Il13ra1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Il13ra1 |
| Entrez Gene ID | 16164 |
| Full Name | interleukin 13 receptor, alpha 1 |
| Synonyms | AI882074,CD213a1,IL-13R-alpha-1,IL-13r[a],Il13ra,NR4 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a transmembrane protein that complexes with interleukin 4 receptor alpha (IL4RA) to form a functional receptor for interleukin-13. Signalling through this pathway mediates allergy response and occurs during bronchial asthma. [provided by RefSeq, May 2015]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_133990.5 | NP_598751.3 | interleukin-13 receptor subunit alpha-1 precursor |
| Mus musculus (house mouse) | Il13ra1 | NP_598751.3 |
| Rattus norvegicus (Norway rat) | Il13ra1 | NP_665732.2 |
| Homo sapiens (human) | IL13RA1 | NP_001551.1 |
| Bos taurus (cattle) | IL13RA1 | NP_001193606.1 |
| Xenopus tropicalis (tropical clawed frog) | il13ra1 | XP_004916986.1 |
| Gallus gallus (chicken) | IL13RA1 | XP_420218.3 |
| Pan troglodytes (chimpanzee) | IL13RA1 | XP_001134844.3 |
| Canis lupus familiaris (dog) | IL13RA1 | XP_538150.3 |
| Rattus norvegicus (Norway rat) | LOC100360218 | XP_003751125.1 |
Related articles in PubMed
Soluble interleukin-13r?1: a circulating regulator of glucose.
Rachmin I, O'Meara CC, Ricci-Blair EM, Feng Y, Christensen EM, Duffy JF, Zitting KM, Czeisler CA, Pancoast JR, Cannon CP, O'Donoghue ML, Morrow DA, Lee RT
American journal of physiology. Endocrinology and metabolism313(6)E663-E671(2017 Dec)
IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis.
Barik S, Ellis JS, Cascio JA, Miller MM, Ukah TK, Cattin-Roy AN, Zaghouani H
Journal of immunology (Baltimore, Md. : 1950)199(7)2236-2248(2017 Oct)
IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage.
Barik S, Miller MM, Cattin-Roy AN, Ukah TK, Chen W, Zaghouani H
Journal of immunology (Baltimore, Md. : 1950)199(8)2767-2776(2017 Oct)
Characterization of the mouse interleukin-13 receptor alpha1 gene.
Osawa M, Miyoshi S, Copeland NG, Gilbert DJ, Jenkins NA, Hiroyama T, Motohashi T, Nakamura Y, Iwama A, Nakauchi H
Immunogenetics51(11)974-81(2000 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Delivery of sIL13ralpha1 to mice by either gene transfer or recombinant protein decreases blood glucose levels. Surprisingly, the glucose-lowering effect of sIL13ralpha1 was preserved in mice lacking IL-13, demonstrating that IL-13 was not required for the effect. In contrast, deletion of IL-4 in mice eliminated the hypoglycemic effect of sIL13ralpha1.
Title: Soluble interleukin-13r?1: a circulating regulator of glucose.
findings indicate that NOD mice lacking the IL-4Ralpha/IL-13Ralpha1 heteroreceptor (HR) display resistance to Type 1 Diabetes as the rise in blood glucose level and islet inflammation were significantly delayed in these HR-deficient relative to HR-sufficient mice
Title: On the Role IL-4/IL-13 Heteroreceptor Plays in Regulation of Type 1 Diabetes.
Chronic stress significantly reduced the number of substantia nigra dopaminergic neurons in Il13a1 knock-out mice.
Title: Lack of interleukin-13 receptor ?1 delays the loss of dopaminergic neurons during chronic stress.
These results show that activation of IL-13Ralpha1 is critical for key aspects of the immune and functional responses to Hb2 infection that facilitate expulsion.
Title: Interleukin-13 Receptor ?1-Dependent Responses in the Intestine Are Critical to Parasite Clearance.
These data establish for the first time a molecular mechanism by which Mac-1 regulates the signaling activity of IL-13 in macrophages.
Title: Mac-1 Regulates IL-13 Activity in Macrophages by Directly Interacting with IL-13R?1.
The following Il13ra1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il13ra1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu20435 | |
| Clone ID Related Accession (Same CDS sequence) | NM_133990.5 | |
| Accession Version | NM_133990.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-17 | |
| Organism | Mus musculus(house mouse) | |
| Product | interleukin-13 receptor subunit alpha-1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL672038.7, BC052425.1, AK082889.1 and CK334115.1. On May 8, 2015 this sequence version replaced NM_133990.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052425.1, AK154675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGCGGC CAGCGCTGCT GGGCGAGCTG TTGGTGCTGC TACTGTGGAC CGCCACCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_598751.3 |
| CDS | 87..1361 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_133990.5 |
ORF Insert Sequence:
1 | ATGGCGCGGC CAGCGCTGCT GGGCGAGCTG TTGGTGCTGC TACTGTGGAC CGCCACCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Soluble interleukin-13r?1: a circulating regulator of glucose. |
|
IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. |
|
IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage. |
|
Characterization of the mouse interleukin-13 receptor alpha1 gene. |