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BMP6 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol BMP6
Entrez Gene ID 654
Full Name bone morphogenetic protein 6
Synonyms VGR,VGR1
General protein information
Preferred Names

bone morphogenetic protein 6

Names

bone morphogenetic protein 6
VG-1-R
VG-1-related protein
vegetal related growth factor (TGFB-related)
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

6

6p24.3
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016].
Disorder MIM:

112266


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001718.5 NP_001709.1 bone morphogenetic protein 6 preproprotein
NM_001718.4 NP_001709.1 bone morphogenetic protein 6 preproprotein
NM_001718.6 NP_001709.1 bone morphogenetic protein 6 preproprotein

Pathways from BioSystems


Homologies


BMP6 XP_001085364.1
Mus musculus (house mouse) Bmp6 NP_031582.1
Homo sapiens (human) BMP6 NP_001709.1
Pan troglodytes (chimpanzee) BMP6 XP_003950760.1
Rattus norvegicus (Norway rat) Bmp6 NP_037239.1
Bos taurus (cattle) BMP6 XP_005223949.1
Gallus gallus (chicken) BMP6 XP_418956.4
Danio rerio (zebrafish) bmp6 NP_001013357.1
Xenopus tropicalis (tropical clawed frog) bmp6 NP_001106378.1

Gene Ontology


Bibliography

Related articles in PubMed

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk
Benn A, Hiepen C, Osterland M, Sch?tte C, Zwijsen A, Knaus P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4720-4733(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

both bone morphogenetic protein 2 (BMP2) and BMP6 are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3) and ALK2, play crucial and distinct roles in this process.
Title: Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk

Our results independently add further evidence to the role of BMP6 mutations as likely contributing factors to late-onset moderate IO unrelated to mutations in the established five HH genes.
Title: Identification of new BMP6 pro-peptide mutations in patients with iron overload.

Further investigation on clinical ESCC samples and non-tumorous adjacent tissue found that tumors with triple-positive BMP6, ALK2 and BMPRII had deeper growth than tumors with only BMP6 expression
Title: BMP signaling pathways affect differently migration and invasion of esophageal squamous cancer cells.

Plasma BMP6 was significantly increased in chronic heart failure patients.
Title: Bone morphogenetic protein 6-a possible new player in pathophysiology of heart failure.

study shows that patients with CRA had high expression of BMP6 and hepcidin and low expression of s-HJV. BMP6 was found to be negatively correlated with s-HJV; both regulate hepcidin expression and play important roles in the development of anemia.
Title: BMP6 and BMP4 expression in patients with cancer-related anemia and its relationship with hepcidin and s-HJV.

