Ppp1r11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1r11
Entrez Gene ID	76497
Full Name	protein phosphatase 1, regulatory (inhibitor) subunit 11
Synonyms	1500041B02Rik,AV117883,Hcgv,Tcte5,Tctex-5,Tctex5
General protein information	Preferred Names protein phosphatase 1, regulatory (inhibitor) subunit 11 Names protein phosphatase 1 regulatory subunit 11 T-complex testis expressed protein 5 t-complex testis-expressed 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17 B1\|17 19.16 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_029632.3	NP_083908.1	E3 ubiquitin-protein ligase PPP1R11

Pathways from BioSystems

Homologies

	PPP1R11	NP_001040601.1
Canis lupus familiaris (dog)	PPP1R11	XP_849792.1
Mus musculus (house mouse)	Ppp1r11	NP_083908.1
Danio rerio (zebrafish)	ppp1r11	NP_001017627.1
Pan troglodytes (chimpanzee)	PPP1R11	NP_001065285.1
Rattus norvegicus (Norway rat)	Ppp1r11	NP_997707.2
Homo sapiens (human)	PPP1R11	NP_068778.1
Bos taurus (cattle)	PPP1R11	NP_001093765.1
Xenopus tropicalis (tropical clawed frog)	ppp1r11	NP_001004815.1

Gene Ontology
Bibliography

Related articles in PubMed

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.
McKelvey AC, Lear TB, Dunn SR, Evankovich J, Londino JD, Bednash JS, Zhang Y, McVerry BJ, Liu Y, Chen BB
eLife5(2016 11)

PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related.
Cheng L, Pilder S, Nairn AC, Ramdas S, Vijayaraghavan S
PloS one4(3)e4861(2009)

Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse.
Han Y, Song XX, Feng HL, Cheung CK, Lam PM, Wang CC, Haines CJ
Asian journal of andrology10(2)219-26(2008 Mar)

Expression of a novel T-complex testis expressed 5 (Tctex5) in mouse testis, epididymis, and spermatozoa.
Han YB, Feng HL, Cheung CK, Lam PM, Wang CC, Haines CJ
Molecular reproduction and development74(9)1132-40(2007 Sep)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections.
Title: RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.

Data show a reciprocal relationship between protein phosphatase isoform PP1gamma2 and its regulator PPP1R11, and suggest that complex formation between them in testis may prevent proteolysis of PPP1R11 and germ cell apoptosis.
Title: PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related.

Tctex5 might be a specific protein phosphatase-1 inhibitor in sperm; various Tctex5 transcripts and isoforms and cellular locations imply its different roles in spermatogenesis.
Title: Expression of a novel T-complex testis expressed 5 (Tctex5) in mouse testis, epididymis, and spermatozoa.

The following Ppp1r11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07252	NM_029632.3 Latest version!	Mus musculus protein phosphatase 1, regulatory inhibitor subunit 11 (Ppp1r11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1r11 ( NM_029632.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083908.1 Mus musculus protein phosphatase 1, regulatory inhibitor subunit 11 (Ppp1r11), mRNA.

Price & Availability↑

CloneID	OMu07252
Clone ID Related Accession (Same CDS sequence)	NM_029632.3
Accession Version	NM_029632.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	E3 ubiquitin-protein ligase PPP1R11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR956641.9, BB842861.1, AK162607.1 and BQ032907.1. On Jun 15, 2010 this sequence version replaced NM_029632.2. ##Evidence-Data-START## Transcript exon combination :: AK162607.1, AK077455.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAGA CAGGGGCCGG GATAAGTGAG ACCGTCACTG AGACAACGGT TACTGAGACA 
ACGGTTACCG AGACAACCGA GCCAGAGAAT CAGAGCCTAA CTATGAAACT TCGGAAACGC 
AAGCCAGAGA AGAAGGTGGA GTGGTCCAGT GACACTGTGG ACAATGAGCA TATGGGGCGA 
CGCTCGTCGA AATGCTGCTG TATTTATGAG AAGCCTCGGG CCTTTGGCGA GAGCTCCACC 
GAGAGTGATG AGGATGAAGA AGAAGGCTGT AGTCATAAGC ACTGTGTACG GGGTCACCGC 
AAAGGACGGC GTCCTACAAC CCCAGCACCC ACCCCAACCA CTCCTCCACA GCCTCCTGAT 
CCCTCTAAGC CCCCTCCAGG ACCTATGCAG CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083908.1
CDS	287..682
Translation	MAETGAGISETVTETTVTETTVTETTEPENQSLTMKLRKRKPEKKVEWSSDTVDNEHMGRRSSKCCCIYEKPRAFGESSTESDEDEEEGCSHKHCVRGHRKGRRPTTPAPTPTTPPQPPDPSKPPPGPMQH

Target ORF information:

RefSeq Version	NM_029632.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 1, regulatory inhibitor subunit 11 (Ppp1r11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029632.3

ORF Insert Sequence:

ATGGCGGAGA CAGGGGCCGG GATAAGTGAG ACCGTCACTG AGACAACGGT TACTGAGACA 
ACGGTTACCG AGACAACCGA GCCAGAGAAT CAGAGCCTAA CTATGAAACT TCGGAAACGC 
AAGCCAGAGA AGAAGGTGGA GTGGTCCAGT GACACTGTGG ACAATGAGCA TATGGGGCGA 
CGCTCGTCGA AATGCTGCTG TATTTATGAG AAGCCTCGGG CCTTTGGCGA GAGCTCCACC 
GAGAGTGATG AGGATGAAGA AGAAGGCTGT AGTCATAAGC ACTGTGTACG GGGTCACCGC 
AAAGGACGGC GTCCTACAAC CCCAGCACCC ACCCCAACCA CTCCTCCACA GCCTCCTGAT 
CCCTCTAAGC CCCCTCCAGG ACCTATGCAG CACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.
eLife5(2016 11)
McKelvey AC,Lear TB,Dunn SR,Evankovich J,Londino JD,Bednash JS,Zhang Y,McVerry BJ,Liu Y,Chen BB

PP1gamma2 and PPP1R11 are parts of a multimeric complex in developing testicular germ cells in which their steady state levels are reciprocally related.
PloS one4(3)e4861(2009)
Cheng L,Pilder S,Nairn AC,Ramdas S,Vijayaraghavan S

Mutations of t-complex testis expressed gene 5 transcripts in the testis of sterile t-haplotype mutant mouse.
Asian journal of andrology10(2)219-26(2008 Mar)
Han Y,Song XX,Feng HL,Cheung CK,Lam PM,Wang CC,Haines CJ

Expression of a novel T-complex testis expressed 5 (Tctex5) in mouse testis, epididymis, and spermatozoa.
Molecular reproduction and development74(9)1132-40(2007 Sep)
Han YB,Feng HL,Cheung CK,Lam PM,Wang CC,Haines CJ

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

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Ppp1r11 cDNA ORF clone, Mus musculus(house mouse)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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