Gene Symbol | Capn6 |
Entrez Gene ID | 12338 |
Full Name | calpain 6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Capn6 cDNA ORF clone
Gene Symbol | Capn6 |
Entrez Gene ID | 12338 |
Full Name | calpain 6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_007603.3 | NP_031629.3 | calpain-6 |
Homo sapiens (human) | CAPN6 | NP_055104.2 |
LOC706434 | XP_002808592.1 | |
Canis lupus familiaris (dog) | CAPN6 | XP_549188.2 |
Bos taurus (cattle) | CAPN6 | NP_001179160.1 |
Rattus norvegicus (Norway rat) | Capn6 | NP_113996.1 |
Gallus gallus (chicken) | CAPN6 | XP_420313.2 |
Pan troglodytes (chimpanzee) | CAPN6 | XP_001146965.1 |
Mus musculus (house mouse) | Capn6 | NP_031629.3 |
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A
The Journal of clinical investigation126(9)3417-32(2016 Sep)
ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.
Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A
Angiogenesis19(1)53-65(2016 Jan)
Sall1 balances self-renewal and differentiation of renal progenitor cells.
Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M
Development (Cambridge, England)141(5)1047-58(2014 Mar)
Calpain-6 deficiency promotes skeletal muscle development and regeneration.
Tonami K, Hata S, Ojima K, Ono Y, Kurihara Y, Amano T, Sato T, Kawamura Y, Kurihara H, Sorimachi H
PLoS genetics9(8)e1003668(2013)
Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development.
Dear TN, Boehm T
Mechanisms of development89(1-2)201-9(1999 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CAPN6 promotes atherogenicity in inflamed macrophages by disturbing CWC22/EJC systems.
Title: Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
These results collectively showed that a loss of CAPN6 promotes skeletal muscle differentiation during both development and regeneration, suggesting a novel physiological function of CAPN6 as a suppressor of skeletal muscle differentiation.
Title: Calpain-6 deficiency promotes skeletal muscle development and regeneration.
CAPN6 acts as a regulator of Rac1 and cell motility through interaction with GEF-H1.
Title: Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1.
Capn6 promotes cytoskeletal organization and microtubule stability in osteoclasts.
Title: Calpain-6, a target molecule of glucocorticoids, regulates osteoclastic bone resorption via cytoskeletal organization and microtubule acetylation.
Capn6 is a microtubule-stabilizing protein expressed in embryonic tissues that may be involved in the regulation of microtubule dynamics and cytoskeletal organization.
Title: Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.
The following Capn6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Capn6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu14861 | |
Clone ID Related Accession (Same CDS sequence) | NM_007603.3 | |
Accession Version | NM_007603.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1926bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | calpain-6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN700442.1, BC052167.1 and AK145116.1. On Oct 6, 2007 this sequence version replaced NM_007603.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052167.1, AK145116.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAGTACC AAGAACTGAA GCAGGAGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_031629.3 |
CDS | 221..2146 |
Translation |
Target ORF information:
Target ORF information:
|
NM_007603.3 |
1 | ATGGGTCCTC CTCTGAAGCT CTTCAAAAAC CAGAAGTACC AAGAACTGAA GCAGGAGTGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. |
ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. |
Sall1 balances self-renewal and differentiation of renal progenitor cells. |
Calpain-6 deficiency promotes skeletal muscle development and regeneration. |
Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. |