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APOBR cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol APOBR
Entrez Gene ID 55911
Full Name apolipoprotein B receptor
Synonyms APOB100R,APOB48R
General protein information
Preferred Names

apolipoprotein B receptor

Names

apolipoprotein B receptor
apoB-48R
apolipoprotein B-100 receptor
apolipoprotein B-48 receptor
apolipoprotein B100 receptor
apolipoprotein B48 receptor
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

16

16p12.1
Summary Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008].
Disorder MIM:

605220


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_018690.3 NP_061160.3 apolipoprotein B receptor
NM_018690.4 NP_061160.3 apolipoprotein B receptor

Pathways from BioSystems


Homologies


Homo sapiens (human) APOBR NP_061160.3
Mus musculus (house mouse) Apobr NP_612183.1
Rattus norvegicus (Norway rat) Apobr NP_001102624.1
Pan troglodytes (chimpanzee) APOBR XP_003954332.1
APOBR XP_001103862.1
Canis lupus familiaris (dog) APOBR XP_005621420.1
Bos taurus (cattle) APOBR XP_002698130.2

Gene Ontology


Bibliography

Related articles in PubMed

Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention.
Volckmar AL, P?tter C, Song JY, Graniger J, Knoll N, Wolters B, Hebebrand J, Scherag A, Reinehr T, Hinney A
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association121(6)334-7(2013 Jun)

Triglyceride-rich lipoprotein regulates APOB48 receptor gene expression in human THP-1 monocytes and macrophages.
Bermudez B, Lopez S, Varela LM, Ortega A, Pacheco YM, Moreda W, Moreno-Luna R, Abia R, Muriana FJ
The Journal of nutrition142(2)227-32(2012 Feb)

A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes.
Varela LM, Ortega A, Bermudez B, Lopez S, Pacheco YM, Villar J, Abia R, Muriana FJ
The American journal of clinical nutrition93(5)918-25(2011 May)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The obesity risk alleles of non-synonymous SNPs at SH2B1 and APOB48R have no strong effect on weight loss-related phenotypes in overweight children after a 1-year lifestyle intervention.
Title: Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention.

These findings suggest that APOB48R represents a molecular target of postprandial lipoproteins via PPAR-dependent pathways in human monocytes and macrophages and advance an important link between postprandial metabolism of dietary fats and atherogenesis.
Title: Triglyceride-rich lipoprotein regulates APOB48 receptor gene expression in human THP-1 monocytes and macrophages.

investigation of apoB48R gene transcription in circulating monocytes: increase in apoB48R gene transcription following high-fat meal
Title: A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes.

Atherogenic remnant lipoproteins induced macrophage foam cell formation via apoB48R, indicating a potential role of apoB48R in atherosclerosis.
Title: Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism.

Nucleotide variations in the apolipoprotein B48 receptor gene is associated with hypercholesterolemia
Title: Association of nucleotide variations in the apolipoprotein B48 receptor gene (APOB48R) with hypercholesterolemia.

