Gene Symbol | PAQR8 |
Entrez Gene ID | 85315 |
Full Name | progestin and adipoQ receptor family member 8 |
Synonyms | C6orf33,LMPB1,MPRB |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » PAQR8 cDNA ORF clone
gRNAs
Gene Symbol | PAQR8 |
Entrez Gene ID | 85315 |
Full Name | progestin and adipoQ receptor family member 8 |
Synonyms | C6orf33,LMPB1,MPRB |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_133367.4 | NP_588608.1 | membrane progestin receptor beta |
NM_133367.5 | NP_588608.1 | membrane progestin receptor beta |
Canis lupus familiaris (dog) | PAQR8 | XP_005627525.1 |
Danio rerio (zebrafish) | LOC100537946 | XP_005158530.1 |
Rattus norvegicus (Norway rat) | Paqr8 | NP_001014121.1 |
Homo sapiens (human) | PAQR8 | NP_588608.1 |
Pan troglodytes (chimpanzee) | PAQR8 | XP_001151884.1 |
Bos taurus (cattle) | PAQR8 | NP_001094605.1 |
Mus musculus (house mouse) | Paqr8 | NP_083105.3 |
Gallus gallus (chicken) | PAQR8 | NP_001008462.1 |
Xenopus tropicalis (tropical clawed frog) | paqr8 | NP_001072419.1 |
PAQR8 | XP_001107033.1 | |
Danio rerio (zebrafish) | paqr8 | NP_899187.1 |
Caenorhabditis elegans (roundworm) | K11C4.2 | NP_504750.2 |
Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.
Charles NJ, Thomas P, Lange CA
Hormones & cancer1(4)167-76(2010 Aug)
Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
Smith JL, Kupchak BR, Garitaonandia I, Hoang LK, Maina AS, Regalla LM, Lyons TJ
Steroids73(11)1160-73(2008 Oct)
PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.
Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD
Journal of molecular evolution61(3)372-80(2005 Sep)
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature425(6960)805-11(2003 Oct)
The further redefining of steroid-mediated signaling.
Hammes SR
Proceedings of the National Academy of Sciences of the United States of America100(5)2168-70(2003 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRalpha protein expression in a panel of commonly used ovarian cancer cell lines.
Title: Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.
Heterologous expression of MPRB in yeast confirms its ability to function as a membrane progesterone receptor.
Title: Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
LMPB1 is indeed an integral membrane protein that targets to lysosomal structures.
Title: A novel gene in the chromosomal region for juvenile myoclonic epilepsy on 6p12 encodes a brain-specific lysosomal membrane protein.
The following PAQR8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAQR8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu08896![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_133367.4 , NM_133367.5 | |
Accession Version | NM_133367.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | membrane progestin receptor beta | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN283490.1, BC030664.2, AF347029.1, AK128085.1, CN395844.1, AI655504.1, AI656485.1 and CD672455.1. On Nov 22, 2018 this sequence version replaced NM_133367.4. Sequence Note: An in-frame AUG is located 5 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.265430.1, SRR1660803.195772.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved MANE Ensembl match :: ENST00000442253.3/ ENSP00000406197.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGACGACCG CCATCTTGGA GCGCCTGAGC ACCCTGTCGG TCAGCGGGCA GCAGCTGCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_588608.1 |
CDS | 152..1216 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGACCG CCATCTTGGA GCGCCTGAGC ACCCTGTCGG TCAGCGGGCA GCAGCTGCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu08896 | |
Clone ID Related Accession (Same CDS sequence) | NM_133367.4 , NM_133367.5 | |
Accession Version | NM_133367.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | membrane progestin receptor beta | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN283490.1, BC030664.2, AF347029.1, AK128085.1, CN395844.1, AI655504.1, AI656485.1 and CD672455.1. On Jan 11, 2008 this sequence version replaced NM_133367.3. Sequence Note: An in-frame AUG is located 5 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. ##Evidence-Data-START## Transcript exon combination :: AF347029.1, SRR1660807.79332.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACGACCG CCATCTTGGA GCGCCTGAGC ACCCTGTCGG TCAGCGGGCA GCAGCTGCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_588608.1 |
CDS | 175..1239 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACGACCG CCATCTTGGA GCGCCTGAGC ACCCTGTCGG TCAGCGGGCA GCAGCTGCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. |
Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors. |
PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. |
The DNA sequence and analysis of human chromosome 6. |
The further redefining of steroid-mediated signaling. |