
Title: Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention.

Homozygous HLA-Cw*0602 carriage in plaque psoriasis may predict a favorable outcome after tonsillectomy. The homozygotes more often had psoriasis onset associated with a throat infection and an increased frequency of streptococcal throat infections per lifetime.
Title: HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series.

The central finding of this study was that several structurally unrelated HLA alleles, including B*08:01:01, B*18:01:01, B*27:05:02, B*55:01:01 and C*06:02:01, were found to be significantly associated with particular phenotypic features of psoriatic arthritis, implying that the clinical diagnosis of psoriatic arthritis designates a genetically heterogeneous subset of individuals
Title: Implications of the diversity of class I HLA associations in psoriatic arthritis.

The absence of KIR-2DS1 in the mother and the presence of HLA-C2 ligand in the child were negatively associated with type 1 diabetes in the child. Our results indicate that maternal KIR genes and their interaction with foetal HLA-C2 may contribute to the risk of type 1 diabetes among Han Chinese children
Title: Interactions between maternal killer cell immunoglobulin receptor genes and foetal HLA ligand genes contribute to type 1 diabetes susceptibility in Han Chinese.

The following HLA-C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HLA-C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu21205
NM_002117.5
Latest version!
Homo sapiens major histocompatibility complex, class I, C (HLA-C), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$149.50-$209.30
$299.00
OHu31524 NM_001243042.1
Latest version!
Homo sapiens major histocompatibility complex, class I, C (HLA-C), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21205
Clone ID Related Accession (Same CDS sequence) NM_002117.5
Accession Version NM_002117.5 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1101bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product HLA class I histocompatibility antigen, Cw-1 alpha chain precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL671883.3 and BC007814.2. On Jul 13, 2011 this sequence version replaced NM_002117.4. Transcript Variant: This variant (1) represents the C*07:02:01 allele of the HLA-C gene, as represented in the assembled chromosome 6 in the primary assembly of the reference genome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033293.1, M24097.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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361
421
481
541
601
661
721
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1081
ATGCGGGTCA TGGCGCCCCG AGCCCTCCTC CTGCTGCTCT CGGGAGGCCT GGCCCTGACC 
GAGACCTGGG CCTGCTCCCA CTCCATGAGG TATTTCGACA CCGCCGTGTC CCGGCCCGGC
CGCGGAGAGC CCCGCTTCAT CTCAGTGGGC TACGTGGACG ACACGCAGTT CGTGCGGTTC
GACAGCGACG CCGCGAGTCC GAGAGGGGAG CCGCGGGCGC CGTGGGTGGA GCAGGAGGGG
CCGGAGTATT GGGACCGGGA GACACAGAAG TACAAGCGCC AGGCACAGGC TGACCGAGTG
AGCCTGCGGA ACCTGCGCGG CTACTACAAC CAGAGCGAGG ACGGGTCTCA CACCCTCCAG
AGGATGTCTG GCTGCGACCT GGGGCCCGAC GGGCGCCTCC TCCGCGGGTA TGACCAGTCC
GCCTACGACG GCAAGGATTA CATCGCCCTG AACGAGGACC TGCGCTCCTG GACCGCCGCG
GACACCGCGG CTCAGATCAC CCAGCGCAAG TTGGAGGCGG CCCGTGCGGC GGAGCAGCTG
AGAGCCTACC TGGAGGGCAC GTGCGTGGAG TGGCTCCGCA GATACCTGGA GAACGGGAAG
GAGACGCTGC AGCGCGCAGA ACCCCCAAAG ACACACGTGA CCCACCACCC CCTCTCTGAC
CATGAGGCCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCGGAGAT CACACTGACC
TGGCAGCGGG ATGGGGAGGA CCAGACCCAG GACACCGAGC TTGTGGAGAC CAGGCCAGCA
GGAGATGGAA CCTTCCAGAA GTGGGCAGCT GTGGTGGTGC CTTCTGGACA AGAGCAGAGA
TACACGTGCC ATATGCAGCA CGAGGGGCTG CAAGAGCCCC TCACCCTGAG CTGGGAGCCA
TCTTCCCAGC CCACCATCCC CATCATGGGC ATCGTTGCTG GCCTGGCTGT CCTGGTTGTC
CTAGCTGTCC TTGGAGCTGT GGTCACCGCT ATGATGTGTA GGAGGAAGAG CTCAGGTGGA
AAAGGAGGGA GCTGCTCTCA GGCTGCGTGC AGCAACAGTG CCCAGGGCTC TGATGAGTCT
CTCATCACTT GTAAAGCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002108.4
CDS66..1166
Misc Feature(1)138..407
Misc Feature(2)141..674
Misc Feature(3)393..395
Misc Feature(4)408..683
Misc Feature(5)684..962
Misc Feature(6)684..959
Misc Feature(7)order(741..743,747..749,828..833,837..845,861..863,867..869)
Misc Feature(8)order(762..770,852..854,927..929)
Misc Feature(9)960..989
Misc Feature(10)990..1064
Misc Feature(11)<1104..1160
Exon (1)1..138
Exon (2)139..408
Exon (3)409..684
Exon (4)685..960
Exon (5)961..1080
Exon (6)1081..1113
Exon (7)1114..1161
Exon (8)1162..1586
Translation

