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CAT cDNA ORF clone, Homo sapiens (human)

Gene Symbol CAT
Entrez Gene ID 847
Full Name catalase
General protein information
Preferred Names
catalase
Names
catalase
NP_001743.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p13

Summary This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene. [provided by RefSeq, Oct 2009]. lac of sum
Disorder MIM:

115500

Disorder Html: Acatalasemia (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001752 NP_001743 catalase



Homo sapiens (human) CAT NP_001743.1
Pan troglodytes (chimpanzee) CAT XP_001147928.1
Macaca mulatta (Rhesus monkey) CAT XP_001115625.1
Canis lupus familiaris (dog) CAT NP_001002984.1
Bos taurus (cattle) CAT NP_001030463.1
Mus musculus (house mouse) Cat NP_033934.2
Rattus norvegicus (Norway rat) Cat NP_036652.1
Gallus gallus (chicken) CAT NP_001026386.1
Danio rerio (zebrafish) cat NP_570987.1
Drosophila melanogaster (fruit fly) Cat NP_536731.1
Drosophila melanogaster (fruit fly) CG9314 NP_001260268.1
Caenorhabditis elegans ctl-3 NP_741058.1
Caenorhabditis elegans ctl-2 NP_001022473.1
Caenorhabditis elegans ctl-1 NP_496979.2
Arabidopsis thaliana (thale cress) CAT2 NP_195235.1
Arabidopsis thaliana (thale cress) CAT1 NP_564121.1
Xenopus (Silurana) tropicalis (western clawed frog) cat.1 NP_001016716.1
Xenopus (Silurana) tropicalis (western clawed frog) cat.2 NP_001072167.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CAT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CAT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu20403
NM_001752 Homo sapiens catalase (CAT), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$219.50-$307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20403
Clone ID Related Accession (Same CDS sequence) NM_001752
Accession Version NM_001752.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1584bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product catalase
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291585.1, AL035079.14 and AW023382.1. This sequence is a reference standard in the RefSeqGene project. On Oct 3, 2009 this sequence version replaced gi:60302919. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291585.1, X04076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCTGACA GCCGGGATCC CGCCAGCGAC CAGATGCAGC ACTGGAAGGA GCAGCGGGCC 
GCGCAGAAAG CTGATGTCCT GACCACTGGA GCTGGTAACC CAGTAGGAGA CAAACTTAAT
GTTATTACAG TAGGGCCCCG TGGGCCCCTT CTTGTTCAGG ATGTGGTTTT CACTGATGAA
ATGGCTCATT TTGACCGAGA GAGAATTCCT GAGAGAGTTG TGCATGCTAA AGGAGCAGGG
GCCTTTGGCT ACTTTGAGGT CACACATGAC ATTACCAAAT ACTCCAAGGC AAAGGTATTT
GAGCATATTG GAAAGAAGAC TCCCATCGCA GTTCGGTTCT CCACTGTTGC TGGAGAATCG
GGTTCAGCTG ACACAGTTCG GGACCCTCGT GGGTTTGCAG TGAAATTTTA CACAGAAGAT
GGTAACTGGG ATCTCGTTGG AAATAACACC CCCATTTTCT TCATCAGGGA TCCCATATTG
TTTCCATCTT TTATCCACAG CCAAAAGAGA AATCCTCAGA CACATCTGAA GGATCCGGAC
ATGGTCTGGG ACTTCTGGAG CCTACGTCCT GAGTCTCTGC ATCAGGTTTC TTTCTTGTTC
AGTGATCGGG GGATTCCAGA TGGACATCGC CACATGAATG GATATGGATC ACATACTTTC
AAGCTGGTTA ATGCAAATGG GGAGGCAGTT TATTGCAAAT TCCATTATAA GACTGACCAG
GGCATCAAAA ACCTTTCTGT TGAAGATGCG GCGAGACTTT CCCAGGAAGA TCCTGACTAT
GGCATCCGGG ATCTTTTTAA CGCCATTGCC ACAGGAAAGT ACCCCTCCTG GACTTTTTAC
ATCCAGGTCA TGACATTTAA TCAGGCAGAA ACTTTTCCAT TTAATCCATT CGATCTCACC
AAGGTTTGGC CTCACAAGGA CTACCCTCTC ATCCCAGTTG GTAAACTGGT CTTAAACCGG
AATCCAGTTA ATTACTTTGC TGAGGTTGAA CAGATAGCCT TCGACCCAAG CAACATGCCA
CCTGGCATTG AGGCCAGTCC TGACAAAATG CTTCAGGGCC GCCTTTTTGC CTATCCTGAC
ACTCACCGCC ATCGCCTGGG ACCCAATTAT CTTCATATAC CTGTGAACTG TCCCTACCGT
GCTCGAGTGG CCAACTACCA GCGTGACGGC CCGATGTGCA TGCAGGACAA TCAGGGTGGT
GCTCCAAATT ACTACCCCAA CAGCTTTGGT GCTCCGGAAC AACAGCCTTC TGCCCTGGAG
CACAGCATCC AATATTCTGG AGAAGTGCGG AGATTCAACA CTGCCAATGA TGATAACGTT
ACTCAGGTGC GGGCATTCTA TGTGAACGTG CTGAATGAGG AACAGAGGAA ACGTCTGTGT
GAGAACATTG CCGGCCACCT GAAGGATGCA CAAATTTTCA TCCAGAAGAA AGCGGTCAAG
AACTTCACTG AGGTCCACCC TGACTACGGG AGCCACATCC AGGCTCTTCT GGACAAGTAC
AATGCTGAGA AGCCTAAGAA TGCGATTCAC ACCTTTGTGC AGTCCGGATC TCACTTGGCG
GCAAGGGAGA AGGCAAATCT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001743.1
CDS90..1673
Misc Feature(1)165..1559(+)
Misc Feature(2)291..1580(+)
Misc Feature(3)291..1520(+)
Misc Feature(4)312..1163(+)
Misc Feature(5)540..1427(+)
Misc Feature(6)780..782(+)
Misc Feature(7)1011..1013(+)
Misc Feature(8)1245..1247(+)
Exon (1)1..155
Gene:CAT
Gene Synonym:
Exon (2)156..327
Gene:CAT
Gene Synonym:
Exon (3)328..438
Gene:CAT
Gene Synonym:
Exon (4)439..569
Gene:CAT
Gene Synonym:
Exon (5)570..674
Gene:CAT
Gene Synonym:
Exon (6)675..800
Gene:CAT
Gene Synonym:
Exon (7)801..992
Gene:CAT
Gene Synonym:
Exon (8)993..1145
Gene:CAT
Gene Synonym:
Exon (9)1146..1284
Gene:CAT
Gene Synonym:
Exon (10)1285..1415
Gene:CAT
Gene Synonym:
Exon (11)1416..1523
Gene:CAT
Gene Synonym:
Exon (12)1524..1607
Gene:CAT
Gene Synonym:
Exon (13)1608..2300
Gene:CAT
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001752
Organism Homo sapiens (human)
Definition Homo sapiens catalase (CAT), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001752