The following BMP6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BMP6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu16359 NM_001718.6
Latest version!		 Homo sapiens bone morphogenetic protein 6 (BMP6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $219.50-$307.30
$439.00
View Old Accession Versions >>
OHu16359 NM_001718.4 Homo sapiens bone morphogenetic protein 6 (BMP6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $219.50-$307.30
$439.00
OHu16359 NM_001718.5 Homo sapiens bone morphogenetic protein 6 (BMP6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $219.50-$307.30
$439.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu16359
Clone ID Related Accession (Same CDS sequence) NM_001718.5 , NM_001718.4 , NM_001718.6
Accession Version NM_001718.5 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1542bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-26
Organism Homo sapiens(human)
Product bone morphogenetic protein 6 preproprotein
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300628.1, AL135778.9, BF732376.1, M60315.1, BC099624.1, AL133541.21 and AA700487.1. On Jul 28, 2016 this sequence version replaced NM_001718.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M60315.1, SRR1803611.262077.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGGGGC TGGGGCGGAG GGCGCAGTGG CTGTGCTGGT GGTGGGGGCT GCTGTGCAGC 
TGCTGCGGGC CCCCGCCGCT GCGGCCGCCC TTGCCCGCTG CCGCGGCCGC CGCCGCCGGG 
GGGCAGCTGC TGGGGGACGG CGGGAGCCCC GGCCGCACGG AGCAGCCGCC GCCGTCGCCG 
CAGTCCTCCT CGGGCTTCCT GTACCGGCGG CTCAAGACGC AGGAGAAGCG GGAGATGCAG 
AAGGAGATCT TGTCGGTGCT GGGGCTCCCG CACCGGCCCC GGCCCCTGCA CGGCCTCCAA 
CAGCCGCAGC CCCCGGCGCT CCGGCAGCAG GAGGAGCAGC AGCAGCAGCA GCAGCTGCCT 
CGCGGAGAGC CCCCTCCCGG GCGACTGAAG TCCGCGCCCC TCTTCATGCT GGATCTGTAC 
AACGCCCTGT CCGCCGACAA CGACGAGGAC GGGGCGTCGG AGGGGGAGAG GCAGCAGTCC 
TGGCCCCACG AAGCAGCCAG CTCGTCCCAG CGTCGGCAGC CGCCCCCGGG CGCCGCGCAC 
CCGCTCAACC GCAAGAGCCT TCTGGCCCCC GGATCTGGCA GCGGCGGCGC GTCCCCACTG 
ACCAGCGCGC AGGACAGCGC CTTCCTCAAC GACGCGGACA TGGTCATGAG CTTTGTGAAC 
CTGGTGGAGT ACGACAAGGA GTTCTCCCCT CGTCAGCGAC ACCACAAAGA GTTCAAGTTC 
AACTTATCCC AGATTCCTGA GGGTGAGGTG GTGACGGCTG CAGAATTCCG CATCTACAAG 
GACTGTGTTA TGGGGAGTTT TAAAAACCAA ACTTTTCTTA TCAGCATTTA TCAAGTCTTA 
CAGGAGCATC AGCACAGAGA CTCTGACCTG TTTTTGTTGG ACACCCGTGT AGTATGGGCC 
TCAGAAGAAG GCTGGCTGGA ATTTGACATC ACGGCCACTA GCAATCTGTG GGTTGTGACT 
CCACAGCATA ACATGGGGCT TCAGCTGAGC GTGGTGACAA GGGATGGAGT CCACGTCCAC 
CCCCGAGCCG CAGGCCTGGT GGGCAGAGAC GGCCCTTACG ACAAGCAGCC CTTCATGGTG 
GCTTTCTTCA AAGTGAGTGA GGTGCACGTG CGCACCACCA GGTCAGCCTC CAGCCGGCGC 
CGACAACAGA GTCGTAATCG CTCTACCCAG TCCCAGGACG TGGCGCGGGT CTCCAGTGCT 
TCAGATTACA ACAGCAGTGA ATTGAAAACA GCCTGCAGGA AGCATGAGCT GTATGTGAGT 
TTCCAAGACC TGGGATGGCA GGACTGGATC ATTGCACCCA AGGGCTATGC TGCCAATTAC 
TGTGATGGAG AATGCTCCTT CCCACTCAAC GCACACATGA ATGCAACCAA CCACGCGATT 
GTGCAGACCT TGGTTCACCT TATGAACCCC GAGTATGTCC CCAAACCGTG CTGTGCGCCA 
ACTAAGCTAA ATGCCATCTC GGTTCTTTAC TTTGATGACA ACTCCAATGT CATTCTGAAA 
AAATACAGGA ATATGGTTGT AAGAGCTTGT GGATGCCACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001709.1
CDS858..2399
Translation

Target ORF information:

