THOC6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	THOC6
Entrez Gene ID	79228
Full Name	THO complex 6
Synonyms	WDR58,fSAP35
General protein information	Preferred Names THO complex 6 Names THO complex subunit 6 homolog WD repeat domain 58 WD repeat-containing protein 58 functional spliceosome-associated protein 35
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	This gene encodes a subunit of the multi-protein THO complex, which is involved in coordination between transcription and mRNA processing. The THO complex is a component of the TREX (transcription/export) complex, which is involved in transcription and export of mRNAs. A missense mutation in this gene is associated with a neurodevelopmental disorder called Beaulieu-Boycott-Innes syndrome. [provided by RefSeq, Dec 2016].
Disorder MIM:	615403
Disorder Html:	Beaulieu-Boycott-Innes syndrome, 613680 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001347704.2	NP_001334633.1	THO complex subunit 6 homolog isoform 1
NM_001347703.2	NP_001334632.1	THO complex subunit 6 homolog isoform 3
NM_024339.4	NP_077315.2	THO complex subunit 6 homolog isoform 1
NM_024339.5	NP_077315.2	THO complex subunit 6 homolog isoform 1
NM_001142350.2	NP_001135822.1	THO complex subunit 6 homolog isoform 2
NM_001347704.1	NP_001334633.1	THO complex subunit 6 homolog isoform 1
NM_001347703.1	NP_001334632.1	THO complex subunit 6 homolog isoform 3
NM_001142350.3	NP_001135822.1	THO complex subunit 6 homolog isoform 2

Pathways from BioSystems

Homologies

	THOC6	XP_001090442.1
Mus musculus (house mouse)	Thoc6	NP_001008425.1
Homo sapiens (human)	THOC6	NP_077315.2
Pan troglodytes (chimpanzee)	THOC6	XP_510762.3
Xenopus tropicalis (tropical clawed frog)	LOC100498236	XP_002943092.1
Canis lupus familiaris (dog)	THOC6	XP_536996.3
Bos taurus (cattle)	THOC6	NP_001098973.1
Rattus norvegicus (Norway rat)	Thoc6	NP_077360.2
Danio rerio (zebrafish)	thoc6	NP_001006095.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005429	XP_315435.4
Drosophila melanogaster (fruit fly)	thoc6	NP_648557.1

Gene Ontology
Bibliography

Related articles in PubMed

Autosomal recessive mutations in THOC6 cause intellectual disability: syndrome delineation requiring forward and reverse phenotyping.
Amos JS, Huang L, Thevenon J, Kariminedjad A, Beaulieu CL, Masurel-Paulet A, Najmabadi H, Fattahi Z, Beheshtian M, Tonekaboni SH, Tang S, Helbig KL, Alcaraz W, Rivi?re JB, Faivre L, Innes AM, Lebel RR, Boycott KM,
Clinical genetics91(1)92-99(2017 Jan)

Confirming the candidacy of THOC6 in the etiology of intellectual disability.
Anazi S, Alshammari M, Moneis D, Abouelhoda M, Ibrahim N, Alkuraya FS
American journal of medical genetics. Part A170A(5)1367-9(2016 May)

Intellectual disability associated with a homozygous missense mutation in THOC6.
Beaulieu CL, Huang L, Innes AM, Akimenko MA, Puffenberger EG, Schwartz C, Jerry P, Ober C, Hegele RA, McLeod DR, Schwartzentruber J, , Majewski J, Bulman DE, Parboosingh JS, Boycott KM
Orphanet journal of rare diseases862(2013 Apr)

A quantitative telomeric chromatin isolation protocol identifies different telomeric states.
Grolimund L, Aeby E, Hamelin R, Armand F, Chiappe D, Moniatte M, Lingner J
Nature communications42848(2013)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate three unrelated patients with bi-allelic mutations in THOC6 associated with intellectual disability and additional clinical features.
Title: Autosomal recessive mutations in THOC6 cause intellectual disability: syndrome delineation requiring forward and reverse phenotyping.

