CRNN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CRNN
Entrez Gene ID	49860
Full Name	cornulin
Synonyms	C1orf10,DRC1,PDRC1,SEP53
General protein information	Preferred Names cornulin Names cornulin 53 kDa putative calcium-binding protein 53 kDa squamous epithelial-induced stress protein 58 kDa heat shock protein squamous epithelial heat shock protein 53 tumor-related protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene encodes a member of the 'fused gene' family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009].
Disorder MIM:	611312

mRNA and Protein(s)

mRNA	Protein	Name
NM_016190.2	NP_057274.1	cornulin
NM_016190.3	NP_057274.1	cornulin

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Crnn	NP_001074669.1
Bos taurus (cattle)	CRNN	NP_001178232.1
	CRNN	XP_001109196.1
Canis lupus familiaris (dog)	CRNN	XP_003432329.1
Rattus norvegicus (Norway rat)	Crnn	XP_227367.4
Homo sapiens (human)	CRNN	NP_057274.1
Pan troglodytes (chimpanzee)	CRNN	XP_003308521.1

Gene Ontology
Bibliography

Related articles in PubMed

Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.
Trzeciak M, Sakowicz-Burkiewicz M, Wesserling M, Gle? J, Dobaczewska D, Bandurski T, Nowicki R, Pawelczyk T
International archives of allergy and immunology172(1)11-19(2017)

Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma.
Salahshourifar I, Vincent-Chong VK, Chang HY, Ser HL, Ramanathan A, Kallarakkal TG, Rahman ZA, Ismail SM, Prepageran N, Mustafa WM, Abraham MT, Tay KK, Zain RB
Clinical oral investigations19(9)2273-83(2015 Dec)

Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma.
Hsu PK, Kao HL, Chen HY, Yen CC, Wu YC, Hsu WH, Chou TY
The Journal of thoracic and cardiovascular surgery147(5)1612-1618.e4(2014 May)

Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.
Chen K, Li Y, Dai Y, Li J, Qin Y, Zhu Y, Zeng T, Ban X, Fu L, Guan XY
PloS one8(7)e68838(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The single-nucleotide polymorphisms of CRNN (rs941934) and RPTN (rs3001978, rs28441202) may contribute to Atopic Dermatitis development, but further studies on a larger group of Atopic Dermatitis patients are needed to verify this assumption.
Title: Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.

This study showed a significant correlation between LOH/MSI at 1q21.3 with clinical outcomes and that downregulation of CRNN gene could be considered as a prognostic marker of OSCC.
Title: Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma.

Loss of CRNN expression correlated with advanced tumor length, greater tumor invasion depth, lymph node metastasis, and poor survival in patients with esophageal squamous cell carcinoma.
Title: Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma.

cornulin is an important molecule in normal esophageal pathology and is likely lost during the conversion of normal to neoplastic epithelium
Title: Downregulation of cornulin in esophageal squamous cell carcinoma.

Findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC.
Title: Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.

The following CRNN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRNN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09168	NM_016190.3 Latest version!	Homo sapiens cornulin (CRNN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
View Old Accession Versions >>
OHu09168	NM_016190.2	Homo sapiens cornulin (CRNN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CRNN ( NM_016190.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057274.1 Homo sapiens cornulin (CRNN), mRNA.