RefSeq Version NM_001718.5
Organism Homo sapiens(human)
Definition Homo sapiens bone morphogenetic protein 6 (BMP6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001718.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGGGGC TGGGGCGGAG GGCGCAGTGG CTGTGCTGGT GGTGGGGGCT GCTGTGCAGC 
TGCTGCGGGC CCCCGCCGCT GCGGCCGCCC TTGCCCGCTG CCGCGGCCGC CGCCGCCGGG 
GGGCAGCTGC TGGGGGACGG CGGGAGCCCC GGCCGCACGG AGCAGCCGCC GCCGTCGCCG 
CAGTCCTCCT CGGGCTTCCT GTACCGGCGG CTCAAGACGC AGGAGAAGCG GGAGATGCAG 
AAGGAGATCT TGTCGGTGCT GGGGCTCCCG CACCGGCCCC GGCCCCTGCA CGGCCTCCAA 
CAGCCGCAGC CCCCGGCGCT CCGGCAGCAG GAGGAGCAGC AGCAGCAGCA GCAGCTGCCT 
CGCGGAGAGC CCCCTCCCGG GCGACTGAAG TCCGCGCCCC TCTTCATGCT GGATCTGTAC 
AACGCCCTGT CCGCCGACAA CGACGAGGAC GGGGCGTCGG AGGGGGAGAG GCAGCAGTCC 
TGGCCCCACG AAGCAGCCAG CTCGTCCCAG CGTCGGCAGC CGCCCCCGGG CGCCGCGCAC 
CCGCTCAACC GCAAGAGCCT TCTGGCCCCC GGATCTGGCA GCGGCGGCGC GTCCCCACTG 
ACCAGCGCGC AGGACAGCGC CTTCCTCAAC GACGCGGACA TGGTCATGAG CTTTGTGAAC 
CTGGTGGAGT ACGACAAGGA GTTCTCCCCT CGTCAGCGAC ACCACAAAGA GTTCAAGTTC 
AACTTATCCC AGATTCCTGA GGGTGAGGTG GTGACGGCTG CAGAATTCCG CATCTACAAG 
GACTGTGTTA TGGGGAGTTT TAAAAACCAA ACTTTTCTTA TCAGCATTTA TCAAGTCTTA 
CAGGAGCATC AGCACAGAGA CTCTGACCTG TTTTTGTTGG ACACCCGTGT AGTATGGGCC 
TCAGAAGAAG GCTGGCTGGA ATTTGACATC ACGGCCACTA GCAATCTGTG GGTTGTGACT 
CCACAGCATA ACATGGGGCT TCAGCTGAGC GTGGTGACAA GGGATGGAGT CCACGTCCAC 
CCCCGAGCCG CAGGCCTGGT GGGCAGAGAC GGCCCTTACG ACAAGCAGCC CTTCATGGTG 
GCTTTCTTCA AAGTGAGTGA GGTGCACGTG CGCACCACCA GGTCAGCCTC CAGCCGGCGC 
CGACAACAGA GTCGTAATCG CTCTACCCAG TCCCAGGACG TGGCGCGGGT CTCCAGTGCT 
TCAGATTACA ACAGCAGTGA ATTGAAAACA GCCTGCAGGA AGCATGAGCT GTATGTGAGT 
TTCCAAGACC TGGGATGGCA GGACTGGATC ATTGCACCCA AGGGCTATGC TGCCAATTAC 
TGTGATGGAG AATGCTCCTT CCCACTCAAC GCACACATGA ATGCAACCAA CCACGCGATT 
GTGCAGACCT TGGTTCACCT TATGAACCCC GAGTATGTCC CCAAACCGTG CTGTGCGCCA 
ACTAAGCTAA ATGCCATCTC GGTTCTTTAC TTTGATGACA ACTCCAATGT CATTCTGAAA 
AAATACAGGA ATATGGTTGT AAGAGCTTGT GGATGCCACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16359
Clone ID Related Accession (Same CDS sequence) NM_001718.5 , NM_001718.4 , NM_001718.6