The following APOBR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the APOBR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu29180 NM_018690.4
Latest version!		 Homo sapiens apolipoprotein B receptor (APOBR), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $559.30
$799.00
View Old Accession Versions >>
OHu29180 NM_018690.3 Homo sapiens apolipoprotein B receptor (APOBR), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $559.30
$799.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu29180
Clone ID Related Accession (Same CDS sequence) NM_018690.3 , NM_018690.4
Accession Version NM_018690.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 3294bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-01
Organism Homo sapiens(human)
Product apolipoprotein B receptor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC138894.2. On Jul 16, 2011 this sequence version replaced NM_018690.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
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361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
ATGGACTTCC TCCGGCTATA CCTCCCTGGG CTGCACCAGG CCTTGAGGGG GGCACTGGAT 
TCCCTCGGCA CCTTTGTCTC CTACCTCCTG GGAGATGCAG TCCCCACTGT AGAGCGGGAG 
GCGCAGGCGG CTGAGGAACT GGGGGTGGTG GCGGTGGGAA AGACAGGGAA GATTGTAGAG 
GAGGAAGCCC AGGAGGACCT GGAGGGCCTT AGAGGCAGCC AAAACGAGGG GGCTGGAAGG 
CTGAGAGGGC CTGGAGATGA CAGAAGACAT GAAGTGGGGA GCTCAGCTGT AGAACAGACC 
TGGGGCTGGG GAGATGGCAG CTCCCATGGG TCCCAAGCAG AGAGGCAGGA CAGTGGGGCT 
GGGGAGACAG CCAAGGCTGC CAGGTGCCAG GAGCCAAGCG CCCACTTGGA GGCCAGAAAG 
AAATCCAAGG CAGGGTCTGG GGCTTGCCAA GACAGGAGCG GCCAAGCCCA GGAGAGGCAG 
GAGTCCCATG AGCAGGAAGT GAACAGAGAA GAGAGGCTGA GAAGCTGGGA ACAGGAGGAG 
GAGGAGGAAG AGGTCAGGGC AAGAGAGCCA GGGATGGCCA GAGGGGCGGA GTCAGAGTGG 
ACCTGGCATG GGGAGACGGA GGGGAAGGCT GGTGCTGTTG GGCCAAAGGC GGCAGGGGAC 
AACCGGGAGA TGGAGCAGGG GGTCAGGGAG GCAGATGCAG GGGAAACTGA GGAGCCTGGG 
GCCGAAGGGG CTGGGAAAGG AGAAGAGGTG GTAGTGGTGG AGAAGGCCTG TGAAAGCACT 
AGGGCATGGG GGACGTGGGG CCCAGGGGCA GAGCCTGAGG ACTGGGGAAT CTTAGGCAGA 
GAGGAGGCCA GGACAACCCC AGGTAGGGAA GAGGCCAGGG CAATTTTAGA TGGGGAGGAA 
GCCAGGACAA TCTCAGGCGG GGAGGAGGCT GAGACAGCCT CAGGCGGGGA GGAGGCTGAA 
ACAGCCTCAG GCGGGGAGGA GGCCGGGACA GCCTCGGGAG GGGAGGAGGC CGGGATAGCC 
TCAGGCGGGG AGGCTGGGAC AGCCTCAGGA GGGGAGGAGG CCGGGACAGC CTCAGGAGGG 
GAGGAGGCCG GGACAGCCTC AGGAGGGGAC GAGGCCTGGA CAACCTCAGG CAAAGAGGAG 
GCTGACCTGC TGGGAGTCAG ACAGACAGAA TATGGAGCAG TCCCAGGAGA AAGGCTCCTA 
