Ttbk1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ttbk1
Entrez Gene ID	106763
Full Name	tau tubulin kinase 1
Synonyms	AU017937,AW048023,C330008L01Rik
General protein information	Preferred Names tau tubulin kinase 1 Names tau-tubulin kinase 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 C

mRNA and Protein(s)

mRNA	Protein	Name
XM_006523445.2	XP_006523508.1	tau-tubulin kinase 1 isoform X1
XM_006523445.3	XP_006523508.1	tau-tubulin kinase 1 isoform X1
NM_001162864.1	NP_001156336.1	tau-tubulin kinase 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ttbk1	NP_001156336.1
Pan troglodytes (chimpanzee)	TTBK1	XP_003311367.1
Gallus gallus (chicken)	TTBK1	NP_001186368.1
Homo sapiens (human)	TTBK1	NP_115927.1
	TTBK1	XP_001088342.2
Rattus norvegicus (Norway rat)	Ttbk1	NP_001258159.1
Canis lupus familiaris (dog)	TTBK1	XP_005627821.1
Danio rerio (zebrafish)	LOC100332125	XP_002663847.3

Gene Ontology
Bibliography

Related articles in PubMed

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T
The American journal of pathology184(3)808-18(2014 Mar)

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.
Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(8)2904-15(2010 Aug)

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.
Sato S, Cerny RL, Buescher JL, Ikezu T
Journal of neurochemistry98(5)1573-84(2006 Sep)

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Okazaki N, F-Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TTBK1 accelerates motor neuron neurodegeneration by recruiting proinflammatory monocytes and enhancing sensitivity to neurotoxicity in inflammatory conditions.
Title: Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.

TTBK1 up-regulation enhances tau phosphorylation and oligomerization, whose toxicity results in enhanced neurodegeneration and locomotor dysfunction in a tauopathy animal model.
Title: Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.

The following Ttbk1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ttbk1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu52987	XM_006523445.3 Latest version!	Mus musculus tau tubulin kinase 1 (Ttbk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
OMu08496	NM_001162864.1 Latest version!	Mus musculus tau tubulin kinase 1 (Ttbk1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$769.30 $1099.00
View Old Accession Versions >>
OMu52987	XM_006523445.2	Mus musculus tau tubulin kinase 1 (Ttbk1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ttbk1 ( XM_006523445.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006523508.1 Mus musculus tau tubulin kinase 1 (Ttbk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu52987
Clone ID Related Accession (Same CDS sequence)	XM_006523445.2 , XM_006523445.3
Accession Version	XM_006523445.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2298bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	tau-tubulin kinase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006523445.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGTGCC TAGCGGCAGC TCTTAAGGAC GAAACCAACA TGAGTGGGGG AGGGGAGCAG 
GCCGACATCC TGCCGGCCAA CTACGTGGTC AAAGATCGCT GGAAGGTGCT GAAAAAGATC 
GGGGGCGGGG GCTTCGGTGA GATCTATGAG GCCATGGACC TGCTGACCAG GGAGAACGTG 
GCTCTCAAGG TGGAGTCAGC CCAACAGCCT AAGCAGGTCC TCAAGATGGA GGTGGCTGTG 
CTCAAAAAGC TTCAAGGCAA GGACCACGTG TGCAGGTTCA TTGGCTGTGG CCGTAACGAG 
AAGTTTAACT ATGTGGTGAT GCAGCTCCAG GGCCGGAACC TGGCTGACCT GCGCCGCAGC 
CAGCCAAGGG GCACTTTCAC GTTGAGTACC ACACTGCGCC TGGGCAAGCA GATCCTGGAG 
TCCATTGAAG CCATTCACTC CGTGGGCTTC CTGCACCGTG ACATCAAGCC GTCCAACTTT 
GCCATGGGCC GGCTGCCCTC GACCTACAGG AAGTGCTACA TGTTGGACTT TGGGCTAGCC 
AGGCAGTACA CTAACACCAC TGGGGACGTC CGGCCTCCTC GGAATGTGGC CGGGTTCCGG 
GGGACTGTCC GCTACGCCTC GGTCAATGCT CACAAGAACC GGGAGATGGG CCGCCATGAT 
GACCTGTGGT CCCTCTTCTA CATGCTGGTG GAGTTTGCTG TGGGCCAGCT GCCCTGGAGG 
AAGATCAAAG ACAAGGAGCA GGTGGGGATG ATCAAAGAGA AATACGAGCA CCGGATGCTA 
CTGAAGCACA TGCCATCCGA GTTTCATCTC TTCCTGGACC ACATTGCCAG CCTCGACTAC 
TTCACCAAGC CCGATTACCA GTTGATCATG TCAGTGTTTG AGAACAGCAT GAAGGAGCGG 
GGCATTGCCG AGAACGAGGC CTTTGACTGG GAGAAGGCAG GCACTGATGC CCTCCTGTCC 
ACGAGCACCT CCACCCCACC CCAGCAGAAC ACGCGACAGA CCGCAGCCAT GTTTGGAGTG 
GTCAATGTGA CACCGGTGCC TGGGGACCTG CTTCGTGAGA ACACTGAGGA CGTACTGCAG 
GGAGAGCACC TGAGTGACCA GGAGAACGCA CCCCCAATCC TGCCCGGGAG GCCTCCAGAG 
GGCTTGGGCC CTGGTCCCCA TCTTGTTCCC CACCCTGGGG GTCCTGAGGC TGAAGTGTGG 
GAGGAGACAG ATGTCAACCG CAACAAACTG CGCATCAACA TTGGCAAAAC CCCCTGTGTG 
GAGGAAGAGC AGAGTCGAGG AGTAGGGGTC CCCAGTTCCC CAGTGCGTGC CCCCCCAGAC 
TCCCCAACAA CCCCAGTGCG GTCTCTATGC TACCGGAGGG TCAACAGCCC AGAGTCGGAG 
AGGCTGTCTA CAGCTGCTGA TGGTCGGGTA GAGCTGCAGG AGAGGAGGTC ACGGATGGAT 
CTGCCTGGCT CCCCCTCCCG CCAGGCCTGC TCCTCACAAC CAGCTCAGAT GCTGTCAGTG 
GACACGGGCC ATGCTGACAG GCAGGCCAGT GGCCGCATGG ACGTCTCTGC CTCTGTGGAG 
CAGGAGGCCC TGAGCAACGC CTTCCGCTCA GTGCCACTGG CTGAGGAGGA AGACTTTGAC 
AGCAAGGAGT GGGTCATTAT TGACAAGGAG ACGGAGCTCA AGGACTTCCC TCCCGGGGCT 
GAGCCTAGCA CATCAGGCAC CACTGATGAA GAGCCCGAGG AGCTGCGGCC CCTGCCCGAG 
GAGGGCGAGG AAAGGAGGCG ACTGGGGACA GAGCCCACTG TCAGGCCGCG TGGACGTGGT 
ATGCACACGC TGACAGAGGA GGACCCACGG CAGATGCTGC CCCAGCCTGC ACCACCTCAG 
TTGAGCCAGG CTGATGGCCG GTCAGAGACA TCACAGCCAC CCACGCCTGG CAGCCCTTCC 
CACTCTCCCT TGCACTCGGG ACCCCGACCT CGACGGAGAG AGTCAGATCC CACGGGCCCT 
CAGAGACAGT TGGAGGAGGA CAGACTCTCG GGGCACTCCC TCCCGCGGTA CAGCCCCCTG 
CGACGACTGG CTTCCTCCGT GTTCTCCTCC TCCACGCTGG AGACGGAGCA CTACCCTCAC 
CCCGGCGGCG GCGGCTCCTC GGGCTCCTCC GGTTCCCTCA TTCAGCGCAG CCGCTCCGCT 
GAGAGCAGCC CGGTGCGTGC GCCCCATCGG CGCCACGCGC CCCTGGCAGC CGGCAACCAC 
AGACTCGTGC CCTCGGTGCT CCGCATCTCG CGGTCCCAGC TGCAGCAGGT GTGGGCACGG 
TTCACCCACA AGACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006523508.1
CDS	300..2597
Translation	MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPPILPGRPPEGLGPGPHLVPHPGGPEAEVWEETDVNRNKLRINIGKTPCVEEEQSRGVGVPSSPVRAPPDSPTTPVRSLCYRRVNSPESERLSTAADGRVELQERRSRMDLPGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGTEPTVRPRGRGMHTLTEEDPRQMLPQPAPPQLSQADGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQLEEDRLSGHSLPRYSPLRRLASSVFSSSTLETEHYPHPGGGGSSGSSGSLIQRSRSAESSPVRAPHRRHAPLAAGNHRLVPSVLRISRSQLQQVWARFTHKT