Accession Version NM_001718.4 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1542bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2015-03-14
Organism Homo sapiens(Human)
Product bone morphogenetic protein 6 preproprotein
Comment 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGGGGC TGGGGCGGAG GGCGCAGTGG CTGTGCTGGT GGTGGGGGCT GCTGTGCAGC 
TGCTGCGGGC CCCCGCCGCT GCGGCCGCCC TTGCCCGCTG CCGCGGCCGC CGCCGCCGGG 
GGGCAGCTGC TGGGGGACGG CGGGAGCCCC GGCCGCACGG AGCAGCCGCC GCCGTCGCCG 
CAGTCCTCCT CGGGCTTCCT GTACCGGCGG CTCAAGACGC AGGAGAAGCG GGAGATGCAG 
AAGGAGATCT TGTCGGTGCT GGGGCTCCCG CACCGGCCCC GGCCCCTGCA CGGCCTCCAA 
CAGCCGCAGC CCCCGGCGCT CCGGCAGCAG GAGGAGCAGC AGCAGCAGCA GCAGCTGCCT 
CGCGGAGAGC CCCCTCCCGG GCGACTGAAG TCCGCGCCCC TCTTCATGCT GGATCTGTAC 
AACGCCCTGT CCGCCGACAA CGACGAGGAC GGGGCGTCGG AGGGGGAGAG GCAGCAGTCC 
TGGCCCCACG AAGCAGCCAG CTCGTCCCAG CGTCGGCAGC CGCCCCCGGG CGCCGCGCAC 
CCGCTCAACC GCAAGAGCCT TCTGGCCCCC GGATCTGGCA GCGGCGGCGC GTCCCCACTG 
ACCAGCGCGC AGGACAGCGC CTTCCTCAAC GACGCGGACA TGGTCATGAG CTTTGTGAAC 
CTGGTGGAGT ACGACAAGGA GTTCTCCCCT CGTCAGCGAC ACCACAAAGA GTTCAAGTTC 
AACTTATCCC AGATTCCTGA GGGTGAGGTG GTGACGGCTG CAGAATTCCG CATCTACAAG 
GACTGTGTTA TGGGGAGTTT TAAAAACCAA ACTTTTCTTA TCAGCATTTA TCAAGTCTTA 
CAGGAGCATC AGCACAGAGA CTCTGACCTG TTTTTGTTGG ACACCCGTGT AGTATGGGCC 
TCAGAAGAAG GCTGGCTGGA ATTTGACATC ACGGCCACTA GCAATCTGTG GGTTGTGACT 
CCACAGCATA ACATGGGGCT TCAGCTGAGC GTGGTGACAA GGGATGGAGT CCACGTCCAC 
CCCCGAGCCG CAGGCCTGGT GGGCAGAGAC GGCCCTTACG ACAAGCAGCC CTTCATGGTG 
GCTTTCTTCA AAGTGAGTGA GGTGCACGTG CGCACCACCA GGTCAGCCTC CAGCCGGCGC 
CGACAACAGA GTCGTAATCG CTCTACCCAG TCCCAGGACG TGGCGCGGGT CTCCAGTGCT 
TCAGATTACA ACAGCAGTGA ATTGAAAACA GCCTGCAGGA AGCATGAGCT GTATGTGAGT 
TTCCAAGACC TGGGATGGCA GGACTGGATC ATTGCACCCA AGGGCTATGC TGCCAATTAC 
TGTGATGGAG AATGCTCCTT CCCACTCAAC GCACACATGA ATGCAACCAA CCACGCGATT 
GTGCAGACCT TGGTTCACCT TATGAACCCC GAGTATGTCC CCAAACCGTG CTGTGCGCCA 
ACTAAGCTAA ATGCCATCTC GGTTCTTTAC TTTGATGACA ACTCCAATGT CATTCTGAAA 
AAATACAGGA ATATGGTTGT AAGAGCTTGT GGATGCCACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001709.1
Translation

