Gene Symbol | Nova2 |
Entrez Gene ID | 384569 |
Full Name | neuro-oncological ventral antigen 2 |
Synonyms | Gm1424 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nova2 cDNA ORF clone
gRNAs
Gene Symbol | Nova2 |
Entrez Gene ID | 384569 |
Full Name | neuro-oncological ventral antigen 2 |
Synonyms | Gm1424 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001029877.3 | NP_001025048.2 | RNA-binding protein Nova-2 |
An alternative splicing program promotes adipose tissue thermogenesis.
Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ
eLife5(2016 09)
NOVA2-mediated RNA regulation is required for axonal pathfinding during development.
Saito Y, Miranda-Rottmann S, Ruggiu M, Park CY, Fak JJ, Zhong R, Duncan JS, Fabella BA, Junge HJ, Chen Z, Araya R, Fritzsch B, Hudspeth AJ, Darnell RB
eLife5(2016 05)
NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.
Leggere JC, Saito Y, Darnell RB, Tessier-Lavigne M, Junge HJ, Chen Z
eLife5(2016 05)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Phenotypic analysis of the NOVA-deficient mice demonstrated increased adipose tissue thermogenesis and improved glycemia.
Title: An alternative splicing program promotes adipose tissue thermogenesis.
NOVA2 uniquely regulates alternative splicing of a coordinate set of transcripts encoding key components in cortical, brainstem and spinal axon guidance/outgrowth pathways during neural differentiation, with severe functional consequences in vivo.
Title: NOVA2-mediated RNA regulation is required for axonal pathfinding during development.
Together, these results demonstrate that the production of DCC splice variants controlled by NOVA has a crucial function during many stages of commissural neuron development.
Title: NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord.
These results reveal that Nova2 functions as an AS regulator in angiogenesis and is a novel member of the angioneurins family.
Title: The alternative splicing factor Nova2 regulates vascular development and lumen formation.
Nova2 regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development.
Title: Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling.
The following Nova2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nova2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu12301 | |
Clone ID Related Accession (Same CDS sequence) | NM_001029877.3 | |
Accession Version | NM_001029877.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1479bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-02 | |
Organism | Mus musculus(house mouse) | |
Product | RNA-binding protein Nova-2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ126741.1, CJ126972.1, BF466030.1, AC170864.2 and BF455773.1. On Sep 11, 2010 this sequence version replaced NM_001029877.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: lack of evidence for use of upstream AUG inferred exon combination :: PMID: 9789075 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCCCG AGGCCCCGGA TTCCCGCAAG AGACCCCTCG AGACGCCCCC CGAGGTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001025048.2 |
CDS | 193..1671 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGCCCG AGGCCCCGGA TTCCCGCAAG AGACCCCTCG AGACGCCCCC CGAGGTGGTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
An alternative splicing program promotes adipose tissue thermogenesis. |
NOVA2-mediated RNA regulation is required for axonal pathfinding during development. |
NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. |