Tlx2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tlx2
Entrez Gene ID	21909
Full Name	T cell leukemia, homeobox 2
Synonyms	Enx,Hox11L.1,Hox11l1,NCX,Ncx1,Tlx1l1,Tlx1l2
General protein information	Preferred Names T cell leukemia, homeobox 2 Names T-cell leukemia homeobox protein 2 PMUR10F enteric neuron homeobox protein homeo box 11-like 1 homeobox TLX-2 homeobox protein Hox-11L1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6 C3\|6 35.94 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_009392.2	NP_033418.1	T-cell leukemia homeobox protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TLX2	XP_855075.1
Bos taurus (cattle)	TLX2	NP_001179087.1
Gallus gallus (chicken)	TLX2	XP_004949910.1
	TLX2	XP_001110250.1
Rattus norvegicus (Norway rat)	Tlx2	NP_001165596.1
Homo sapiens (human)	TLX2	NP_057254.1
Mus musculus (house mouse)	Tlx2	NP_033418.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)

Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart.
Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI
Biophysical journal99(3)755-64(2010 Aug)

Ncx (Enx, Hox11L.1) is required for neuronal cell death in enteric ganglia of mice.
Aoki T, Jusuf AA, Iitsuka Y, Isono K, Tokuhisa T, Hatano M
Journal of pediatric surgery42(6)1081-8(2007 Jun)

Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia.
Kintner DB, Luo J, Gerdts J, Ballard AJ, Shull GE, Sun D
American journal of physiology. Cell physiology292(3)C1113-22(2007 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that high subsarcolemmal Ca2+ is required to ensure synchronous triggering with short spark latency in the absence of NCX.
Title: Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart.

Ncx participates in normal developmental cell death of enteric neurons. Ncx may modulate, if not directly target, expression of the caspase-3 at the transcriptional level to participate in neuronal cell death in the enteric nervous system.
Title: Ncx (Enx, Hox11L.1) is required for neuronal cell death in enteric ganglia of mice.

Our study suggests that NKCC1 acting in concert with NCX causes a perturbation of Ca(m)(2+) homeostasis and mitochondrial dysfunction and cell death following in vitro ischemia.
Title: Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia.

Alignment of sequences obtained from rat, human, and mouse indicates that putative regulatory elements of the Hox11L1 gene are conserved in rat, mice, and humans.
Title: Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction.

Intestinal dysmotility in Hox11L1-null animals may not be a primary neural disorder.
Title: Hox11L1 expression by precursors of enteric smooth muscle: an alternative explanation for megacecum in HOX11L1-/- mice.

The following Tlx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tlx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04063	NM_009392.2 Latest version!	Mus musculus T cell leukemia, homeobox 2 (Tlx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tlx2 ( NM_009392.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033418.1 Mus musculus T cell leukemia, homeobox 2 (Tlx2), mRNA.

Price & Availability↑

CloneID	OMu04063
Clone ID Related Accession (Same CDS sequence)	NM_009392.2
Accession Version	NM_009392.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	T-cell leukemia homeobox protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK013072.1, M75953.1 and AC134899.4. On Jul 18, 2005 this sequence version replaced NM_009392.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M75953.1, BC138240.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCCG CGGTGTTGGC TGCGCACCAC CTTCCGCACC ACGAACCCAT CAGCTTCGGC 
ATCGATCAGA TCCTGAGCGG TCCCGAACCC CCGGGGGGCG GTCTGGGTCC CGGTCAGTCG 
GGCCAGAGCC ACGGAGAAAG TGCGGCGTTT TCCAGTGGAT TCCACGGAGC CTCGGGCTAT 
GCTCCAGCCG GCTCGCTGGC CTCCTTGCCT AGAGGCTCGG GAGTGGGCCC CGGCGGCGTG 
ATCCGCGTCC CCGCGCACCG CCCGCTGCCC GTGCCGCCAC CCTCGGGTGC GGCCCCCGCC 
GTGCCCGGAC CCTCTGGTTT GGGTGGCGCC GGGGGCCTAG CGGGACTCAC CTTCCCCTGG 
ATGGACAGCG GCCGCCGCTT TGCAAAGGAC AGGCTCACGG CTGCGCTCTC GCCCTTCTCT 
GGGACACGTC GCATAGGCCA TCCCTACCAA AACCGGACCC CCCCGAAGCG CAAGAAGCCG 
CGCACCTCCT TTTCCCGCTC GCAGGTGCTG GAGCTGGAGC GCCGCTTCTT GCGCCAGAAG 
TACCTGGCCT CCGCAGAGAG GGCGGCGCTG GCCAAGGCCC TGCGCATGAC GGACGCGCAG 
GTCAAGACCT GGTTCCAGAA CCGACGCACC AAGTGGCGGC GCCAGACCGC GGAGGAGCGC 
GAGGCCGAGC GGCACCGCGC TGGTCGCCTG CTGCTGCACC TGCAGCAAGA CGCGCTGCCC 
CGGCCGCTGC GGCCACCGCT GCCACCGGAC CCGCTTTGCC TGCACAACTC GTCGCTCTTC 
GCGCTGCAGA ATCTGCAGCC CTGGGCGGAA GACAACAAGG TGGCTTCGGT GTCCGGGCTC 
GCCTCGGTGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033418.1
CDS	147..1001
Translation	MEPAVLAAHHLPHHEPISFGIDQILSGPEPPGGGLGPGQSGQSHGESAAFSSGFHGASGYAPAGSLASLPRGSGVGPGGVIRVPAHRPLPVPPPSGAAPAVPGPSGLGGAGGLAGLTFPWMDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALPRPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV

Target ORF information:

RefSeq Version	NM_009392.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus T cell leukemia, homeobox 2 (Tlx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009392.2

ORF Insert Sequence:

ATGGAGCCCG CGGTGTTGGC TGCGCACCAC CTTCCGCACC ACGAACCCAT CAGCTTCGGC 
ATCGATCAGA TCCTGAGCGG TCCCGAACCC CCGGGGGGCG GTCTGGGTCC CGGTCAGTCG 
GGCCAGAGCC ACGGAGAAAG TGCGGCGTTT TCCAGTGGAT TCCACGGAGC CTCGGGCTAT 
GCTCCAGCCG GCTCGCTGGC CTCCTTGCCT AGAGGCTCGG GAGTGGGCCC CGGCGGCGTG 
ATCCGCGTCC CCGCGCACCG CCCGCTGCCC GTGCCGCCAC CCTCGGGTGC GGCCCCCGCC 
GTGCCCGGAC CCTCTGGTTT GGGTGGCGCC GGGGGCCTAG CGGGACTCAC CTTCCCCTGG 
ATGGACAGCG GCCGCCGCTT TGCAAAGGAC AGGCTCACGG CTGCGCTCTC GCCCTTCTCT 
GGGACACGTC GCATAGGCCA TCCCTACCAA AACCGGACCC CCCCGAAGCG CAAGAAGCCG 
CGCACCTCCT TTTCCCGCTC GCAGGTGCTG GAGCTGGAGC GCCGCTTCTT GCGCCAGAAG 
TACCTGGCCT CCGCAGAGAG GGCGGCGCTG GCCAAGGCCC TGCGCATGAC GGACGCGCAG 
GTCAAGACCT GGTTCCAGAA CCGACGCACC AAGTGGCGGC GCCAGACCGC GGAGGAGCGC 
GAGGCCGAGC GGCACCGCGC TGGTCGCCTG CTGCTGCACC TGCAGCAAGA CGCGCTGCCC 
CGGCCGCTGC GGCCACCGCT GCCACCGGAC CCGCTTTGCC TGCACAACTC GTCGCTCTTC 
GCGCTGCAGA ATCTGCAGCC CTGGGCGGAA GACAACAAGG TGGCTTCGGT GTCCGGGCTC 
GCCTCGGTGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Gastroenterology(2017 Oct)
Memic F,Knoflach V,Morarach K,Sadler R,Laranjeira C,Hjerling-Leffler J,Sundstr?m E,Pachnis V,Marklund U

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Neuron83(2)309-323(2014 Jul)
Thompson CL,Ng L,Menon V,Martinez S,Lee CK,Glattfelder K,Sunkin SM,Henry A,Lau C,Dang C,Garcia-Lopez R,Martinez-Ferre A,Pombero A,Rubenstein JLR,Wakeman WB,Hohmann J,Dee N,Sodt AJ,Young R,Smith K,Nguyen TN,Kidney J,Kuan L,Jeromin A,Kaykas A,Miller J,Page D,Orta G,Bernard A,Riley Z,Smith S,Wohnoutka P,Hawrylycz MJ,Puelles L,Jones AR

Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart.
Biophysical journal99(3)755-64(2010 Aug)
Neco P,Rose B,Huynh N,Zhang R,Bridge JH,Philipson KD,Goldhaber JI

Ncx (Enx, Hox11L.1) is required for neuronal cell death in enteric ganglia of mice.
Journal of pediatric surgery42(6)1081-8(2007 Jun)
Aoki T,Jusuf AA,Iitsuka Y,Isono K,Tokuhisa T,Hatano M

Role of Na+-K+-Cl- cotransport and Na+/Ca2+ exchange in mitochondrial dysfunction in astrocytes following in vitro ischemia.
American journal of physiology. Cell physiology292(3)C1113-22(2007 Mar)
Kintner DB,Luo J,Gerdts J,Ballard AJ,Shull GE,Sun D

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Tlx2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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