Target ORF information:

RefSeq Version NM_001718.4
Organism Homo sapiens(Human)
Definition Homo sapiens bone morphogenetic protein 6 (BMP6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001718.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGGGGC TGGGGCGGAG GGCGCAGTGG CTGTGCTGGT GGTGGGGGCT GCTGTGCAGC 
TGCTGCGGGC CCCCGCCGCT GCGGCCGCCC TTGCCCGCTG CCGCGGCCGC CGCCGCCGGG 
GGGCAGCTGC TGGGGGACGG CGGGAGCCCC GGCCGCACGG AGCAGCCGCC GCCGTCGCCG 
CAGTCCTCCT CGGGCTTCCT GTACCGGCGG CTCAAGACGC AGGAGAAGCG GGAGATGCAG 
AAGGAGATCT TGTCGGTGCT GGGGCTCCCG CACCGGCCCC GGCCCCTGCA CGGCCTCCAA 
CAGCCGCAGC CCCCGGCGCT CCGGCAGCAG GAGGAGCAGC AGCAGCAGCA GCAGCTGCCT 
CGCGGAGAGC CCCCTCCCGG GCGACTGAAG TCCGCGCCCC TCTTCATGCT GGATCTGTAC 
AACGCCCTGT CCGCCGACAA CGACGAGGAC GGGGCGTCGG AGGGGGAGAG GCAGCAGTCC 
TGGCCCCACG AAGCAGCCAG CTCGTCCCAG CGTCGGCAGC CGCCCCCGGG CGCCGCGCAC 
CCGCTCAACC GCAAGAGCCT TCTGGCCCCC GGATCTGGCA GCGGCGGCGC GTCCCCACTG 
ACCAGCGCGC AGGACAGCGC CTTCCTCAAC GACGCGGACA TGGTCATGAG CTTTGTGAAC 
CTGGTGGAGT ACGACAAGGA GTTCTCCCCT CGTCAGCGAC ACCACAAAGA GTTCAAGTTC 
AACTTATCCC AGATTCCTGA GGGTGAGGTG GTGACGGCTG CAGAATTCCG CATCTACAAG 
GACTGTGTTA TGGGGAGTTT TAAAAACCAA ACTTTTCTTA TCAGCATTTA TCAAGTCTTA 
CAGGAGCATC AGCACAGAGA CTCTGACCTG TTTTTGTTGG ACACCCGTGT AGTATGGGCC 
TCAGAAGAAG GCTGGCTGGA ATTTGACATC ACGGCCACTA GCAATCTGTG GGTTGTGACT 
CCACAGCATA ACATGGGGCT TCAGCTGAGC GTGGTGACAA GGGATGGAGT CCACGTCCAC 
CCCCGAGCCG CAGGCCTGGT GGGCAGAGAC GGCCCTTACG ACAAGCAGCC CTTCATGGTG 
GCTTTCTTCA AAGTGAGTGA GGTGCACGTG CGCACCACCA GGTCAGCCTC CAGCCGGCGC 
CGACAACAGA GTCGTAATCG CTCTACCCAG TCCCAGGACG TGGCGCGGGT CTCCAGTGCT 
TCAGATTACA ACAGCAGTGA ATTGAAAACA GCCTGCAGGA AGCATGAGCT GTATGTGAGT 
TTCCAAGACC TGGGATGGCA GGACTGGATC ATTGCACCCA AGGGCTATGC TGCCAATTAC 
TGTGATGGAG AATGCTCCTT CCCACTCAAC GCACACATGA ATGCAACCAA CCACGCGATT 
GTGCAGACCT TGGTTCACCT TATGAACCCC GAGTATGTCC CCAAACCGTG CTGTGCGCCA 
ACTAAGCTAA ATGCCATCTC GGTTCTTTAC TTTGATGACA ACTCCAATGT CATTCTGAAA 
AAATACAGGA ATATGGTTGT AAGAGCTTGT GGATGCCACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16359
Clone ID Related Accession (Same CDS sequence) NM_001718.5 , NM_001718.4 , NM_001718.6
Accession Version NM_001718.6 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1542bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-29
Organism Homo sapiens(human)
