Gene Symbol | Itgb8 |
Entrez Gene ID | 320910 |
Full Name | integrin beta 8 |
Synonyms | 4832412O06Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Itgb8 cDNA ORF clone
Gene Symbol | Itgb8 |
Entrez Gene ID | 320910 |
Full Name | integrin beta 8 |
Synonyms | 4832412O06Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_177290.3 | NP_796264.2 | integrin beta-8 precursor |
Pan troglodytes (chimpanzee) | ITGB8 | XP_518987.2 |
Gallus gallus (chicken) | ITGB8 | XP_003640734.2 |
Xenopus tropicalis (tropical clawed frog) | itgb8 | XP_002933344.2 |
ITGB8 | XP_001103130.1 | |
Mus musculus (house mouse) | Itgb8 | NP_796264.2 |
Rattus norvegicus (Norway rat) | Itgb8 | NP_001102196.1 |
Homo sapiens (human) | ITGB8 | NP_002205.1 |
Canis lupus familiaris (dog) | ITGB8 | XP_532487.1 |
Bos taurus (cattle) | ITGB8 | NP_001179804.1 |
Danio rerio (zebrafish) | itgb8 | XP_001919626.4 |
D-mannose induces regulatory T cells and suppresses immunopathology.
Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, Chen Q, Sun L, Chen ZJ, Chen W
Nature medicine23(9)1036-1045(2017 Sep)
A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis.
Ma S, Santhosh D, Kumar T P, Huang Z
Developmental cell41(4)366-381.e4(2017 05)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF. Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice.
Title: Integrin ?8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.
data show that the combination of cell lineage, immune mediators and both dietary and microbe-derived environmental factors shape intestinal dendritic cells into critical gatekeepers of TGF-beta-dependent immune responses through regulation of beta8 integrin expression
Title: ?8 Integrin Expression and Activation of TGF-? by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.
Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta.
Title: Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-?.
Nrp1 in endothelial cells suppresses TGFbeta activation and signaling by forming intercellular protein complexes with beta8 integrin.
Title: Neuropilin 1 balances ?8 integrin-activated TGF? signaling to control sprouting angiogenesis in the brain.
ITGB8 is involved in the embryo implantation process through regulation of activation of TGFB1
Title: Integrin beta 8 (ITGB8) regulates embryo implantation potentially via controlling the activity of TGF-B1 in mice.
The following Itgb8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgb8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13350 | |
Clone ID Related Accession (Same CDS sequence) | NM_177290.3 | |
Accession Version | NM_177290.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2304bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | integrin beta-8 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC120691.1. On or before Jan 29, 2007 this sequence version replaced XM_484197.3, XM_901358.2, XM_901353.2, XM_986421.1, XM_986389.1, XM_986358.1, XM_906066.2, XM_919665.2, XM_919658.2, NM_177290.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC120691.1, SRR1660815.282081.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGTGCGGCT CGGCCCTGGC TTTTCTGACT GCTGCACTGC TCTCTCTGCA CAACTGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_796264.2 |
CDS | 479..2782 |
Translation |
Target ORF information:
Target ORF information:
|
NM_177290.3 |
1 | ATGTGCGGCT CGGCCCTGGC TTTTCTGACT GCTGCACTGC TCTCTCTGCA CAACTGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
D-mannose induces regulatory T cells and suppresses immunopathology. |
A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. |