In addition to confirming the morbid nature of THOC6 by providing an independent homozygous apparently loss of function allele in a patient with a compatible phenotype, our data also expand THOC6-related phenotype to include previously unreported imperforate anus and undescended testicles.
Title: Confirming the candidacy of THOC6 in the etiology of intellectual disability.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following THOC6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THOC6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31447	NM_001347704.2 Latest version!	Homo sapiens THO complex 6 (THOC6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu31447	NM_024339.5 Latest version!	Homo sapiens THO complex 6 (THOC6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu102237	NM_001347703.2 Latest version!	Homo sapiens THO complex 6 (THOC6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu32046	NM_001142350.3 Latest version!	Homo sapiens THO complex 6 (THOC6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu31447	NM_024339.4	Homo sapiens THO complex 6 (THOC6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu31447	NM_001347704.1	Homo sapiens THO complex 6 (THOC6), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu102237	NM_001347703.1	Homo sapiens THO complex 6 (THOC6), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu32046	NM_001142350.2	Homo sapiens THO complex 6 (THOC6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THOC6 ( NM_001347704.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001334633.1 Homo sapiens THO complex 6 (THOC6), transcript variant 4, mRNA.

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CloneID	OHu31447
Clone ID Related Accession (Same CDS sequence)	NM_001347704.2 , NM_024339.4 , NM_024339.5 , NM_001347704.1
Accession Version	NM_001347704.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC108134.3 and BM457458.1. On May 31, 2019 this sequence version replaced NM_001347704.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode trhe same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.223968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334633.1
CDS	187..1212
Translation	MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_001347704.2
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347704.2

ORF Insert Sequence:

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOC6 ( NM_024339.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_077315.2 Homo sapiens THO complex 6 (THOC6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31447
Clone ID Related Accession (Same CDS sequence)	NM_001347704.2 , NM_024339.4 , NM_024339.5 , NM_001347704.1
Accession Version	NM_024339.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-03
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX425088.2, BC050674.1 and BM457458.1. This sequence is a reference standard in the RefSeqGene project. On Dec 9, 2016 this sequence version replaced NM_024339.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.103093.1, SRR1163658.369003.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077315.2
CDS	309..1334
Translation	MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_024339.4
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024339.4

ORF Insert Sequence:

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOC6 ( NM_024339.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_077315.2 Homo sapiens THO complex 6 (THOC6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu31447
Clone ID Related Accession (Same CDS sequence)	NM_001347704.2 , NM_024339.4 , NM_024339.5 , NM_001347704.1
Accession Version	NM_024339.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX425088.2, BC050674.1 and BM457458.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_024339.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same isoform. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.158290.1, SRR5189661.384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000326266.13/ ENSP00000326531.8 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077315.2
CDS	293..1318
Translation	MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_024339.5
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024339.5

ORF Insert Sequence:

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOC6 ( NM_001347704.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001334633.1 Homo sapiens THO complex 6 (THOC6), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu31447
Clone ID Related Accession (Same CDS sequence)	NM_001347704.2 , NM_024339.4 , NM_024339.5 , NM_001347704.1
Accession Version	NM_001347704.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC108134.3 and BM457458.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 encode trhe same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.223968.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334633.1
CDS	203..1228
Translation	MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_001347704.1
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347704.1

ORF Insert Sequence:

