Gene Symbol | UTP6 |
Entrez Gene ID | 55813 |
Full Name | UTP6, small subunit processome component |
Synonyms | C17orf40,HCA66 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » UTP6 cDNA ORF clone
gRNAs
Gene Symbol | UTP6 |
Entrez Gene ID | 55813 |
Full Name | UTP6, small subunit processome component |
Synonyms | C17orf40,HCA66 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017024845.1 | XP_016880334.1 | U3 small nucleolar RNA-associated protein 6 homolog isoform X1 |
XM_011524997.2 | XP_011523299.1 | U3 small nucleolar RNA-associated protein 6 homolog isoform X2 |
NM_018428.2 | NP_060898.2 | U3 small nucleolar RNA-associated protein 6 homolog |
XM_005258012.3 | XP_005258069.1 | U3 small nucleolar RNA-associated protein 6 homolog isoform X3 |
NM_018428.3 | NP_060898.2 | U3 small nucleolar RNA-associated protein 6 homolog |
XM_011524997.3 | XP_011523299.1 | U3 small nucleolar RNA-associated protein 6 homolog isoform X2 |
XM_005258012.2 | XP_005258069.1 | U3 small nucleolar RNA-associated protein 6 homolog isoform X3 |
XM_017024845.2 | XP_016880334.1 | U3 small nucleolar RNA-associated protein 6 homolog isoform X1 |
Pan troglodytes (chimpanzee) | UTP6 | XP_511397.4 |
Danio rerio (zebrafish) | utp6 | NP_001104677.1 |
Arabidopsis thaliana (thale cress) | AT4G28200 | NP_194549.1 |
UTP6 | XP_001112332.1 | |
Canis lupus familiaris (dog) | UTP6 | XP_853877.1 |
Bos taurus (cattle) | UTP6 | NP_001092610.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008427 | XP_317018.3 |
Oryza sativa (rice) | Os02g0103900 | NP_001045609.1 |
Mus musculus (house mouse) | Utp6 | NP_659075.1 |
Gallus gallus (chicken) | UTP6 | NP_001006207.1 |
Drosophila melanogaster (fruit fly) | CG7246 | NP_572520.1 |
Homo sapiens (human) | UTP6 | NP_060898.2 |
Rattus norvegicus (Norway rat) | Utp6 | XP_006247026.1 |
Xenopus tropicalis (tropical clawed frog) | utp6 | NP_001016855.1 |
Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication.
Bonnart C, Gérus M, Hoareau-Aveilla C, Kiss T, Caizergues-Ferrer M, Henry Y, Henras AK
Nucleic acids research40(13)6270-89(2012 Jul)
Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus.
Fant X, Gnadt N, Haren L, Merdes A
Journal of cell science122(Pt 8)1134-44(2009 Apr)
Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.
Douglas J, Cilliers D, Coleman K, Tatton-Brown K, Barker K, Bernhard B, Burn J, Huson S, Josifova D, Lacombe D, Malik M, Mansour S, Reid E, Cormier-Daire V, Cole T, , Rahman N
Nature genetics39(8)963-5(2007 Aug)
Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients.
Piddubnyak V, Rigou P, Michel L, Rain JC, Geneste O, Wolkenstein P, Vidaud D, Hickman JA, Mauviel A, Poyet JL
Cell death and differentiation14(6)1222-33(2007 Jun)
Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval.
Venturin M, Bentivegna A, Moroni R, Larizza L, Riva P
Annals of human genetics69(Pt 5)508-16(2005 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus.
Title: Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus.
Results suggest that reduced expression of HCA66, owing to haploinsufficiency of HCA66 gene, could render NF1 microdeleted patients-derived cells less susceptible to apoptosis.
Title: Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients.
The following UTP6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UTP6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu13148 | |
Clone ID Related Accession (Same CDS sequence) | NM_018428.2 , NM_018428.3 | |
Accession Version | NM_018428.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-30 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF334386.1, BC035325.1 and BC015454.1. On Jul 1, 2004 this sequence version replaced NM_018428.1. ##Evidence-Data-START## Transcript exon combination :: AF334386.1, SRR1803613.129859.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060898.2 |
CDS | 84..1877 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13148 | |
Clone ID Related Accession (Same CDS sequence) | NM_018428.2 , NM_018428.3 | |
Accession Version | NM_018428.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF334386.1, BC035325.1, BC015454.1 and AC004253.2. On Nov 23, 2018 this sequence version replaced NM_018428.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.209100.1, SRR1803613.129859.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000261708.9/ ENSP00000261708.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060898.2 |
CDS | 82..1875 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu50524 | |
Clone ID Related Accession (Same CDS sequence) | XM_005258012.3 , XM_005258012.2 | |
Accession Version | XM_005258012.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005258012.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGATTGA GAATTCTATT GTACACCGGG TACAAGGTGT TTTCCAGCGT GCCTCAGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005258069.1 |
CDS | 299..1729 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGATTGA GAATTCTATT GTACACCGGG TACAAGGTGT TTTCCAGCGT GCCTCAGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu50524 | |
Clone ID Related Accession (Same CDS sequence) | XM_005258012.3 , XM_005258012.2 | |
Accession Version | XM_005258012.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1431bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005258012.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGATTGA GAATTCTATT GTACACCGGG TACAAGGTGT TTTCCAGCGT GCCTCAGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005258069.1 |
CDS | 299..1729 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAGATTGA GAATTCTATT GTACACCGGG TACAAGGTGT TTTCCAGCGT GCCTCAGCAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu69810 | |
Clone ID Related Accession (Same CDS sequence) | XM_011524997.2 , XM_011524997.3 | |
Accession Version | XM_011524997.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011524997.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011523299.1 |
CDS | 55..1638 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu69810 | |
Clone ID Related Accession (Same CDS sequence) | XM_011524997.2 , XM_011524997.3 | |
Accession Version | XM_011524997.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011524997.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011523299.1 |
CDS | 76..1659 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu86985 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024845.1 , XM_017024845.2 | |
Accession Version | XM_017024845.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016880334.1 |
CDS | 55..1716 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu86985 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024845.1 , XM_017024845.2 | |
Accession Version | XM_017024845.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1662bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | U3 small nucleolar RNA-associated protein 6 homolog isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017024845.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016880334.1 |
CDS | 76..1737 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCAGAGA TAATTCAGGA ACGCATAGAA GATCGGCTCC CGGAATTGGA ACAGCTGGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication. |
Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. |
Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth. |
Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients. |
Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. |