Gene Symbol | Clec5a |
Entrez Gene ID | 23845 |
Full Name | C-type lectin domain family 5, member a |
Synonyms | Clecsf5,Ly100,MDL-1,Mdl1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Clec5a cDNA ORF clone
Gene Symbol | Clec5a |
Entrez Gene ID | 23845 |
Full Name | C-type lectin domain family 5, member a |
Synonyms | Clecsf5,Ly100,MDL-1,Mdl1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001038604.1 | NP_001033693.1 | C-type lectin domain family 5 member A isoform 1 |
NM_021364.2 | NP_067339.1 | C-type lectin domain family 5 member A isoform 2 |
Pan troglodytes (chimpanzee) | CLEC5A | XP_001156954.1 |
CLEC5A | XP_001085243.1 | |
Mus musculus (house mouse) | Clec5a | NP_001033693.1 |
Canis lupus familiaris (dog) | CLEC5A | XP_851464.3 |
Rattus norvegicus (Norway rat) | Clec5a | NP_001102847.1 |
Homo sapiens (human) | CLEC5A | NP_037384.1 |
Bos taurus (cattle) | CLEC5A | NP_001193132.1 |
The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival.
Xiong W, Wang H, Lu L, Xi R, Wang F, Gu G, Tao R
Journal of translational medicine15(1)234(2017 Nov)
CLEC5A is a critical receptor in innate immunity against Listeria infection.
Chen ST, Li FJ, Hsu TY, Liang SM, Yeh YC, Liao WY, Chou TY, Chen NJ, Hsiao M, Yang WB, Hsieh SL
Nature communications8(1)299(2017 08)
CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo.
Teng O, Chen ST, Hsu TL, Sia SF, Cole S, Valkenburg SA, Hsu TY, Zheng JT, Tu W, Bruzzone R, Peiris JS, Hsieh SL, Yen HL
Journal of virology91(1)(2017 Jan)
CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis.
Huang YL, Chen ST, Liu RS, Chen YH, Lin CY, Huang CH, Shu PY, Liao CL, Hsieh SL
Journal of molecular medicine (Berlin, Germany)94(9)1025-37(2016 Sep)
Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.
Wortham BW, Eppert BL, Flury JL, Garcia SM, Donica WR, Osterburg A, Joyce-Shaikh B, Cua DJ, Borchers MT
Journal of immunology (Baltimore, Md. : 1950)196(8)3227-31(2016 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show that C-type lectin member 5A (CLEC5A) is needed for optimal reactive oxygen species (ROS) production, neutrophil extracellular traps (NETs) formation and other immune responses to Listeria monocytogenes in mice.
Title: CLEC5A is a critical receptor in innate immunity against Listeria infection.
The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals.
Title: CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo.
cigarette smoke-induced macrophage responsiveness is mediated by CLEC5A, and CLEC5A is required for the development of inflammation, proinflammatory cytokine expression, and airspace enlargement.
Title: Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.
Japanese encephalitis virus (JEV) directly interacts with CLEC5A and induces DAP12 phosphorylation in macrophages.
Title: CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality.
triggering of MDL-1 on immature myeloid cells and production of NO and TNF-alpha may play a critical role in the pathogenesis of shock
Title: Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice.
The following Clec5a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clec5a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu23494 | |
Clone ID Related Accession (Same CDS sequence) | NM_021364.2 | |
Accession Version | NM_021364.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Mus musculus(house mouse) | |
Product | C-type lectin domain family 5 member A isoform 2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BY205833.1, AK137482.1 and AK036697.1. On Jan 5, 2006 this sequence version replaced NM_021364.1. Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK036697.1, AK137482.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849381 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAACTGGC ACATGATCAT CTCGGGGCTT ATCGTAGTAG TGATCAAAGT TGTTGGAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067339.1 |
CDS | 180..677 |
Translation |
Target ORF information:
Target ORF information:
|
NM_021364.2 |
1 | ATGAACTGGC ACATGATCAT CTCGGGGCTT ATCGTAGTAG TGATCAAAGT TGTTGGAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu23488 | |
Clone ID Related Accession (Same CDS sequence) | NM_001038604.1 | |
Accession Version | NM_001038604.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-19 | |
Organism | Mus musculus(house mouse) | |
Product | C-type lectin domain family 5 member A isoform 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BY205833.1, CN670295.1, AK137482.1 and AK036697.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC104364.1, AA186015.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849375, SAMN00849380 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGAACTGGC ACATGATCAT CTCGGGGCTT ATCGTAGTAG TGATCAAAGT TGTTGGAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001033693.1 |
CDS | 180..752 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001038604.1 |
1 | ATGAACTGGC ACATGATCAT CTCGGGGCTT ATCGTAGTAG TGATCAAAGT TGTTGGAATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival. |
CLEC5A is a critical receptor in innate immunity against Listeria infection. |
CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo. |
CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis. |
Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies. |