GAGGCTACTG GAAAAGTCTG GGTCCTAGAG GAGGAGGGGG ATGAGGAGAG AGAGGCTGAG 
GTGAGCCCTT TCCCCAAACA GCCCCAGGTC CTGGGCACTG AAAGAACAGA AGAGGCTGCT 
GAGAGCCAGA CCGCAGGGAG GGAAGCTGTG GGAGGCCAGG AGGCAGGGGA GAGCTTTGAG 
GGCCAGGTAG ACCTGCGTGG TAAGGAGGCT GAGATGAGGC AGGACTTGGG GATCAGGGCC 
GACCGGGCCA GGATGGAAGA GCTGGTACAG GCAGAGGAGG CCCAGGAGGA GAGAGGGAGC 
AGCAGGGATC CAGTGGCTGA GCTGCCCTCA GATGGAGAGG CTGAAGGCAC TGCCGACTTG 
GAGGCAACTC CAGAGGCCAG GCCTGAGGAG GAGCTCACAG GGGAGGAGAG TGAGGCGGCC 
CAGACTAGCT GTGGCCTACT GGGCGTGGAA TGGGGTGGCC TCACACACAG CGTCACCAAA 
GGCCAAGGAC CTGAGCTGAT GGGGGGCGCC CAGACCCCAA CTAAGCAACC CGAGGAAAGG 
GAGGCAGGGG AGGTGGAGCT CATGGGAGTT CTGGCCCTGA GCAAAGAGGA GCAGGAGAGG 
AGCCTGGAGG CAGGTCCCAG GCACGCGGGG TCTGTAAAGC CTGAGGCCTC CGAGGCCTTC 
CCAGGAGCCT GGGAAAACCG CACGAGAAAG GACATGGAGA GAGGAAATAC TCAGGAGGAT 
GCGGCCGATG GCGAGCAGCG GGAGGAGGAG GAGACTGCGG GAGGCCAGAC CCTGGCGGCT 
GAGGCTGAAG GAGACCGAGA GTCTGAACTA TCAGAAGTCC CAGAGGCAGG CGGGGAGGGG 
CTGACAACCC AGGACGCGGG ATGTGGAACT GAGGAGGGAG AGGCATCTGT CTCAGAGAAC 
CAGGAGCTGG ACGGAAGCAC AGGGGCAGAC GCAGGGCCTT GCCCGTCACT GGGAGAGGCC 
TATGCCAGAG AAACTGAGGA TGAGGAGGCG GAGGCTGACA GAACATCCAG AAGAGGCTGG 
AGGCTGCAAG CGGTGGCTGT GGGCCTCCCG GACCGTGAGG ATGCACAGAC TGGCTCTGTG 
GCTGCTGGGA TTATGGGGGG TGATGTGGTC CCACACATCA GCGCTGCTGG CGCTGGTGAA 
GCTTTGGAAG GGGTGCTTGG GCAAGGCTGG GACTCGAAAG AAAAGGAAGA GGCAGCAGCA 
GGAGAGCATG CAGGTGGGCA AGAATTTGGT CTGGAGGGCT CAGCAGAGGA AGAGGTGACT 
GGCAGAGGCA GCCAAGTAGA GGCTTTTGAG TCCAGGGAGG GAGGACCTTG GGGAGGGCGG 
GTAGAGGCCG AGGAATCTGC AGGCGCAGAG GACAGCTGTG GGCTGGATCC CGCGGGCTCC 
CAGACAGCGA GGGCAGAGGG GATGGGAGCC ATGGTGGAGG CTGGGGGGCT TCTAGAAAAG 
TGGACGCTGT TGGAAGAAGA GGCTGTTGGA TGGCAGGAGA GAGAACAGAG GGAAGACAGT 
GAGGGGCGGT GTGGGGACTA CCACCCTGAG GGAGAGGCAC CAAGGCTCCT TGATGCAGAG 
GGTCTCATGG TGACCGGGGG CCGGAGGGCA GAGGCCAAGG AGACTGAGCC AGAAAGCCTG 
GAACATGTCA GGGGCCAGGA GGAGCAGCCA ACACACCAGG CCCCTGCAGA AGCTGCGCCG 
GAGTCAGTCG GGGAAGCCGA GACGGCTGAG GCCATGGGCA GTGCCAGAGG AGGTGCTGCC 
AACAGCTGGA GCGAGGCCCC GCTCCCCGGG TCCCTCCTAG ACGTCTCTGT CCCAAGGAGT 
CGCGTGCACC TCTCGAGAAG CTCCTCACAG CGTCGCTCCC GGCCCTCTTT TCGTCGGACT 
CCGGCCTGGG AGCAGCAGGA GGAGCCCCCA GCCCCCAACC CTCCTGAGGA GGAGCTGTCA 
GCTCCTGAGC AGAGACCCCT CCAGCTGGAG GAACCCCTGG AGCCAAGCCC TCTGAGGCAT 
GATGGGACCC CGGTGCCAGC CAGGAGAAGG CCCCTGGGAC ACGGGTTTGG CCTCGCGCAC 
CCTGGCATGA TGCAGGAGCT GCAAGCCCGT CTGGGCCGGC CTAAGCCCCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_061160.3
CDS34..3327
Translation