Price & Availability↑

CloneID	OHu09168
Clone ID Related Accession (Same CDS sequence)	NM_016190.2 , NM_016190.3
Accession Version	NM_016190.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	cornulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA420219.1, AF077831.1 and BC030807.1. On Jan 24, 2009 this sequence version replaced NM_016190.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030807.1, AK291301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCAGT TACTGCAAAA CATTAATGGG ATCATCGAGG CCTTCAGGCG CTATGCAAGG 
ACGGAGGGCA ACTGCACAGC GCTCACCCGA GGGGAGCTGA AAAGACTCTT GGAGCAAGAG 
TTTGCCGATG TGATTGTGAA ACCCCACGAT CCAGCAACTG TGGATGAGGT CCTGCGTCTG 
CTGGATGAAG ACCACACAGG GACTGTGGAA TTCAAGGAAT TCCTGGTCTT AGTGTTTAAA 
GTTGCCCAGG CCTGTTTCAA GACACTGAGC GAGAGTGCTG AGGGAGCCTG CGGCTCTCAA 
GAGTCTGGAA GCCTCCACTC TGGGGCCTCG CAGGAGCTGG GCGAAGGACA GAGAAGTGGC 
ACTGAAGTGG GAAGGGCGGG GAAAGGGCAG CATTATGAGG GGAGCAGCCA CAGACAGAGC 
CAGCAGGGTT CCAGAGGGCA GAACAGGCCT GGGGTTCAGA CCCAGGGTCA GGCCACTGGC 
TCTGCGTGGG TCAGCAGCTA TGACAGGCAA GCTGAGTCCC AGAGCCAGGA AAGAATAAGC 
CCGCAGATAC AACTCTCTGG GCAGACAGAG CAGACCCAGA AAGCTGGAGA AGGCAAGAGG 
AATCAGACAA CAGAGATGAG GCCAGAGAGA CAGCCACAGA CCAGGGAACA GGACAGAGCC 
CACCAGACAG GTGAGACTGT GACTGGATCT GGAACTCAGA CCCAGGCAGG TGCCACCCAG 
ACTGTGGAGC AGGACAGCAG CCACCAGACA GGAAGAACCA GCAAGCAGAC ACAGGAGGCC 
ACCAATGACC AGAACAGAGG GACTGAGACC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACATGC TCAGATACAG GCAGGGACAC ACACCCAGAC ACCCACCCAG 
ACCGTGGAGC AGGACAGCAG CCACCAGACA GGAAGCACCA GCACCCAGAC ACAGGAGTCC 
ACCAATGGCC AGAACAGAGG GACTGAGATC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACACAC TCAGATACAG GCAGGGTCAC ACACCGAGAC TGTGGAGCAG 
GACAGAAGCC AAACTGTAAG CCACGGAGGG GCTAGAGAAC AGGGACAGAC CCAGACGCAG 
CCAGGCAGTG GTCAAAGATG GATGCAAGTG AGCAACCCTG AGGCAGGAGA GACAGTACCG 
GGAGGACAGG CCCAGACTGG GGCAAGCACT GAGTCAGGAA GGCAGGAGTG GAGCAGCACT 
CACCCAAGGC GCTGTGTGAC AGAAGGGCAG GGAGACAGAC AGCCCACAGT GGTTGGTGAG 
GAATGGGTTG ATGACCACTC AAGGGAGACA GTGATCCTCA GGCTGGACCA GGGCAACTTG 
CATACCAGTG TTTCCTCAGC ACAGGGCCAG GATGCAGCCC AGTCAGAAGA GAAGCGAGGC 
ATCACAGCTA GAGAGCTGTA TTCCTACTTG AGAAGCACCA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057274.1
CDS	75..1562
Translation	MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATGSAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQDAAQSEEKRGITARELYSYLRSTKP

Target ORF information:

RefSeq Version	NM_016190.2
Organism	Homo sapiens(human)
Definition	Homo sapiens cornulin (CRNN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016190.2

ORF Insert Sequence:

ATGCCTCAGT TACTGCAAAA CATTAATGGG ATCATCGAGG CCTTCAGGCG CTATGCAAGG 
ACGGAGGGCA ACTGCACAGC GCTCACCCGA GGGGAGCTGA AAAGACTCTT GGAGCAAGAG 
TTTGCCGATG TGATTGTGAA ACCCCACGAT CCAGCAACTG TGGATGAGGT CCTGCGTCTG 
CTGGATGAAG ACCACACAGG GACTGTGGAA TTCAAGGAAT TCCTGGTCTT AGTGTTTAAA 
GTTGCCCAGG CCTGTTTCAA GACACTGAGC GAGAGTGCTG AGGGAGCCTG CGGCTCTCAA 
GAGTCTGGAA GCCTCCACTC TGGGGCCTCG CAGGAGCTGG GCGAAGGACA GAGAAGTGGC 
ACTGAAGTGG GAAGGGCGGG GAAAGGGCAG CATTATGAGG GGAGCAGCCA CAGACAGAGC 
CAGCAGGGTT CCAGAGGGCA GAACAGGCCT GGGGTTCAGA CCCAGGGTCA GGCCACTGGC 
TCTGCGTGGG TCAGCAGCTA TGACAGGCAA GCTGAGTCCC AGAGCCAGGA AAGAATAAGC 
CCGCAGATAC AACTCTCTGG GCAGACAGAG CAGACCCAGA AAGCTGGAGA AGGCAAGAGG 
AATCAGACAA CAGAGATGAG GCCAGAGAGA CAGCCACAGA CCAGGGAACA GGACAGAGCC 
CACCAGACAG GTGAGACTGT GACTGGATCT GGAACTCAGA CCCAGGCAGG TGCCACCCAG 
ACTGTGGAGC AGGACAGCAG CCACCAGACA GGAAGAACCA GCAAGCAGAC ACAGGAGGCC 
ACCAATGACC AGAACAGAGG GACTGAGACC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACATGC TCAGATACAG GCAGGGACAC ACACCCAGAC ACCCACCCAG 
ACCGTGGAGC AGGACAGCAG CCACCAGACA GGAAGCACCA GCACCCAGAC ACAGGAGTCC 
ACCAATGGCC AGAACAGAGG GACTGAGATC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACACAC TCAGATACAG GCAGGGTCAC ACACCGAGAC TGTGGAGCAG 
GACAGAAGCC AAACTGTAAG CCACGGAGGG GCTAGAGAAC AGGGACAGAC CCAGACGCAG 
CCAGGCAGTG GTCAAAGATG GATGCAAGTG AGCAACCCTG AGGCAGGAGA GACAGTACCG 
GGAGGACAGG CCCAGACTGG GGCAAGCACT GAGTCAGGAA GGCAGGAGTG GAGCAGCACT 
CACCCAAGGC GCTGTGTGAC AGAAGGGCAG GGAGACAGAC AGCCCACAGT GGTTGGTGAG 
GAATGGGTTG ATGACCACTC AAGGGAGACA GTGATCCTCA GGCTGGACCA GGGCAACTTG 
CATACCAGTG TTTCCTCAGC ACAGGGCCAG GATGCAGCCC AGTCAGAAGA GAAGCGAGGC 
ATCACAGCTA GAGAGCTGTA TTCCTACTTG AGAAGCACCA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CRNN ( NM_016190.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057274.1 Homo sapiens cornulin (CRNN), mRNA.

