Socs1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Socs1
Entrez Gene ID	12703
Full Name	suppressor of cytokine signaling 1
Synonyms	Cish1,Cish7,JAB,SOCS-1,SSI-1
General protein information	Preferred Names suppressor of cytokine signaling 1 Names suppressor of cytokine signaling 1 JAK2-binding protein STAT-induced STAT inhibitor 1 cytokine inducible SH2-containing protein 1 cytokine inducible SH2-containing protein 7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A1\|16 5.81 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271603.1	NP_001258532.1	suppressor of cytokine signaling 1
NM_009896.2	NP_034026.1	suppressor of cytokine signaling 1

Pathways from BioSystems

Homologies

	SOCS1	XP_001104595.1
Bos taurus (cattle)	SOCS1	XP_002698010.1
Danio rerio (zebrafish)	socs1a	NP_001003467.1
Mus musculus (house mouse)	Socs1	NP_001258532.1
Homo sapiens (human)	SOCS1	NP_003736.1
Rattus norvegicus (Norway rat)	Socs1	NP_665886.1
Xenopus tropicalis (tropical clawed frog)	socs1	NP_001011327.1
Pan troglodytes (chimpanzee)	SOCS1	XP_001141793.1
Canis lupus familiaris (dog)	SOCS1	XP_005622136.1
Gallus gallus (chicken)	SOCS1	NP_001131120.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of SOCS-1 expression by translational repression.
Gregorieff A, Pyronnet S, Sonenberg N, Veillette A
The Journal of biological chemistry275(28)21596-604(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

loss of SOCS1 in CD11c+ cells skewed the balance of immune response to infection by increasing innate responses while decreasing antigen-specific adaptive responses to infectious antigens
Title: Amplifying IFN-? Signaling in Dendritic Cells by CD11c-Specific Loss of SOCS1 Increases Innate Immunity to Infection while Decreasing Adaptive Immunity.

IFN-lambda signaling is regulated by SOCS1 but not by SOCS3 or USP18.
Title: SOCS1 is an inducible negative regulator of interferon ? (IFN-?)-induced gene expression

results indicate that SOCS1 is one of the essential molecules that maintain regulatory T cell stability, particularly under the inflammatory conditions in which APCs are highly activated
Title: SOCS1 Is a Key Molecule That Prevents Regulatory T Cell Plasticity under Inflammatory Conditions.

nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway
Title: Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway.

Study conclude that under pro-proliferative cytokine stimulation at the onset of myeloproliferative diseases SOCS1 acts as a tumor suppressor, while under anti-proliferative conditions it exerts oncogenic function.
Title: SOCS1 function in BCR-ABL mediated myeloproliferative disease is dependent on the cytokine environment.

The following Socs1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Socs1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17813	NM_001271603.1 Latest version!	Mus musculus suppressor of cytokine signaling 1 (Socs1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OMu17813	NM_009896.2 Latest version!	Mus musculus suppressor of cytokine signaling 1 (Socs1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Socs1 ( NM_001271603.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001258532.1 Mus musculus suppressor of cytokine signaling 1 (Socs1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17813
Clone ID Related Accession (Same CDS sequence)	NM_001271603.1 , NM_009896.2
Accession Version	NM_001271603.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	suppressor of cytokine signaling 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT010583.8. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BY191806.1, BY186444.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTAGCAC GCAACCAGGT GGCAGCCGAC AATGCGATCT CCCCGGCAGC AGAGCCCCGA 
CGGCGGTCAG AGCCCTCCTC GTCCTCGTCT TCGTCCTCGC CAGCGGCCCC CGTGCGTCCC 
CGGCCCTGCC CGGCGGTCCC AGCCCCAGCC CCTGGCGACA CTCACTTCCG CACCTTCCGC 
TCCCACTCCG ATTACCGGCG CATCACGCGG ACCAGCGCGC TCCTGGACGC CTGCGGCTTC 
TATTGGGGAC CCCTGAGCGT GCACGGGGCG CACGAGCGGC TGCGTGCCGA GCCCGTGGGC 
ACCTTCTTGG TGCGCGACAG TCGCCAACGG AACTGCTTCT TCGCGCTCAG CGTGAAGATG 
GCTTCGGGCC CCACGAGCAT CCGCGTGCAC TTCCAGGCCG GCCGCTTCCA CTTGGACGGC 
AGCCGCGAGA CCTTCGACTG CCTTTTCGAG CTGCTGGAGC ACTACGTGGC GGCGCCGCGC 
CGCATGTTGG GGGCCCCGCT GCGCCAGCGC CGCGTGCGGC CGCTGCAGGA GCTGTGTCGC 
CAGCGCATCG TGGCCGCCGT GGGTCGCGAG AACCTGGCGC GCATCCCTCT TAACCCGGTA 
CTCCGTGACT ACCTGAGTTC CTTCCCCTTC CAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258532.1
CDS	277..915
Translation	MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI

Target ORF information:

RefSeq Version	NM_001271603.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus suppressor of cytokine signaling 1 (Socs1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271603.1

ORF Insert Sequence:

ATGGTAGCAC GCAACCAGGT GGCAGCCGAC AATGCGATCT CCCCGGCAGC AGAGCCCCGA 
CGGCGGTCAG AGCCCTCCTC GTCCTCGTCT TCGTCCTCGC CAGCGGCCCC CGTGCGTCCC 
CGGCCCTGCC CGGCGGTCCC AGCCCCAGCC CCTGGCGACA CTCACTTCCG CACCTTCCGC 
TCCCACTCCG ATTACCGGCG CATCACGCGG ACCAGCGCGC TCCTGGACGC CTGCGGCTTC 
TATTGGGGAC CCCTGAGCGT GCACGGGGCG CACGAGCGGC TGCGTGCCGA GCCCGTGGGC 
ACCTTCTTGG TGCGCGACAG TCGCCAACGG AACTGCTTCT TCGCGCTCAG CGTGAAGATG 
GCTTCGGGCC CCACGAGCAT CCGCGTGCAC TTCCAGGCCG GCCGCTTCCA CTTGGACGGC 
AGCCGCGAGA CCTTCGACTG CCTTTTCGAG CTGCTGGAGC ACTACGTGGC GGCGCCGCGC 
CGCATGTTGG GGGCCCCGCT GCGCCAGCGC CGCGTGCGGC CGCTGCAGGA GCTGTGTCGC 
CAGCGCATCG TGGCCGCCGT GGGTCGCGAG AACCTGGCGC GCATCCCTCT TAACCCGGTA 
CTCCGTGACT ACCTGAGTTC CTTCCCCTTC CAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Socs1 ( NM_009896.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034026.1 Mus musculus suppressor of cytokine signaling 1 (Socs1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17813
Clone ID Related Accession (Same CDS sequence)	NM_001271603.1 , NM_009896.2
Accession Version	NM_009896.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 639bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	suppressor of cytokine signaling 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CT010583.8 and AF120490.1. On Feb 8, 2006 this sequence version replaced NM_009896.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF120490.1, U88325.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## regulatory uORF :: PMID: 10764816 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTAGCAC GCAACCAGGT GGCAGCCGAC AATGCGATCT CCCCGGCAGC AGAGCCCCGA 
CGGCGGTCAG AGCCCTCCTC GTCCTCGTCT TCGTCCTCGC CAGCGGCCCC CGTGCGTCCC 
CGGCCCTGCC CGGCGGTCCC AGCCCCAGCC CCTGGCGACA CTCACTTCCG CACCTTCCGC 
TCCCACTCCG ATTACCGGCG CATCACGCGG ACCAGCGCGC TCCTGGACGC CTGCGGCTTC 
TATTGGGGAC CCCTGAGCGT GCACGGGGCG CACGAGCGGC TGCGTGCCGA GCCCGTGGGC 
ACCTTCTTGG TGCGCGACAG TCGCCAACGG AACTGCTTCT TCGCGCTCAG CGTGAAGATG 
GCTTCGGGCC CCACGAGCAT CCGCGTGCAC TTCCAGGCCG GCCGCTTCCA CTTGGACGGC 
AGCCGCGAGA CCTTCGACTG CCTTTTCGAG CTGCTGGAGC ACTACGTGGC GGCGCCGCGC 
CGCATGTTGG GGGCCCCGCT GCGCCAGCGC CGCGTGCGGC CGCTGCAGGA GCTGTGTCGC 
CAGCGCATCG TGGCCGCCGT GGGTCGCGAG AACCTGGCGC GCATCCCTCT TAACCCGGTA 
CTCCGTGACT ACCTGAGTTC CTTCCCCTTC CAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034026.1
CDS	157..795
Translation	MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI

Target ORF information:

RefSeq Version	NM_009896.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus suppressor of cytokine signaling 1 (Socs1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009896.2

ORF Insert Sequence:

ATGGTAGCAC GCAACCAGGT GGCAGCCGAC AATGCGATCT CCCCGGCAGC AGAGCCCCGA 
CGGCGGTCAG AGCCCTCCTC GTCCTCGTCT TCGTCCTCGC CAGCGGCCCC CGTGCGTCCC 
CGGCCCTGCC CGGCGGTCCC AGCCCCAGCC CCTGGCGACA CTCACTTCCG CACCTTCCGC 
TCCCACTCCG ATTACCGGCG CATCACGCGG ACCAGCGCGC TCCTGGACGC CTGCGGCTTC 
TATTGGGGAC CCCTGAGCGT GCACGGGGCG CACGAGCGGC TGCGTGCCGA GCCCGTGGGC 
ACCTTCTTGG TGCGCGACAG TCGCCAACGG AACTGCTTCT TCGCGCTCAG CGTGAAGATG 
GCTTCGGGCC CCACGAGCAT CCGCGTGCAC TTCCAGGCCG GCCGCTTCCA CTTGGACGGC 
AGCCGCGAGA CCTTCGACTG CCTTTTCGAG CTGCTGGAGC ACTACGTGGC GGCGCCGCGC 
CGCATGTTGG GGGCCCCGCT GCGCCAGCGC CGCGTGCGGC CGCTGCAGGA GCTGTGTCGC 
CAGCGCATCG TGGCCGCCGT GGGTCGCGAG AACCTGGCGC GCATCCCTCT TAACCCGGTA 
CTCCGTGACT ACCTGAGTTC CTTCCCCTTC CAGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of SOCS-1 expression by translational repression.
The Journal of biological chemistry275(28)21596-604(2000 Jul)
Gregorieff A,Pyronnet S,Sonenberg N,Veillette A

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Socs1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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