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG ATTCTGTCAG CTGGCCAGGG CCGCTGCGTC 
AACCAGTGGC AGCTGAGCGG GGAGCTGAAG GCCCAGGTGC CTGGCTCCTC CCCAGGGCTG 
CTCAGCCTCA GCCTCAACCA GCAGCCTGCC GCGCCTGAGT GCAAGGTCCT GACAGCTGCA 
GGCAACAGCT GCCGGGTGGA TGTCTTCACC AACCTGGGTT ACCGAGCCTT CTCCCTGTCC 
TTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOC6 ( NM_001347703.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001334632.1 Homo sapiens THO complex 6 (THOC6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu102237
Clone ID Related Accession (Same CDS sequence)	NM_001347703.2 , NM_001347703.1
Accession Version	NM_001347703.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX425088.2, BC003118.1 and BM457458.1. On May 31, 2019 this sequence version replaced NM_001347703.1. Transcript Variant: This variant (3) differs in the 5' structure, resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATCT TCTCCCAGAG CGTCTCACCA TGTGGGAAGT TTCTGGCGGC TGGCAACAAT 
TACGGGCAGA TTGCCATCTT CAGCTTGTCC TCTGCTTTGA GCTCAGAAGC CAAAGAGGAA 
AGTAAGAAGC CGGTGGTGAC TTTCCAAGCC CATGATGGGC CCGTCTATAG CATGGTTTCC 
ACCGATCGAC ATCTGCTTAG TGCTGGGGAT GGGGAGGTGA AGGCCTGGCT TTGGGCGGAG 
ATGCTCAAGA AGGGCTGTAA GGAGCTGTGG CGTCGTCAGC CTCCATACAG GACCAGCCTG 
GAAGTGCCTG AGATCAACGC TTTGCTGCTG GTCCCCAAGG AGAATTCCCT CATCCTGGCT 
GGGGGAGACT GTCAGTTGCA CACTATGGAC CTTGAAACTG GGACTTTCAC GAGGGTCCTC 
CGGGGCCACA CAGACTACAT CCACTGCCTG GCACTGCGGG AAAGGAGCCC AGAGGTGCTG 
TCAGGTGGCG AGGATGGAGC TGTTCGACTT TGGGACCTGC GCACAGCCAA GGAGGTCCAG 
ACGATCGAGG TCTATAAGCA CGAGGAGTGC TCGAGGCCCC ACAATGGGCG CTGGATTGGA 
TGTTTGGCAA CTGATTCCGA CTGGATGGTC TGTGGAGGGG GCCCAGCCCT CACCCTCTGG 
CACCTCCGAT CCTCCACACC CACCACCATC TTCCCCATCC GGGCGCCACA GAAGCACGTC 
ACCTTCTACC AGGACCTGAT TCTGTCAGCT GGCCAGGGCC GCTGCGTCAA CCAGTGGCAG 
CTGAGCGGGG AGCTGAAGGC CCAGGTGCCT GGCTCCTCCC CAGGGCTGCT CAGCCTCAGC 
CTCAACCAGC AGCCTGCCGC GCCTGAGTGC AAGGTCCTGA CAGCTGCAGG CAACAGCTGC 
CGGGTGGATG TCTTCACCAA CCTGGGTTAC CGAGCCTTCT CCCTGTCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334632.1
CDS	255..1208
Translation	MTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_001347703.2
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347703.2

ORF Insert Sequence:

ATGACCATCT TCTCCCAGAG CGTCTCACCA TGTGGGAAGT TTCTGGCGGC TGGCAACAAT 
TACGGGCAGA TTGCCATCTT CAGCTTGTCC TCTGCTTTGA GCTCAGAAGC CAAAGAGGAA 
AGTAAGAAGC CGGTGGTGAC TTTCCAAGCC CATGATGGGC CCGTCTATAG CATGGTTTCC 
ACCGATCGAC ATCTGCTTAG TGCTGGGGAT GGGGAGGTGA AGGCCTGGCT TTGGGCGGAG 
ATGCTCAAGA AGGGCTGTAA GGAGCTGTGG CGTCGTCAGC CTCCATACAG GACCAGCCTG 
GAAGTGCCTG AGATCAACGC TTTGCTGCTG GTCCCCAAGG AGAATTCCCT CATCCTGGCT 
GGGGGAGACT GTCAGTTGCA CACTATGGAC CTTGAAACTG GGACTTTCAC GAGGGTCCTC 
CGGGGCCACA CAGACTACAT CCACTGCCTG GCACTGCGGG AAAGGAGCCC AGAGGTGCTG 
TCAGGTGGCG AGGATGGAGC TGTTCGACTT TGGGACCTGC GCACAGCCAA GGAGGTCCAG 
ACGATCGAGG TCTATAAGCA CGAGGAGTGC TCGAGGCCCC ACAATGGGCG CTGGATTGGA 
TGTTTGGCAA CTGATTCCGA CTGGATGGTC TGTGGAGGGG GCCCAGCCCT CACCCTCTGG 
CACCTCCGAT CCTCCACACC CACCACCATC TTCCCCATCC GGGCGCCACA GAAGCACGTC 
ACCTTCTACC AGGACCTGAT TCTGTCAGCT GGCCAGGGCC GCTGCGTCAA CCAGTGGCAG 
CTGAGCGGGG AGCTGAAGGC CCAGGTGCCT GGCTCCTCCC CAGGGCTGCT CAGCCTCAGC 
CTCAACCAGC AGCCTGCCGC GCCTGAGTGC AAGGTCCTGA CAGCTGCAGG CAACAGCTGC 
CGGGTGGATG TCTTCACCAA CCTGGGTTAC CGAGCCTTCT CCCTGTCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOC6 ( NM_001347703.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001334632.1 Homo sapiens THO complex 6 (THOC6), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu102237
Clone ID Related Accession (Same CDS sequence)	NM_001347703.2 , NM_001347703.1
Accession Version	NM_001347703.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-14
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX425088.2, BC003118.1 and BM457458.1. Transcript Variant: This variant (3) differs in the 5' structure, resulting in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC003118.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATCT TCTCCCAGAG CGTCTCACCA TGTGGGAAGT TTCTGGCGGC TGGCAACAAT 
TACGGGCAGA TTGCCATCTT CAGCTTGTCC TCTGCTTTGA GCTCAGAAGC CAAAGAGGAA 
AGTAAGAAGC CGGTGGTGAC TTTCCAAGCC CATGATGGGC CCGTCTATAG CATGGTTTCC 
ACCGATCGAC ATCTGCTTAG TGCTGGGGAT GGGGAGGTGA AGGCCTGGCT TTGGGCGGAG 
ATGCTCAAGA AGGGCTGTAA GGAGCTGTGG CGTCGTCAGC CTCCATACAG GACCAGCCTG 
GAAGTGCCTG AGATCAACGC TTTGCTGCTG GTCCCCAAGG AGAATTCCCT CATCCTGGCT 
GGGGGAGACT GTCAGTTGCA CACTATGGAC CTTGAAACTG GGACTTTCAC GAGGGTCCTC 
CGGGGCCACA CAGACTACAT CCACTGCCTG GCACTGCGGG AAAGGAGCCC AGAGGTGCTG 
TCAGGTGGCG AGGATGGAGC TGTTCGACTT TGGGACCTGC GCACAGCCAA GGAGGTCCAG 
ACGATCGAGG TCTATAAGCA CGAGGAGTGC TCGAGGCCCC ACAATGGGCG CTGGATTGGA 
TGTTTGGCAA CTGATTCCGA CTGGATGGTC TGTGGAGGGG GCCCAGCCCT CACCCTCTGG 
CACCTCCGAT CCTCCACACC CACCACCATC TTCCCCATCC GGGCGCCACA GAAGCACGTC 
ACCTTCTACC AGGACCTGAT TCTGTCAGCT GGCCAGGGCC GCTGCGTCAA CCAGTGGCAG 
CTGAGCGGGG AGCTGAAGGC CCAGGTGCCT GGCTCCTCCC CAGGGCTGCT CAGCCTCAGC 
CTCAACCAGC AGCCTGCCGC GCCTGAGTGC AAGGTCCTGA CAGCTGCAGG CAACAGCTGC 
CGGGTGGATG TCTTCACCAA CCTGGGTTAC CGAGCCTTCT CCCTGTCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001334632.1
CDS	271..1224
Translation	MTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLILSAGQGRCVNQWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_001347703.1
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001347703.1

ORF Insert Sequence:

ATGACCATCT TCTCCCAGAG CGTCTCACCA TGTGGGAAGT TTCTGGCGGC TGGCAACAAT 
TACGGGCAGA TTGCCATCTT CAGCTTGTCC TCTGCTTTGA GCTCAGAAGC CAAAGAGGAA 
AGTAAGAAGC CGGTGGTGAC TTTCCAAGCC CATGATGGGC CCGTCTATAG CATGGTTTCC 
ACCGATCGAC ATCTGCTTAG TGCTGGGGAT GGGGAGGTGA AGGCCTGGCT TTGGGCGGAG 
ATGCTCAAGA AGGGCTGTAA GGAGCTGTGG CGTCGTCAGC CTCCATACAG GACCAGCCTG 
GAAGTGCCTG AGATCAACGC TTTGCTGCTG GTCCCCAAGG AGAATTCCCT CATCCTGGCT 
GGGGGAGACT GTCAGTTGCA CACTATGGAC CTTGAAACTG GGACTTTCAC GAGGGTCCTC 
CGGGGCCACA CAGACTACAT CCACTGCCTG GCACTGCGGG AAAGGAGCCC AGAGGTGCTG 
TCAGGTGGCG AGGATGGAGC TGTTCGACTT TGGGACCTGC GCACAGCCAA GGAGGTCCAG 
ACGATCGAGG TCTATAAGCA CGAGGAGTGC TCGAGGCCCC ACAATGGGCG CTGGATTGGA 
TGTTTGGCAA CTGATTCCGA CTGGATGGTC TGTGGAGGGG GCCCAGCCCT CACCCTCTGG 
CACCTCCGAT CCTCCACACC CACCACCATC TTCCCCATCC GGGCGCCACA GAAGCACGTC 
ACCTTCTACC AGGACCTGAT TCTGTCAGCT GGCCAGGGCC GCTGCGTCAA CCAGTGGCAG 
CTGAGCGGGG AGCTGAAGGC CCAGGTGCCT GGCTCCTCCC CAGGGCTGCT CAGCCTCAGC 
CTCAACCAGC AGCCTGCCGC GCCTGAGTGC AAGGTCCTGA CAGCTGCAGG CAACAGCTGC 
CGGGTGGATG TCTTCACCAA CCTGGGTTAC CGAGCCTTCT CCCTGTCCTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOC6 ( NM_001142350.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135822.1 Homo sapiens THO complex 6 (THOC6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu32046
Clone ID Related Accession (Same CDS sequence)	NM_001142350.2 , NM_001142350.3
Accession Version	NM_001142350.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX425088.2, AK075330.1, AC108134.3 and BM457458.1. On Dec 9, 2016 this sequence version replaced NM_001142350.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152719, SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG GTCCTGACAG CTGCAGGCAA CAGCTGCCGG 
GTGGATGTCT TCACCAACCT GGGTTACCGA GCCTTCTCCC TGTCCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135822.1
CDS	309..1199
Translation	MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_001142350.2
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142350.2

ORF Insert Sequence:

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG GTCCTGACAG CTGCAGGCAA CAGCTGCCGG 
GTGGATGTCT TCACCAACCT GGGTTACCGA GCCTTCTCCC TGTCCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THOC6 ( NM_001142350.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001135822.1 Homo sapiens THO complex 6 (THOC6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu32046
Clone ID Related Accession (Same CDS sequence)	NM_001142350.2 , NM_001142350.3
Accession Version	NM_001142350.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 891bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	THO complex subunit 6 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX425088.2, AK075330.1, AC108134.3 and BM457458.1. On May 31, 2019 this sequence version replaced NM_001142350.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK075330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152719, SAMEA2153031 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG GTCCTGACAG CTGCAGGCAA CAGCTGCCGG 
GTGGATGTCT TCACCAACCT GGGTTACCGA GCCTTCTCCC TGTCCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001135822.1
CDS	293..1183
Translation	MERAVPLAVPLGQTEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSSALSSEAKEESKKPVVTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTIFPIRAPQKHVTFYQDLVLTAAGNSCRVDVFTNLGYRAFSLSF

