Fbxo2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fbxo2
Entrez Gene ID	230904
Full Name	F-box protein 2
Synonyms	FBG1,FBX2,Fbs1,Fbs2,NFB42,Prpl4
General protein information	Preferred Names F-box protein 2 Names F-box only protein 2 prion protein ligand 4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4 E2\|4 78.68 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006538814.2	XP_006538877.1	F-box only protein 2 isoform X1
NM_176848.1	NP_789818.1	F-box only protein 2
XM_006538814.4	XP_006538877.1	F-box only protein 2 isoform X1
XM_006538814.3	XP_006538877.1	F-box only protein 2 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FBXO2	NP_001069037.1
Gallus gallus (chicken)	FBXO2	XP_004947571.1
Danio rerio (zebrafish)	zgc:175088	NP_001107270.1
Xenopus tropicalis (tropical clawed frog)	LOC101733128	XP_004916577.1
Mus musculus (house mouse)	Fbxo2	NP_789818.1
Homo sapiens (human)	FBXO2	NP_036300.2
Pan troglodytes (chimpanzee)	FBXO2	XP_514389.2
Canis lupus familiaris (dog)	FBXO2	XP_535406.3
Rattus norvegicus (Norway rat)	Fbxo2	NP_445963.1

Gene Ontology
Bibliography

Related articles in PubMed

Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice.
Liu B, Lu H, Li D, Xiong X, Gao L, Wu Z, Lu Y
Diabetes66(3)689-698(2017 03)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.
Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H
The Journal of neuroscience : the official journal of the Society for Neuroscience35(15)6165-78(2015 Apr)

FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
Wen JH, Wen H, Gibson-Corley KN, Glenn KA
PloS one10(8)e0135591(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

F-box only protein 2 (FBXO2), a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex, was upregulated in livers of obese mice. Furthermore, using a protein purification approach combined with high-performance liquid chromatography/tandem mass spectrometry, we carried out a system-wide screening of FBXO2 substrates, in which the insulin receptor (IR) was identified as a substrate
Title: Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice.

The results of this study suggested that Fbxo2 controls the abundance and localization of specific NMDAR subunits in the brain and may influence synapse formation and maintenance.
Title: Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.

FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy.
Title: FBG1 Is the Final Arbitrator of A1AT-Z Degradation.

these results suggest that Fbxo2 regulates APP levels and processing in the brain and may play a role in modulating Alzheimer disease pathogenesis.
Title: F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing.

our studies support a non-essential role for FBG1 on the degradation of torsinA and uncover a novel link of FBG1 to the autophagy pathway.
Title: The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy.

The following Fbxo2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbxo2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu06264	NM_176848.1 Latest version!	Mus musculus F-box protein 2 (Fbxo2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu06264	XM_006538814.4 Latest version!	Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OMu06264	XM_006538814.2	Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
OMu06264	XM_006538814.3	Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fbxo2 ( NM_176848.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_789818.1 Mus musculus F-box protein 2 (Fbxo2), mRNA.

Price & Availability↑

CloneID	OMu06264
Clone ID Related Accession (Same CDS sequence)	XM_006538814.2 , NM_176848.1 , XM_006538814.4 , XM_006538814.3
Accession Version	NM_176848.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	F-box only protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC046586.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC046586.1, AK140175.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_789818.1
CDS	23..916
Translation	MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQLREAEEEEEAEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWRVEELPGDNGVEFTQDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENEDVLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Target ORF information:

RefSeq Version	NM_176848.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus F-box protein 2 (Fbxo2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_176848.1

ORF Insert Sequence:

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fbxo2 ( XM_006538814.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006538877.1 Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu06264
Clone ID Related Accession (Same CDS sequence)	XM_006538814.2 , NM_176848.1 , XM_006538814.4 , XM_006538814.3
Accession Version	XM_006538814.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	F-box only protein 2 isoform X1
Comment

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006538877.1
Translation	MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQLREAEEEEEAEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWRVEELPGDNGVEFTQDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENEDVLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Target ORF information:

RefSeq Version	XM_006538814.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006538814.2

ORF Insert Sequence:

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fbxo2 ( XM_006538814.4 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006538877.1 Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu06264
Clone ID Related Accession (Same CDS sequence)	XM_006538814.2 , NM_176848.1 , XM_006538814.4 , XM_006538814.3
Accession Version	XM_006538814.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	F-box only protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006538814.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006538877.1
CDS	116..1009
Translation	MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQLREAEEEEEAEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWRVEELPGDNGVEFTQDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENEDVLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Target ORF information:

RefSeq Version	XM_006538814.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006538814.4

ORF Insert Sequence:

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fbxo2 ( XM_006538814.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006538877.1 Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu06264
Clone ID Related Accession (Same CDS sequence)	XM_006538814.2 , NM_176848.1 , XM_006538814.4 , XM_006538814.3
Accession Version	XM_006538814.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	F-box only protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006538814.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006538877.1
CDS	110..1003
Translation	MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQLREAEEEEEAEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWRVEELPGDNGVEFTQDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENEDVLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP

Target ORF information:

RefSeq Version	XM_006538814.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus F-box protein 2 (Fbxo2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006538814.3

ORF Insert Sequence:

ATGGATGGAG ATGGTGATCC AGAGAGTGTG AGCCACCCCG AAGAAGCGAG CCCAGAGGAG 
CAGCCAGAGG AGGCGGGCGC CGAGGCGAGT GCGGAGGAGG AGCAGCTCCG GGAGGCGGAG 
GAGGAGGAAG AGGCGGAGGC CGTGGAGTAC CTGGCCGAGC TGCCGGAGCC ACTGCTGCTG 
CGCGTGCTGG CCGAGCTGCC AGCTACGGAG CTGGTGCAGG CCTGCCGCCT GGTGTGCCTG 
CGCTGGAAGG AGCTGGTGGA CGGCGCCCCA CTGTGGCTGC TCAAGTGCCA GCAGGAGGGG 
CTGGTGCCCG AGGGCAGCGC TGATGAGGAG CGGGACCACT GGCAACAGTT CTACTTTCTG 
AGCAAGAGGA GGCGCAACCT GCTGCGCAAC CCTTGTGGGG AAGAGGACTT GGAGGGCTGG 
AGCGACGTGG AGCACGGTGG GGACGGCTGG AGGGTGGAGG AACTGCCCGG AGACAATGGG 
GTGGAATTTA CCCAAGATGA CAGCGTTAAG AAATACTTCG CCTCCTCCTT CGAGTGGTGT 
CGCAAAGCGC AGGTCATTGA TCTGCAGGCA GAGGGCTACT GGGAGGAGCT ACTGGACACC 
ACCCAGCCCG CCATCGTGGT GAAGGACTGG TACTCGGGTC GCACTGATGC GGGCAGCCTG 
TATGAGCTCA CTGTGAGGCT GCTGTCGGAG AACGAAGATG TGCTGGCGGA GTTCGCTACA 
GGACAGGTGG CTGTGCCAGA GGACGGCAGT TGGATGGAGA TCTCCCACAC CTTCATCGAC 
TACGGGCCAG GTGTCCGCTT TGTCCGCTTC GAGCACGGAG GGCAGGACTC GGTCTACTGG 
AAGGGCTGGT TCGGGGCCCG GGTGACCAAC AGTAGCGTGT GGGTGGAACC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice.
Diabetes66(3)689-698(2017 03)
Liu B,Lu H,Li D,Xiong X,Gao L,Wu Z,Lu Y

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(15)6165-78(2015 Apr)
Atkin G,Moore S,Lu Y,Nelson RF,Tipper N,Rajpal G,Hunt J,Tennant W,Hell JW,Murphy GG,Paulson H

FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
PloS one10(8)e0135591(2015)
Wen JH,Wen H,Gibson-Corley KN,Glenn KA

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Fbxo2 cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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