Product bone morphogenetic protein 6 preproprotein
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK300628.1, AL135778.9, BF732376.1, M60315.1, BC099624.1, AL133541.21 and AA700487.1. On Nov 22, 2018 this sequence version replaced NM_001718.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M60315.1, SRR1803611.262077.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000283147.7/ ENSP00000283147.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGGGGC TGGGGCGGAG GGCGCAGTGG CTGTGCTGGT GGTGGGGGCT GCTGTGCAGC 
TGCTGCGGGC CCCCGCCGCT GCGGCCGCCC TTGCCCGCTG CCGCGGCCGC CGCCGCCGGG 
GGGCAGCTGC TGGGGGACGG CGGGAGCCCC GGCCGCACGG AGCAGCCGCC GCCGTCGCCG 
CAGTCCTCCT CGGGCTTCCT GTACCGGCGG CTCAAGACGC AGGAGAAGCG GGAGATGCAG 
AAGGAGATCT TGTCGGTGCT GGGGCTCCCG CACCGGCCCC GGCCCCTGCA CGGCCTCCAA 
CAGCCGCAGC CCCCGGCGCT CCGGCAGCAG GAGGAGCAGC AGCAGCAGCA GCAGCTGCCT 
CGCGGAGAGC CCCCTCCCGG GCGACTGAAG TCCGCGCCCC TCTTCATGCT GGATCTGTAC 
AACGCCCTGT CCGCCGACAA CGACGAGGAC GGGGCGTCGG AGGGGGAGAG GCAGCAGTCC 
TGGCCCCACG AAGCAGCCAG CTCGTCCCAG CGTCGGCAGC CGCCCCCGGG CGCCGCGCAC 
CCGCTCAACC GCAAGAGCCT TCTGGCCCCC GGATCTGGCA GCGGCGGCGC GTCCCCACTG 
ACCAGCGCGC AGGACAGCGC CTTCCTCAAC GACGCGGACA TGGTCATGAG CTTTGTGAAC 
CTGGTGGAGT ACGACAAGGA GTTCTCCCCT CGTCAGCGAC ACCACAAAGA GTTCAAGTTC 
AACTTATCCC AGATTCCTGA GGGTGAGGTG GTGACGGCTG CAGAATTCCG CATCTACAAG 
GACTGTGTTA TGGGGAGTTT TAAAAACCAA ACTTTTCTTA TCAGCATTTA TCAAGTCTTA 
CAGGAGCATC AGCACAGAGA CTCTGACCTG TTTTTGTTGG ACACCCGTGT AGTATGGGCC 
TCAGAAGAAG GCTGGCTGGA ATTTGACATC ACGGCCACTA GCAATCTGTG GGTTGTGACT 
CCACAGCATA ACATGGGGCT TCAGCTGAGC GTGGTGACAA GGGATGGAGT CCACGTCCAC 
CCCCGAGCCG CAGGCCTGGT GGGCAGAGAC GGCCCTTACG ACAAGCAGCC CTTCATGGTG 
GCTTTCTTCA AAGTGAGTGA GGTGCACGTG CGCACCACCA GGTCAGCCTC CAGCCGGCGC 
CGACAACAGA GTCGTAATCG CTCTACCCAG TCCCAGGACG TGGCGCGGGT CTCCAGTGCT 
TCAGATTACA ACAGCAGTGA ATTGAAAACA GCCTGCAGGA AGCATGAGCT GTATGTGAGT 
TTCCAAGACC TGGGATGGCA GGACTGGATC ATTGCACCCA AGGGCTATGC TGCCAATTAC 
TGTGATGGAG AATGCTCCTT CCCACTCAAC GCACACATGA ATGCAACCAA CCACGCGATT 
GTGCAGACCT TGGTTCACCT TATGAACCCC GAGTATGTCC CCAAACCGTG CTGTGCGCCA 
ACTAAGCTAA ATGCCATCTC GGTTCTTTAC TTTGATGACA ACTCCAATGT CATTCTGAAA 
AAATACAGGA ATATGGTTGT AAGAGCTTGT GGATGCCACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001709.1
CDS858..2399
Translation