Target ORF information:

RefSeq Version NM_018690.3
Organism Homo sapiens(human)
Definition Homo sapiens apolipoprotein B receptor (APOBR), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_018690.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
ATGGACTTCC TCCGGCTATA CCTCCCTGGG CTGCACCAGG CCTTGAGGGG GGCACTGGAT 
TCCCTCGGCA CCTTTGTCTC CTACCTCCTG GGAGATGCAG TCCCCACTGT AGAGCGGGAG 
GCGCAGGCGG CTGAGGAACT GGGGGTGGTG GCGGTGGGAA AGACAGGGAA GATTGTAGAG 
GAGGAAGCCC AGGAGGACCT GGAGGGCCTT AGAGGCAGCC AAAACGAGGG GGCTGGAAGG 
CTGAGAGGGC CTGGAGATGA CAGAAGACAT GAAGTGGGGA GCTCAGCTGT AGAACAGACC 
TGGGGCTGGG GAGATGGCAG CTCCCATGGG TCCCAAGCAG AGAGGCAGGA CAGTGGGGCT 
GGGGAGACAG CCAAGGCTGC CAGGTGCCAG GAGCCAAGCG CCCACTTGGA GGCCAGAAAG 
AAATCCAAGG CAGGGTCTGG GGCTTGCCAA GACAGGAGCG GCCAAGCCCA GGAGAGGCAG 
GAGTCCCATG AGCAGGAAGT GAACAGAGAA GAGAGGCTGA GAAGCTGGGA ACAGGAGGAG 
GAGGAGGAAG AGGTCAGGGC AAGAGAGCCA GGGATGGCCA GAGGGGCGGA GTCAGAGTGG 
ACCTGGCATG GGGAGACGGA GGGGAAGGCT GGTGCTGTTG GGCCAAAGGC GGCAGGGGAC 
AACCGGGAGA TGGAGCAGGG GGTCAGGGAG GCAGATGCAG GGGAAACTGA GGAGCCTGGG 
GCCGAAGGGG CTGGGAAAGG AGAAGAGGTG GTAGTGGTGG AGAAGGCCTG TGAAAGCACT 
AGGGCATGGG GGACGTGGGG CCCAGGGGCA GAGCCTGAGG ACTGGGGAAT CTTAGGCAGA 
GAGGAGGCCA GGACAACCCC AGGTAGGGAA GAGGCCAGGG CAATTTTAGA TGGGGAGGAA 
GCCAGGACAA TCTCAGGCGG GGAGGAGGCT GAGACAGCCT CAGGCGGGGA GGAGGCTGAA 
ACAGCCTCAG GCGGGGAGGA GGCCGGGACA GCCTCGGGAG GGGAGGAGGC CGGGATAGCC 
TCAGGCGGGG AGGCTGGGAC AGCCTCAGGA GGGGAGGAGG CCGGGACAGC CTCAGGAGGG 
GAGGAGGCCG GGACAGCCTC AGGAGGGGAC GAGGCCTGGA CAACCTCAGG CAAAGAGGAG 
GCTGACCTGC TGGGAGTCAG ACAGACAGAA TATGGAGCAG TCCCAGGAGA AAGGCTCCTA 
GAGGCTACTG GAAAAGTCTG GGTCCTAGAG GAGGAGGGGG ATGAGGAGAG AGAGGCTGAG 
GTGAGCCCTT TCCCCAAACA GCCCCAGGTC CTGGGCACTG AAAGAACAGA AGAGGCTGCT 
GAGAGCCAGA CCGCAGGGAG GGAAGCTGTG GGAGGCCAGG AGGCAGGGGA GAGCTTTGAG 
GGCCAGGTAG ACCTGCGTGG TAAGGAGGCT GAGATGAGGC AGGACTTGGG GATCAGGGCC 
GACCGGGCCA GGATGGAAGA GCTGGTACAG GCAGAGGAGG CCCAGGAGGA GAGAGGGAGC 
AGCAGGGATC CAGTGGCTGA GCTGCCCTCA GATGGAGAGG CTGAAGGCAC TGCCGACTTG 
GAGGCAACTC CAGAGGCCAG GCCTGAGGAG GAGCTCACAG GGGAGGAGAG TGAGGCGGCC 
CAGACTAGCT GTGGCCTACT GGGCGTGGAA TGGGGTGGCC TCACACACAG CGTCACCAAA 
GGCCAAGGAC CTGAGCTGAT GGGGGGCGCC CAGACCCCAA CTAAGCAACC CGAGGAAAGG 
GAGGCAGGGG AGGTGGAGCT CATGGGAGTT CTGGCCCTGA GCAAAGAGGA GCAGGAGAGG 
AGCCTGGAGG CAGGTCCCAG GCACGCGGGG TCTGTAAAGC CTGAGGCCTC CGAGGCCTTC 
CCAGGAGCCT GGGAAAACCG CACGAGAAAG GACATGGAGA GAGGAAATAC TCAGGAGGAT 
GCGGCCGATG GCGAGCAGCG GGAGGAGGAG GAGACTGCGG GAGGCCAGAC CCTGGCGGCT 
GAGGCTGAAG GAGACCGAGA GTCTGAACTA TCAGAAGTCC CAGAGGCAGG CGGGGAGGGG 
CTGACAACCC AGGACGCGGG ATGTGGAACT GAGGAGGGAG AGGCATCTGT CTCAGAGAAC 
CAGGAGCTGG ACGGAAGCAC AGGGGCAGAC GCAGGGCCTT GCCCGTCACT GGGAGAGGCC 
TATGCCAGAG AAACTGAGGA TGAGGAGGCG GAGGCTGACA GAACATCCAG AAGAGGCTGG 