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCTGACA GCCGGGATCC CGCCAGCGAC CAGATGCAGC ACTGGAAGGA GCAGCGGGCC 
GCGCAGAAAG CTGATGTCCT GACCACTGGA GCTGGTAACC CAGTAGGAGA CAAACTTAAT
GTTATTACAG TAGGGCCCCG TGGGCCCCTT CTTGTTCAGG ATGTGGTTTT CACTGATGAA
ATGGCTCATT TTGACCGAGA GAGAATTCCT GAGAGAGTTG TGCATGCTAA AGGAGCAGGG
GCCTTTGGCT ACTTTGAGGT CACACATGAC ATTACCAAAT ACTCCAAGGC AAAGGTATTT
GAGCATATTG GAAAGAAGAC TCCCATCGCA GTTCGGTTCT CCACTGTTGC TGGAGAATCG
GGTTCAGCTG ACACAGTTCG GGACCCTCGT GGGTTTGCAG TGAAATTTTA CACAGAAGAT
GGTAACTGGG ATCTCGTTGG AAATAACACC CCCATTTTCT TCATCAGGGA TCCCATATTG
TTTCCATCTT TTATCCACAG CCAAAAGAGA AATCCTCAGA CACATCTGAA GGATCCGGAC
ATGGTCTGGG ACTTCTGGAG CCTACGTCCT GAGTCTCTGC ATCAGGTTTC TTTCTTGTTC
AGTGATCGGG GGATTCCAGA TGGACATCGC CACATGAATG GATATGGATC ACATACTTTC
AAGCTGGTTA ATGCAAATGG GGAGGCAGTT TATTGCAAAT TCCATTATAA GACTGACCAG
GGCATCAAAA ACCTTTCTGT TGAAGATGCG GCGAGACTTT CCCAGGAAGA TCCTGACTAT
GGCATCCGGG ATCTTTTTAA CGCCATTGCC ACAGGAAAGT ACCCCTCCTG GACTTTTTAC
ATCCAGGTCA TGACATTTAA TCAGGCAGAA ACTTTTCCAT TTAATCCATT CGATCTCACC
AAGGTTTGGC CTCACAAGGA CTACCCTCTC ATCCCAGTTG GTAAACTGGT CTTAAACCGG
AATCCAGTTA ATTACTTTGC TGAGGTTGAA CAGATAGCCT TCGACCCAAG CAACATGCCA
CCTGGCATTG AGGCCAGTCC TGACAAAATG CTTCAGGGCC GCCTTTTTGC CTATCCTGAC
ACTCACCGCC ATCGCCTGGG ACCCAATTAT CTTCATATAC CTGTGAACTG TCCCTACCGT
GCTCGAGTGG CCAACTACCA GCGTGACGGC CCGATGTGCA TGCAGGACAA TCAGGGTGGT
GCTCCAAATT ACTACCCCAA CAGCTTTGGT GCTCCGGAAC AACAGCCTTC TGCCCTGGAG
CACAGCATCC AATATTCTGG AGAAGTGCGG AGATTCAACA CTGCCAATGA TGATAACGTT
ACTCAGGTGC GGGCATTCTA TGTGAACGTG CTGAATGAGG AACAGAGGAA ACGTCTGTGT
GAGAACATTG CCGGCCACCT GAAGGATGCA CAAATTTTCA TCCAGAAGAA AGCGGTCAAG
AACTTCACTG AGGTCCACCC TGACTACGGG AGCCACATCC AGGCTCTTCT GGACAAGTAC
AATGCTGAGA AGCCTAAGAA TGCGATTCAC ACCTTTGTGC AGTCCGGATC TCACTTGGCG
GCAAGGGAGA AGGCAAATCT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Loss of plasma membrane integrity, complement response and formation of reactive oxygen species during early myocardial ischemia/reperfusion
Mol. Immunol. 56 (4), 507-512 (2013)
Charlagorla P, Liu J, Patel M, Rushbrook JI and Zhang M.