Target ORF information:

RefSeq Version NM_001718.6
Organism Homo sapiens(human)
Definition Homo sapiens bone morphogenetic protein 6 (BMP6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001718.6

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCCGGGGC TGGGGCGGAG GGCGCAGTGG CTGTGCTGGT GGTGGGGGCT GCTGTGCAGC 
TGCTGCGGGC CCCCGCCGCT GCGGCCGCCC TTGCCCGCTG CCGCGGCCGC CGCCGCCGGG 
GGGCAGCTGC TGGGGGACGG CGGGAGCCCC GGCCGCACGG AGCAGCCGCC GCCGTCGCCG 
CAGTCCTCCT CGGGCTTCCT GTACCGGCGG CTCAAGACGC AGGAGAAGCG GGAGATGCAG 
AAGGAGATCT TGTCGGTGCT GGGGCTCCCG CACCGGCCCC GGCCCCTGCA CGGCCTCCAA 
CAGCCGCAGC CCCCGGCGCT CCGGCAGCAG GAGGAGCAGC AGCAGCAGCA GCAGCTGCCT 
CGCGGAGAGC CCCCTCCCGG GCGACTGAAG TCCGCGCCCC TCTTCATGCT GGATCTGTAC 
AACGCCCTGT CCGCCGACAA CGACGAGGAC GGGGCGTCGG AGGGGGAGAG GCAGCAGTCC 
TGGCCCCACG AAGCAGCCAG CTCGTCCCAG CGTCGGCAGC CGCCCCCGGG CGCCGCGCAC 
CCGCTCAACC GCAAGAGCCT TCTGGCCCCC GGATCTGGCA GCGGCGGCGC GTCCCCACTG 
ACCAGCGCGC AGGACAGCGC CTTCCTCAAC GACGCGGACA TGGTCATGAG CTTTGTGAAC 
CTGGTGGAGT ACGACAAGGA GTTCTCCCCT CGTCAGCGAC ACCACAAAGA GTTCAAGTTC 
AACTTATCCC AGATTCCTGA GGGTGAGGTG GTGACGGCTG CAGAATTCCG CATCTACAAG 
GACTGTGTTA TGGGGAGTTT TAAAAACCAA ACTTTTCTTA TCAGCATTTA TCAAGTCTTA 
CAGGAGCATC AGCACAGAGA CTCTGACCTG TTTTTGTTGG ACACCCGTGT AGTATGGGCC 
TCAGAAGAAG GCTGGCTGGA ATTTGACATC ACGGCCACTA GCAATCTGTG GGTTGTGACT 
CCACAGCATA ACATGGGGCT TCAGCTGAGC GTGGTGACAA GGGATGGAGT CCACGTCCAC 
CCCCGAGCCG CAGGCCTGGT GGGCAGAGAC GGCCCTTACG ACAAGCAGCC CTTCATGGTG 
GCTTTCTTCA AAGTGAGTGA GGTGCACGTG CGCACCACCA GGTCAGCCTC CAGCCGGCGC 
CGACAACAGA GTCGTAATCG CTCTACCCAG TCCCAGGACG TGGCGCGGGT CTCCAGTGCT 
TCAGATTACA ACAGCAGTGA ATTGAAAACA GCCTGCAGGA AGCATGAGCT GTATGTGAGT 
TTCCAAGACC TGGGATGGCA GGACTGGATC ATTGCACCCA AGGGCTATGC TGCCAATTAC 
TGTGATGGAG AATGCTCCTT CCCACTCAAC GCACACATGA ATGCAACCAA CCACGCGATT 
GTGCAGACCT TGGTTCACCT TATGAACCCC GAGTATGTCC CCAAACCGTG CTGTGCGCCA 
ACTAAGCTAA ATGCCATCTC GGTTCTTTAC TTTGATGACA ACTCCAATGT CATTCTGAAA 
AAATACAGGA ATATGGTTGT AAGAGCTTGT GGATGCCACT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(11)4720-4733(2017 Nov)
Benn A,Hiepen C,Osterland M,Sch?tte C,Zwijsen A,Knaus P