Gene Symbol | PDE2A |
Entrez Gene ID | 5138 |
Full Name | phosphodiesterase 2A |
Synonyms | CGS-PDE,PDE2A1,PED2A4,cGSPDE |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » PDE2A cDNA ORF clone
Gene Symbol | PDE2A |
Entrez Gene ID | 5138 |
Full Name | phosphodiesterase 2A |
Synonyms | CGS-PDE,PDE2A1,PED2A4,cGSPDE |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_005274040.2 | XP_005274097.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 |
NM_002599.4 | NP_002590.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 |
NM_002599.5 | NP_002590.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 |
XM_005274040.3 | XP_005274097.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 |
NM_001143839.3 | NP_001137311.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor |
NM_001243784.1 | NP_001230713.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1 |
XM_011545096.2 | XP_011543398.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 |
XM_017017910.1 | XP_016873399.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 |
NM_001146209.2 | NP_001139681.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A4 |
NM_001143839.4 | NP_001137311.1 | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor |
Homo sapiens (human) | PDE2A | NP_001139681.1 |
PDE2A | NP_001124298.1 | |
Xenopus tropicalis (tropical clawed frog) | pde2a | NP_001072607.1 |
Pan troglodytes (chimpanzee) | PDE2A | XP_001174746.1 |
Bos taurus (cattle) | PDE2A | NP_001137318.1 |
Mus musculus (house mouse) | Pde2a | NP_001137320.1 |
Rattus norvegicus (Norway rat) | Pde2a | NP_001137319.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008304 | XP_317162.4 |
Canis lupus familiaris (dog) | PDE2A | XP_851951.2 |
PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.
Monterisi S, Lobo MJ, Livie C, Castle JC, Weinberger M, Baillie G, Surdo NC, Musheshe N, Stangherlin A, Gottlieb E, Maizels R, Bortolozzi M, Micaroni M, Zaccolo M
eLife6(2017 May)
Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants.
Hern?ndez-Ram?rez LC, Trivellin G, Stratakis CA
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme49(4)286-295(2017 Apr)
Characterisation of Lu AF33241: A novel, brain-penetrant, dual inhibitor of phosphodiesterase (PDE) 2A and PDE10A.
Redrobe JP, Rasmussen LK, Christoffersen CT, Bundgaard C, J?rgensen M
European journal of pharmacology76179-85(2015 Aug)
Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ?-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.
Wu H, Lee J, Vincent LG, Wang Q, Gu M, Lan F, Churko JM, Sallam KI, Matsa E, Sharma A, Gold JD, Engler AJ, Xiang YK, Bers DM, Wu JC
Cell stem cell17(1)89-100(2015 Jul)
Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition.
Abusnina A, Keravis T, Zhou Q, Justiniano H, Lobstein A, Lugnier C
Thrombosis and haemostasis113(2)319-28(2015 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
the well-known interaction between AIP and 2 different isoforms of phosphodiesterases (PDEs), PDE2A3 and PDE4A5, is of particular interest. While the interaction with over-expressed AIP does not seem to affect PDE2A3 function, the reported effect on PDE4A5 is, in contrast, reduced enzymatic activity.
Title: Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants.
Lu AF33241 represents a novel PDE2A/PDE10A inhibitor tool which can penetrate the blood brain barrier.
Title: Characterisation of Lu AF33241: A novel, brain-penetrant, dual inhibitor of phosphodiesterase (PDE) 2A and PDE10A.
Epigenetic regulation of phosphodiesterases 2A and 3A underlies compromised beta-adrenergic Signaling in an induced pluripotent stem cell model of dilated cardiomyopathy.
Title: Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ?-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.
curcumin exerts its in vitro anti-angiogenic and in vivo anti-tumour properties through combined PDE2 and PDE4 inhibition
Title: Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition.
PDE2A is involved in growth and invasion of human malignant melanoma PMP cells.
Title: Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.
The following PDE2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDE2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu11799 | |
Clone ID Related Accession (Same CDS sequence) | NM_002599.4 , NM_002599.5 | |
Accession Version | NM_002599.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2826bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-27 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA243617.1, U67733.1, AP005019.1, BC040974.1 and AI498038.1. On Aug 27, 2011 this sequence version replaced NM_002599.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform, PDE2A3 (see PMID:9210593). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040974.1, SRR1803615.238044.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGGCAGG CATGCGGCCA CTCCATCCTC TGCAGGAGCC AGCAGTACCC GGCAGCGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_002590.1 |
CDS | 247..3072 |
Translation |
Target ORF information:
Target ORF information:
|
NM_002599.4 |
1 | ATGGGGCAGG CATGCGGCCA CTCCATCCTC TGCAGGAGCC AGCAGTACCC GGCAGCGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11799 | |
Clone ID Related Accession (Same CDS sequence) | NM_002599.4 , NM_002599.5 | |
Accession Version | NM_002599.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2826bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-06 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP003065.2 and AP005019.1. On Nov 23, 2018 this sequence version replaced NM_002599.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform, PDE2A3 (see PMID:9210593). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040974.1, SRR1660809.137939.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000334456.10/ ENSP00000334910.5 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGGGCAGG CATGCGGCCA CTCCATCCTC TGCAGGAGCC AGCAGTACCC GGCAGCGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_002590.1 |
CDS | 216..3041 |
Translation |
Target ORF information:
Target ORF information:
|
NM_002599.5 |
1 | ATGGGGCAGG CATGCGGCCA CTCCATCCTC TGCAGGAGCC AGCAGTACCC GGCAGCGCGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu59560 | |
Clone ID Related Accession (Same CDS sequence) | XM_011545096.2 , XM_017017910.1 | |
Accession Version | XM_011545096.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011545096.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGGGCT GTGAGCTGCA GGCCATGCTC TGTGTCCCTG TCATCAGCCG GGCCACTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011543398.1 |
CDS | 727..2589 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011545096.2 |
1 | ATGTTGGGCT GTGAGCTGCA GGCCATGCTC TGTGTCCCTG TCATCAGCCG GGCCACTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu59560 | |