Target ORF information:

RefSeq Version	XM_006523445.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus tau tubulin kinase 1 (Ttbk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006523445.2

ORF Insert Sequence:

ATGCAGTGCC TAGCGGCAGC TCTTAAGGAC GAAACCAACA TGAGTGGGGG AGGGGAGCAG 
GCCGACATCC TGCCGGCCAA CTACGTGGTC AAAGATCGCT GGAAGGTGCT GAAAAAGATC 
GGGGGCGGGG GCTTCGGTGA GATCTATGAG GCCATGGACC TGCTGACCAG GGAGAACGTG 
GCTCTCAAGG TGGAGTCAGC CCAACAGCCT AAGCAGGTCC TCAAGATGGA GGTGGCTGTG 
CTCAAAAAGC TTCAAGGCAA GGACCACGTG TGCAGGTTCA TTGGCTGTGG CCGTAACGAG 
AAGTTTAACT ATGTGGTGAT GCAGCTCCAG GGCCGGAACC TGGCTGACCT GCGCCGCAGC 
CAGCCAAGGG GCACTTTCAC GTTGAGTACC ACACTGCGCC TGGGCAAGCA GATCCTGGAG 
TCCATTGAAG CCATTCACTC CGTGGGCTTC CTGCACCGTG ACATCAAGCC GTCCAACTTT 
GCCATGGGCC GGCTGCCCTC GACCTACAGG AAGTGCTACA TGTTGGACTT TGGGCTAGCC 
AGGCAGTACA CTAACACCAC TGGGGACGTC CGGCCTCCTC GGAATGTGGC CGGGTTCCGG 
GGGACTGTCC GCTACGCCTC GGTCAATGCT CACAAGAACC GGGAGATGGG CCGCCATGAT 
GACCTGTGGT CCCTCTTCTA CATGCTGGTG GAGTTTGCTG TGGGCCAGCT GCCCTGGAGG 
AAGATCAAAG ACAAGGAGCA GGTGGGGATG ATCAAAGAGA AATACGAGCA CCGGATGCTA 
CTGAAGCACA TGCCATCCGA GTTTCATCTC TTCCTGGACC ACATTGCCAG CCTCGACTAC 
TTCACCAAGC CCGATTACCA GTTGATCATG TCAGTGTTTG AGAACAGCAT GAAGGAGCGG 
GGCATTGCCG AGAACGAGGC CTTTGACTGG GAGAAGGCAG GCACTGATGC CCTCCTGTCC 
ACGAGCACCT CCACCCCACC CCAGCAGAAC ACGCGACAGA CCGCAGCCAT GTTTGGAGTG 
GTCAATGTGA CACCGGTGCC TGGGGACCTG CTTCGTGAGA ACACTGAGGA CGTACTGCAG 
GGAGAGCACC TGAGTGACCA GGAGAACGCA CCCCCAATCC TGCCCGGGAG GCCTCCAGAG 
GGCTTGGGCC CTGGTCCCCA TCTTGTTCCC CACCCTGGGG GTCCTGAGGC TGAAGTGTGG 
GAGGAGACAG ATGTCAACCG CAACAAACTG CGCATCAACA TTGGCAAAAC CCCCTGTGTG 
GAGGAAGAGC AGAGTCGAGG AGTAGGGGTC CCCAGTTCCC CAGTGCGTGC CCCCCCAGAC 
TCCCCAACAA CCCCAGTGCG GTCTCTATGC TACCGGAGGG TCAACAGCCC AGAGTCGGAG 
AGGCTGTCTA CAGCTGCTGA TGGTCGGGTA GAGCTGCAGG AGAGGAGGTC ACGGATGGAT 
CTGCCTGGCT CCCCCTCCCG CCAGGCCTGC TCCTCACAAC CAGCTCAGAT GCTGTCAGTG 
GACACGGGCC ATGCTGACAG GCAGGCCAGT GGCCGCATGG ACGTCTCTGC CTCTGTGGAG 
CAGGAGGCCC TGAGCAACGC CTTCCGCTCA GTGCCACTGG CTGAGGAGGA AGACTTTGAC 
AGCAAGGAGT GGGTCATTAT TGACAAGGAG ACGGAGCTCA AGGACTTCCC TCCCGGGGCT 
GAGCCTAGCA CATCAGGCAC CACTGATGAA GAGCCCGAGG AGCTGCGGCC CCTGCCCGAG 
GAGGGCGAGG AAAGGAGGCG ACTGGGGACA GAGCCCACTG TCAGGCCGCG TGGACGTGGT 
ATGCACACGC TGACAGAGGA GGACCCACGG CAGATGCTGC CCCAGCCTGC ACCACCTCAG 
TTGAGCCAGG CTGATGGCCG GTCAGAGACA TCACAGCCAC CCACGCCTGG CAGCCCTTCC 
CACTCTCCCT TGCACTCGGG ACCCCGACCT CGACGGAGAG AGTCAGATCC CACGGGCCCT 
CAGAGACAGT TGGAGGAGGA CAGACTCTCG GGGCACTCCC TCCCGCGGTA CAGCCCCCTG 
CGACGACTGG CTTCCTCCGT GTTCTCCTCC TCCACGCTGG AGACGGAGCA CTACCCTCAC 
CCCGGCGGCG GCGGCTCCTC GGGCTCCTCC GGTTCCCTCA TTCAGCGCAG CCGCTCCGCT 
GAGAGCAGCC CGGTGCGTGC GCCCCATCGG CGCCACGCGC CCCTGGCAGC CGGCAACCAC 
AGACTCGTGC CCTCGGTGCT CCGCATCTCG CGGTCCCAGC TGCAGCAGGT GTGGGCACGG 
TTCACCCACA AGACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ttbk1 ( XM_006523445.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006523508.1 Mus musculus tau tubulin kinase 1 (Ttbk1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu52987
Clone ID Related Accession (Same CDS sequence)	XM_006523445.2 , XM_006523445.3
Accession Version	XM_006523445.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2298bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	tau-tubulin kinase 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006523445.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAGTGCC TAGCGGCAGC TCTTAAGGAC GAAACCAACA TGAGTGGGGG AGGGGAGCAG 
GCCGACATCC TGCCGGCCAA CTACGTGGTC AAAGATCGCT GGAAGGTGCT GAAAAAGATC 
GGGGGCGGGG GCTTCGGTGA GATCTATGAG GCCATGGACC TGCTGACCAG GGAGAACGTG 
GCTCTCAAGG TGGAGTCAGC CCAACAGCCT AAGCAGGTCC TCAAGATGGA GGTGGCTGTG 
CTCAAAAAGC TTCAAGGCAA GGACCACGTG TGCAGGTTCA TTGGCTGTGG CCGTAACGAG 
AAGTTTAACT ATGTGGTGAT GCAGCTCCAG GGCCGGAACC TGGCTGACCT GCGCCGCAGC 
CAGCCAAGGG GCACTTTCAC GTTGAGTACC ACACTGCGCC TGGGCAAGCA GATCCTGGAG 
TCCATTGAAG CCATTCACTC CGTGGGCTTC CTGCACCGTG ACATCAAGCC GTCCAACTTT 
GCCATGGGCC GGCTGCCCTC GACCTACAGG AAGTGCTACA TGTTGGACTT TGGGCTAGCC 
AGGCAGTACA CTAACACCAC TGGGGACGTC CGGCCTCCTC GGAATGTGGC CGGGTTCCGG 
GGGACTGTCC GCTACGCCTC GGTCAATGCT CACAAGAACC GGGAGATGGG CCGCCATGAT 
GACCTGTGGT CCCTCTTCTA CATGCTGGTG GAGTTTGCTG TGGGCCAGCT GCCCTGGAGG 
AAGATCAAAG ACAAGGAGCA GGTGGGGATG ATCAAAGAGA AATACGAGCA CCGGATGCTA 
CTGAAGCACA TGCCATCCGA GTTTCATCTC TTCCTGGACC ACATTGCCAG CCTCGACTAC 
TTCACCAAGC CCGATTACCA GTTGATCATG TCAGTGTTTG AGAACAGCAT GAAGGAGCGG 
GGCATTGCCG AGAACGAGGC CTTTGACTGG GAGAAGGCAG GCACTGATGC CCTCCTGTCC 
ACGAGCACCT CCACCCCACC CCAGCAGAAC ACGCGACAGA CCGCAGCCAT GTTTGGAGTG 
GTCAATGTGA CACCGGTGCC TGGGGACCTG CTTCGTGAGA ACACTGAGGA CGTACTGCAG 
GGAGAGCACC TGAGTGACCA GGAGAACGCA CCCCCAATCC TGCCCGGGAG GCCTCCAGAG 
GGCTTGGGCC CTGGTCCCCA TCTTGTTCCC CACCCTGGGG GTCCTGAGGC TGAAGTGTGG 
GAGGAGACAG ATGTCAACCG CAACAAACTG CGCATCAACA TTGGCAAAAC CCCCTGTGTG 
GAGGAAGAGC AGAGTCGAGG AGTAGGGGTC CCCAGTTCCC CAGTGCGTGC CCCCCCAGAC 
TCCCCAACAA CCCCAGTGCG GTCTCTATGC TACCGGAGGG TCAACAGCCC AGAGTCGGAG 
AGGCTGTCTA CAGCTGCTGA TGGTCGGGTA GAGCTGCAGG AGAGGAGGTC ACGGATGGAT 
CTGCCTGGCT CCCCCTCCCG CCAGGCCTGC TCCTCACAAC CAGCTCAGAT GCTGTCAGTG 
GACACGGGCC ATGCTGACAG GCAGGCCAGT GGCCGCATGG ACGTCTCTGC CTCTGTGGAG 
CAGGAGGCCC TGAGCAACGC CTTCCGCTCA GTGCCACTGG CTGAGGAGGA AGACTTTGAC 
AGCAAGGAGT GGGTCATTAT TGACAAGGAG ACGGAGCTCA AGGACTTCCC TCCCGGGGCT 
GAGCCTAGCA CATCAGGCAC CACTGATGAA GAGCCCGAGG AGCTGCGGCC CCTGCCCGAG 
GAGGGCGAGG AAAGGAGGCG ACTGGGGACA GAGCCCACTG TCAGGCCGCG TGGACGTGGT 
ATGCACACGC TGACAGAGGA GGACCCACGG CAGATGCTGC CCCAGCCTGC ACCACCTCAG 
TTGAGCCAGG CTGATGGCCG GTCAGAGACA TCACAGCCAC CCACGCCTGG CAGCCCTTCC 
CACTCTCCCT TGCACTCGGG ACCCCGACCT CGACGGAGAG AGTCAGATCC CACGGGCCCT 
CAGAGACAGT TGGAGGAGGA CAGACTCTCG GGGCACTCCC TCCCGCGGTA CAGCCCCCTG 
CGACGACTGG CTTCCTCCGT GTTCTCCTCC TCCACGCTGG AGACGGAGCA CTACCCTCAC 
CCCGGCGGCG GCGGCTCCTC GGGCTCCTCC GGTTCCCTCA TTCAGCGCAG CCGCTCCGCT 
GAGAGCAGCC CGGTGCGTGC GCCCCATCGG CGCCACGCGC CCCTGGCAGC CGGCAACCAC 
AGACTCGTGC CCTCGGTGCT CCGCATCTCG CGGTCCCAGC TGCAGCAGGT GTGGGCACGG 
TTCACCCACA AGACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006523508.1
CDS	300..2597
Translation	MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPPILPGRPPEGLGPGPHLVPHPGGPEAEVWEETDVNRNKLRINIGKTPCVEEEQSRGVGVPSSPVRAPPDSPTTPVRSLCYRRVNSPESERLSTAADGRVELQERRSRMDLPGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGTEPTVRPRGRGMHTLTEEDPRQMLPQPAPPQLSQADGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQLEEDRLSGHSLPRYSPLRRLASSVFSSSTLETEHYPHPGGGGSSGSSGSLIQRSRSAESSPVRAPHRRHAPLAAGNHRLVPSVLRISRSQLQQVWARFTHKT

Target ORF information:

RefSeq Version	XM_006523445.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tau tubulin kinase 1 (Ttbk1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006523445.3

ORF Insert Sequence:

ATGCAGTGCC TAGCGGCAGC TCTTAAGGAC GAAACCAACA TGAGTGGGGG AGGGGAGCAG 
GCCGACATCC TGCCGGCCAA CTACGTGGTC AAAGATCGCT GGAAGGTGCT GAAAAAGATC 
GGGGGCGGGG GCTTCGGTGA GATCTATGAG GCCATGGACC TGCTGACCAG GGAGAACGTG 
GCTCTCAAGG TGGAGTCAGC CCAACAGCCT AAGCAGGTCC TCAAGATGGA GGTGGCTGTG 
CTCAAAAAGC TTCAAGGCAA GGACCACGTG TGCAGGTTCA TTGGCTGTGG CCGTAACGAG 
AAGTTTAACT ATGTGGTGAT GCAGCTCCAG GGCCGGAACC TGGCTGACCT GCGCCGCAGC 
CAGCCAAGGG GCACTTTCAC GTTGAGTACC ACACTGCGCC TGGGCAAGCA GATCCTGGAG 
TCCATTGAAG CCATTCACTC CGTGGGCTTC CTGCACCGTG ACATCAAGCC GTCCAACTTT 
GCCATGGGCC GGCTGCCCTC GACCTACAGG AAGTGCTACA TGTTGGACTT TGGGCTAGCC 
AGGCAGTACA CTAACACCAC TGGGGACGTC CGGCCTCCTC GGAATGTGGC CGGGTTCCGG 
GGGACTGTCC GCTACGCCTC GGTCAATGCT CACAAGAACC GGGAGATGGG CCGCCATGAT 
GACCTGTGGT CCCTCTTCTA CATGCTGGTG GAGTTTGCTG TGGGCCAGCT GCCCTGGAGG 
AAGATCAAAG ACAAGGAGCA GGTGGGGATG ATCAAAGAGA AATACGAGCA CCGGATGCTA 
CTGAAGCACA TGCCATCCGA GTTTCATCTC TTCCTGGACC ACATTGCCAG CCTCGACTAC 
TTCACCAAGC CCGATTACCA GTTGATCATG TCAGTGTTTG AGAACAGCAT GAAGGAGCGG 
GGCATTGCCG AGAACGAGGC CTTTGACTGG GAGAAGGCAG GCACTGATGC CCTCCTGTCC 
ACGAGCACCT CCACCCCACC CCAGCAGAAC ACGCGACAGA CCGCAGCCAT GTTTGGAGTG 
GTCAATGTGA CACCGGTGCC TGGGGACCTG CTTCGTGAGA ACACTGAGGA CGTACTGCAG 
GGAGAGCACC TGAGTGACCA GGAGAACGCA CCCCCAATCC TGCCCGGGAG GCCTCCAGAG 
GGCTTGGGCC CTGGTCCCCA TCTTGTTCCC CACCCTGGGG GTCCTGAGGC TGAAGTGTGG 
GAGGAGACAG ATGTCAACCG CAACAAACTG CGCATCAACA TTGGCAAAAC CCCCTGTGTG 
GAGGAAGAGC AGAGTCGAGG AGTAGGGGTC CCCAGTTCCC CAGTGCGTGC CCCCCCAGAC 
TCCCCAACAA CCCCAGTGCG GTCTCTATGC TACCGGAGGG TCAACAGCCC AGAGTCGGAG 
AGGCTGTCTA CAGCTGCTGA TGGTCGGGTA GAGCTGCAGG AGAGGAGGTC ACGGATGGAT 
CTGCCTGGCT CCCCCTCCCG CCAGGCCTGC TCCTCACAAC CAGCTCAGAT GCTGTCAGTG 
GACACGGGCC ATGCTGACAG GCAGGCCAGT GGCCGCATGG ACGTCTCTGC CTCTGTGGAG 
CAGGAGGCCC TGAGCAACGC CTTCCGCTCA GTGCCACTGG CTGAGGAGGA AGACTTTGAC 
AGCAAGGAGT GGGTCATTAT TGACAAGGAG ACGGAGCTCA AGGACTTCCC TCCCGGGGCT 
GAGCCTAGCA CATCAGGCAC CACTGATGAA GAGCCCGAGG AGCTGCGGCC CCTGCCCGAG 
GAGGGCGAGG AAAGGAGGCG ACTGGGGACA GAGCCCACTG TCAGGCCGCG TGGACGTGGT 
ATGCACACGC TGACAGAGGA GGACCCACGG CAGATGCTGC CCCAGCCTGC ACCACCTCAG 
TTGAGCCAGG CTGATGGCCG GTCAGAGACA TCACAGCCAC CCACGCCTGG CAGCCCTTCC 
CACTCTCCCT TGCACTCGGG ACCCCGACCT CGACGGAGAG AGTCAGATCC CACGGGCCCT 
CAGAGACAGT TGGAGGAGGA CAGACTCTCG GGGCACTCCC TCCCGCGGTA CAGCCCCCTG 
CGACGACTGG CTTCCTCCGT GTTCTCCTCC TCCACGCTGG AGACGGAGCA CTACCCTCAC 
CCCGGCGGCG GCGGCTCCTC GGGCTCCTCC GGTTCCCTCA TTCAGCGCAG CCGCTCCGCT 
GAGAGCAGCC CGGTGCGTGC GCCCCATCGG CGCCACGCGC CCCTGGCAGC CGGCAACCAC 
AGACTCGTGC CCTCGGTGCT CCGCATCTCG CGGTCCCAGC TGCAGCAGGT GTGGGCACGG 
TTCACCCACA AGACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Ttbk1 ( NM_001162864.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001156336.1 Mus musculus tau tubulin kinase 1 (Ttbk1), mRNA.

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CloneID	OMu08496
Clone ID Related Accession (Same CDS sequence)	NM_001162864.1
Accession Version	NM_001162864.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3927bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	tau-tubulin kinase 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC151275.3. On or before Jun 28, 2009 this sequence version replaced XM_001476670.1, XM_001480065.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164141 [ECO:0000348] ##Evidence-Data-END##

ATGCAGTGCC TAGCGGCAGC TCTTAAGGAC GAAACCAACA TGAGTGGGGG AGGGGAGCAG 
GCCGACATCC TGCCGGCCAA CTACGTGGTC AAAGATCGCT GGAAGGTGCT GAAAAAGATC 
GGGGGCGGGG GCTTCGGTGA GATCTATGAG GCCATGGACC TGCTGACCAG GGAGAACGTG 
GCTCTCAAGG TGGAGTCAGC CCAACAGCCT AAGCAGGTCC TCAAGATGGA GGTGGCTGTG 
CTCAAAAAGC TTCAAGGCAA GGACCACGTG TGCAGGTTCA TTGGCTGTGG CCGTAACGAG 
AAGTTTAACT ATGTGGTGAT GCAGCTCCAG GGCCGGAACC TGGCTGACCT GCGCCGCAGC 
CAGCCAAGGG GCACTTTCAC GTTGAGTACC ACACTGCGCC TGGGCAAGCA GATCCTGGAG 
TCCATTGAAG CCATTCACTC CGTGGGCTTC CTGCACCGTG ACATCAAGCC GTCCAACTTT 
GCCATGGGCC GGCTGCCCTC GACCTACAGG AAGTGCTACA TGTTGGACTT TGGGCTAGCC 
AGGCAGTACA CTAACACCAC TGGGGACGTC CGGCCTCCTC GGAATGTGGC CGGGTTCCGG 
GGGACTGTCC GCTACGCCTC GGTCAATGCT CACAAGAACC GGGAGATGGG CCGCCATGAT 
GACCTGTGGT CCCTCTTCTA CATGCTGGTG GAGTTTGCTG TGGGCCAGCT GCCCTGGAGG 
AAGATCAAAG ACAAGGAGCA GGTGGGGATG ATCAAAGAGA AATACGAGCA CCGGATGCTA 
CTGAAGCACA TGCCATCCGA GTTTCATCTC TTCCTGGACC ACATTGCCAG CCTCGACTAC 
TTCACCAAGC CCGATTACCA GTTGATCATG TCAGTGTTTG AGAACAGCAT GAAGGAGCGG 
GGCATTGCCG AGAACGAGGC CTTTGACTGG GAGAAGGCAG GCACTGATGC CCTCCTGTCC 
ACGAGCACCT CCACCCCACC CCAGCAGAAC ACGCGACAGA CCGCAGCCAT GTTTGGAGTG 
GTCAATGTGA CACCGGTGCC TGGGGACCTG CTTCGTGAGA ACACTGAGGA CGTACTGCAG 
GGAGAGCACC TGAGTGACCA GGAGAACGCA CCCCCAATCC TGCCCGGGAG GCCTCCAGAG 
GGCTTGGGCC CTGGTCCCCA TCTTGTTCCC CACCCTGGGG GTCCTGAGGC TGAAGTGTGG 
GAGGAGACAG ATGTCAACCG CAACAAACTG CGCATCAACA TTGGCAAAAC CCCCTGTGTG 
GAGGAAGAGC AGAGTCGAGG AGTAGGGGTC CCCAGTTCCC CAGTGCGTGC CCCCCCAGAC 
TCCCCAACAA CCCCAGTGCG GTCTCTATGC TACCGGAGGG TCAACAGCCC AGAGTCGGAG 
AGGCTGTCTA CAGCTGCTGA TGGTCGGGTA GAGCTGCAGG AGAGGAGGTC ACGGATGGAT 
CTGCCTGGCT CCCCCTCCCG CCAGGCCTGC TCCTCACAAC CAGCTCAGAT GCTGTCAGTG 
GACACGGGCC ATGCTGACAG GCAGGCCAGT GGCCGCATGG ACGTCTCTGC CTCTGTGGAG 
CAGGAGGCCC TGAGCAACGC CTTCCGCTCA GTGCCACTGG CTGAGGAGGA AGACTTTGAC 
AGCAAGGAGT GGGTCATTAT TGACAAGGAG ACGGAGCTCA AGGACTTCCC TCCCGGGGCT 
GAGCCTAGCA CATCAGGCAC CACTGATGAA GAGCCCGAGG AGCTGCGGCC CCTGCCCGAG 
GAGGGCGAGG AAAGGAGGCG ACTGGGGACA GAGCCCACTG TCAGGCCGCG TGGACGTGGT 
ATGCACACGC TGACAGAGGA GGACCCACGG CAGATGCTGC CCCAGCCTGC ACCACCTCAG 
TTGAGCCAGG CTGATGGCCG GTCAGAGACA TCACAGCCAC CCACGCCTGG CAGCCCTTCC 
CACTCTCCCT TGCACTCGGG ACCCCGACCT CGACGGAGAG AGTCAGATCC CACGGGCCCT 
CAGAGACAGG TGTTCTCTGT GGCGCCCCCG TTCGAGGTGA ATGGCCTTCC ACGAGCTGTG 
CCTCTAGCCT TGCCCTACCA GGACTTCAAG AGAGACCTCT CTGATTATCG AGAACGGGCC 
CGGCTGCTCA ACAGGGTCCG GAGGGTGGGC TTCTCACACA TGCTACTCAC CGCCCCTCAG 
GTCCCATTGG CTCCCTTTCA GCCTCAGGCC AATGGGAAAG AGGGAGAAGA GGAAGAGGAG 
GAGGAAGAGG AGGAGGAGGA AGAAGAAGAA GAAGAAGAGG AAGAAGAAGA GGAGGAAGAG 
GAGGAAGAGG AAGAGGAGGA GGAGGCAGGG GCCCTTGGGG AGGTGCTGGG GCCTCGAAGT 
GGCTCAAGCA GTGAGGGTAG CGAGCGGAGC ACCGAGCGGA GCCAGGAGGG CGCCCCGTCC 
ACACTGCTGG CTGACGACCA GAAAGAGGCC AGGGGCCGGG CCTCCATGGC TGATGGGGAC 
CTGGAGCCTG AGGAGGGCTC CAAAACGCTG GTGCTCGTCT CCCCTGGTGA CATGAAGAAG 
TCACCAGTCA CTGCCGAACT GGCCCCCGAC CCTGATCTGG GCACCTTGGC TGCGCTCACC 
CCTCAGCACG AGCGGCCTCA GCCCACTGGA AGCCAGCTGG ACGTATCAGA GCCAGGCACC 
TTGTCCTCCA TCCTCAAGTC CGAACCCAAG CCCTCAGGAC CTGGAGCAGG GGGTGGGGTT 
GGGCTGGTGG CCCCTGGGGC TGGGGTCACA GCAGTGACGT CACCATTCAC CAAAGTCGAA 
AGGACTTTTG TTCACATTGC AGAGAAGTCC CACCTCAACG TCATGTCTTC CGGGGGACAG 
GCCTCCAGGC CAGAGGAGTT GAGCACTGGG GGCGAGTTGG GCCTGGAGGT GCTCTCTGAG 
GGGGGCATCG CAGAGGAAGG GGCCCCAGCA CCTCTGGAGA ATGGCATGGC TTTGGCAGGG 
CTGGACGGGA CTGAGATGGA AAGTTGTGCT CTGTCGGGCC CTCCCGGAGA AACGCCCTCA 
GAAGTAGTCA CAGACTCCTT GCCCAATGGG CCAGCCCTTG CTGATGGACC AGCTCCAGCA 
TCCCAACAAG AGCCAGTAAC CAAGAAAGGG ACCACCATCT CCCCCAGTCG CCATGCTATG 
CCAGGATCTC GCCCCAGAAG CCGTATTCCT GTCTTGTTGT CTGAAGAGGA TACAGGCTCA 
GAGCCTTCGG GCTCACTGTC GGCCAAAGAG CGGTGGAGCA AGAGGGCTCG GCCACAGCAG 
GACCTGGCAC GGCTGGTGAT GGAGAAAAGG CAGGGTCGGC TGTTGCTGCG GCTGGCCTCA 
GGAGCCTCAT CCTCCTCTAG TGAGGAGCAG CGCCGTGCCT CTGAGACACT CTCAGGCACT 
GGATCTGAGG AGGACACACC TGCCTCAGAA CCCACAACAG CCTTGCCTAG GAAGGCTGTG 
CGGGCAGCGA CCACCCGGAG CCGGATTCCC CGTCCCATCA GTGTGTCCAT GCCTGTGGAA 
GGCCAGCAGC TTCCTGGAAG ACCCCACGGT GCGGCCTCAG CGACCGACTT GGCCATCACC 
AGCAGGCTCC AGCTGCAGAA GCCCTCAGGG TTGGCCCCTG CTGCTGACCT CCGTCCCAAA 
CAGTCCGCGA GCCGGGGTCC CGGCCCAGGT CGCGCCCAAG TCTCCAAGCC CGCAGCACCC 
CGCAGTCCCG GCCTCCCCGC CTCCACCGCG CGCCACCCCA GCGGGTCCCC GCGGAGCCAG 
TCCCTGTCCC GTAAAGAGAG CTCCTCCCCC TCGCACCAAG CCCGGCCTGG CGTCCCTCCA 
TCCCGGGGGG TCCTCCAAGT CAGATCTCAG CCGGAGGCCT CCCCGGTGGC CCCCAAGAAA 
GGACCCAAGG GGAAACAACT GCAGACTCAG CGCGCAGCAA CCAAAGGCCG GGCGGTGGTT 
TCAGAGGGTC GGCCCGGGGC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156336.1
CDS	305..4231
Translation	MQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWEKAGTDALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLRENTEDVLQGEHLSDQENAPPILPGRPPEGLGPGPHLVPHPGGPEAEVWEETDVNRNKLRINIGKTPCVEEEQSRGVGVPSSPVRAPPDSPTTPVRSLCYRRVNSPESERLSTAADGRVELQERRSRMDLPGSPSRQACSSQPAQMLSVDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPGAEPSTSGTTDEEPEELRPLPEEGEERRRLGTEPTVRPRGRGMHTLTEEDPRQMLPQPAPPQLSQADGRSETSQPPTPGSPSHSPLHSGPRPRRRESDPTGPQRQVFSVAPPFEVNGLPRAVPLALPYQDFKRDLSDYRERARLLNRVRRVGFSHMLLTAPQVPLAPFQPQANGKEGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAGALGEVLGPRSGSSSEGSERSTERSQEGAPSTLLADDQKEARGRASMADGDLEPEEGSKTLVLVSPGDMKKSPVTAELAPDPDLGTLAALTPQHERPQPTGSQLDVSEPGTLSSILKSEPKPSGPGAGGGVGLVAPGAGVTAVTSPFTKVERTFVHIAEKSHLNVMSSGGQASRPEELSTGGELGLEVLSEGGIAEEGAPAPLENGMALAGLDGTEMESCALSGPPGETPSEVVTDSLPNGPALADGPAPASQQEPVTKKGTTISPSRHAMPGSRPRSRIPVLLSEEDTGSEPSGSLSAKERWSKRARPQQDLARLVMEKRQGRLLLRLASGASSSSSEEQRRASETLSGTGSEEDTPASEPTTALPRKAVRAATTRSRIPRPISVSMPVEGQQLPGRPHGAASATDLAITSRLQLQKPSGLAPAADLRPKQSASRGPGPGRAQVSKPAAPRSPGLPASTARHPSGSPRSQSLSRKESSSPSHQARPGVPPSRGVLQVRSQPEASPVAPKKGPKGKQLQTQRAATKGRAVVSEGRPGAR

Target ORF information:

RefSeq Version	NM_001162864.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus tau tubulin kinase 1 (Ttbk1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001162864.1

ORF Insert Sequence:

ATGCAGTGCC TAGCGGCAGC TCTTAAGGAC GAAACCAACA TGAGTGGGGG AGGGGAGCAG 
GCCGACATCC TGCCGGCCAA CTACGTGGTC AAAGATCGCT GGAAGGTGCT GAAAAAGATC 
GGGGGCGGGG GCTTCGGTGA GATCTATGAG GCCATGGACC TGCTGACCAG GGAGAACGTG 
GCTCTCAAGG TGGAGTCAGC CCAACAGCCT AAGCAGGTCC TCAAGATGGA GGTGGCTGTG 
CTCAAAAAGC TTCAAGGCAA GGACCACGTG TGCAGGTTCA TTGGCTGTGG CCGTAACGAG 
AAGTTTAACT ATGTGGTGAT GCAGCTCCAG GGCCGGAACC TGGCTGACCT GCGCCGCAGC 
CAGCCAAGGG GCACTTTCAC GTTGAGTACC ACACTGCGCC TGGGCAAGCA GATCCTGGAG 
TCCATTGAAG CCATTCACTC CGTGGGCTTC CTGCACCGTG ACATCAAGCC GTCCAACTTT 
GCCATGGGCC GGCTGCCCTC GACCTACAGG AAGTGCTACA TGTTGGACTT TGGGCTAGCC 
AGGCAGTACA CTAACACCAC TGGGGACGTC CGGCCTCCTC GGAATGTGGC CGGGTTCCGG 
GGGACTGTCC GCTACGCCTC GGTCAATGCT CACAAGAACC GGGAGATGGG CCGCCATGAT 
GACCTGTGGT CCCTCTTCTA CATGCTGGTG GAGTTTGCTG TGGGCCAGCT GCCCTGGAGG 
AAGATCAAAG ACAAGGAGCA GGTGGGGATG ATCAAAGAGA AATACGAGCA CCGGATGCTA 
CTGAAGCACA TGCCATCCGA GTTTCATCTC TTCCTGGACC ACATTGCCAG CCTCGACTAC 
TTCACCAAGC CCGATTACCA GTTGATCATG TCAGTGTTTG AGAACAGCAT GAAGGAGCGG 
GGCATTGCCG AGAACGAGGC CTTTGACTGG GAGAAGGCAG GCACTGATGC CCTCCTGTCC 
ACGAGCACCT CCACCCCACC CCAGCAGAAC ACGCGACAGA CCGCAGCCAT GTTTGGAGTG 
GTCAATGTGA CACCGGTGCC TGGGGACCTG CTTCGTGAGA ACACTGAGGA CGTACTGCAG 
GGAGAGCACC TGAGTGACCA GGAGAACGCA CCCCCAATCC TGCCCGGGAG GCCTCCAGAG 
GGCTTGGGCC CTGGTCCCCA TCTTGTTCCC CACCCTGGGG GTCCTGAGGC TGAAGTGTGG 
GAGGAGACAG ATGTCAACCG CAACAAACTG CGCATCAACA TTGGCAAAAC CCCCTGTGTG 
GAGGAAGAGC AGAGTCGAGG AGTAGGGGTC CCCAGTTCCC CAGTGCGTGC CCCCCCAGAC 
TCCCCAACAA CCCCAGTGCG GTCTCTATGC TACCGGAGGG TCAACAGCCC AGAGTCGGAG 
AGGCTGTCTA CAGCTGCTGA TGGTCGGGTA GAGCTGCAGG AGAGGAGGTC ACGGATGGAT 
CTGCCTGGCT CCCCCTCCCG CCAGGCCTGC TCCTCACAAC CAGCTCAGAT GCTGTCAGTG 
GACACGGGCC ATGCTGACAG GCAGGCCAGT GGCCGCATGG ACGTCTCTGC CTCTGTGGAG 
CAGGAGGCCC TGAGCAACGC CTTCCGCTCA GTGCCACTGG CTGAGGAGGA AGACTTTGAC 
AGCAAGGAGT GGGTCATTAT TGACAAGGAG ACGGAGCTCA AGGACTTCCC TCCCGGGGCT 
GAGCCTAGCA CATCAGGCAC CACTGATGAA GAGCCCGAGG AGCTGCGGCC CCTGCCCGAG 
GAGGGCGAGG AAAGGAGGCG ACTGGGGACA GAGCCCACTG TCAGGCCGCG TGGACGTGGT 
ATGCACACGC TGACAGAGGA GGACCCACGG CAGATGCTGC CCCAGCCTGC ACCACCTCAG 
TTGAGCCAGG CTGATGGCCG GTCAGAGACA TCACAGCCAC CCACGCCTGG CAGCCCTTCC 
CACTCTCCCT TGCACTCGGG ACCCCGACCT CGACGGAGAG AGTCAGATCC CACGGGCCCT 
CAGAGACAGG TGTTCTCTGT GGCGCCCCCG TTCGAGGTGA ATGGCCTTCC ACGAGCTGTG 
CCTCTAGCCT TGCCCTACCA GGACTTCAAG AGAGACCTCT CTGATTATCG AGAACGGGCC 
CGGCTGCTCA ACAGGGTCCG GAGGGTGGGC TTCTCACACA TGCTACTCAC CGCCCCTCAG 
GTCCCATTGG CTCCCTTTCA GCCTCAGGCC AATGGGAAAG AGGGAGAAGA GGAAGAGGAG 
GAGGAAGAGG AGGAGGAGGA AGAAGAAGAA GAAGAAGAGG AAGAAGAAGA GGAGGAAGAG 
GAGGAAGAGG AAGAGGAGGA GGAGGCAGGG GCCCTTGGGG AGGTGCTGGG GCCTCGAAGT 
GGCTCAAGCA GTGAGGGTAG CGAGCGGAGC ACCGAGCGGA GCCAGGAGGG CGCCCCGTCC 
ACACTGCTGG CTGACGACCA GAAAGAGGCC AGGGGCCGGG CCTCCATGGC TGATGGGGAC 
CTGGAGCCTG AGGAGGGCTC CAAAACGCTG GTGCTCGTCT CCCCTGGTGA CATGAAGAAG 
TCACCAGTCA CTGCCGAACT GGCCCCCGAC CCTGATCTGG GCACCTTGGC TGCGCTCACC 
CCTCAGCACG AGCGGCCTCA GCCCACTGGA AGCCAGCTGG ACGTATCAGA GCCAGGCACC 
TTGTCCTCCA TCCTCAAGTC CGAACCCAAG CCCTCAGGAC CTGGAGCAGG GGGTGGGGTT 
GGGCTGGTGG CCCCTGGGGC TGGGGTCACA GCAGTGACGT CACCATTCAC CAAAGTCGAA 
AGGACTTTTG TTCACATTGC AGAGAAGTCC CACCTCAACG TCATGTCTTC CGGGGGACAG 
GCCTCCAGGC CAGAGGAGTT GAGCACTGGG GGCGAGTTGG GCCTGGAGGT GCTCTCTGAG 
GGGGGCATCG CAGAGGAAGG GGCCCCAGCA CCTCTGGAGA ATGGCATGGC TTTGGCAGGG 
CTGGACGGGA CTGAGATGGA AAGTTGTGCT CTGTCGGGCC CTCCCGGAGA AACGCCCTCA 
GAAGTAGTCA CAGACTCCTT GCCCAATGGG CCAGCCCTTG CTGATGGACC AGCTCCAGCA 
TCCCAACAAG AGCCAGTAAC CAAGAAAGGG ACCACCATCT CCCCCAGTCG CCATGCTATG 
CCAGGATCTC GCCCCAGAAG CCGTATTCCT GTCTTGTTGT CTGAAGAGGA TACAGGCTCA 
GAGCCTTCGG GCTCACTGTC GGCCAAAGAG CGGTGGAGCA AGAGGGCTCG GCCACAGCAG 
GACCTGGCAC GGCTGGTGAT GGAGAAAAGG CAGGGTCGGC TGTTGCTGCG GCTGGCCTCA 
GGAGCCTCAT CCTCCTCTAG TGAGGAGCAG CGCCGTGCCT CTGAGACACT CTCAGGCACT 
GGATCTGAGG AGGACACACC TGCCTCAGAA CCCACAACAG CCTTGCCTAG GAAGGCTGTG 
CGGGCAGCGA CCACCCGGAG CCGGATTCCC CGTCCCATCA GTGTGTCCAT GCCTGTGGAA 
GGCCAGCAGC TTCCTGGAAG ACCCCACGGT GCGGCCTCAG CGACCGACTT GGCCATCACC 
AGCAGGCTCC AGCTGCAGAA GCCCTCAGGG TTGGCCCCTG CTGCTGACCT CCGTCCCAAA 
CAGTCCGCGA GCCGGGGTCC CGGCCCAGGT CGCGCCCAAG TCTCCAAGCC CGCAGCACCC 
CGCAGTCCCG GCCTCCCCGC CTCCACCGCG CGCCACCCCA GCGGGTCCCC GCGGAGCCAG 
TCCCTGTCCC GTAAAGAGAG CTCCTCCCCC TCGCACCAAG CCCGGCCTGG CGTCCCTCCA 
TCCCGGGGGG TCCTCCAAGT CAGATCTCAG CCGGAGGCCT CCCCGGTGGC CCCCAAGAAA 
GGACCCAAGG GGAAACAACT GCAGACTCAG CGCGCAGCAA CCAAAGGCCG GGCGGTGGTT 
TCAGAGGGTC GGCCCGGGGC CAGATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.
The American journal of pathology184(3)808-18(2014 Mar)
Asai H,Ikezu S,Woodbury ME,Yonemoto GM,Cui L,Ikezu T

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology24(8)2904-15(2010 Aug)
Xu J,Sato S,Okuyama S,Swan RJ,Jacobsen MT,Strunk E,Ikezu T

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.
Journal of neurochemistry98(5)1573-84(2006 Sep)
Sato S,Cerny RL,Buescher JL,Ikezu T

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
DNA research : an international journal for rapid publication of reports on genes and genomes11(3)205-18(2004 Jun)
Okazaki N,F-Kikuno R,Ohara R,Inamoto S,Koseki H,Hiraoka S,Saga Y,Seino S,Nishimura M,Kaisho T,Hoshino K,Kitamura H,Nagase T,Ohara O,Koga H

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Ttbk1 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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