Rpl13a cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Rpl13a
Entrez Gene ID	22121
Full Name	ribosomal protein L13A
Synonyms	1810026N22Rik,Tstap198-7,tum-antigen
General protein information	Preferred Names ribosomal protein L13A Names 60S ribosomal protein L13a tissue specific transplantation antigen P198-7 transplantation antigen P198 tum-P198 antigen tum-transplantation antigen P198
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7 B3\|7 29.14 cM

mRNA and Protein(s)

mRNA Protein Name

NM_009438.5 NP_033464.2 60S ribosomal protein L13a
Pathways from BioSystems

mRNA	Protein	Name
NM_009438.5	NP_033464.2	60S ribosomal protein L13a

Homologies

Schizosaccharomyces pombe (fission yeast)	rpl1602	NP_594441.1
Xenopus tropicalis (tropical clawed frog)	rpl13a	NP_001016486.1
Mus musculus (house mouse)	Rpl13a	NP_033464.2
Rattus norvegicus (Norway rat)	Rpl13a	NP_775462.2
Danio rerio (zebrafish)	rpl13a	NP_997949.1
Caenorhabditis elegans (roundworm)	rpl-16	NP_497721.1
Neurospora crassa	NCU01221	XP_961587.1
Pan troglodytes (chimpanzee)	RPL13A	XP_003953607.1
	RPL13A	XP_001115079.1
Canis lupus familiaris (dog)	RPL13A	XP_003432774.1
Eremothecium gossypii	AGOS_AER367C	NP_985223.1
Magnaporthe oryzae (rice blast fungus)	MGG_05449	XP_003710310.1
Homo sapiens (human)	RPL13A	NP_036555.1
Drosophila melanogaster (fruit fly)	RpL13A	NP_649560.1
Kluyveromyces lactis	KLLA0F04675g	XP_455291.1
Schizosaccharomyces pombe (fission yeast)	rpl1601	NP_595253.1
Bos taurus (cattle)	RPL13A	NP_001070466.1
Schizosaccharomyces pombe (fission yeast)	rpl1603	NP_596434.1

Gene Ontology
Bibliography

Related articles in PubMed

Nuclear export factor 3 regulates localization of small nucleolar RNAs.
Li MW, Sletten AC, Lee J, Pyles KD, Matkovich SJ, Ory DS, Schaffer JE
The Journal of biological chemistry292(49)20228-20239(2017 12)

Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE
The Journal of clinical investigation126(12)4616-4625(2016 Dec)

L13a-dependent translational control in macrophages limits the pathogenesis of colitis.
Poddar D, Kaur R, Baldwin WM 3rd, Mazumder B
Cellular & molecular immunology13(6)816-827(2016 Nov)

Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation.
Basu A, Poddar D, Robinet P, Smith JD, Febbraio M, Baldwin WM 3rd, Mazumder B
Arteriosclerosis, thrombosis, and vascular biology34(3)533-42(2014 Mar)

An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation.
Poddar D, Basu A, Baldwin WM 3rd, Kondratov RV, Barik S, Mazumder B
Journal of immunology (Baltimore, Md. : 1950)190(7)3600-12(2013 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified nuclear export factor 3 (NXF3) as a transporter that alters the nucleocytoplasmic distribution of box C/D snoRNAs from the ribosomal protein L13a (Rpl13a) locus
Title: Nuclear export factor 3 regulates localization of small nucleolar RNAs.

Loss of Rpl13a snoRNAs altered mitochondrial metabolism and lowered reactive oxygen species tone, leading to increased glucose-stimulated insulin secretion from pancreatic islets and enhanced systemic glucose tolerance.
Title: Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.

these results reveal an essential role for L13a in the endogenous protection against ulcerative colitis.
Title: L13a-dependent translational control in macrophages limits the pathogenesis of colitis.

Loss of L13a in macrophages increases susceptibility to atherosclerosis in apolipoprotein E-deficient mice, revealing an important role of L13a-dependent translational control as an endogenous protection mechanism against atherosclerosis.
Title: Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation.

our studies provide the first evidence of an essential extraribosomal function of ribosomal protein L13a in resolving physiological inflammation in a mammalian host.
Title: An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation.

The following Rpl13a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rpl13a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18419	NM_009438.5 Latest version!	Mus musculus ribosomal protein L13A (Rpl13a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rpl13a ( NM_009438.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_033464.2 Mus musculus ribosomal protein L13A (Rpl13a), mRNA.

Price & Availability↑

CloneID	OMu18419
Clone ID Related Accession (Same CDS sequence)	NM_009438.5
Accession Version	NM_009438.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Mus musculus(house mouse)
Product	60S ribosomal protein L13a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AV445288.1, BC086896.1 and BC042392.1. On or before Jun 3, 2011 this sequence version replaced XR_105101.1, XR_105102.1, XR_107897.1, NM_009438.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146318.1, AK077512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGG GGCAGGTTCT GGTATTGGAT GGCCGAGGCC ATCTTCTTGG CCGCCTGGCG 
GCCATTGTGG CCAAGCAGGT ACTTCTGGGC CGGAAGGTGG TGGTCGTACG CTGTGAAGGC 
ATCAACATTT CTGGAAACTT CTACAGAAAC AAGTTAAAGT ATCTGGCCTT TCTCCGGAAG 
CGGATGAATA CCAACCCCTC CCGAGGCCCC TACCACTTCC GAGCCCCCAG CCGCATTTTC 
TGGCGCACTG TGCGAGGCAT GCTGCCCCAC AAGACCAAGA GAGGCCAGGC TGCCCTGGAG 
CGCCTCAAGG TGTTGGATGG GATCCCTCCA CCCTATGACA AGAAAAAGCG GATGGTGGTC 
CCTGCTGCTC TCAAGGTTGT TCGGCTGAAG CCTACCAGAA AGTTTGCTTA CCTGGGGCGT 
CTGGCGCATG AGGTCGGGTG GAAGTACCAG GCAGTGACAG CCACTCTGGA GGAGAAACGG 
AAGGAAAAGG CCAAGATGCA CTATCGGAAG AAGAAGCAGA TCTTGAGGTT ACGGAAACAG 
GCAGAAAAGA ATGTGGAGAA GAAAATCTGC AAGTTCACAG AGGTCCTCAA GACCAACGGA 
CTCCTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_033464.2
CDS	32..643
Translation	MAEGQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALERLKVLDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKMHYRKKKQILRLRKQAEKNVEKKICKFTEVLKTNGLLV

Target ORF information:

RefSeq Version	NM_009438.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus ribosomal protein L13A (Rpl13a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_009438.5

ORF Insert Sequence:

ATGGCGGAGG GGCAGGTTCT GGTATTGGAT GGCCGAGGCC ATCTTCTTGG CCGCCTGGCG 
GCCATTGTGG CCAAGCAGGT ACTTCTGGGC CGGAAGGTGG TGGTCGTACG CTGTGAAGGC 
ATCAACATTT CTGGAAACTT CTACAGAAAC AAGTTAAAGT ATCTGGCCTT TCTCCGGAAG 
CGGATGAATA CCAACCCCTC CCGAGGCCCC TACCACTTCC GAGCCCCCAG CCGCATTTTC 
TGGCGCACTG TGCGAGGCAT GCTGCCCCAC AAGACCAAGA GAGGCCAGGC TGCCCTGGAG 
CGCCTCAAGG TGTTGGATGG GATCCCTCCA CCCTATGACA AGAAAAAGCG GATGGTGGTC 
CCTGCTGCTC TCAAGGTTGT TCGGCTGAAG CCTACCAGAA AGTTTGCTTA CCTGGGGCGT 
CTGGCGCATG AGGTCGGGTG GAAGTACCAG GCAGTGACAG CCACTCTGGA GGAGAAACGG 
AAGGAAAAGG CCAAGATGCA CTATCGGAAG AAGAAGCAGA TCTTGAGGTT ACGGAAACAG 
GCAGAAAAGA ATGTGGAGAA GAAAATCTGC AAGTTCACAG AGGTCCTCAA GACCAACGGA 
CTCCTGGTGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Nuclear export factor 3 regulates localization of small nucleolar RNAs.
The Journal of biological chemistry292(49)20228-20239(2017 12)
Li MW,Sletten AC,Lee J,Pyles KD,Matkovich SJ,Ory DS,Schaffer JE

Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.
The Journal of clinical investigation126(12)4616-4625(2016 Dec)
Lee J,Harris AN,Holley CL,Mahadevan J,Pyles KD,Lavagnino Z,Scherrer DE,Fujiwara H,Sidhu R,Zhang J,Huang SC,Piston DW,Remedi MS,Urano F,Ory DS,Schaffer JE

L13a-dependent translational control in macrophages limits the pathogenesis of colitis.
Cellular & molecular immunology13(6)816-827(2016 Nov)
Poddar D,Kaur R,Baldwin WM 3rd,Mazumder B

Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation.
Arteriosclerosis, thrombosis, and vascular biology34(3)533-42(2014 Mar)
Basu A,Poddar D,Robinet P,Smith JD,Febbraio M,Baldwin WM 3rd,Mazumder B

An extraribosomal function of ribosomal protein L13a in macrophages resolves inflammation.
Journal of immunology (Baltimore, Md. : 1950)190(7)3600-12(2013 Apr)
Poddar D,Basu A,Baldwin WM 3rd,Kondratov RV,Barik S,Mazumder B

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Rpl13a cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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