AGGCTGCAAG CGGTGGCTGT GGGCCTCCCG GACCGTGAGG ATGCACAGAC TGGCTCTGTG 
GCTGCTGGGA TTATGGGGGG TGATGTGGTC CCACACATCA GCGCTGCTGG CGCTGGTGAA 
GCTTTGGAAG GGGTGCTTGG GCAAGGCTGG GACTCGAAAG AAAAGGAAGA GGCAGCAGCA 
GGAGAGCATG CAGGTGGGCA AGAATTTGGT CTGGAGGGCT CAGCAGAGGA AGAGGTGACT 
GGCAGAGGCA GCCAAGTAGA GGCTTTTGAG TCCAGGGAGG GAGGACCTTG GGGAGGGCGG 
GTAGAGGCCG AGGAATCTGC AGGCGCAGAG GACAGCTGTG GGCTGGATCC CGCGGGCTCC 
CAGACAGCGA GGGCAGAGGG GATGGGAGCC ATGGTGGAGG CTGGGGGGCT TCTAGAAAAG 
TGGACGCTGT TGGAAGAAGA GGCTGTTGGA TGGCAGGAGA GAGAACAGAG GGAAGACAGT 
GAGGGGCGGT GTGGGGACTA CCACCCTGAG GGAGAGGCAC CAAGGCTCCT TGATGCAGAG 
GGTCTCATGG TGACCGGGGG CCGGAGGGCA GAGGCCAAGG AGACTGAGCC AGAAAGCCTG 
GAACATGTCA GGGGCCAGGA GGAGCAGCCA ACACACCAGG CCCCTGCAGA AGCTGCGCCG 
GAGTCAGTCG GGGAAGCCGA GACGGCTGAG GCCATGGGCA GTGCCAGAGG AGGTGCTGCC 
AACAGCTGGA GCGAGGCCCC GCTCCCCGGG TCCCTCCTAG ACGTCTCTGT CCCAAGGAGT 
CGCGTGCACC TCTCGAGAAG CTCCTCACAG CGTCGCTCCC GGCCCTCTTT TCGTCGGACT 
CCGGCCTGGG AGCAGCAGGA GGAGCCCCCA GCCCCCAACC CTCCTGAGGA GGAGCTGTCA 
GCTCCTGAGC AGAGACCCCT CCAGCTGGAG GAACCCCTGG AGCCAAGCCC TCTGAGGCAT 
GATGGGACCC CGGTGCCAGC CAGGAGAAGG CCCCTGGGAC ACGGGTTTGG CCTCGCGCAC 
CCTGGCATGA TGCAGGAGCT GCAAGCCCGT CTGGGCCGGC CTAAGCCCCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu29180
Clone ID Related Accession (Same CDS sequence) NM_018690.3 , NM_018690.4
Accession Version NM_018690.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 3294bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-07-05
Organism Homo sapiens(human)
Product apolipoprotein B receptor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC138894.2. On Nov 23, 2018 this sequence version replaced NM_018690.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000564831.6/ ENSP00000457539.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
ATGGACTTCC TCCGGCTATA CCTCCCTGGG CTGCACCAGG CCTTGAGGGG GGCACTGGAT 
TCCCTCGGCA CCTTTGTCTC CTACCTCCTG GGAGATGCAG TCCCCACTGT AGAGCGGGAG 
GCGCAGGCGG CTGAGGAACT GGGGGTGGTG GCGGTGGGAA AGACAGGGAA GATTGTAGAG 
GAGGAAGCCC AGGAGGACCT GGAGGGCCTT AGAGGCAGCC AAAACGAGGG GGCTGGAAGG 
CTGAGAGGGC CTGGAGATGA CAGAAGACAT GAAGTGGGGA GCTCAGCTGT AGAACAGACC 
TGGGGCTGGG GAGATGGCAG CTCCCATGGG TCCCAAGCAG AGAGGCAGGA CAGTGGGGCT 
GGGGAGACAG CCAAGGCTGC CAGGTGCCAG GAGCCAAGCG CCCACTTGGA GGCCAGAAAG 
AAATCCAAGG CAGGGTCTGG GGCTTGCCAA GACAGGAGCG GCCAAGCCCA GGAGAGGCAG 
GAGTCCCATG AGCAGGAAGT GAACAGAGAA GAGAGGCTGA GAAGCTGGGA ACAGGAGGAG 
GAGGAGGAAG AGGTCAGGGC AAGAGAGCCA GGGATGGCCA GAGGGGCGGA GTCAGAGTGG 
ACCTGGCATG GGGAGACGGA GGGGAAGGCT GGTGCTGTTG GGCCAAAGGC GGCAGGGGAC 
AACCGGGAGA TGGAGCAGGG GGTCAGGGAG GCAGATGCAG GGGAAACTGA GGAGCCTGGG 
GCCGAAGGGG CTGGGAAAGG AGAAGAGGTG GTAGTGGTGG AGAAGGCCTG TGAAAGCACT 
AGGGCATGGG GGACGTGGGG CCCAGGGGCA GAGCCTGAGG ACTGGGGAAT CTTAGGCAGA 
GAGGAGGCCA GGACAACCCC AGGTAGGGAA GAGGCCAGGG CAATTTTAGA TGGGGAGGAA 
