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MYOZ2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MYOZ2
Entrez Gene ID 51778
Full Name myozenin 2
Synonyms C4orf5,CMH16,CS-1
General protein information
Preferred Names

myozenin 2

Names

myozenin-2
FATZ-related protein 2
calcineurin-binding protein calsarcin-1
muscle-specific protein

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4q26

Disorder MIM:

605602


mRNA and Protein(s)

mRNA Protein Name
XM_006714234.3 XP_006714297.1 myozenin-2 isoform X1
NM_016599.4 NP_057683.1 myozenin-2



Pan troglodytes (chimpanzee) MYOZ2 XP_001148878.1
Danio rerio (zebrafish) myoz2b NP_957148.2
Bos taurus (cattle) MYOZ2 NP_001015676.1
Gallus gallus (chicken) MYOZ2 NP_001264756.1
Canis lupus familiaris (dog) MYOZ2 XP_535703.3
Xenopus tropicalis (tropical clawed frog) myoz2 NP_001011415.1
Homo sapiens (human) MYOZ2 NP_057683.1
Mus musculus (house mouse) Myoz2 NP_067478.1
Macaca mulatta (rhesus monkey) MYOZ2 XP_001098621.1


Related articles in PubMed

Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations.
Guo X, Fan C, Wang Y, Wang M, Cai C, Yang Y, Zhao S, Duan F, Li Y
Medicine96(11)e6249(2017 Mar)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.
Ruggiero A, Chen SN, Lombardi R, Rodriguez G, Marian AJ
Cardiovascular research97(1)44-54(2013 Jan)

Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy.
Posch MG, Perrot A, Dietz R, Ozcelik C, Pankuweit S, Ruppert V, Richter A, Maisch B
Molecular genetics and metabolism91(2)207-8(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

may play a modifying role in hypertrophic cardiomyopathy by affecting the penetrance or degree of performance of the MYH7 gene
Title: Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations.

The cardiac phenotype in hypertrophic cardiomyopathy caused by MYOZ2 mutations might be independent of calcineurin activity in the heart.
Title: Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.

Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.

Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate-gene testing for orphan limb-girdle muscular dystrophies.

Observational study of gene-disease association. (HuGE Navigator)
Title: Sequence analysis of myozenin 2 in 438 European patients with familial hypertrophic cardiomyopathy.

The following MYOZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYOZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu21456 NM_016599.4
Latest version!
Homo sapiens myozenin 2 (MYOZ2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu38965 XM_006714234.3
Latest version!
Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21456
Clone ID Related Accession (Same CDS sequence) NM_016599.4
Accession Version NM_016599.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 795bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-02
Organism Homo sapiens(Human)
Product myozenin-2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP370492.1, BC020932.1, AC092656.1 and BM091578.1. This sequence is a reference standard in the RefSeqGene project. On Aug 11, 2011 this sequence version replaced NM_016599.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY013295.1, AJ252149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT
GATTACAGGA GCTTTAACAG GGTTGCCACA CCATTTGGAG GTTTTGAAAA AGCATCAAGA
ATGGTTAAAT TTAAAGTTCC AGATTTTGAG CTACTATTGC TAACAGATCC CAGGTTTATG
TCCTTTGTCA ATCCCCTTTC TGGCAGACGG TCCTTTAATA GGACTCCTAA GGGATGGATA
TCTGAGAATA TTCCTATAGT GATAACAACC GAACCTACAG ATGATACCAC TGTACCAGAA
TCAGAAGACC TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057683.1
CDS214..1008
Misc Feature(1)190..192
Misc Feature(2)214..1005
Misc Feature(3)370..372
Misc Feature(4)514..516
Misc Feature(5)532..534
Misc Feature(6)544..546
Misc Feature(7)559..561
Exon (1)1..199
Exon (2)200..289
Exon (3)290..459
Exon (4)460..589
Exon (5)590..773
Exon (6)774..2597
Translation

Target ORF information:

RefSeq Version NM_016599.4
Organism Homo sapiens(Human)
Definition Homo sapiens myozenin 2 (MYOZ2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016599.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT
GATTACAGGA GCTTTAACAG GGTTGCCACA CCATTTGGAG GTTTTGAAAA AGCATCAAGA
ATGGTTAAAT TTAAAGTTCC AGATTTTGAG CTACTATTGC TAACAGATCC CAGGTTTATG
TCCTTTGTCA ATCCCCTTTC TGGCAGACGG TCCTTTAATA GGACTCCTAA GGGATGGATA
TCTGAGAATA TTCCTATAGT GATAACAACC GAACCTACAG ATGATACCAC TGTACCAGAA
TCAGAAGACC TATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu38965
Clone ID Related Accession (Same CDS sequence) XM_006714234.3
Accession Version XM_006714234.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 588bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product myozenin-2 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_006714234.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT
GATTACAGGA GCTTTAACAG GGGTTCAAGA CTTCATTGGA GGAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006714297.1
CDS182..769
Misc Feature(1)182..>742
Translation

Target ORF information:

RefSeq Version XM_006714234.3
Organism Homo sapiens(Human)
Definition Homo sapiens myozenin 2 (MYOZ2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006714234.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGCTATCAC ATAATACTAT GATGAAGCAG AGAAAACAGC AAGCAACAGC CATCATGAAG 
GAAGTCCATG GAAATGATGT TGATGGCATG GACCTGGGCA AAAAGGTCAG CATCCCCAGA
GACATCATGT TGGAAGAATT ATCCCATCTC AGTAACCGTG GTGCCAGGCT ATTTAAGATG
CGTCAAAGAA GATCTGACAA ATACACATTT GAAAATTTCC AGTATCAATC TAGAGCACAA
ATAAATCACA GTATTGCTAT GCAGAATGGG AAAGTGGATG GAAGTAACTT GGAAGGTGGT
TCGCAGCAAG CCCCCTTGAC TCCTCCCAAC ACCCCAGATC CACGAAGCCC TCCAAATCCA
GACAACATTG CTCCAGGATA TTCTGGACCA CTGAAGGAAA TTCCTCCTGA AAAATTCAAC
ACCACAGCTG TCCCTAAGTA CTATCAATCT CCCTGGGAAC AAGCCATTAG CAATGATCCG
GAGCTTTTAG AGGCTTTATA TCCTAAACTT TTCAAGCCTG AAGGAAAGGC AGAACTGCCT
GATTACAGGA GCTTTAACAG GGGTTCAAGA CTTCATTGGA GGAAGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genetic anticipation in a special form of hypertrophic cardiomyopathy with sudden cardiac death in a family with 74 members across 5 generations.
Medicine96(11)e6249(2017 Mar)
Guo X,Fan C,Wang Y,Wang M,Cai C,Yang Y,Zhao S,Duan F,Li Y


book

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kovács IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barabási AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M


book

Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.
Cardiovascular research97(1)44-54(2013 Jan)
Ruggiero A,Chen SN,Lombardi R,Rodriguez G,Marian AJ


book

Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy.
Molecular genetics and metabolism91(2)207-8(2007 Jun)
Posch MG,Perrot A,Dietz R,Ozcelik C,Pankuweit S,Ruppert V,Richter A,Maisch B


 
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