Ubc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Ubc
Entrez Gene ID	22190
Full Name	ubiquitin C
Synonyms	2700054O04Rik,AI194771,Rps27a,TI-225,Uba52,Ubb
General protein information	Preferred Names ubiquitin C Names polyubiquitin-C polyubiquitin C
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 G1.1\|5 64.18 cM

mRNA and Protein(s)

mRNA Protein Name

NM_019639.4 NP_062613.3 polyubiquitin-C
Pathways from BioSystems

mRNA	Protein	Name
NM_019639.4	NP_062613.3	polyubiquitin-C

Homologies

	LOC712934	XP_002798876.1
Homo sapiens (human)	UBC	NP_066289.2
Bos taurus (cattle)	UBC	NP_001193236.1
Drosophila melanogaster (fruit fly)	Ubi-p63E	NP_001261383.1
Arabidopsis thaliana (thale cress)	UBQ8	NP_566357.1
Pan troglodytes (chimpanzee)	UBC	NP_001129078.1
Mus musculus (house mouse)	Ubc	NP_062613.3
Rattus norvegicus (Norway rat)	Ubc	NP_059010.1
Canis lupus familiaris (dog)	UBC	XP_853060.1
Xenopus tropicalis (tropical clawed frog)	ubb	XP_004911738.1

Gene Ontology
Bibliography

Related articles in PubMed

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P
American journal of human genetics100(5)706-724(2017 May)

Motor neurons control blood vessel patterning in the developing spinal cord.
Himmels P, Paredes I, Adler H, Karakatsani A, Luck R, Marti HH, Ermakova O, Rempel E, Stoeckli ET, Ruiz de Almod?var C
Nature communications814583(2017 Mar)

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osborne G, Bates GP, Glickman MH, Trost M, Knebel A, Marchesi F, Kurz T
Cell166(4)935-949(2016 Aug)

Identification of Novel Host Interactors of Effectors Secreted by
Sontag RL, Nakayasu ES, Brown RN, Niemann GS, Sydor MA, Sanchez O, Ansong C, Lu SY, Choi H, Valleau D, Weitz KK, Savchenko A, Cambronne ED, Adkins JN
mSystems1(4)(2016 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ubc-/- mouse embryonic fibroblasts (MEFs) exhibited reduced viability under As(III) exposure, although the Nrf2-Keap1 pathway was activated as a cytoprotective response.
Title: Disruption of polyubiquitin gene Ubc leads to attenuated resistance against arsenite-induced toxicity in mouse embryonic fibroblasts.

phosphorylation of Parkin at Ser-65 following dissipation of DeltaPsim triggers ubiquitin-ester transfer by the RING2 domain of Parkin to Cys-431.
Title: Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.

Defective proliferation of fetal liver cells contributes to severe reduction of fetal liver size and potentially mid-gestation lethality of Ubc-deficient embryos
Title: Disruption of polyubiquitin gene Ubc leads to defective proliferation of hepatocytes and bipotent fetal liver epithelial progenitor cells.

Data indicate that Ubc and Ywhaz were best correlated for B cells and lymphocytes, whereas Ubc and Gapdh were the best combination for non-B cells, and Actb and Hprt1 were the least stably expressed genes for B cells and non-B cell.
Title: Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes.

the lethality of Ubc(-/-) embryos is not the result of intrinsic HSC failure
Title: Perturbation of the hematopoietic system during embryonic liver development due to disruption of polyubiquitin gene Ubc in mice.

The following Ubc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ubc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu21038	NM_019639.4 Latest version!	Mus musculus ubiquitin C (Ubc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ubc ( NM_019639.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062613.3 Mus musculus ubiquitin C (Ubc), mRNA.

Price & Availability↑

CloneID	OMu21038
Clone ID Related Accession (Same CDS sequence)	NM_019639.4
Accession Version	NM_019639.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2205bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Mus musculus(house mouse)
Product	polyubiquitin-C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF172065.1, AC138613.6 and AI839133.1. On Sep 26, 2007 this sequence version replaced NM_019639.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF172065.1, CA319141.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGATCT TTGTGAAAAC CTTAACTGGT AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATTG AGAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTC CTTCGCCTCA GAGGTGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATAGAG 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTCCT TCGCCTCAGA GGTGGGATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATAGAGAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTCCTTC GCCTCAGAGG TGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATTGAGAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAAGAGTCCA CCCTGCACTT AGTCCTTCGC 
CTCAGAGGTG GGATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAAACCAT CACCCTGGAG 
GTCGAGCCCA GTGACACCAT TGAGAATGTC AAGGCAAAGA TCCAGGACAA GGAGGGCATC 
CCCCCTGACC AGCAGAGGCT GATCTTTGCA GGCAAGCAGC TGGAAGATGG CCGCACCCTG 
TCAGACTACA ACATCCAGAA AGAGTCCACC CTGCACCTGG TCCTTCGCCT CAGAGGTGGG 
ATGCAGATCT TTGTGAAGAC CCTGACAGGC AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATAG AGAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTC CTTCGCCTCA GAGGTGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATAGAG 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTCCT TCGCCTCAGA GGTGGGATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATAGAGAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTCCTTC GCCTCAGAGG TGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATAGAGAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAAGAGTCCA CCCTGCACCT GGTCCTTCGC 
CTCAGAGGTG GCATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAGACCAT CACCCTGGAC 
GTCGAGCCCA GTGTTACCAC CAAGAAGGTC AAACAGGAAG ACAGACGTAC CTTCCTCACC 
ACAGTATCTA AAAAGAGCCC TCCTTGTGCT TGTTCTTGGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062613.3
CDS	112..2316
Translation	MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLDVEPSVTTKKVKQEDRRTFLTTVSKKSPPCACSWV

