Gene Symbol | Alad |
Entrez Gene ID | 17025 |
Full Name | aminolevulinate, delta-, dehydratase |
Synonyms | ALADH,Lv |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Alad cDNA ORF clone
gRNAs
Gene Symbol | Alad |
Entrez Gene ID | 17025 |
Full Name | aminolevulinate, delta-, dehydratase |
Synonyms | ALADH,Lv |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001276446.1 | NP_001263375.1 | delta-aminolevulinic acid dehydratase |
NM_008525.4 | NP_032551.3 | delta-aminolevulinic acid dehydratase |
XM_006537639.2 | XP_006537702.1 | delta-aminolevulinic acid dehydratase isoform X1 |
ALAD | XP_001101576.1 | |
Danio rerio (zebrafish) | alad | NP_001017645.1 |
Kluyveromyces lactis | KLLA0F09273g | XP_455502.1 |
Xenopus tropicalis (tropical clawed frog) | alad | NP_001072186.1 |
Gallus gallus (chicken) | HDHD3 | XP_004945820.1 |
Drosophila melanogaster (fruit fly) | Pbgs | NP_648564.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010935 | XP_309759.4 |
Magnaporthe oryzae (rice blast fungus) | MGG_10655 | XP_003710087.1 |
Homo sapiens (human) | ALAD | NP_000022.3 |
Canis lupus familiaris (dog) | ALAD | XP_855370.1 |
Bos taurus (cattle) | ALAD | NP_001014895.1 |
Neurospora crassa | NCU01013 | XP_961625.1 |
Pan troglodytes (chimpanzee) | ALAD | XP_001152445.2 |
Mus musculus (house mouse) | Alad | NP_032551.3 |
Eremothecium gossypii | AGOS_AGR015C | NP_986680.1 |
Arabidopsis thaliana (thale cress) | HEMB1 | NP_001077800.1 |
Rattus norvegicus (Norway rat) | Alad | NP_037031.1 |
Saccharomyces cerevisiae (baker's yeast) | HEM2 | NP_011475.1 |
Schizosaccharomyces pombe (fission yeast) | hem2 | NP_593917.1 |
Oryza sativa (rice) | Os06g0704600 | NP_001058510.1 |
?-Aminolevulinate Dehydratase Activity is Stimulated in a MPTP Mouse Model of Parkinson's Disease: Correlation with Myeloperoxidase Activity.
Sampaio TB, Marcondes Sari MH, Pesarico AP, Nogueira CW
Cellular and molecular neurobiology37(5)911-917(2017 Jul)
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.
Nakahara M, Tateyama H, Araki M, Nakagata N, Yamamura K, Araki K
Mammalian genome : official journal of the International Mammalian Genome Society24(5-6)228-39(2013 Jun)
Regulation of delta-aminolevulinic acid dehydratase by kr?ppel-like factor 1.
Desgardin AD, Abramova T, Rosanwo TO, Kartha S, Shim EH, Jane SM, Cunningham JM
PloS one7(10)e46482(2012)
Delta-aminolevulinic dehydratase is a proteasome interacting protein.
Bardag-Gorce F, French SW
Experimental and molecular pathology91(2)485-9(2011 Oct)
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells.
Tallack MR, Whitington T, Yuen WS, Wainwright EN, Keys JR, Gardiner BB, Nourbakhsh E, Cloonan N, Grimmond SM, Bailey TL, Perkins AC
Genome research20(8)1052-63(2010 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Similar to its role at the beta-globin promoter, KLF1 induces factor recruitment and chromatin changes at the Alad1b promoter in a temporally-specific manner
Title: Regulation of delta-aminolevulinic acid dehydratase by kr?ppel-like factor 1.
The data supports the hypothesis that ALAD, an important enzyme for heme synthesis, is also important as a proteasome interacting protein.
Title: Delta-aminolevulinic dehydratase is a proteasome interacting protein.
Delta-ALA-D from D. melanogaster and M.musculus has a different profile of optimum pH and different sensitivity for diphenyl diselenide and lead, two inhibitors.
Title: Diphenyl diselenide [(PhSe)2] inhibits Drosophila melanogaster delta-aminolevulinate dehydratase (delta-ALA-D) gene transcription and enzyme activity.
The following Alad gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alad cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16466 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276446.1 , NM_008525.4 , XM_006537639.2 | |
Accession Version | NM_001276446.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | delta-aminolevulinic acid dehydratase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY208737.1, AK002300.1, AK032908.1, CB524263.1 and AL732594.5. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK002300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCACCACC AGTCTGTTCT GCACAGCGGC TACTTTCACC CACTGCTTCG GAGCTGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263375.1 |
CDS | 190..1182 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCACCACC AGTCTGTTCT GCACAGCGGC TACTTTCACC CACTGCTTCG GAGCTGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16466 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276446.1 , NM_008525.4 , XM_006537639.2 | |
Accession Version | NM_008525.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | delta-aminolevulinic acid dehydratase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL732594.5, AK032908.1 and CB524263.1. On Feb 14, 2013 this sequence version replaced NM_008525.3. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC055930.1, AK168119.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCACCACC AGTCTGTTCT GCACAGCGGC TACTTTCACC CACTGCTTCG GAGCTGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032551.3 |
CDS | 279..1271 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCACCACC AGTCTGTTCT GCACAGCGGC TACTTTCACC CACTGCTTCG GAGCTGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16466 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276446.1 , NM_008525.4 , XM_006537639.2 | |
Accession Version | XM_006537639.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | delta-aminolevulinic acid dehydratase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006537639.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCACCACC AGTCTGTTCT GCACAGCGGC TACTTTCACC CACTGCTTCG GAGCTGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006537702.1 |
CDS | 205..1197 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCACCACC AGTCTGTTCT GCACAGCGGC TACTTTCACC CACTGCTTCG GAGCTGGCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
?-Aminolevulinate Dehydratase Activity is Stimulated in a MPTP Mouse Model of Parkinson's Disease: Correlation with Myeloperoxidase Activity. |
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. |
Regulation of delta-aminolevulinic acid dehydratase by kr?ppel-like factor 1. |
Delta-aminolevulinic dehydratase is a proteasome interacting protein. |
A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. |