GCCAGGACAA TCTCAGGCGG GGAGGAGGCT GAGACAGCCT CAGGCGGGGA GGAGGCTGAA 
ACAGCCTCAG GCGGGGAGGA GGCCGGGACA GCCTCGGGAG GGGAGGAGGC CGGGATAGCC 
TCAGGCGGGG AGGCTGGGAC AGCCTCAGGA GGGGAGGAGG CCGGGACAGC CTCAGGAGGG 
GAGGAGGCCG GGACAGCCTC AGGAGGGGAC GAGGCCTGGA CAACCTCAGG CAAAGAGGAG 
GCTGACCTGC TGGGAGTCAG ACAGACAGAA TATGGAGCAG TCCCAGGAGA AAGGCTCCTA 
GAGGCTACTG GAAAAGTCTG GGTCCTAGAG GAGGAGGGGG ATGAGGAGAG AGAGGCTGAG 
GTGAGCCCTT TCCCCAAACA GCCCCAGGTC CTGGGCACTG AAAGAACAGA AGAGGCTGCT 
GAGAGCCAGA CCGCAGGGAG GGAAGCTGTG GGAGGCCAGG AGGCAGGGGA GAGCTTTGAG 
GGCCAGGTAG ACCTGCGTGG TAAGGAGGCT GAGATGAGGC AGGACTTGGG GATCAGGGCC 
GACCGGGCCA GGATGGAAGA GCTGGTACAG GCAGAGGAGG CCCAGGAGGA GAGAGGGAGC 
AGCAGGGATC CAGTGGCTGA GCTGCCCTCA GATGGAGAGG CTGAAGGCAC TGCCGACTTG 
GAGGCAACTC CAGAGGCCAG GCCTGAGGAG GAGCTCACAG GGGAGGAGAG TGAGGCGGCC 
CAGACTAGCT GTGGCCTACT GGGCGTGGAA TGGGGTGGCC TCACACACAG CGTCACCAAA 
GGCCAAGGAC CTGAGCTGAT GGGGGGCGCC CAGACCCCAA CTAAGCAACC CGAGGAAAGG 
GAGGCAGGGG AGGTGGAGCT CATGGGAGTT CTGGCCCTGA GCAAAGAGGA GCAGGAGAGG 
AGCCTGGAGG CAGGTCCCAG GCACGCGGGG TCTGTAAAGC CTGAGGCCTC CGAGGCCTTC 
CCAGGAGCCT GGGAAAACCG CACGAGAAAG GACATGGAGA GAGGAAATAC TCAGGAGGAT 
GCGGCCGATG GCGAGCAGCG GGAGGAGGAG GAGACTGCGG GAGGCCAGAC CCTGGCGGCT 
GAGGCTGAAG GAGACCGAGA GTCTGAACTA TCAGAAGTCC CAGAGGCAGG CGGGGAGGGG 
CTGACAACCC AGGACGCGGG ATGTGGAACT GAGGAGGGAG AGGCATCTGT CTCAGAGAAC 
CAGGAGCTGG ACGGAAGCAC AGGGGCAGAC GCAGGGCCTT GCCCGTCACT GGGAGAGGCC 
TATGCCAGAG AAACTGAGGA TGAGGAGGCG GAGGCTGACA GAACATCCAG AAGAGGCTGG 
AGGCTGCAAG CGGTGGCTGT GGGCCTCCCG GACCGTGAGG ATGCACAGAC TGGCTCTGTG 
GCTGCTGGGA TTATGGGGGG TGATGTGGTC CCACACATCA GCGCTGCTGG CGCTGGTGAA 
GCTTTGGAAG GGGTGCTTGG GCAAGGCTGG GACTCGAAAG AAAAGGAAGA GGCAGCAGCA 
GGAGAGCATG CAGGTGGGCA AGAATTTGGT CTGGAGGGCT CAGCAGAGGA AGAGGTGACT 
GGCAGAGGCA GCCAAGTAGA GGCTTTTGAG TCCAGGGAGG GAGGACCTTG GGGAGGGCGG 
GTAGAGGCCG AGGAATCTGC AGGCGCAGAG GACAGCTGTG GGCTGGATCC CGCGGGCTCC 
CAGACAGCGA GGGCAGAGGG GATGGGAGCC ATGGTGGAGG CTGGGGGGCT TCTAGAAAAG 
TGGACGCTGT TGGAAGAAGA GGCTGTTGGA TGGCAGGAGA GAGAACAGAG GGAAGACAGT 
GAGGGGCGGT GTGGGGACTA CCACCCTGAG GGAGAGGCAC CAAGGCTCCT TGATGCAGAG 
GGTCTCATGG TGACCGGGGG CCGGAGGGCA GAGGCCAAGG AGACTGAGCC AGAAAGCCTG 
GAACATGTCA GGGGCCAGGA GGAGCAGCCA ACACACCAGG CCCCTGCAGA AGCTGCGCCG 
GAGTCAGTCG GGGAAGCCGA GACGGCTGAG GCCATGGGCA GTGCCAGAGG AGGTGCTGCC 
AACAGCTGGA GCGAGGCCCC GCTCCCCGGG TCCCTCCTAG ACGTCTCTGT CCCAAGGAGT 
CGCGTGCACC TCTCGAGAAG CTCCTCACAG CGTCGCTCCC GGCCCTCTTT TCGTCGGACT 
CCGGCCTGGG AGCAGCAGGA GGAGCCCCCA GCCCCCAACC CTCCTGAGGA GGAGCTGTCA 
GCTCCTGAGC AGAGACCCCT CCAGCTGGAG GAACCCCTGG AGCCAAGCCC TCTGAGGCAT 
GATGGGACCC CGGTGCCAGC CAGGAGAAGG CCCCTGGGAC ACGGGTTTGG CCTCGCGCAC 
CCTGGCATGA TGCAGGAGCT GCAAGCCCGT CTGGGCCGGC CTAAGCCCCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_061160.3
CDS40..3333
Translation