Target ORF information:

RefSeq Version	NM_019639.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquitin C (Ubc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019639.4

ORF Insert Sequence:

ATGCAGATCT TTGTGAAAAC CTTAACTGGT AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATTG AGAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTC CTTCGCCTCA GAGGTGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATAGAG 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTCCT TCGCCTCAGA GGTGGGATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATAGAGAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTCCTTC GCCTCAGAGG TGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATTGAGAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAAGAGTCCA CCCTGCACTT AGTCCTTCGC 
CTCAGAGGTG GGATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAAACCAT CACCCTGGAG 
GTCGAGCCCA GTGACACCAT TGAGAATGTC AAGGCAAAGA TCCAGGACAA GGAGGGCATC 
CCCCCTGACC AGCAGAGGCT GATCTTTGCA GGCAAGCAGC TGGAAGATGG CCGCACCCTG 
TCAGACTACA ACATCCAGAA AGAGTCCACC CTGCACCTGG TCCTTCGCCT CAGAGGTGGG 
ATGCAGATCT TTGTGAAGAC CCTGACAGGC AAGACCATCA CCCTGGAGGT CGAGCCCAGT 
GACACCATAG AGAATGTCAA GGCAAAGATC CAGGACAAGG AGGGCATCCC CCCTGACCAG 
CAGAGGCTGA TCTTTGCAGG CAAGCAGCTG GAAGATGGCC GCACCCTGTC AGACTACAAC 
ATCCAGAAAG AGTCCACCCT GCACCTGGTC CTTCGCCTCA GAGGTGGCAT GCAGATCTTT 
GTGAAGACCC TGACAGGCAA GACCATCACC CTGGAGGTCG AGCCCAGTGA CACCATAGAG 
AATGTCAAGG CAAAGATCCA GGACAAGGAG GGCATCCCCC CTGACCAGCA GAGGCTGATC 
TTTGCAGGCA AGCAGCTGGA AGATGGCCGC ACCCTGTCAG ACTACAACAT CCAGAAAGAG 
TCCACCCTGC ACCTGGTCCT TCGCCTCAGA GGTGGGATGC AGATCTTTGT GAAGACCCTG 
ACAGGCAAGA CCATCACCCT GGAGGTCGAG CCCAGTGACA CCATAGAGAA TGTCAAGGCA 
AAGATCCAGG ACAAGGAGGG CATCCCCCCT GACCAGCAGA GGCTGATCTT TGCAGGCAAG 
CAGCTGGAAG ATGGCCGCAC CCTGTCAGAC TACAACATCC AGAAAGAGTC CACCCTGCAC 
CTGGTCCTTC GCCTCAGAGG TGGCATGCAG ATCTTTGTGA AGACCCTGAC AGGCAAGACC 
ATCACCCTGG AGGTCGAGCC CAGTGACACC ATAGAGAATG TCAAGGCAAA GATCCAGGAC 
AAGGAGGGCA TCCCCCCTGA CCAGCAGAGG CTGATCTTTG CAGGCAAGCA GCTGGAAGAT 
GGCCGCACCC TGTCAGACTA CAACATCCAG AAAGAGTCCA CCCTGCACCT GGTCCTTCGC 
CTCAGAGGTG GCATGCAGAT CTTTGTGAAG ACCCTGACAG GCAAGACCAT CACCCTGGAC 
GTCGAGCCCA GTGTTACCAC CAAGAAGGTC AAACAGGAAG ACAGACGTAC CTTCCTCACC 
ACAGTATCTA AAAAGAGCCC TCCTTGTGCT TGTTCTTGGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
American journal of human genetics100(5)706-724(2017 May)
Hall EA,Nahorski MS,Murray LM,Shaheen R,Perkins E,Dissanayake KN,Kristaryanto Y,Jones RA,Vogt J,Rivagorda M,Handley MT,Mali GR,Quidwai T,Soares DC,Keighren MA,McKie L,Mort RL,Gammoh N,Garcia-Munoz A,Davey T,Vermeren M,Walsh D,Budd P,Aligianis IA,Faqeih E,Quigley AJ,Jackson IJ,Kulathu Y,Jackson M,Ribchester RR,von Kriegsheim A,Alkuraya FS,Woods CG,Maher ER,Mill P

Motor neurons control blood vessel patterning in the developing spinal cord.
Nature communications814583(2017 Mar)
Himmels P,Paredes I,Adler H,Karakatsani A,Luck R,Marti HH,Ermakova O,Rempel E,Stoeckli ET,Ruiz de Almod?var C

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Cell166(4)935-949(2016 Aug)
Hjerpe R,Bett JS,Keuss MJ,Solovyova A,McWilliams TG,Johnson C,Sahu I,Varghese J,Wood N,Wightman M,Osborne G,Bates GP,Glickman MH,Trost M,Knebel A,Marchesi F,Kurz T

Identification of Novel Host Interactors of Effectors Secreted by
mSystems1(4)(2016 Jul-Aug)
Sontag RL,Nakayasu ES,Brown RN,Niemann GS,Sydor MA,Sanchez O,Ansong C,Lu SY,Choi H,Valleau D,Weitz KK,Savchenko A,Cambronne ED,Adkins JN

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Ubc cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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