Gene Symbol | Bag2 |
Entrez Gene ID | 213539 |
Full Name | BCL2-associated athanogene 2 |
Synonyms | 2610042A13Rik,BC016230 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Bag2 cDNA ORF clone
Gene Symbol | Bag2 |
Entrez Gene ID | 213539 |
Full Name | BCL2-associated athanogene 2 |
Synonyms | 2610042A13Rik,BC016230 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_145392.2 | NP_663367.1 | BAG family molecular chaperone regulator 2 |
XM_017319691.1 | XP_017175180.1 | BAG family molecular chaperone regulator 2 isoform X1 |
Homo sapiens (human) | BAG2 | NP_004273.1 |
Gallus gallus (chicken) | BAG2 | XP_419897.4 |
Canis lupus familiaris (dog) | BAG2 | XP_853118.1 |
Mus musculus (house mouse) | Bag2 | NP_663367.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010983 | XP_309711.2 |
Pan troglodytes (chimpanzee) | BAG2 | XP_001158523.1 |
Rattus norvegicus (Norway rat) | Bag2 | NP_001121667.1 |
Danio rerio (zebrafish) | bag2 | NP_957294.1 |
Xenopus tropicalis (tropical clawed frog) | bag2 | NP_001006729.1 |
BAG2 | XP_001110620.1 | |
Bos taurus (cattle) | BAG2 | NP_001029436.1 |
Drosophila melanogaster (fruit fly) | CG7945 | NP_648773.1 |
Caenorhabditis elegans (roundworm) | unc-23 | NP_505307.1 |
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
Qu D, Hage A, Don-Carolis K, Huang E, Joselin A, Safarpour F, Marcogliese PC, Rousseaux MW, Hewitt SJ, Huang T, Im DS, Callaghan S, Dewar-Darch D, Figeys D, Slack RS, Park DS
The Journal of biological chemistry290(51)30441-52(2015 Dec)
Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus.
Page RC, Xu Z, Amick J, Nix JC, Misra S
Acta crystallographica. Section F, Structural biology and crystallization communications68(Pt 6)647-51(2012 Jun)
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.
Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS
The Journal of neuroscience : the official journal of the Society for Neuroscience29(7)2151-61(2009 Feb)
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.
Xu Z, Page RC, Gomes MM, Kohli E, Nix JC, Herr AB, Patterson C, Misra S
Nature structural & molecular biology15(12)1309-17(2008 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
findings support the notion that BAG2 is an upstream regulator of the PINK1/PARKIN signaling pathway.
Title: BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival.
Native Bag2-NTD crystals diffracted to 2.27 A resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 75.5, b = 84.7, c = 114.1 A
Title: Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus.
Free and Hsc70-bound crystal structures of Bag2-BNB show its dimeric structure, in which a flanking linker helix and loop bind to Hsc70 to promote nucleotide exchange.
Title: Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.
The following Bag2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bag2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu77069 | |
Clone ID Related Accession (Same CDS sequence) | XM_017319691.1 | |
Accession Version | XM_017319691.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | BAG family molecular chaperone regulator 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGATCCACA GTATCCAAAA CAGCCAGGAC ATGAGGCAGA TTAGCGATGG AGAAAGAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017175180.1 |
CDS | 224..682 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017319691.1 |
1 | ATGATCCACA GTATCCAAAA CAGCCAGGAC ATGAGGCAGA TTAGCGATGG AGAAAGAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11494 | |
Clone ID Related Accession (Same CDS sequence) | NM_145392.2 | |
Accession Version | NM_145392.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 633bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | BAG family molecular chaperone regulator 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY014303.1, AK144720.1 and BB144537.1. On Apr 15, 2006 this sequence version replaced NM_145392.1. ##Evidence-Data-START## Transcript exon combination :: BC028944.1, AK144720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCCAGG CGAAGATCAG CGCCAAGGCC CACGAGGGCC GCTTCTGCCG CTCGTCTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_663367.1 |
CDS | 60..692 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145392.2 |
1 | ATGGCCCAGG CGAAGATCAG CGCCAAGGCC CACGAGGGCC GCTTCTGCCG CTCGTCTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival. |
Crystallization and preliminary X-ray crystallographic analysis of the Bag2 amino-terminal domain from Mus musculus. |
The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. |
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2. |