Clone ID Related Accession (Same CDS sequence) | XM_011545096.2 , XM_017017910.1 | |
Accession Version | XM_017017910.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1863bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGGGCT GTGAGCTGCA GGCCATGCTC TGTGTCCCTG TCATCAGCCG GGCCACTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016873399.1 |
CDS | 1443..3305 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017017910.1 |
1 | ATGTTGGGCT GTGAGCTGCA GGCCATGCTC TGTGTCCCTG TCATCAGCCG GGCCACTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11942 | |
Clone ID Related Accession (Same CDS sequence) | NM_001143839.3 , NM_001143839.4 | |
Accession Version | NM_001143839.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2805bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-12-14 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA227593.1, U67733.1, AP005019.1, BC040974.1 and AI498038.1. On Aug 27, 2011 this sequence version replaced NM_001143839.2. Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (PDE2A2) is shorter and has a distinct N-terminus, compared to isoform PDE2A3. This variant (2) is assembled from partial human transcripts. The full-length exon combination is inferred from the mouse ortholog (NM_001143849.1, see PMID: 21724846). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.29177.1, SRR1803615.130405.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTCCTGG TGCTGCACCA CATCCTCATC GCTGTTGTCC AATTCCTCAG GCGGGGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001137311.1 |
CDS | 85..2889 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001143839.3 |
1 | ATGGTCCTGG TGCTGCACCA CATCCTCATC GCTGTTGTCC AATTCCTCAG GCGGGGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11942 | |
Clone ID Related Accession (Same CDS sequence) | NM_001143839.3 , NM_001143839.4 | |
Accession Version | NM_001143839.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2805bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP003065.2 and AP005019.1. On May 31, 2019 this sequence version replaced NM_001143839.3. Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (PDE2A2) is shorter and has a distinct N-terminus, compared to isoform PDE2A3. This variant (2) is assembled from partial human transcripts. The full-length exon combination is inferred from the mouse ortholog (NM_001143849.1, see PMID: 21724846). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.130405.1, SRR1803617.272878.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGTCCTGG TGCTGCACCA CATCCTCATC GCTGTTGTCC AATTCCTCAG GCGGGGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001137311.1 |
CDS | 68..2872 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001143839.4 |
1 | ATGGTCCTGG TGCTGCACCA CATCCTCATC GCTGTTGTCC AATTCCTCAG GCGGGGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11977 | |
Clone ID Related Accession (Same CDS sequence) | NM_001243784.1 | |
Accession Version | NM_001243784.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2763bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-05 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA219662.1, DA329075.1, U67733.1, AP005019.1, BC040974.1 and AI498038.1. On Aug 27, 2011 this sequence version replaced NR_026572.2. Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (PDE2A1) is shorter and has a distinct N-terminus, compared to isoform 1. This variant (2) is assembled from partial human transcripts. The full-length exon combination is inferred from the mouse ortholog (NM_001243757.1, see PMID: 19632989). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.177996.1, SRR1660809.146630.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCGCCGAC AGCCTGCAGC CAGCCTGGAC CCCCTTGCAA AGGAGCCAGG ACCCCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001230713.1 |
CDS | 189..2951 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001243784.1 |
1 | ATGCGCCGAC AGCCTGCAGC CAGCCTGGAC CCCCTTGCAA AGGAGCCAGG ACCCCCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu12172 | |
Clone ID Related Accession (Same CDS sequence) | NM_001146209.2 | |
Accession Version | NM_001146209.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2799bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-04 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY495087.1, U67733.1, AP005019.1, BC040974.1 and AI498038.1. On Aug 27, 2011 this sequence version replaced NM_001146209.1. Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform, PDE2A4 (AY495087.1), is shorter and has a distinct N-terminus, compared to isoform PDE2A3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY495087.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGAAAC AGAGGATCCA GGAGGGGAAA TCGCTTGCCC ACAGGCGGGG CCAGCAGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001139681.1 |
CDS | 141..2939 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001146209.2 |
1 | ATGAAGAAAC AGAGGATCCA GGAGGGGAAA TCGCTTGCCC ACAGGCGGGG CCAGCAGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu45358 | |
Clone ID Related Accession (Same CDS sequence) | XM_005274040.2 , XM_005274040.3 | |
Accession Version | XM_005274040.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2823bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005274040.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTCCCA TCCACGGTTG CCTCTACTGG GGGCTGCCAC TGGGAGACAG GAAGGGCATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005274097.1 |
CDS | 73..2895 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005274040.2 |
1 | ATGCCTCCCA TCCACGGTTG CCTCTACTGG GGGCTGCCAC TGGGAGACAG GAAGGGCATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu45358 | |
Clone ID Related Accession (Same CDS sequence) | XM_005274040.2 , XM_005274040.3 | |
Accession Version | XM_005274040.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2823bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005274040.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTCCCA TCCACGGTTG CCTCTACTGG GGGCTGCCAC TGGGAGACAG GAAGGGCATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005274097.1 |
CDS | 68..2890 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005274040.3 |
1 | ATGCCTCCCA TCCACGGTTG CCTCTACTGG GGGCTGCCAC TGGGAGACAG GAAGGGCATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. |
Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants. |
Characterisation of Lu AF33241: A novel, brain-penetrant, dual inhibitor of phosphodiesterase (PDE) 2A and PDE10A. |
Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised ?-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy. |
Tumour growth inhibition and anti-angiogenic effects using curcumin correspond to combined PDE2 and PDE4 inhibition. |