Target ORF information:

RefSeq Version	NM_001142350.3
Organism	Homo sapiens(human)
Definition	Homo sapiens THO complex 6 (THOC6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001142350.3

ORF Insert Sequence:

ATGGAGCGAG CTGTGCCGCT CGCGGTGCCT CTGGGTCAGA CAGAGGTGTT CCAGGCCTTG 
CAGCGGCTCC ATATGACCAT CTTCTCCCAG AGCGTCTCAC CATGTGGGAA GTTTCTGGCG 
GCTGGCAACA ATTACGGGCA GATTGCCATC TTCAGCTTGT CCTCTGCTTT GAGCTCAGAA 
GCCAAAGAGG AAAGTAAGAA GCCGGTGGTG ACTTTCCAAG CCCATGATGG GCCCGTCTAT 
AGCATGGTTT CCACCGATCG ACATCTGCTT AGTGCTGGGG ATGGGGAGGT GAAGGCCTGG 
CTTTGGGCGG AGATGCTCAA GAAGGGCTGT AAGGAGCTGT GGCGTCGTCA GCCTCCATAC 
AGGACCAGCC TGGAAGTGCC TGAGATCAAC GCTTTGCTGC TGGTCCCCAA GGAGAATTCC 
CTCATCCTGG CTGGGGGAGA CTGTCAGTTG CACACTATGG ACCTTGAAAC TGGGACTTTC 
ACGAGGGTCC TCCGGGGCCA CACAGACTAC ATCCACTGCC TGGCACTGCG GGAAAGGAGC 
CCAGAGGTGC TGTCAGGTGG CGAGGATGGA GCTGTTCGAC TTTGGGACCT GCGCACAGCC 
AAGGAGGTCC AGACGATCGA GGTCTATAAG CACGAGGAGT GCTCGAGGCC CCACAATGGG 
CGCTGGATTG GATGTTTGGC AACTGATTCC GACTGGATGG TCTGTGGAGG GGGCCCAGCC 
CTCACCCTCT GGCACCTCCG ATCCTCCACA CCCACCACCA TCTTCCCCAT CCGGGCGCCA 
CAGAAGCACG TCACCTTCTA CCAGGACCTG GTCCTGACAG CTGCAGGCAA CAGCTGCCGG 
GTGGATGTCT TCACCAACCT GGGTTACCGA GCCTTCTCCC TGTCCTTCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Autosomal recessive mutations in THOC6 cause intellectual disability: syndrome delineation requiring forward and reverse phenotyping.
Clinical genetics91(1)92-99(2017 Jan)
Amos JS,Huang L,Thevenon J,Kariminedjad A,Beaulieu CL,Masurel-Paulet A,Najmabadi H,Fattahi Z,Beheshtian M,Tonekaboni SH,Tang S,Helbig KL,Alcaraz W,Rivi?re JB,Faivre L,Innes AM,Lebel RR,Boycott KM,

Confirming the candidacy of THOC6 in the etiology of intellectual disability.
American journal of medical genetics. Part A170A(5)1367-9(2016 May)
Anazi S,Alshammari M,Moneis D,Abouelhoda M,Ibrahim N,Alkuraya FS

Intellectual disability associated with a homozygous missense mutation in THOC6.
Orphanet journal of rare diseases862(2013 Apr)
Beaulieu CL,Huang L,Innes AM,Akimenko MA,Puffenberger EG,Schwartz C,Jerry P,Ober C,Hegele RA,McLeod DR,Schwartzentruber J,,Majewski J,Bulman DE,Parboosingh JS,Boycott KM

A quantitative telomeric chromatin isolation protocol identifies different telomeric states.
Nature communications42848(2013)
Grolimund L,Aeby E,Hamelin R,Armand F,Chiappe D,Moniatte M,Lingner J

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

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THOC6 cDNA ORF clone, Homo sapiens(human)

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