Target ORF information:

RefSeq Version NM_002117.5
Organism Homo sapiens(Human)
Definition Homo sapiens major histocompatibility complex, class I, C (HLA-C), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002117.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCGGGTCA TGGCGCCCCG AGCCCTCCTC CTGCTGCTCT CGGGAGGCCT GGCCCTGACC 
GAGACCTGGG CCTGCTCCCA CTCCATGAGG TATTTCGACA CCGCCGTGTC CCGGCCCGGC
CGCGGAGAGC CCCGCTTCAT CTCAGTGGGC TACGTGGACG ACACGCAGTT CGTGCGGTTC
GACAGCGACG CCGCGAGTCC GAGAGGGGAG CCGCGGGCGC CGTGGGTGGA GCAGGAGGGG
CCGGAGTATT GGGACCGGGA GACACAGAAG TACAAGCGCC AGGCACAGGC TGACCGAGTG
AGCCTGCGGA ACCTGCGCGG CTACTACAAC CAGAGCGAGG ACGGGTCTCA CACCCTCCAG
AGGATGTCTG GCTGCGACCT GGGGCCCGAC GGGCGCCTCC TCCGCGGGTA TGACCAGTCC
GCCTACGACG GCAAGGATTA CATCGCCCTG AACGAGGACC TGCGCTCCTG GACCGCCGCG
GACACCGCGG CTCAGATCAC CCAGCGCAAG TTGGAGGCGG CCCGTGCGGC GGAGCAGCTG
AGAGCCTACC TGGAGGGCAC GTGCGTGGAG TGGCTCCGCA GATACCTGGA GAACGGGAAG
GAGACGCTGC AGCGCGCAGA ACCCCCAAAG ACACACGTGA CCCACCACCC CCTCTCTGAC
CATGAGGCCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCGGAGAT CACACTGACC
TGGCAGCGGG ATGGGGAGGA CCAGACCCAG GACACCGAGC TTGTGGAGAC CAGGCCAGCA
GGAGATGGAA CCTTCCAGAA GTGGGCAGCT GTGGTGGTGC CTTCTGGACA AGAGCAGAGA
TACACGTGCC ATATGCAGCA CGAGGGGCTG CAAGAGCCCC TCACCCTGAG CTGGGAGCCA
TCTTCCCAGC CCACCATCCC CATCATGGGC ATCGTTGCTG GCCTGGCTGT CCTGGTTGTC
CTAGCTGTCC TTGGAGCTGT GGTCACCGCT ATGATGTGTA GGAGGAAGAG CTCAGGTGGA
AAAGGAGGGA GCTGCTCTCA GGCTGCGTGC AGCAACAGTG CCCAGGGCTC TGATGAGTCT
CTCATCACTT GTAAAGCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu31524
Clone ID Related Accession (Same CDS sequence) NM_001243042.1
Accession Version NM_001243042.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1101bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-06
Organism Homo sapiens(Human)
Product HLA class I histocompatibility antigen, Cw-1 alpha chain precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662833.4. This sequence is a reference standard in the RefSeqGene project. On or before Aug 3, 2011 this sequence version replaced XM_003403558.1, XM_003403559.1, XM_003403560.1, XM_003403561.1, XM_003403562.1, XM_003403563.1, XM_003403564.1, XM_003403565.1, XM_003403566.1, XM_003403567.1, XM_003403568.1, XM_003119247.1, XM_003403569.1, XM_003119251.1, XM_003403570.1, XM_003119244.1, XM_003119245.1, XM_003403571.1, XM_003119246.1, XM_003119250.1, XM_003119366.1, XM_003119254.1, XM_003119365.1, XM_003119248.1, XM_003119359.1, XM_003119255.1, XM_003119361.1, XM_003119256.1, XM_003119360.1, XM_003119253.1, XM_003119364.1, XM_003119249.1, XM_003119369