Hspe1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Hspe1
Entrez Gene ID	15528
Full Name	heat shock protein 1 (chaperonin 10)
Synonyms	10kDa,Hsp10,mt-cpn10
General protein information	Preferred Names heat shock protein 1 (chaperonin 10) Names 10 kDa heat shock protein, mitochondrial 10 kDa chaperonin CPN10 chaperonin 10 heat shock 10 kDa protein 1 (chaperonin 10) mitochondrial chaperonin 10
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C1.2

mRNA and Protein(s)

mRNA Protein Name

NM_008303.4 NP_032329.1 10 kDa heat shock protein, mitochondrial
Pathways from BioSystems

mRNA	Protein	Name
NM_008303.4	NP_032329.1	10 kDa heat shock protein, mitochondrial

Homologies

	LOC721815	XP_001118014.2
Rattus norvegicus (Norway rat)	Hspe1	NP_037098.1
Xenopus tropicalis (tropical clawed frog)	hspe1	NP_001006882.1
	LOC696316	XP_001084953.1
	LOC720015	XP_001114974.1
Canis lupus familiaris (dog)	HSPE1	XP_536017.2
Danio rerio (zebrafish)	hspe1	NP_571601.1
Kluyveromyces lactis	KLLA0E09307g	XP_454370.1
Schizosaccharomyces pombe (fission yeast)	hsp10	NP_588098.1
Neurospora crassa	NCU04334	XP_956315.1
Oryza sativa (rice)	Os07g0641700	NP_001060431.1
	HSPE1	XP_002799059.1
Bos taurus (cattle)	HSPE1	NP_776771.1
Mus musculus (house mouse)	Hspe1	NP_032329.1
Arabidopsis thaliana (thale cress)	CPN10	NP_563961.1
Arabidopsis thaliana (thale cress)	AT1G23100	NP_173723.1
Canis lupus familiaris (dog)	LOC609748	XP_852207.1
Caenorhabditis elegans (roundworm)	Y22D7AL.10	NP_497428.1
Magnaporthe oryzae (rice blast fungus)	MGG_13221	XP_003711926.1
Homo sapiens (human)	HSPE1	NP_002148.1
	LOC711695	XP_001100531.2
	LOC710026	XP_001105898.1
Saccharomyces cerevisiae (baker's yeast)	HSP10	NP_014663.1
Eremothecium gossypii	AGOS_AEL235W	NP_984626.2
Oryza sativa (rice)	Os03g0366000	NP_001050177.2

Gene Ontology
Bibliography

Related articles in PubMed

Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function.
Lu Z, Chen Y, Aponte AM, Battaglia V, Gucek M, Sack MN
The Journal of biological chemistry290(4)2466-76(2015 Jan)

Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.
Hoekstra EJ, von Oerthel L, van der Linden AJ, Schellevis RD, Scheppink G, Holstege FC, Groot-Koerkamp MJ, van der Heide LP, Smidt MP
The European journal of neuroscience37(1)23-32(2013 Jan)

Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle Cross-Sectional Area.
Kayani AC, Close GL, Dillmann WH, Mestril R, Jackson MJ, McArdle A
American journal of physiology. Regulatory, integrative and comparative physiology299(1)R268-76(2010 Jul)

Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.
Fan L, Fan L, Ling J, Ma X, Cui YG, Liu JY
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology25(6)392-7(2009 Jun)

Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse.
Walsh A, Whelan D, Bielanowicz A, Skinner B, Aitken RJ, O'Bryan MK, Nixon B
Biology of reproduction78(6)983-93(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

heat shock protein 10 is a Sirtuin 3 substrate
Title: Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function.

expression increased as larger area and higher level of density during ovarian follicular development
Title: Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.

interaction between HSPE1 and HSPD1 in the reproductive tract and in capacitating spermatozoa
Title: Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse.

Hsp10 exerts anti-inflammatory activity by inhibiting Toll-like receptor signaling possibly by interacting with extracellular Hsp60
Title: Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production.

The following Hspe1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hspe1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15361	NM_008303.4 Latest version!	Mus musculus heat shock protein 1 (chaperonin 10) (Hspe1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hspe1 ( NM_008303.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032329.1 Mus musculus heat shock protein 1 (chaperonin 10) (Hspe1), mRNA.

Price & Availability↑

CloneID	OMu15361
Clone ID Related Accession (Same CDS sequence)	NM_008303.4
Accession Version	NM_008303.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 309bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	10 kDa heat shock protein, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AV570511.1, BC099385.1 and CJ238411.1. On Apr 17, 2008 this sequence version replaced NM_008303.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG801679.1, BI659233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCTGGAC AAGCTTTTAG GAAGTTTCTT CCGCTCTTTG ACAGAGTATT GGTTGAAAGG 
AGTGCTGCCG AAACTGTAAC CAAAGGTGGC ATTATGCTTC CAGAAAAGTC TCAAGGAAAA 
GTGTTGCAAG CAACGGTCGT GGCTGTGGGG TCAGGAGGGA AAGGAAAGAG TGGAGAGATT 
GAGCCTGTCA GTGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA 
GTAGTTCTAG ATGACAAGGA TTATTTCTTA TTTAGAGATA GTGACATTCT TGGAAAGTAT 
GTCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032329.1
CDS	263..571
Translation	MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGGKGKSGEIEPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDSDILGKYVD

Target ORF information:

RefSeq Version	NM_008303.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus heat shock protein 1 (chaperonin 10) (Hspe1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008303.4

ORF Insert Sequence:

ATGGCTGGAC AAGCTTTTAG GAAGTTTCTT CCGCTCTTTG ACAGAGTATT GGTTGAAAGG 
AGTGCTGCCG AAACTGTAAC CAAAGGTGGC ATTATGCTTC CAGAAAAGTC TCAAGGAAAA 
GTGTTGCAAG CAACGGTCGT GGCTGTGGGG TCAGGAGGGA AAGGAAAGAG TGGAGAGATT 
GAGCCTGTCA GTGTGAAAGT TGGAGATAAA GTTCTTCTCC CAGAATATGG AGGCACCAAA 
GTAGTTCTAG ATGACAAGGA TTATTTCTTA TTTAGAGATA GTGACATTCT TGGAAAGTAT 
GTCGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prolonged fasting identifies heat shock protein 10 as a Sirtuin 3 substrate: elucidating a new mechanism linking mitochondrial protein acetylation to fatty acid oxidation enzyme folding and function.
The Journal of biological chemistry290(4)2466-76(2015 Jan)
Lu Z,Chen Y,Aponte AM,Battaglia V,Gucek M,Sack MN

Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.
The European journal of neuroscience37(1)23-32(2013 Jan)
Hoekstra EJ,von Oerthel L,van der Linden AJ,Schellevis RD,Scheppink G,Holstege FC,Groot-Koerkamp MJ,van der Heide LP,Smidt MP

Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle Cross-Sectional Area.
American journal of physiology. Regulatory, integrative and comparative physiology299(1)R268-76(2010 Jul)
Kayani AC,Close GL,Dillmann WH,Mestril R,Jackson MJ,McArdle A

Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology25(6)392-7(2009 Jun)
Fan L,Fan L,Ling J,Ma X,Cui YG,Liu JY

Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse.
Biology of reproduction78(6)983-93(2008 Jun)
Walsh A,Whelan D,Bielanowicz A,Skinner B,Aitken RJ,O'Bryan MK,Nixon B

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Hspe1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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