Agr2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Agr2
Entrez Gene ID	23795
Full Name	anterior gradient 2
Synonyms	Agr2h,Gob-4,HAG-2,XAG-2,mAG-2
General protein information	Preferred Names anterior gradient 2 Names anterior gradient protein 2 homolog AG-2 anterior gradient 2 homolog protein Gob-4 secreted cement gland protein XAG-2 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 A3

mRNA and Protein(s)

mRNA Protein Name

NM_011783.2 NP_035913.1 anterior gradient protein 2 homolog precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_011783.2	NP_035913.1	anterior gradient protein 2 homolog precursor

Homologies

	AGR2	XP_001105285.1
Canis lupus familiaris (dog)	AGR2	XP_003431957.1
Mus musculus (house mouse)	Agr2	NP_035913.1
Xenopus tropicalis (tropical clawed frog)	agr2	NP_001016627.1
Homo sapiens (human)	AGR2	NP_006399.1
Danio rerio (zebrafish)	agr2	NP_001012499.1
Pan troglodytes (chimpanzee)	AGR2	XP_003318380.1
Bos taurus (cattle)	AGR2	NP_001035590.1
Rattus norvegicus (Norway rat)	Agr2	NP_001100195.1
Gallus gallus (chicken)	AGR2	XP_004939390.1

Gene Ontology
Bibliography

Related articles in PubMed

Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain.
Zhu Q, Mangukiya HB, Mashausi DS, Guo H, Negi H, Merugu SB, Wu Z, Li D
The FEBS journal284(17)2856-2869(2017 Sep)

ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.
Dumartin L, Alrawashdeh W, Trabulo SM, Radon TP, Steiger K, Feakins RM, di Magliano MP, Heeschen C, Esposito I, Lemoine NR, Crnogorac-Jurcevic T
Oncogene36(22)3094-3103(2017 Jun)

Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.
Wodziak D, Dong A, Basin MF, Lowe AW
PloS one11(10)e0164968(2016)

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.
Bonser LR, Schroeder BW, Ostrin LA, Baumlin N, Olson JL, Salathe M, Erle DJ
American journal of respiratory cell and molecular biology53(4)536-43(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

AGR2 accelerates skin wound healing through regulation of cell migration.
Title: Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain.

AGR2 induced in ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cells with an important functional role in PDAC initiation.
Title: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.

impact of AGR2 expression and EGFR signaling on tissue regeneration
Title: Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.

EGFR-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression.
Title: Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface.

AGR2 has both intracellular and extracellular effects in the intestine
Title: AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus.

The following Agr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Agr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13478	NM_011783.2 Latest version!	Mus musculus anterior gradient 2 (Agr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Agr2 ( NM_011783.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_035913.1 Mus musculus anterior gradient 2 (Agr2), mRNA.

Price & Availability↑

CloneID	OMu13478
Clone ID Related Accession (Same CDS sequence)	NM_011783.2
Accession Version	NM_011783.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Mus musculus(house mouse)
Product	anterior gradient protein 2 homolog precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CT030196.9. On Nov 17, 2006 this sequence version replaced NM_011783.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF044262.1, DV039513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAAAT TTTCAGTGTC TGCAATCCTG CTTCTTGTGG CCATTTCTGG TACCTTGGCC 
AAAGACACCA CAGTCAAATC TGGAGCCAAA AAGGACCCAA AGGACTCTCG GCCCAAACTA 
CCTCAGACAC TCTCCAGAGG TTGGGGCGAT CAGCTCATCT GGACTCAGAC ATACGAAGAA 
GCTTTATACA GATCCAAGAC AAGCAACAGA CCCTTGATGG TCATTCATCA CTTGGACGAA 
TGCCCACACA GTCAAGCCTT AAAGAAAGTG TTTGCTGAAC ATAAAGAAAT CCAGAAATTG 
GCAGAGCAGT TTGTTCTCCT CAACCTGGTC TATGAAACAA CTGACAAGCA CCTTTCTCCT 
GATGGCCAGT ATGTCCCCAG AATTGTGTTT GTAGACCCAT CCCTGACGGT GAGGGCAGAC 
ATCACTGGAC GATACTCAAA CCGGCTCTAC GCTTATGAAC CTTCTGACAC AGCTCTGTTG 
TACGACAACA TGAAGAAAGC TCTCAAGCTG CTAAAGACAG AATTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_035913.1
CDS	53..580
Translation	MEKFSVSAILLLVAISGTLAKDTTVKSGAKKDPKDSRPKLPQTLSRGWGDQLIWTQTYEEALYRSKTSNRPLMVIHHLDECPHSQALKKVFAEHKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIVFVDPSLTVRADITGRYSNRLYAYEPSDTALLYDNMKKALKLLKTEL

Target ORF information:

RefSeq Version	NM_011783.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus anterior gradient 2 (Agr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_011783.2

ORF Insert Sequence:

ATGGAGAAAT TTTCAGTGTC TGCAATCCTG CTTCTTGTGG CCATTTCTGG TACCTTGGCC 
AAAGACACCA CAGTCAAATC TGGAGCCAAA AAGGACCCAA AGGACTCTCG GCCCAAACTA 
CCTCAGACAC TCTCCAGAGG TTGGGGCGAT CAGCTCATCT GGACTCAGAC ATACGAAGAA 
GCTTTATACA GATCCAAGAC AAGCAACAGA CCCTTGATGG TCATTCATCA CTTGGACGAA 
TGCCCACACA GTCAAGCCTT AAAGAAAGTG TTTGCTGAAC ATAAAGAAAT CCAGAAATTG 
GCAGAGCAGT TTGTTCTCCT CAACCTGGTC TATGAAACAA CTGACAAGCA CCTTTCTCCT 
GATGGCCAGT ATGTCCCCAG AATTGTGTTT GTAGACCCAT CCCTGACGGT GAGGGCAGAC 
ATCACTGGAC GATACTCAAA CCGGCTCTAC GCTTATGAAC CTTCTGACAC AGCTCTGTTG 
TACGACAACA TGAAGAAAGC TCTCAAGCTG CTAAAGACAG AATTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Anterior gradient 2 is induced in cutaneous wound and promotes wound healing through its adhesion domain.
The FEBS journal284(17)2856-2869(2017 Sep)
Zhu Q,Mangukiya HB,Mashausi DS,Guo H,Negi H,Merugu SB,Wu Z,Li D

ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation.
Oncogene36(22)3094-3103(2017 Jun)
Dumartin L,Alrawashdeh W,Trabulo SM,Radon TP,Steiger K,Feakins RM,di Magliano MP,Heeschen C,Esposito I,Lemoine NR,Crnogorac-Jurcevic T

Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.
PloS one11(10)e0164968(2016)
Wodziak D,Dong A,Basin MF,Lowe AW

The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.
American journal of respiratory cell and molecular biology53(4)536-43(2015 Oct)
Bonser LR,Schroeder BW,Ostrin LA,Baumlin N,Olson JL,Salathe M,Erle DJ

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Agr2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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