Gene Symbol | CASQ2 |
Entrez Gene ID | 12373 |
Full Name | calsequestrin 2 |
Synonyms | AA033488,AW146219,Csq2,ESTM52,cCSQ |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
ORF » Species Summary » Mus musculus » CASQ2 cDNA ORF clone
gRNAs
Gene Symbol | CASQ2 |
Entrez Gene ID | 12373 |
Full Name | calsequestrin 2 |
Synonyms | AA033488,AW146219,Csq2,ESTM52,cCSQ |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001355663.1 | NP_001342592.1 | calsequestrin-2 isoform 1 precursor |
NM_009814.4 | NP_033944.2 | calsequestrin-2 isoform 2 precursor |
NM_009814.3 | NP_033944.2 | calsequestrin-2 precursor |
XM_006500947.3 | XP_006501010.1 | calsequestrin-2 isoform X1 |
Rattus norvegicus (Norway rat) | Casq2 | NP_058827.3 |
Homo sapiens (human) | CASQ2 | NP_001223.2 |
Mus musculus (house mouse) | Casq2 | NP_033944.2 |
Danio rerio (zebrafish) | casq2 | NP_001002682.1 |
Gallus gallus (chicken) | CASQ2 | NP_989857.1 |
Pan troglodytes (chimpanzee) | CASQ2 | XP_513677.3 |
Canis lupus familiaris (dog) | CASQ2 | XP_540252.4 |
Bos taurus (cattle) | CASQ2 | NP_001030451.1 |
Xenopus tropicalis (tropical clawed frog) | MGC76326 | NP_989136.1 |
Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only.
Valle G, Vergani B, Sacchetto R, Reggiani C, De Rosa E, Maccatrozzo L, Nori A, Villa A, Volpe P
Journal of muscle research and cell motility37(6)225-233(2016 Dec)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bućan M, Murray SA
Nature537(7621)508-514(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data suggest a functional role of CSQ2 not only in the ventricle but also in the atrium of mammalian hearts
Title: Evidence for a functional role of calsequestrin 2 in mouse atrium.
CASQ2-/- causes increase in calsequestrin 1 (CASQ1) expression.
Title: Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only.
Calcium entry activated by ablation of both JP45-CASQ1 and JP45-CASQ2 complexes supports tetanic force development in slow twitch soleus muscles.
Title: Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles.
The minimal KEKE motif of TRN involved in the interactions with CSQ2, HRC and RyR2 within the Ca2+ release units of cardiac sarcoplasmic reticulum has been defined.
Title: Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum.
While CASQ2 stabilizes RyR2 rendering it refractory in the diastolic phase, HRC enhances RyR2 activity facilitating RyR2 recovery from refractoriness.
Title: Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.
The following CASQ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASQ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21862 | |
Clone ID Related Accession (Same CDS sequence) | NM_009814.4 , NM_009814.3 | |
Accession Version | NM_009814.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | calsequestrin-2 isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC166072.2, AI114962.1 and BC092229.1. On Sep 23, 2017 this sequence version replaced NM_009814.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092229.1, SRR1660813.82167.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGAGGA TTTACCTGCT CATGGTGGGG GTTTATCTGC TGTCCCTGAG CGGGGCAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033944.2 |
CDS | 225..1472 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGAGGA TTTACCTGCT CATGGTGGGG GTTTATCTGC TGTCCCTGAG CGGGGCAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21862 | |
Clone ID Related Accession (Same CDS sequence) | NM_009814.4 , NM_009814.3 | |
Accession Version | NM_009814.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1248bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-04-22 | |
Organism | Mus musculus(House mouse) | |
Product | calsequestrin-2 precursor | |
Comment | VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI114962.1 and BC092229.1. On Oct 24, 2012 this sequence version replaced NM_009814.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC092229.1, AF068244.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGAGGA TTTACCTGCT CATGGTGGGG GTTTATCTGC TGTCCCTGAG CGGGGCAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033944.2 |
CDS | 185..1432 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGAGGA TTTACCTGCT CATGGTGGGG GTTTATCTGC TGTCCCTGAG CGGGGCAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu83690 | |
Clone ID Related Accession (Same CDS sequence) | NM_001355663.1 | |
Accession Version | NM_001355663.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1257bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | calsequestrin-2 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC166072.2, AC159255.3 and BC092229.1. On Sep 23, 2017 this sequence version replaced XM_006500947.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660821.95297.1, SRR1660815.103657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGAGGA TTTACCTGCT CATGGTGGGG GTTTATCTGC TGTCCCTGAG CGGGGCAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001342592.1 |
CDS | 225..1481 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGAGGA TTTACCTGCT CATGGTGGGG GTTTATCTGC TGTCCCTGAG CGGGGCAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31586 | |
Clone ID Related Accession (Same CDS sequence) | XM_006500947.3 | |
Accession Version | XM_006500947.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | calsequestrin-2 isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006500947.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATCTCTA TTCTGGAGAC TGAGAAGCAA GACTTTTCCC AAATGAAGAG GATTTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501010.1 |
CDS | 178..1476 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGATCTCTA TTCTGGAGAC TGAGAAGCAA GACTTTTCCC AAATGAAGAG GATTTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Characterization of fast-twitch and slow-twitch skeletal muscles of calsequestrin 2 (CASQ2)-knock out mice: unexpected adaptive changes of fast-twitch muscles only. |
High-throughput discovery of novel developmental phenotypes. |