book

Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells
Int. J. Oncol. 43 (3), 936-946 (2013)
Yang YX, Li XL, Wang L, Han SY, Zhang YR, Pratheeshkumar P, Wang X, Lu J, Yin YQ, Sun LJ, Budhraja A, Hitron AJ and Ding SZ.


book

Manganese superoxide dismutase Ile58Thr, catalase C-262T and myeloperoxidase G-463A gene polymorphisms in patients with prostate cancer: relation to advanced and metastatic disease
BJU Int. 112 (4), E406-E414 (2013)
Tefik T, Kucukgergin C, Sanli O, Oktar T, Seckin S and Ozsoy C.


book

Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix
Cancer Res. 73 (12), 3704-3715 (2013)
Davison CA, Durbin SM, Thau MR, Zellmer VR, Chapman SE, Diener J, Wathen C, Leevy WM and Schafer ZT.


book

A catalase promoter variant rs1001179 is associated with visual acuity but not with primary angle closure glaucoma in Saudi patients
BMC Med. Genet. 14, 84 (2013)
Abu-Amero KK, Azad TA, Mousa A, Osman EA, Sultan T and Al-Obeidan SA.


book

Detection of a common mutation of the catalase gene in Japanese acatalasemic patients
Hum. Genet. 88 (5), 487-490 (1992)
Kishimoto Y, Murakami Y, Hayashi K, Takahara S, Sugimura T and Sekiya T.


book

Molecular analysis of an acatalasemic mouse mutant
Biochem. Biophys. Res. Commun. 173 (3), 1043-1050 (1990)
Shaffer JB and Preston KE.


book

Molecular analysis of human acatalasemia. Identification of a splicing mutation
J. Mol. Biol. 211 (2), 383-393 (1990)
Wen JK, Osumi T, Hashimoto T and Ogata M.


book

Isolation and characterization of the human catalase gene
Nucleic Acids Res. 14 (13), 5321-5335 (1986)
Quan,F., Korneluk,R.G., Tropak,M.B. and Gravel,R.A.


book

Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin, and insulin-like growth factor II
Proc. Natl. Acad. Sci. U.S.A. 82 (15), 5064-5067 (1985)
Kittur,S.D., Hoppener,J.W., Antonarakis,S.E., Daniels,J.D., Meyers,D.A., Maestri,N.E., Jansen,M., Korneluk,R.G., Nelkin,B.D. and Kazazian,H.H. Jr.


 
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