Target ORF information:

RefSeq Version NM_018690.4
Organism Homo sapiens(human)
Definition Homo sapiens apolipoprotein B receptor (APOBR), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_018690.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
ATGGACTTCC TCCGGCTATA CCTCCCTGGG CTGCACCAGG CCTTGAGGGG GGCACTGGAT 
TCCCTCGGCA CCTTTGTCTC CTACCTCCTG GGAGATGCAG TCCCCACTGT AGAGCGGGAG 
GCGCAGGCGG CTGAGGAACT GGGGGTGGTG GCGGTGGGAA AGACAGGGAA GATTGTAGAG 
GAGGAAGCCC AGGAGGACCT GGAGGGCCTT AGAGGCAGCC AAAACGAGGG GGCTGGAAGG 
CTGAGAGGGC CTGGAGATGA CAGAAGACAT GAAGTGGGGA GCTCAGCTGT AGAACAGACC 
TGGGGCTGGG GAGATGGCAG CTCCCATGGG TCCCAAGCAG AGAGGCAGGA CAGTGGGGCT 
GGGGAGACAG CCAAGGCTGC CAGGTGCCAG GAGCCAAGCG CCCACTTGGA GGCCAGAAAG 
AAATCCAAGG CAGGGTCTGG GGCTTGCCAA GACAGGAGCG GCCAAGCCCA GGAGAGGCAG 
GAGTCCCATG AGCAGGAAGT GAACAGAGAA GAGAGGCTGA GAAGCTGGGA ACAGGAGGAG 
GAGGAGGAAG AGGTCAGGGC AAGAGAGCCA GGGATGGCCA GAGGGGCGGA GTCAGAGTGG 
ACCTGGCATG GGGAGACGGA GGGGAAGGCT GGTGCTGTTG GGCCAAAGGC GGCAGGGGAC 
AACCGGGAGA TGGAGCAGGG GGTCAGGGAG GCAGATGCAG GGGAAACTGA GGAGCCTGGG 
GCCGAAGGGG CTGGGAAAGG AGAAGAGGTG GTAGTGGTGG AGAAGGCCTG TGAAAGCACT 
AGGGCATGGG GGACGTGGGG CCCAGGGGCA GAGCCTGAGG ACTGGGGAAT CTTAGGCAGA 
GAGGAGGCCA GGACAACCCC AGGTAGGGAA GAGGCCAGGG CAATTTTAGA TGGGGAGGAA 
GCCAGGACAA TCTCAGGCGG GGAGGAGGCT GAGACAGCCT CAGGCGGGGA GGAGGCTGAA 
ACAGCCTCAG GCGGGGAGGA GGCCGGGACA GCCTCGGGAG GGGAGGAGGC CGGGATAGCC 
TCAGGCGGGG AGGCTGGGAC AGCCTCAGGA GGGGAGGAGG CCGGGACAGC CTCAGGAGGG 
GAGGAGGCCG GGACAGCCTC AGGAGGGGAC GAGGCCTGGA CAACCTCAGG CAAAGAGGAG 
GCTGACCTGC TGGGAGTCAG ACAGACAGAA TATGGAGCAG TCCCAGGAGA AAGGCTCCTA 
GAGGCTACTG GAAAAGTCTG GGTCCTAGAG GAGGAGGGGG ATGAGGAGAG AGAGGCTGAG 
GTGAGCCCTT TCCCCAAACA GCCCCAGGTC CTGGGCACTG AAAGAACAGA AGAGGCTGCT 
GAGAGCCAGA CCGCAGGGAG GGAAGCTGTG GGAGGCCAGG AGGCAGGGGA GAGCTTTGAG 
GGCCAGGTAG ACCTGCGTGG TAAGGAGGCT GAGATGAGGC AGGACTTGGG GATCAGGGCC 
GACCGGGCCA GGATGGAAGA GCTGGTACAG GCAGAGGAGG CCCAGGAGGA GAGAGGGAGC 
AGCAGGGATC CAGTGGCTGA GCTGCCCTCA GATGGAGAGG CTGAAGGCAC TGCCGACTTG 
GAGGCAACTC CAGAGGCCAG GCCTGAGGAG GAGCTCACAG GGGAGGAGAG TGAGGCGGCC 
CAGACTAGCT GTGGCCTACT GGGCGTGGAA TGGGGTGGCC TCACACACAG CGTCACCAAA 
GGCCAAGGAC CTGAGCTGAT GGGGGGCGCC CAGACCCCAA CTAAGCAACC CGAGGAAAGG 
GAGGCAGGGG AGGTGGAGCT CATGGGAGTT CTGGCCCTGA GCAAAGAGGA GCAGGAGAGG 
AGCCTGGAGG CAGGTCCCAG GCACGCGGGG TCTGTAAAGC CTGAGGCCTC CGAGGCCTTC 