Price & Availability↑

CloneID	OHu09168
Clone ID Related Accession (Same CDS sequence)	NM_016190.2 , NM_016190.3
Accession Version	NM_016190.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1488bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-04
Organism	Homo sapiens(human)
Product	cornulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA420219.1, AF077831.1 and BC030807.1. On May 17, 2019 this sequence version replaced NM_016190.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC030807.1, AF077831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000271835.3/ ENSP00000271835.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCTCAGT TACTGCAAAA CATTAATGGG ATCATCGAGG CCTTCAGGCG CTATGCAAGG 
ACGGAGGGCA ACTGCACAGC GCTCACCCGA GGGGAGCTGA AAAGACTCTT GGAGCAAGAG 
TTTGCCGATG TGATTGTGAA ACCCCACGAT CCAGCAACTG TGGATGAGGT CCTGCGTCTG 
CTGGATGAAG ACCACACAGG GACTGTGGAA TTCAAGGAAT TCCTGGTCTT AGTGTTTAAA 
GTTGCCCAGG CCTGTTTCAA GACACTGAGC GAGAGTGCTG AGGGAGCCTG CGGCTCTCAA 
GAGTCTGGAA GCCTCCACTC TGGGGCCTCG CAGGAGCTGG GCGAAGGACA GAGAAGTGGC 
ACTGAAGTGG GAAGGGCGGG GAAAGGGCAG CATTATGAGG GGAGCAGCCA CAGACAGAGC 
CAGCAGGGTT CCAGAGGGCA GAACAGGCCT GGGGTTCAGA CCCAGGGTCA GGCCACTGGC 
TCTGCGTGGG TCAGCAGCTA TGACAGGCAA GCTGAGTCCC AGAGCCAGGA AAGAATAAGC 
CCGCAGATAC AACTCTCTGG GCAGACAGAG CAGACCCAGA AAGCTGGAGA AGGCAAGAGG 
AATCAGACAA CAGAGATGAG GCCAGAGAGA CAGCCACAGA CCAGGGAACA GGACAGAGCC 
CACCAGACAG GTGAGACTGT GACTGGATCT GGAACTCAGA CCCAGGCAGG TGCCACCCAG 
ACTGTGGAGC AGGACAGCAG CCACCAGACA GGAAGAACCA GCAAGCAGAC ACAGGAGGCC 
ACCAATGACC AGAACAGAGG GACTGAGACC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACATGC TCAGATACAG GCAGGGACAC ACACCCAGAC ACCCACCCAG 
ACCGTGGAGC AGGACAGCAG CCACCAGACA GGAAGCACCA GCACCCAGAC ACAGGAGTCC 
ACCAATGGCC AGAACAGAGG GACTGAGATC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACACAC TCAGATACAG GCAGGGTCAC ACACCGAGAC TGTGGAGCAG 
GACAGAAGCC AAACTGTAAG CCACGGAGGG GCTAGAGAAC AGGGACAGAC CCAGACGCAG 
CCAGGCAGTG GTCAAAGATG GATGCAAGTG AGCAACCCTG AGGCAGGAGA GACAGTACCG 
GGAGGACAGG CCCAGACTGG GGCAAGCACT GAGTCAGGAA GGCAGGAGTG GAGCAGCACT 
CACCCAAGGC GCTGTGTGAC AGAAGGGCAG GGAGACAGAC AGCCCACAGT GGTTGGTGAG 
GAATGGGTTG ATGACCACTC AAGGGAGACA GTGATCCTCA GGCTGGACCA GGGCAACTTG 
CATACCAGTG TTTCCTCAGC ACAGGGCCAG GATGCAGCCC AGTCAGAAGA GAAGCGAGGC 
ATCACAGCTA GAGAGCTGTA TTCCTACTTG AGAAGCACCA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057274.1
CDS	64..1551
Translation	MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATGSAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQDAAQSEEKRGITARELYSYLRSTKP

Target ORF information:

RefSeq Version	NM_016190.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cornulin (CRNN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016190.3

ORF Insert Sequence:

ATGCCTCAGT TACTGCAAAA CATTAATGGG ATCATCGAGG CCTTCAGGCG CTATGCAAGG 
ACGGAGGGCA ACTGCACAGC GCTCACCCGA GGGGAGCTGA AAAGACTCTT GGAGCAAGAG 
TTTGCCGATG TGATTGTGAA ACCCCACGAT CCAGCAACTG TGGATGAGGT CCTGCGTCTG 
CTGGATGAAG ACCACACAGG GACTGTGGAA TTCAAGGAAT TCCTGGTCTT AGTGTTTAAA 
GTTGCCCAGG CCTGTTTCAA GACACTGAGC GAGAGTGCTG AGGGAGCCTG CGGCTCTCAA 
GAGTCTGGAA GCCTCCACTC TGGGGCCTCG CAGGAGCTGG GCGAAGGACA GAGAAGTGGC 
ACTGAAGTGG GAAGGGCGGG GAAAGGGCAG CATTATGAGG GGAGCAGCCA CAGACAGAGC 
CAGCAGGGTT CCAGAGGGCA GAACAGGCCT GGGGTTCAGA CCCAGGGTCA GGCCACTGGC 
TCTGCGTGGG TCAGCAGCTA TGACAGGCAA GCTGAGTCCC AGAGCCAGGA AAGAATAAGC 
CCGCAGATAC AACTCTCTGG GCAGACAGAG CAGACCCAGA AAGCTGGAGA AGGCAAGAGG 
AATCAGACAA CAGAGATGAG GCCAGAGAGA CAGCCACAGA CCAGGGAACA GGACAGAGCC 
CACCAGACAG GTGAGACTGT GACTGGATCT GGAACTCAGA CCCAGGCAGG TGCCACCCAG 
ACTGTGGAGC AGGACAGCAG CCACCAGACA GGAAGAACCA GCAAGCAGAC ACAGGAGGCC 
ACCAATGACC AGAACAGAGG GACTGAGACC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACATGC TCAGATACAG GCAGGGACAC ACACCCAGAC ACCCACCCAG 
ACCGTGGAGC AGGACAGCAG CCACCAGACA GGAAGCACCA GCACCCAGAC ACAGGAGTCC 
ACCAATGGCC AGAACAGAGG GACTGAGATC CACGGTCAAG GCAGGAGCCA GACCAGCCAG 
GCTGTGACAG GAGGACACAC TCAGATACAG GCAGGGTCAC ACACCGAGAC TGTGGAGCAG 
GACAGAAGCC AAACTGTAAG CCACGGAGGG GCTAGAGAAC AGGGACAGAC CCAGACGCAG 
CCAGGCAGTG GTCAAAGATG GATGCAAGTG AGCAACCCTG AGGCAGGAGA GACAGTACCG 
GGAGGACAGG CCCAGACTGG GGCAAGCACT GAGTCAGGAA GGCAGGAGTG GAGCAGCACT 
CACCCAAGGC GCTGTGTGAC AGAAGGGCAG GGAGACAGAC AGCCCACAGT GGTTGGTGAG 
GAATGGGTTG ATGACCACTC AAGGGAGACA GTGATCCTCA GGCTGGACCA GGGCAACTTG 
CATACCAGTG TTTCCTCAGC ACAGGGCCAG GATGCAGCCC AGTCAGAAGA GAAGCGAGGC 
ATCACAGCTA GAGAGCTGTA TTCCTACTTG AGAAGCACCA AGCCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.
International archives of allergy and immunology172(1)11-19(2017)
Trzeciak M,Sakowicz-Burkiewicz M,Wesserling M,Gle? J,Dobaczewska D,Bandurski T,Nowicki R,Pawelczyk T

Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma.
Clinical oral investigations19(9)2273-83(2015 Dec)
Salahshourifar I,Vincent-Chong VK,Chang HY,Ser HL,Ramanathan A,Kallarakkal TG,Rahman ZA,Ismail SM,Prepageran N,Mustafa WM,Abraham MT,Tay KK,Zain RB

Loss of CRNN expression is associated with advanced tumor stage and poor survival in patients with esophageal squamous cell carcinoma.
The Journal of thoracic and cardiovascular surgery147(5)1612-1618.e4(2014 May)
Hsu PK,Kao HL,Chen HY,Yen CC,Wu YC,Hsu WH,Chou TY

Characterization of tumor suppressive function of cornulin in esophageal squamous cell carcinoma.
PloS one8(7)e68838(2013)
Chen K,Li Y,Dai Y,Li J,Qin Y,Zhu Y,Zeng T,Ban X,Fu L,Guan XY