.1, XM_003119257.1, XM_003119363.1, XM_003119252.1, XM_003119370.1, XM_003119371.1, XM_003119368.1, XM_003119372.1, XM_003119362.1, XM_003119367.1, XM_003119373.1, XM_003119412.1, XM_003119405.1, XM_003119411.1, XM_003119406.1, XM_003119407.1, XM_003119410.1, XM_003119409.1, XM_003119415.1, XM_003119416.1, XM_003119417.1, XM_003119414.1, XM_003119418.1, XM_003119408.1, XM_003119419.1, XM_003119413.1, XM_003403557.1. Transcript Variant: This variant (2) represents the C*07:01:01:01 allele of the HLA-C gene, as represented in the alternate locus group ALT_REF_LOCI_2 of the reference genome. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.53722.1, SRR1163655.499321.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149398, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCGGGTCA TGGCGCCCCG AGCCCTCCTC CTGCTGCTCT CGGGAGGCCT GGCCCTGACC 
GAGACCTGGG CCTGCTCCCA CTCCATGAGG TATTTCGACA CCGCCGTGTC CCGGCCCGGC
CGCGGAGAGC CCCGCTTCAT CTCAGTGGGC TACGTGGACG ACACGCAGTT CGTGCGGTTC
GACAGCGACG CCGCGAGTCC GAGAGGGGAG CCGCGGGCGC CGTGGGTGGA GCAGGAGGGG
CCGGAGTATT GGGACCGGGA GACACAGAAC TACAAGCGCC AGGCACAGGC TGACCGAGTG
AGCCTGCGGA ACCTGCGCGG CTACTACAAC CAGAGCGAGG ACGGGTCTCA CACCCTCCAG
AGGATGTATG GCTGCGACCT GGGGCCCGAC GGGCGCCTCC TCCGCGGGTA TGACCAGTCC
GCCTACGACG GCAAGGATTA CATCGCCCTG AACGAGGACC TGCGCTCCTG GACCGCCGCG
GACACCGCGG CTCAGATCAC CCAGCGCAAG TTGGAGGCGG CCCGTGCGGC GGAGCAGCTG
AGAGCCTACC TGGAGGGCAC GTGCGTGGAG TGGCTCCGCA GATACCTGGA GAACGGGAAG
GAGACGCTGC AGCGCGCAGA ACCCCCAAAG ACACACGTGA CCCACCACCC CCTCTCTGAC
CATGAGGCCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCGGAGAT CACACTGACC
TGGCAGCGGG ATGGGGAGGA CCAGACCCAG GACACCGAGC TTGTGGAGAC CAGGCCAGCA
GGAGATGGAA CCTTCCAGAA GTGGGCAGCT GTGGTGGTGC CTTCTGGACA AGAGCAGAGA
TACACGTGCC ATATGCAGCA CGAGGGGCTG CAAGAGCCCC TCACCCTGAG CTGGGAGCCA
TCTTCCCAGC CCACCATCCC CATCATGGGC ATCGTTGCTG GCCTGGCTGT CCTGGTTGTC
CTAGCTGTCC TTGGAGCTGT GGTCACCGCT ATGATGTGTA GGAGGAAGAG CTCAGGTGGA
AAAGGAGGGA GCTGCTCTCA GGCTGCGTGC AGCAACAGTG CCCAGGGCTC TGATGAGTCT
CTCATCACTT GTAAAGCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001229971.1
CDS66..1166
Misc Feature(1)138..407
Misc Feature(2)141..674
Misc Feature(3)408..683
Misc Feature(4)684..962
Misc Feature(5)684..959
Misc Feature(6)order(741..743,747..749,828..833,837..845,861..863,867..869)
Misc Feature(7)order(762..770,852..854,927..929)
Misc Feature(8)960..989
Misc Feature(9)990..1064
Misc Feature(10)<1104..1160
Exon (1)1..138
Exon (2)139..408
Exon (3)409..684
Exon (4)685..960
Exon (5)961..1080
Exon (6)1081..1113
Exon (7)1114..1161
Exon (8)1162..1586
Translation

Target ORF information:

RefSeq Version NM_001243042.1
Organism Homo sapiens(Human)
Definition Homo sapiens major histocompatibility complex, class I, C (HLA-C), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001243042.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCGGGTCA TGGCGCCCCG AGCCCTCCTC CTGCTGCTCT CGGGAGGCCT GGCCCTGACC 
GAGACCTGGG CCTGCTCCCA CTCCATGAGG TATTTCGACA CCGCCGTGTC CCGGCCCGGC
CGCGGAGAGC CCCGCTTCAT CTCAGTGGGC TACGTGGACG ACACGCAGTT CGTGCGGTTC
GACAGCGACG CCGCGAGTCC GAGAGGGGAG CCGCGGGCGC CGTGGGTGGA GCAGGAGGGG
CCGGAGTATT GGGACCGGGA GACACAGAAC TACAAGCGCC AGGCACAGGC TGACCGAGTG
AGCCTGCGGA ACCTGCGCGG CTACTACAAC CAGAGCGAGG ACGGGTCTCA CACCCTCCAG
AGGATGTATG GCTGCGACCT GGGGCCCGAC GGGCGCCTCC TCCGCGGGTA TGACCAGTCC
GCCTACGACG GCAAGGATTA CATCGCCCTG AACGAGGACC TGCGCTCCTG GACCGCCGCG
GACACCGCGG CTCAGATCAC CCAGCGCAAG TTGGAGGCGG CCCGTGCGGC GGAGCAGCTG
AGAGCCTACC TGGAGGGCAC GTGCGTGGAG TGGCTCCGCA GATACCTGGA GAACGGGAAG
GAGACGCTGC AGCGCGCAGA ACCCCCAAAG ACACACGTGA CCCACCACCC CCTCTCTGAC
CATGAGGCCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCGGAGAT CACACTGACC
TGGCAGCGGG ATGGGGAGGA CCAGACCCAG GACACCGAGC TTGTGGAGAC CAGGCCAGCA
GGAGATGGAA CCTTCCAGAA GTGGGCAGCT GTGGTGGTGC CTTCTGGACA AGAGCAGAGA
TACACGTGCC ATATGCAGCA CGAGGGGCTG CAAGAGCCCC TCACCCTGAG CTGGGAGCCA
TCTTCCCAGC CCACCATCCC CATCATGGGC ATCGTTGCTG GCCTGGCTGT CCTGGTTGTC
CTAGCTGTCC TTGGAGCTGT GGTCACCGCT ATGATGTGTA GGAGGAAGAG CTCAGGTGGA
AAAGGAGGGA GCTGCTCTCA GGCTGCGTGC AGCAACAGTG CCCAGGGCTC TGATGAGTCT
CTCATCACTT GTAAAGCCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.
JAMA ophthalmology135(4)355-360(2017 Apr)
Wakamatsu TH,Ueta M,Tokunaga K,Okada Y,Loureiro RR,Costa KA,Sallum JMF,Milhomens JA,Inoue C,Sotozono C,Gomes JÁP,Kinoshita S


book

HLA-C levels impact natural killer cell subset distribution and function.
Human immunology77(12)1147-1153(2016 Dec)
Sips M,Liu Q,Draghi M,Ghebremichael M,Berger CT,Suscovich TJ,Sun Y,Walker BD,Carrington M,Altfeld M,Brouckaert P,De Jager PL,Alter G


book

HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series.
Journal of the American Academy of Dermatology75(5)889-896(2016 Nov)
Thorleifsdottir RH,Sigurdardottir SL,Sigurgeirsson B,Olafsson JH,Petersen H,Sigurdsson MI,Gudjonsson JE,Johnston A,Valdimarsson H


book

Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis.
Clinical immunology (Orlando, Fla.)166-16781-8(2016 05)
Saruhan-Direskeneli G,Hughes T,Yilmaz V,Durmus H,Adler A,Alahgholi-Hajibehzad M,Aysal F,Yentür SP,Akalin MA,Dogan O,Marx A,Gülsen-Parman Y,Oflazer P,Deymeer F,Sawalha AH


book

Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and LCE3 risk alleles in Indian population.
Scientific reports624059(2016 Apr)
Chandra A,Lahiri A,Senapati S,Basu B,Ghosh S,Mukhopadhyay I,Behra A,Sarkar S,Chatterjee G,Chatterjee R


 
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