Sem1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Sem1
Entrez Gene ID	20422
Full Name	SEM1, 26S proteasome complex subunit
Synonyms	DSS1,Shfdg1,Shfg,Shfm1
General protein information	Preferred Names SEM1, 26S proteasome complex subunit Names 26S proteasome complex subunit SEM1 26S proteasome complex subunit DSS1 deleted in split hand/split foot protein 1 homolog split hand/foot deleted gene 1 split hand/foot deleted protein 1 homolog split hand/foot malformation (ectrodactyly) type 1 split hand/foot malformation type 1 protein homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 A1

mRNA and Protein(s)

mRNA Protein Name

NM_009169.2 NP_033195.1 26S proteasome complex subunit SEM1
Pathways from BioSystems

mRNA	Protein	Name
NM_009169.2	NP_033195.1	26S proteasome complex subunit SEM1

Homologies

Bos taurus (cattle)	SHFM1	NP_001106788.1
Pan troglodytes (chimpanzee)	SHFM1	XP_003318642.1
Homo sapiens (human)	SHFM1	NP_006295.1
	SHFM1	XP_001091523.1
Mus musculus (house mouse)	Shfm1	NP_033195.1
Gallus gallus (chicken)	SHFM1	NP_001078908.1
Rattus norvegicus (Norway rat)	Shfm1	NP_001119562.1
Danio rerio (zebrafish)	shfm1	NP_955887.1

Gene Ontology
Bibliography

Related articles in PubMed

Evaluation of TRAP-sequencing technology with a versatile conditional mouse model.
Hupe M, Li MX, Gertow Gillner K, Adams RH, Stenman JM
Nucleic acids research42(2)e14(2014 Jan)

Functional characterization of tissue-specific enhancers in the DLX5/6 locus.
Birnbaum RY, Everman DB, Murphy KK, Gurrieri F, Schwartz CE, Ahituv N
Human molecular genetics21(22)4930-8(2012 Nov)

Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.
Wei SJ, Williams JG, Dang H, Darden TA, Betz BL, Humble MM, Chang FM, Trempus CS, Johnson K, Cannon RE, Tennant RW
Journal of molecular biology383(3)693-712(2008 Nov)

Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.
Krizhanovsky V, Soreq L, Kliminski V, Ben-Arie N
Journal of molecular neuroscience : MN28(2)211-29(2006)

Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.
Ono R, Nakamura K, Inoue K, Naruse M, Usami T, Wakisaka-Saito N, Hino T, Suzuki-Migishima R, Ogonuki N, Miki H, Kohda T, Ogura A, Yokoyama M, Kaneko-Ishino T, Ishino F
Nature genetics38(1)101-6(2006 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

expression in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis
Title: Identification of Dss1 as a 12-O-tetradecanoylphorbol-13-acetate-responsive gene expressed in keratinocyte progenitor cells, with possible involvement in early skin tumorigenesis.

3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif
Title: BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

The following Sem1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sem1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03655	NM_009169.2 Latest version!	Mus musculus SEM1, 26S proteasome complex subunit (Sem1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sem1 ( NM_009169.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033195.1 Mus musculus SEM1, 26S proteasome complex subunit (Sem1), mRNA.

Price & Availability↑

CloneID	OMu03655
Clone ID Related Accession (Same CDS sequence)	NM_009169.2
Accession Version	NM_009169.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 213bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Mus musculus(house mouse)
Product	26S proteasome complex subunit SEM1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124582.4 and AK160432.1. On May 2, 2007 this sequence version replaced NM_009169.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV452471.1, AV501474.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849378 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGAAA AGAAGCAGCC GGTCGACTTG GGTCTCTTGG AAGAGGACGA CGAGTTCGAG 
GAGTTTCCCG CGGAAGACTG GGCTGGCTTA GATGAAGATG AAGATGCACA TGTCTGGGAG 
GATAATTGGG ATGATGACAA TGTAGAAGAT GACTTCTCTA ACCAGTTACG TGCTGAGCTG 
GAGAAGCACG GCTACAAGAT GGAGACATCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033195.1
CDS	105..317
Translation	MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS

Target ORF information:

RefSeq Version	NM_009169.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus SEM1, 26S proteasome complex subunit (Sem1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009169.2

ORF Insert Sequence:

ATGTCCGAAA AGAAGCAGCC GGTCGACTTG GGTCTCTTGG AAGAGGACGA CGAGTTCGAG 
GAGTTTCCCG CGGAAGACTG GGCTGGCTTA GATGAAGATG AAGATGCACA TGTCTGGGAG 
GATAATTGGG ATGATGACAA TGTAGAAGAT GACTTCTCTA ACCAGTTACG TGCTGAGCTG 
GAGAAGCACG GCTACAAGAT GGAGACATCA TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Evaluation of TRAP-sequencing technology with a versatile conditional mouse model.
Nucleic acids research42(2)e14(2014 Jan)
Hupe M,Li MX,Gertow Gillner K,Adams RH,Stenman JM

Functional characterization of tissue-specific enhancers in the DLX5/6 locus.
Human molecular genetics21(22)4930-8(2012 Nov)
Birnbaum RY,Everman DB,Murphy KK,Gurrieri F,Schwartz CE,Ahituv N

Identification of a specific motif of the DSS1 protein required for proteasome interaction and p53 protein degradation.
Journal of molecular biology383(3)693-712(2008 Nov)
Wei SJ,Williams JG,Dang H,Darden TA,Betz BL,Humble MM,Chang FM,Trempus CS,Johnson K,Cannon RE,Tennant RW

Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.
Journal of molecular neuroscience : MN28(2)211-29(2006)
Krizhanovsky V,Soreq L,Kliminski V,Ben-Arie N

Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality.
Nature genetics38(1)101-6(2006 Jan)
Ono R,Nakamura K,Inoue K,Naruse M,Usami T,Wakisaka-Saito N,Hino T,Suzuki-Migishima R,Ogonuki N,Miki H,Kohda T,Ogura A,Yokoyama M,Kaneko-Ishino T,Ishino F

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Sem1 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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