Gene Symbol | Myoz2 |
Entrez Gene ID | 59006 |
Full Name | myozenin 2 |
Synonyms | 1110012I24Rik,Fatz-2,Myozl2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Myoz2 cDNA ORF clone
gRNAs
Gene Symbol | Myoz2 |
Entrez Gene ID | 59006 |
Full Name | myozenin 2 |
Synonyms | 1110012I24Rik,Fatz-2,Myozl2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006501829.3 | XP_006501892.1 | myozenin-2 isoform X1 |
NM_021503.2 | NP_067478.1 | myozenin-2 isoform 1 |
NM_001355462.1 | NP_001342391.1 | myozenin-2 isoform 2 |
XM_006501828.3 | XP_006501891.1 | myozenin-2 isoform X1 |
XM_006501830.3 | XP_006501893.1 | myozenin-2 isoform X2 |
Pan troglodytes (chimpanzee) | MYOZ2 | XP_001148878.1 |
Danio rerio (zebrafish) | myoz2b | NP_957148.2 |
Bos taurus (cattle) | MYOZ2 | NP_001015676.1 |
Gallus gallus (chicken) | MYOZ2 | NP_001264756.1 |
Canis lupus familiaris (dog) | MYOZ2 | XP_535703.3 |
Xenopus tropicalis (tropical clawed frog) | myoz2 | NP_001011415.1 |
Homo sapiens (human) | MYOZ2 | NP_057683.1 |
MYOZ2 | XP_001098621.1 | |
Mus musculus (house mouse) | Myoz2 | NP_067478.1 |
The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling.
Dierck F, Kuhn C, Rohr C, Hille S, Braune J, Sossalla S, Molt S, van der Ven PFM, F?rst DO, Frey N
The Journal of biological chemistry292(37)15180-15191(2017 09)
Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.
Bang ML
Journal of cellular physiology232(1)38-52(2017 Jan)
Identification of candidate downstream targets of TGF? signaling during palate development by genome-wide transcript profiling.
Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG
Journal of cellular biochemistry114(4)796-807(2013 Apr)
NF-kappaB mediates the transcription of mouse calsarcin-1 gene, but not calsarcin-2, in C2C12 cells.
Wang H, Yang S, Yang E, Zhu Z, Mu Y, Feng S, Li K
BMC molecular biology819(2007 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
analysis of post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy
Title: Post-translational regulation of calsarcin-1 during pressure overload-induced cardiac hypertrophy.
MYOZ2 mutations are rare causes of familial familial hypertrophic cardiomyopathy.
Title: Sequence analysis of myozenin 2 in 438 European patients with familial hypertrophic cardiomyopathy.
The sarcomeric protein CS1 prevents Ang-II-induced cardiomyocyte hypertrophy at least in part via inhibition of calcineurin signaling.
Title: Calsarcin-1 protects against angiotensin-II induced cardiac hypertrophy.
study defined proximal promoter region of calsarcin-1 (CS-1)& calsarcin-2 (CS-2)genes; data suggest NF-kappaB is required for transcription of CS-1 gene, but not CS-2
Title: NF-kappaB mediates the transcription of mouse calsarcin-1 gene, but not calsarcin-2, in C2C12 cells.
calsarcin-1 negatively modulates the functions of calcineurin.
Title: Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress.
The following Myoz2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myoz2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu12422 | |
Clone ID Related Accession (Same CDS sequence) | NM_021503.2 | |
Accession Version | NM_021503.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | myozenin-2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121540.14. On Jun 18, 2009 this sequence version replaced NM_021503.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC024360.1, AJ252148.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849390, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTATCAC ATAGTGCCAT GGTGAAGCAA AGGAAACAGC AAGCATCAGC CATCACGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067478.1 |
CDS | 182..976 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCTATCAC ATAGTGCCAT GGTGAAGCAA AGGAAACAGC AAGCATCAGC CATCACGAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32145 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501829.3 , NM_001355462.1 , XM_006501828.3 | |
Accession Version | NM_001355462.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-02 | |
Organism | Mus musculus(house mouse) | |
Product | myozenin-2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC121540.14. On Sep 16, 2017 this sequence version replaced XM_006501829.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB589142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164142 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACCTGG GCAAAAAAGT TAGCATCCCC AGAGACATCA TGATAGAAGA ATTGTCCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001342391.1 |
CDS | 441..1148 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACCTGG GCAAAAAAGT TAGCATCCCC AGAGACATCA TGATAGAAGA ATTGTCCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32145 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501829.3 , NM_001355462.1 , XM_006501828.3 | |
Accession Version | XM_006501829.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | myozenin-2 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006501829.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCTGG GCAAAAAAGT TAGCATCCCC AGAGACATCA TGATAGAAGA ATTGTCCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501892.1 |
CDS | 457..1164 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACCTGG GCAAAAAAGT TAGCATCCCC AGAGACATCA TGATAGAAGA ATTGTCCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32145 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501829.3 , NM_001355462.1 , XM_006501828.3 | |
Accession Version | XM_006501828.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 708bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | myozenin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006501828.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCTGG GCAAAAAAGT TAGCATCCCC AGAGACATCA TGATAGAAGA ATTGTCCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501891.1 |
CDS | 335..1042 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACCTGG GCAAAAAAGT TAGCATCCCC AGAGACATCA TGATAGAAGA ATTGTCCCAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu32146 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501830.3 | |
Accession Version | XM_006501830.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | myozenin-2 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006501830.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACATGC ACAATATCGC CATGCAGAAT GGGAGAGTTG ATGGAAGCAA CCTGGAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501893.1 |
CDS | 264..821 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACATGC ACAATATCGC CATGCAGAAT GGGAGAGTTG ATGGAAGCAA CCTGGAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The novel cardiac z-disc protein CEFIP regulates cardiomyocyte hypertrophy by modulating calcineurin signaling. |
Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins. |
Identification of candidate downstream targets of TGF? signaling during palate development by genome-wide transcript profiling. |
NF-kappaB mediates the transcription of mouse calsarcin-1 gene, but not calsarcin-2, in C2C12 cells. |