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TCAP cDNA ORF clone, Homo sapiens (human)

Gene Symbol TCAP
Entrez Gene ID 8557
Full Name titin-cap
Synonyms CMD1N, CMH25, LGMD2G, T-cap, TELE, telethonin
General protein information
Preferred Names
telethonin
Names
telethonin
titin cap protein
19 kDa sarcomeric protein
limb girdle muscular dystrophy 2G (autosomal recessive)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q12

Summary Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604488

Disorder Html: Muscular dystrophy, limb-girdle, type 2G, 601954 (3);

mRNA and Protein(s)

mRNA Protein Name
NM_003673 NP_003664 telethonin



Homo sapiens (human) TCAP NP_003664.1
Pan troglodytes (chimpanzee) TCAP XP_511458.3
Macaca mulatta (Rhesus monkey) TCAP XP_001089621.1
Canis lupus familiaris (dog) TCAP NP_001128597.1
Bos taurus (cattle) TCAP NP_001014915.1
Mus musculus (house mouse) Tcap NP_035670.2
Danio rerio (zebrafish) tcap XP_684103.1
Xenopus (Silurana) tropicalis (western clawed frog) tcap XP_002940414.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TCAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TCAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18837
NM_003673 Homo sapiens titin-cap (TCAP), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18837
Clone ID Related Accession (Same CDS sequence) NM_003673
Accession Version NM_003673.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 504bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product telethonin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA899335.1 and AJ000491.1. This sequence is a reference standard in the RefSeqGene project. On Oct 21, 2008 this sequence version replaced gi:19924299. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ000491.1, BC012628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_003664.1
CDS15..518
Misc Feature(1)3..5(+)
Misc Feature(2)15..515(+)
Misc Feature(3)483..485(+)
Misc Feature(4)483..485(+)
Exon (1)1..124
Gene:TCAP
Gene Synonym:
Exon (2)125..963
Gene:TCAP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_003673
Organism Homo sapiens (human)
Definition Homo sapiens titin-cap (TCAP), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_003673

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCTACCT CAGAGCTGAG CTGCGAGGTG TCGGAGGAGA ACTGTGAGCG CCGGGAGGCC 
TTCTGGGCAG AATGGAAGGA TCTGACACTG TCCACACGGC CCGAGGAGGG CTGCTCCCTG
CATGAGGAGG ACACCCAGAG ACATGAGACC TACCACCAGC AGGGGCAGTG CCAGGTGCTG
GTGCAGCGCT CGCCCTGGCT GATGATGCGG ATGGGCATCC TCGGCCGTGG GCTGCAGGAG
TACCAGCTGC CCTACCAGCG GGTACTGCCG CTGCCCATCT TCACCCCTGC CAAGATGGGC
GCCACCAAGG AGGAGCGTGA GGACACCCCC ATCCAGCTTC AGGAGCTGCT GGCGCTGGAG
ACAGCCCTGG GTGGCCAGTG TGTGGACCGC CAGGAGGTGG CTGAGATCAC AAAGCAGCTG
CCCCCTGTGG TGCCTGTCAG CAAGCCCGGT GCACTTCGTC GCTCCCTGTC CCGCTCCATG
TCCCAGGAAG CACAGAGAGG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes
J. Biol. Chem. 289 (3), 1282-1293 (2014)
Candasamy AJ, Haworth RS, Cuello F, Ibrahim M, Aravamudhan S, Kruger M, Holt MR, Terracciano CM, Mayr M, Gautel M and Avkiran M.


book

A study of FHL1, BAG3, MATR3, PTRF and TCAP in Australian muscular dystrophy patients
Neuromuscul. Disord. 21 (11), 776-781 (2011)
Waddell LB, Tran J, Zheng XF, Bonnemann CG, Hu Y, Evesson FJ, Lek M, Arbuckle S, Wang MX, Smith RL, North KN and Clarke NF.


book

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Pharmacogenomics 11 (7), 959-971 (2010)
Ruano G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR and Wu AH.


book

A novel custom resequencing array for dilated cardiomyopathy
Genet. Med. 12 (5), 268-278 (2010)
Zimmerman RS, Cox S, Lakdawala NK, Cirino A, Mancini-DiNardo D, Clark E, Leon A, Duffy E, White E, Baxter S, Alaamery M, Farwell L, Weiss S, Seidman CE, Seidman JG, Ho CY, Rehm HL and Funke BH.


book

Structural basis for activation of the titin kinase domain during myofibrillogenesis
Nature 395 (6705), 863-869 (1998)
Mayans O, van der Ven PF, Wilm M, Mues A, Young P, Furst DO, Wilmanns M and Gautel M.


book

Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin
FEBS Lett. 428 (1-2), 111-114 (1998)
Mues A, van der Ven PF, Young P, Furst DO and Gautel M.


book

Telethonin, a novel sarcomeric protein of heart and skeletal muscle
FEBS Lett. 415 (2), 163-168 (1997)
Valle G, Faulkner G, De Antoni A, Pacchioni B, Pallavicini A, Pandolfo D, Tiso N, Toppo S, Trevisan S and Lanfranchi G.


book

The seventh form of autosomal recessive limb-girdle muscular dystrophy is mapped to 17q11-12
Am. J. Hum. Genet. 61 (1), 151-159 (1997)
Moreira ES, Vainzof M, Marie SK, Sertie AL, Zatz M and Passos-Bueno MR.


book

Hypertrophic Cardiomyopathy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Cirino,A.L. and Ho,C.


book

Dilated Cardiomyopathy Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Hershberger,R.E. and Morales,A.


 
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