CCAGGAGCCT GGGAAAACCG CACGAGAAAG GACATGGAGA GAGGAAATAC TCAGGAGGAT 
GCGGCCGATG GCGAGCAGCG GGAGGAGGAG GAGACTGCGG GAGGCCAGAC CCTGGCGGCT 
GAGGCTGAAG GAGACCGAGA GTCTGAACTA TCAGAAGTCC CAGAGGCAGG CGGGGAGGGG 
CTGACAACCC AGGACGCGGG ATGTGGAACT GAGGAGGGAG AGGCATCTGT CTCAGAGAAC 
CAGGAGCTGG ACGGAAGCAC AGGGGCAGAC GCAGGGCCTT GCCCGTCACT GGGAGAGGCC 
TATGCCAGAG AAACTGAGGA TGAGGAGGCG GAGGCTGACA GAACATCCAG AAGAGGCTGG 
AGGCTGCAAG CGGTGGCTGT GGGCCTCCCG GACCGTGAGG ATGCACAGAC TGGCTCTGTG 
GCTGCTGGGA TTATGGGGGG TGATGTGGTC CCACACATCA GCGCTGCTGG CGCTGGTGAA 
GCTTTGGAAG GGGTGCTTGG GCAAGGCTGG GACTCGAAAG AAAAGGAAGA GGCAGCAGCA 
GGAGAGCATG CAGGTGGGCA AGAATTTGGT CTGGAGGGCT CAGCAGAGGA AGAGGTGACT 
GGCAGAGGCA GCCAAGTAGA GGCTTTTGAG TCCAGGGAGG GAGGACCTTG GGGAGGGCGG 
GTAGAGGCCG AGGAATCTGC AGGCGCAGAG GACAGCTGTG GGCTGGATCC CGCGGGCTCC 
CAGACAGCGA GGGCAGAGGG GATGGGAGCC ATGGTGGAGG CTGGGGGGCT TCTAGAAAAG 
TGGACGCTGT TGGAAGAAGA GGCTGTTGGA TGGCAGGAGA GAGAACAGAG GGAAGACAGT 
GAGGGGCGGT GTGGGGACTA CCACCCTGAG GGAGAGGCAC CAAGGCTCCT TGATGCAGAG 
GGTCTCATGG TGACCGGGGG CCGGAGGGCA GAGGCCAAGG AGACTGAGCC AGAAAGCCTG 
GAACATGTCA GGGGCCAGGA GGAGCAGCCA ACACACCAGG CCCCTGCAGA AGCTGCGCCG 
GAGTCAGTCG GGGAAGCCGA GACGGCTGAG GCCATGGGCA GTGCCAGAGG AGGTGCTGCC 
AACAGCTGGA GCGAGGCCCC GCTCCCCGGG TCCCTCCTAG ACGTCTCTGT CCCAAGGAGT 
CGCGTGCACC TCTCGAGAAG CTCCTCACAG CGTCGCTCCC GGCCCTCTTT TCGTCGGACT 
CCGGCCTGGG AGCAGCAGGA GGAGCCCCCA GCCCCCAACC CTCCTGAGGA GGAGCTGTCA 
GCTCCTGAGC AGAGACCCCT CCAGCTGGAG GAACCCCTGG AGCCAAGCCC TCTGAGGCAT 
GATGGGACCC CGGTGCCAGC CAGGAGAAGG CCCCTGGGAC ACGGGTTTGG CCTCGCGCAC 
CCTGGCATGA TGCAGGAGCT GCAAGCCCGT CTGGGCCGGC CTAAGCCCCA GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association121(6)334-7(2013 Jun)
Volckmar AL,P?tter C,Song JY,Graniger J,Knoll N,Wolters B,Hebebrand J,Scherag A,Reinehr T,Hinney A


book

Triglyceride-rich lipoprotein regulates APOB48 receptor gene expression in human THP-1 monocytes and macrophages.
The Journal of nutrition142(2)227-32(2012 Feb)
Bermudez B,Lopez S,Varela LM,Ortega A,Pacheco YM,Moreda W,Moreno-Luna R,Abia R,Muriana FJ


book

A high-fat meal promotes lipid-load and apolipoprotein B-48 receptor transcriptional activity in circulating monocytes.
The American journal of clinical nutrition93(5)918-25(2011 May)
Varela LM,Ortega A,Bermudez B,Lopez S,Pacheco YM,Villar J,Abia R,Muriana FJ


book

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA