Selenom cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Selenom |
| Entrez Gene ID | 114679 |
| Full Name | selenoprotein M |
| Synonyms | 1500040L08Rik,A230103K18,Selm,Sepm |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_053267.3 | NP_444497.1 | selenoprotein M precursor |
| Homo sapiens (human) | SELM | NP_536355.1 |
| Mus musculus (house mouse) | Selm | NP_444497.1 |
| Pan troglodytes (chimpanzee) | SELM | NP_001140172.1 |
| Xenopus tropicalis (tropical clawed frog) | selm | NP_001165078.1 |
| SELM | NP_001152871.1 | |
| Canis lupus familiaris (dog) | SELM | NP_001108486.1 |
| Rattus norvegicus (Norway rat) | Selm | NP_001108485.1 |
| Danio rerio (zebrafish) | selm | NP_840071.2 |
| Gallus gallus (chicken) | SELM | NP_001264788.1 |
| Bos taurus (cattle) | SELM | NP_001156643.1 |
Related articles in PubMed
Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Deletion of selenoprotein M leads to obesity without cognitive deficits.
Pitts MW, Reeves MA, Hashimoto AC, Ogawa A, Kremer P, Seale LA, Berry MJ
The Journal of biological chemistry288(36)26121-34(2013 Sep)
In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord.
Lai HC, Klisch TJ, Roberts R, Zoghbi HY, Johnson JE
The Journal of neuroscience : the official journal of the Society for Neuroscience31(30)10859-71(2011 Jul)
The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.
Reeves MA, Bellinger FP, Berry MJ
Antioxidants & redox signaling12(7)809-18(2010 Apr)
NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
Ferguson AD, Labunskyy VM, Fomenko DE, Ara? D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J
The Journal of biological chemistry281(6)3536-43(2006 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
SelM plays an important role in the regulation of body weight and energy metabolism.
Title: Deletion of selenoprotein M leads to obesity without cognitive deficits.
These results suggest that selenoprotein M may have an important role in protecting against oxidative damage in the brain and may potentially function in calcium regulation.
Title: The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.
Sep15 and SelM have roles as thiol-disulfide oxidoreductases
Title: NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
mouse SelM had significantly suppressed on its transcriptional products in transgenic brains
Title: Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease.
The following Selenom gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenom cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu18836 | |
| Clone ID Related Accession (Same CDS sequence) | NM_053267.3 | |
| Accession Version | NM_053267.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-24 | |
| Organism | Mus musculus(house mouse) | |
| Product | selenoprotein M precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BB589016.2, BC147333.1 and AW049879.1. On Dec 13, 2016 this sequence version replaced NM_053267.2. ##Evidence-Data-START## Transcript exon combination :: BQ939285.1, AK018791.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 11839807 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGCATCC TACTGTCGCC GCCGTCGCTG CTGCTGCTTC TTGCAGCCCT TGTGGCTCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_444497.1 |
| CDS | 262..699 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_053267.3 |
ORF Insert Sequence:
1 | ATGAGCATCC TACTGTCGCC GCCGTCGCTG CTGCTGCTTC TTGCAGCCCT TGTGGCTCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Selenoprotein Gene Nomenclature. |
|
Deletion of selenoprotein M leads to obesity without cognitive deficits. |
|
In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. |
|
The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation. |
|
NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. |